Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line

Chemical Communications

Volumn , Issue 4, 2005, Pages 516-518

  Bayer, Elena ^a,b   Thutewohl, Michael ^a,c   Christner, Claudia ^d   Tradler, Thomas ^d   Osterkamp, Frank ^d   Waldmann, Herbert ^a,c   Bayer, Peter ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b Interdisziplinares Zentrum Mag R   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

^d Jerini AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN; PEPTICINNAMIN DERIVATIVE; PEPTICINNAMIN E; PEPTIDYLPROLYL ISOMERASE INHIBITOR 1; PROLYL ENDOPEPTIDASE INHIBITOR; PROLYL ISOMERASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL LINE; CELL TRANSFORMATION; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ANALYSIS; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION;

EID: 13244271985     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b414037k     Document Type: Article

References (16)

1. (a) H. Miyashita, S. Mori, K. Motegi, M. Fukumoto and T. Uchida, Oncol. Rep., 2003, 10, 455-61;
2. (b) G. Wulf, A. Ryo, Y. C. Liou and K. P. Lu, Breast Cancer Res., 2003, 5, 76-82.
3. (a) K. P. Lu, S. D. Hanes and T. Hunter, Nature, 1996, 380, 544-547;
4. (b) J. F. Rippmann, S. Hobbie, C. Daiber, B. Guilliard, M. Bauer, J. Birk, H. Nar, P. Garin-Chesa, W. J. Rettig and A. Schnapp, Cell Growth Differ., 2000, 11, 409-416.
5. (a) F. Fujimori, K. Takahashi, C. Uchida and T. Uchida, Biochem. Biophys. Res. Commun., 1999, 265, 658-63;
6. (b) R. Maleszka, S. D. Hanes, R. L. Hackett, H. G. D. Couet and G. L. G. Miklos, Proc. Natl. Acad. Sci. USA, 1996, 93, 447-451.
7. A. Ryo, Y. C. Liou, K. P. Lu and G. Wulf, J. Cell Sci., 2003, 116, 773-83.
8. X. Z. Zhou, P. J. Lu, G. Wulf and K. P. Lu, Cell Mol. Life Sci., 1999, 56, 788-806; G. M. Wulf, A. Ryo, G. G. Wulf, S. W. Lee, T. Niu, V. Petkova and K. P. Lu, EMBO J., 2001, 20, 3459-7279.
9. X. Z. Zhou, P. J. Lu, G. Wulf and K. P. Lu, Cell Mol. Life Sci., 1999, 56, 788-806; G. M. Wulf, A. Ryo, G. G. Wulf, S. W. Lee, T. Niu, V. Petkova and K. P. Lu, EMBO J., 2001, 20, 3459-7279.
10. L. Hennig, C. Christner, M. Kipping, B. Schelbert, K. P. Rucknagel, S. Grabley, G. Kullertz and G. Fischer, Biochemistry, 1998, 37, 5953-60.
11. (a) Y. Zhang, S. Fussel, U. Reimer, M. Schutkowski and G. Fischer, Biochemistry, 2002, 41, 11868-77;
12. (b) T. Uchida, M. Takamiya, M. Takahashi, H. Miyashita, H. Ikeda, T. Terada, Y. Matsuo, M. Shirouzu, S. Yokoyama, F. Fujimori and T. Hunter, Chem. Biol., 2003, 10, 15-24;
13. (c) X. J. Wang, S. A. Hart, B. Xu, M. D. Mason, J. R. Goodell and F. Etzkorn, J. Org. Chem., 2003, 68, 2343-2349.
14. R. Breinbauer, I. Vetter and H. Waldmann, Angew. Chem., Int. Ed., 2002, 41, 2878-2890.
15. (a) M. Thutewohl, L. Kissau, B. Popkirova, I.-M. Karaguni, T. Novak, M. Bate, J. Kuhlmann, O. Müller and H. Waldmann, Bioorg. Med. Chem., 2003, 11, 2617-2626;
16. (b) M. Thutewohl and H. Waldmann, Bioorg. Med. Chem., 2003, 11, 2591-2615.