Geminin coordinates cell cycle and developmental control

Cell Cycle

Volumn 3, Issue 6, 2004, Pages 709-712

  Luo, Lingfei ^a   Kessel, Michael ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Cdt1; Cell cycle; Coordination; Embryonic patterning; Geminin; Hox; Polycomb

Indexed keywords

ANAPHASE PROMOTING COMPLEX; GEMININ; TRANSCRIPTION FACTOR;

CELL CYCLE; CELL DIVISION; CELL FATE; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CELL SPECIFICITY; EMBRYO DEVELOPMENT; GENE CLUSTER; GENE CONTROL; HOMEOBOX; HOX GENE; MORPHOGENESIS; NONHUMAN; PROTEIN FUNCTION; REVIEW; ZYGOTE;

EID: 13244259164     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.6.941     Document Type: Review

References (36)

1. Bell SP, Stillman B. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 1992; 357:114-5.
2. Coleman TR, Carpenter PB, Dunphy WG. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 1996; 87:53-63.
3. Maiorano D, Moreau J, Mechali M. XCDT1 is required for the assembly of prereplicative complexes in Xenopus laevis. Nature 2000; 404:560-1.
4. Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J 1999; 18:396-410,
5. Delmolino LM, Saha P, Dutta A. Multiple mechanisms regulate subcellular localization of human CDC6. J Biol Chem 2001; 276:26947-54.
6. Ishimi Y, Komamura-Kohno Y, You Z, Omori A, Kitagawa M. Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2. J Biol Chem 2000; 275:16253-41.
7. Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 2000; 290:2309-12.
8. McGarry TJ, Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 1998; 93:1043-53.
9. Hodgson B, Li A, Tada S, Blow JJ. Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Curr Biol 2002; 12:678-83.
10. Li A, Blow JJ. Nonproteolytic inactivation of geminin requires CDK-dependent ubiquitination. Nat Cell Biol 2004; 6:260-7.
11. Duboule D. Vertebrate Hox gene regulation: Clustering and/or colinearity? Curr Opin Genet Dev 1998; 8:514-18.
12. Krumlauf R. Hox genes in vertebrate development. Cell 1994; 78:191-200.
13. Kessel M, Gruss P. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 1991; 67:89-104.
14. Greer JM, Puetz J, Thomas KR, Capecchi MR. Maintenance of functional equivalence during paralogous Hox gene evolution. Nature 2000; 403:661-5.
15. Wellik DM, Capecchi MR. Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science 2003; 301:363-7.
16. Simon JA, Tamkun JW. Programming off and on states in chromatin: Mechanisms of Polycomb and trithorax group complexes. Curr Opin Genet Dev 2002; 12:210-8.
17. Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, et al. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev Cell 2002; 3:499-510.
18. Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M, Koseki H. A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development 1996; 122:1513-22.
19. Coré N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A, et al. Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 1997; 124:721-9.
20. Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, et al. Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 2002; 129:4171-83.
21. Care A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, et al. HOXB7 constitutively activates basic fibroblast growth factor in melanomas. Mol Cell Biol 1996; 16:4842-51.
22. Krosl J, Baban S, Krosl G, Rozenfeld S, Largman C, Sauvageau G. Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1. Oncogene 1998; 16:3403-12.
23. Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J 1998; 17:3714-25.
24. Krosl J, Sauvageau G. AP-1 complex is effector of Hox-induced cellular proliferation and transformation. Oncogene 2000; 19:5134-41.
25. Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003; 423:255-60.
26. Voncken JW, Roelen BA, Roefs M, de Vries S, Verhoeven E, Marino S, et al. Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci USA 2003; 100:2468-73.
27. Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M. The cell cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature 2004; 427:749-53.
28. Buchenau P, Hodgson J, Strutt H, Arndt-Jovin DJ. The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: Impact on models for silencing. J Cell Biol 1998; 141:469-81.
29. Gabellini D, Colaluca IN, Vodermaier HC, Biamonti G, Giacca M, Falaschi A, et al. Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. EMBO J 2003; 22:3715-24.
30. Francis NJ, Kingston RE. Mechanisms of transcriptional memory. Nat Rev Mol Cell Biol 2001; 2:409-21.
31. Kroll KL, Salic AN, Evans LM, Kirschner MW. Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development 1998; 125:3247-58.
32. Del Bene F, Tessmar-Raible K, Wittbrodt J. Direct interaction of geminin and Six3 in eye development. Nature 2004; 427:745-49.
33. Carl M, Loosli F, Wittbrodt J. Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. Development 2002; 129:4057-63.
34. Kulartz M, Kreitz S, Hiller E, Damoc EC, Przybylski M, Knippers R. Expression and phosphorylation of the replication regulator protein geminin. Biochem Biophys Res Commun 2003; 305:412-20.
35. Bateson W. Materials for the study of variation treated with special regard to discontinuity in the origin of species. London: Macmillan, 1894.
36. Lygerou Z, Nurse P. Cell cycle. License withheld-geminin blocks DNA replication. Science 2000; 290:2271-73.