-
1
-
-
0019467329
-
Mutation and cancer: A model for human carcinogenesis
-
Moolgavkar SH, Knudson AG Jr: Mutation and cancer: a model for human carcinogenesis. J Natl Cancer Inst 1981, 66:1037-1052.
-
(1981)
J Natl Cancer Inst
, vol.66
, pp. 1037-1052
-
-
Moolgavkar, S.H.1
Knudson Jr., A.G.2
-
2
-
-
1342266242
-
Fitting the two-stage model of carcinogenesis to nested case-control data on the Colorado Plateau uranium miners: Dependence on data assumptions
-
Haylock RG, Muirhead CR: Fitting the two-stage model of carcinogenesis to nested case-control data on the Colorado Plateau uranium miners: dependence on data assumptions. Radiat Environ Biophys 2004, 42:257-263.
-
(2004)
Radiat Environ Biophys
, vol.42
, pp. 257-263
-
-
Haylock, R.G.1
Muirhead, C.R.2
-
3
-
-
0142093085
-
The use of biologically based cancer risk models in radiation epidemiology
-
Krewski D, Zielinski JM, Hazelton WD, et al.: The use of biologically based cancer risk models in radiation epidemiology. Radiat Prot Dosimetry 2003, 104:367-376.
-
(2003)
Radiat Prot Dosimetry
, vol.104
, pp. 367-376
-
-
Krewski, D.1
Zielinski, J.M.2
Hazelton, W.D.3
-
4
-
-
0038718907
-
Somatic mosaicism and cancer: Inference based on a conditional Luria-Delbruck distribution
-
Frank SA: Somatic mosaicism and cancer: inference based on a conditional Luria-Delbruck distribution. J Theor Biol 2003, 223:405-412. An elegant article describing the accumulation of somatic mutations in embryonic development, with application to two-hit cancers.
-
(2003)
J Theor Biol
, vol.223
, pp. 405-412
-
-
Frank, S.A.1
-
5
-
-
1942500211
-
Cancer death statistics: Analogy between epidemiology and critical systems in physics
-
Floche M, Schwartz L: Cancer death statistics: analogy between epidemiology and critical systems in physics. Med Hypotheses 2004, 62:704-709. An analysis of French cancer death statistics, yielding a large difference between cancers of early and late ages.
-
(2004)
Med Hypotheses
, vol.62
, pp. 704-709
-
-
Floche, M.1
Schwartz, L.2
-
6
-
-
2542643176
-
Genetic variation in cancer predisposition: Mutational decay of a robust genetic control network
-
Frank SA: Genetic variation in cancer predisposition: mutational decay of a robust genetic control network. Proc Natl Acad Sci U S A 2004, 101:8061-8065. An interesting analysis of cancer viewed as a control system. Predisposition mutations in the population are correlated with the number of stages in multistage carcinogenesis.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8061-8065
-
-
Frank, S.A.1
-
7
-
-
0344844367
-
Multistage carcinogenesis and the incidence of human cancer
-
Moolgavkar SH, Luebeck EG: Multistage carcinogenesis and the incidence of human cancer. Genes Chromosomes Cancer 2003, 38:302-306. The paper uses the Moolgavkar-Venzon-Knudson multistage carcinogenesis model in the context of the discussion of the role of genetic instability in cancer progression.
-
(2003)
Genes Chromosomes Cancer
, vol.38
, pp. 302-306
-
-
Moolgavkar, S.H.1
Luebeck, E.G.2
-
8
-
-
0242610896
-
Power law distribution of chromosome aberrations in cancer
-
Frigyesi A, Gisselsson D, Mitelman F, et al.: Power law distribution of chromosome aberrations in cancer. Cancer Res 2003, 63:7094-7097. The pattern of chromosome aberrations in various cancers is analyzed, and a model is proposed that explains the observed power law distribution.
-
(2003)
Cancer Res
, vol.63
, pp. 7094-7097
-
-
Frigyesi, A.1
Gisselsson, D.2
Mitelman, F.3
-
9
-
-
2542640835
-
A model for karyotypic evolution in testicular germ cell tumors
-
Frigyesi A, Gisselsson D, Hansen GB, et al.: A model for karyotypic evolution in testicular germ cell tumors. Genes Chromosomes Cancer 2004, 40:172-178. A technique is developed, based on statistical analysis of aberrations in cancer, which allows tracing the sequence of chromosome changes in a particular cancer.
-
(2004)
Genes Chromosomes Cancer
, vol.40
, pp. 172-178
-
-
Frigyesi, A.1
Gisselsson, D.2
Hansen, G.B.3
-
11
-
-
0347504530
-
Mathematical modelling of comedo ductal carcinoma in situ of the breast
-
Franks SJ, Byrne HM, Mudhar HS, et al.: Mathematical modelling of comedo ductal carcinoma in situ of the breast. Math Med Biol 2003, 20:277-308.
-
(2003)
Math Med Biol
, vol.20
, pp. 277-308
-
-
Franks, S.J.1
Byrne, H.M.2
Mudhar, H.S.3
-
12
-
-
0346031985
-
Modelling the early growth of ductal carcinoma in situ of the breast
-
Franks SJ, Byrne HM, King JR, et al.: Modelling the early growth of ductal carcinoma in situ of the breast. J Math Biol 2003, 47:424-452. The article presents a mechanistic model of an avascular cylindrical tumor in a duct.
-
(2003)
J Math Biol
, vol.47
, pp. 424-452
-
-
Franks, S.J.1
Byrne, H.M.2
King, J.R.3
-
13
-
-
0042562209
-
Interactions between a uniformly proliferating tumour and its surroundings: Uniform material properties
-
Franks SJ, King JR: Interactions between a uniformly proliferating tumour and its surroundings: uniform material properties. Math Med Biol 2003, 20:47-89.
-
(2003)
Math Med Biol
, vol.20
, pp. 47-89
-
-
Franks, S.J.1
King, J.R.2
-
14
-
-
0842281982
-
Modelling solid tumour growth using the theory of mixtures
-
Byrne H, Preziosi L: Modelling solid tumour growth using the theory of mixtures. Math Med Biol 2003, 20:341-366.
-
(2003)
Math Med Biol
, vol.20
, pp. 341-366
-
-
Byrne, H.1
Preziosi, L.2
-
15
-
-
0842348242
-
Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sites
-
Owen MR, Byrne HM, Lewis CE: Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sites. J Theor Biol 2004, 226:377-391. This article presents a mechanistic model of an avascular growing tumor and studies how drugs can reduce tumor size.
-
(2004)
J Theor Biol
, vol.226
, pp. 377-391
-
-
Owen, M.R.1
Byrne, H.M.2
Lewis, C.E.3
-
16
-
-
1642348723
-
Mathematical modelling of the spatio-temporal response of cytotoxic T-lymphocytes to a solid tumour
-
Matzavinos A, Chaplain MA, Kuznetsov VA: Mathematical modelling of the spatio-temporal response of cytotoxic T-lymphocytes to a solid tumour. Math Med Biol 2004, 21:1-34. A model is presented that describes the interactions of an avascular tumor with the immune system.
-
(2004)
Math Med Biol
, vol.21
, pp. 1-34
-
-
Matzavinos, A.1
Chaplain, M.A.2
Kuznetsov, V.A.3
-
17
-
-
1342310604
-
Analysis of a model of a virus that replicates selectively in tumor cells
-
Friedman A, Tao Y: Analysis of a model of a virus that replicates selectively in tumor cells. J Math Biol 2003, 47:391-423.
-
(2003)
J Math Biol
, vol.47
, pp. 391-423
-
-
Friedman, A.1
Tao, Y.2
-
18
-
-
0142124428
-
The impact of "search precision" in an agent-based tumor model
-
Mansury Y, Deisboeck TS: The impact of "search precision" in an agent-based tumor model. J Theor Biol 2003, 224:325-337. This article presents a model of tumor cells, which can migrate depending on the nutrition level and toxicity, using a local search algorithm.
-
(2003)
J Theor Biol
, vol.224
, pp. 325-337
-
-
Mansury, Y.1
Deisboeck, T.S.2
-
19
-
-
0142248836
-
Does tumor growth follow a "universal law"?
-
Guiot C, Degiorgis PG, Delsanto PP, et al.: Does tumor growth follow a "universal law"? J Theor Biol 2003, 225:147-151. This article talks about similarities between prevascular tumor growth and ontogenic growth of organisms, claiming that they obey the same law.
-
(2003)
J Theor Biol
, vol.225
, pp. 147-151
-
-
Guiot, C.1
Degiorgis, P.G.2
Delsanto, P.P.3
-
20
-
-
2342445433
-
Mathematical modelling of tumour-induced angiogenesis: Network growth and structure
-
Chaplain M, Anderson A: Mathematical modelling of tumour-induced angiogenesis: network growth and structure. Cancer Treat Res 2004, 117:51-75. An excellent review of mathematical modeling of angiogenesis, also describing new advances in the authors' modeling of tumor neovasculature formation.
-
(2004)
Cancer Treat Res
, vol.117
, pp. 51-75
-
-
Chaplain, M.1
Anderson, A.2
-
21
-
-
0038306402
-
A multiphase model describing vascular tumour growth
-
Breward CJ, Byrne HM, Lewis CE: A multiphase model describing vascular tumour growth. Bull Math Biol 2003, 65:609-640. A mechanistic model of vascular tumor growth describing cell migration in response to stress and lack of nutrition.
-
(2003)
Bull Math Biol
, vol.65
, pp. 609-640
-
-
Breward, C.J.1
Byrne, H.M.2
Lewis, C.E.3
-
22
-
-
0042863949
-
A reinforced random walk model of tumour angiogenesis and anti-angiogenic strategies
-
Plank MJ, Sleeman BD: A reinforced random walk model of tumour angiogenesis and anti-angiogenic strategies. Math Med Biol 2003, 20:135-181. An individual cell-based mathematical model of angiogenesis is developed and analyzed in the context of the antiangiogenic potential of angiostatin.
-
(2003)
Math Med Biol
, vol.20
, pp. 135-181
-
-
Plank, M.J.1
Sleeman, B.D.2
-
23
-
-
0142248828
-
A cellular automaton model for tumour growth in inhomogeneous environment
-
Alarcon T, Byrne HM, Maini PK: A cellular automaton model for tumour growth in inhomogeneous environment. J Theor Biol 2003, 225:257-274. This article combines an engineering approach to modeling the blood flow through the vasculature with a cellular automaton model of tumor growth.
-
(2003)
J Theor Biol
, vol.225
, pp. 257-274
-
-
Alarcon, T.1
Byrne, H.M.2
Maini, P.K.3
-
24
-
-
2442568750
-
Towards whole-organ modelling of tumour growth
-
Alarcon T, Byrne HM, Maini PK: Towards whole-organ modelling of tumour growth. Prog Biophys Mol Biol 2004, 85:451-472. A nice article that describes the modeling of tumor growth in which both vascular adaptation and cell-cycle dynamics are taken into account.
-
(2004)
Prog Biophys Mol Biol
, vol.85
, pp. 451-472
-
-
Alarcon, T.1
Byrne, H.M.2
Maini, P.K.3
-
25
-
-
2342520039
-
New insights into vascular collapse and growth dynamics in solid tumors
-
Araujo RP, McElwain DL: New insights into vascular collapse and growth dynamics in solid tumors. J Theor Biol 2004, 228:335-346. A good example of how a mathematical model of tumorigenesis can be used to address interesting biological questions.
-
(2004)
J Theor Biol
, vol.228
, pp. 335-346
-
-
Araujo, R.P.1
McElwain, D.L.2
-
26
-
-
0242322492
-
The universal dynamics of tumor growth
-
Bru A, Albertos S, Luis Subiza J, et al.: The universal dynamics of tumor growth. Biophys J 2003, 85:2948-2961. An excellent article on tumor growth that combines a mathematical model with experiments.
-
(2003)
Biophys J
, vol.85
, pp. 2948-2961
-
-
Bru, A.1
Albertos, S.2
Luis Subiza, J.3
-
27
-
-
0032170064
-
Continuous and discrete mathematical models of tumor-induced angiogenesis
-
Anderson AR, Chaplain MA: Continuous and discrete mathematical models of tumor-induced angiogenesis. Bull Math Biol 1998, 60:857-899.
-
(1998)
Bull Math Biol
, vol.60
, pp. 857-899
-
-
Anderson, A.R.1
Chaplain, M.A.2
-
28
-
-
0742304073
-
Simulation of tumor-induced angiogenesis and its response to anti-angiogenic drug treatment: Mode of drug delivery and clearance rate dependencies
-
Tee D, DiStefano J 3rd: Simulation of tumor-induced angiogenesis and its response to anti-angiogenic drug treatment: mode of drug delivery and clearance rate dependencies. J Cancer Res Clin Oncol 2004, 130:15-24. This article uses the Anderson-Chaplain model of angiogenic growth to study different regimens and dosages of antiangiogenic treatment.
-
(2004)
J Cancer Res Clin Oncol
, vol.130
, pp. 15-24
-
-
Tee, D.1
DiStefano III, J.2
-
29
-
-
0242607878
-
Virtual and real brain tumors: Using mathematical modeling to quantify glioma growth and invasion
-
Swanson KR, Bridge C, Murray JD, et al.: Virtual and real brain tumors: using mathematical modeling to quantify glioma growth and invasion. J Neurol Sci 2003, 216:1-10.
-
(2003)
J Neurol Sci
, vol.216
, pp. 1-10
-
-
Swanson, K.R.1
Bridge, C.2
Murray, J.D.3
-
30
-
-
0036941569
-
Quantifying efficacy of chemotherapy of brain tumors with homogeneous and heterogeneous drug delivery
-
Swanson KR, Alvord EC Jr, Murray JD: Quantifying efficacy of chemotherapy of brain tumors with homogeneous and heterogeneous drug delivery. Acta Biotheor 2002, 50:223-237.
-
(2002)
Acta Biotheor
, vol.50
, pp. 223-237
-
-
Swanson, K.R.1
Alvord Jr., E.C.2
Murray, J.D.3
-
31
-
-
1942438998
-
A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan
-
Evans ND, Errington RJ, Shelley M, et al.: A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan. Math Biosci 2004, 189:185-217. This model describes how the effect of topotecan treatment depends on the dosage and method of administration, and puts emphasis on the structural identifiability analysis.
-
(2004)
Math Biosci
, vol.189
, pp. 185-217
-
-
Evans, N.D.1
Errington, R.J.2
Shelley, M.3
-
32
-
-
1642344491
-
A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction
-
Moore H, Li NK: A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction. J Theor Biol 2004, 227:513-523. This model studies the interaction among naive and effector T cells and CML cancer cells, and provides a careful analysis of the parameter dependence of the results.
-
(2004)
J Theor Biol
, vol.227
, pp. 513-523
-
-
Moore, H.1
Li, N.K.2
-
33
-
-
13144268858
-
Computational approaches to study oncolytic virus therapy: Insights and challenges
-
Wodarz D: Computational approaches to study oncolytic virus therapy: insights and challenges. Gene Ther Mol Biol 2004, 8:137-146. This article describes a model that helps find optimal characteristics of viruses to result in cancer remission.
-
(2004)
Gene Ther Mol Biol
, vol.8
, pp. 137-146
-
-
Wodarz, D.1
-
34
-
-
0037375761
-
Predicting the concentration level of an anti-cancer drug during treatment of a living organism
-
Moxnes JF, Hausken K: Predicting the concentration level of an anti-cancer drug during treatment of a living organism. Med Hypotheses 2003, 60:498-500. This article presents an empirical model for determining drug concentration depending on intake parameters.
-
(2003)
Med Hypotheses
, vol.60
, pp. 498-500
-
-
Moxnes, J.F.1
Hausken, K.2
-
35
-
-
1842453122
-
The dynamics of cell proliferation
-
Moxnes JF, Haux J, Hausken K: The dynamics of cell proliferation. Med Hypotheses 2004, 62:556-563. This article presents an age-structured model of a cell population and compares it with experimental results for digitoxin-treated cells.
-
(2004)
Med Hypotheses
, vol.62
, pp. 556-563
-
-
Moxnes, J.F.1
Haux, J.2
Hausken, K.3
-
36
-
-
0842282616
-
Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents
-
Simeoni M, Magni P, Cammia C, et al.: Predictive pharmacokinetic- pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents. Cancer Res 2004, 64:1094-1101. An empirical model predicting the drug concentration depending on intake parameters.
-
(2004)
Cancer Res
, vol.64
, pp. 1094-1101
-
-
Simeoni, M.1
Magni, P.2
Cammia, C.3
-
37
-
-
1342332020
-
A mathematical model for analysis of the cell cycle in cell lines derived from human tumors
-
Basse B, Baguley BC, Marshall ES, et al.: A mathematical model for analysis of the cell cycle in cell lines derived from human tumors. J Math Biol 2003, 47:295-312. This article models a population of cells going through the cell cycle; the results are compared with flow-cytometry measurements of the amount of the DNA in each phase.
-
(2003)
J Math Biol
, vol.47
, pp. 295-312
-
-
Basse, B.1
Baguley, B.C.2
Marshall, E.S.3
-
38
-
-
2442536949
-
Modelling cell population growth with applications to cancer therapy in human tumour cell lines
-
Basse B, Baguley BC, Marshall ES, et al.: Modelling cell population growth with applications to cancer therapy in human tumour cell lines. Prog Biophys Mol Biol 2004, 85:353-368.
-
(2004)
Prog Biophys Mol Biol
, vol.85
, pp. 353-368
-
-
Basse, B.1
Baguley, B.C.2
Marshall, E.S.3
-
39
-
-
9644288331
-
Cytostatic and cytotoxic effects of topotecan decoded by a novel mathematical simulation approach
-
Lupi M, Matera G, Branduardi D, et al.: Cytostatic and cytotoxic effects of topotecan decoded by a novel mathematical simulation approach. Cancer Res 2004, 64:2825-2832. This article uses modeling to predict the outcome of various treatment schedules in the context of ovarian cancer cell lines.
-
(2004)
Cancer Res
, vol.64
, pp. 2825-2832
-
-
Lupi, M.1
Matera, G.2
Branduardi, D.3
-
40
-
-
0001167877
-
Simulating cancer cell kinetics after drug treatment: Application to cisplatin on ovarian carcinoma
-
Montalenti F, Sena G, Capella P, et al.: Simulating cancer cell kinetics after drug treatment: application to cisplatin on ovarian carcinoma. Phys Rev E Stat Nonlin Soft Matter Phys 1999, 57:5877-5887.
-
(1999)
Phys Rev E Stat Nonlin Soft Matter Phys
, vol.57
, pp. 5877-5887
-
-
Montalenti, F.1
Sena, G.2
Capella, P.3
-
41
-
-
0141481981
-
A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: Implications for antiangiogenic therapy
-
Stoll BR, Migliorini C, Kadambi A, et al.: A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy. Blood 2003, 102:2555-2561. This article presents the first model aimed at determining the role of circulating endothelial progenitor cells in tumor neovascularization.
-
(2003)
Blood
, vol.102
, pp. 2555-2561
-
-
Stoll, B.R.1
Migliorini, C.2
Kadambi, A.3
-
42
-
-
0042242676
-
The glycolytic phenotype in carcinogenesis and tumor invasion: Insights through mathematical models
-
Gatenby RA, Gawlinski ET: The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Res 2003, 63:3847-3854. This article presents a mathematical model based on the acid-mediated tumor invasion hypothesis.
-
(2003)
Cancer Res
, vol.63
, pp. 3847-3854
-
-
Gatenby, R.A.1
Gawlinski, E.T.2
-
43
-
-
0141988694
-
An evolutionary model of carcinogenesis
-
Gatenby RA, Vincent TL: An evolutionary model of carcinogenesis. Cancer Res 2003, 63:6212-6220. This article talks about cancer heterogeneity and evolvability of cancers using the elegant theory of fitness generating function.
-
(2003)
Cancer Res
, vol.63
, pp. 6212-6220
-
-
Gatenby, R.A.1
Vincent, T.L.2
-
44
-
-
0642349133
-
Application of quantitative models from population biology and evolutionary game theory to tumor therapeutic strategies
-
Gatenby RA, Vincent TL: Application of quantitative models from population biology and evolutionary game theory to tumor therapeutic strategies. Mol Cancer Ther 2003, 2:919-927.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 919-927
-
-
Gatenby, R.A.1
Vincent, T.L.2
-
45
-
-
1842581858
-
An error catastrophe in cancer?
-
Sole RV, Deisboeck TS: An error catastrophe in cancer? J Theor Biol 2004, 228:47-54. This article uses quasispecies theory to explain the competition between stable and unstable phenotypes in cancer.
-
(2004)
J Theor Biol
, vol.228
, pp. 47-54
-
-
Sole, R.V.1
Deisboeck, T.S.2
-
46
-
-
0003291373
-
Mutation-selection networks of cancer initiation: Tumor suppressor genes and chromosomal instability
-
Komarova NL, Sengupta A, Nowak MA: Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability. J Theor Biol 2003, 223:433-450. This article considers the inactivation of a tumor suppressor gene with and without chromosomal instability and calculates the rates of cancer initiation for different cases.
-
(2003)
J Theor Biol
, vol.223
, pp. 433-450
-
-
Komarova, N.L.1
Sengupta, A.2
Nowak, M.A.3
-
47
-
-
2342539600
-
The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer
-
Komarova NL, Wodarz D: The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer. Proc Natl Acad Sci U S A 2004, 101:7017-7021. This article considers the role of chromosome loss in the context of tumor suppressor gene inactivation and calculates the optimal (for cancer) rate of chromosome loss.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 7017-7021
-
-
Komarova, N.L.1
Wodarz, D.2
-
48
-
-
13144259661
-
Does cancer solve an optimization problem?
-
Komarova N: Does cancer solve an optimization problem? Cell Cycle 2004, 3. This article explains that chromosomal instability does not occur in cancer simply because it leads to higher mutability, but requires other reasons, like environment or mutagens.
-
(2004)
Cell Cycle
, vol.3
-
-
Komarova, N.1
-
49
-
-
0142219899
-
Evolutionary dynamics of mutator phenotypes in cancer: Implications for chemotherapy
-
Komarova NL, Wodarz D: Evolutionary dynamics of mutator phenotypes in cancer: implications for chemotherapy. Cancer Res 2003, 63:6635-6642. This article examines the role of environmental stress for the selection of genomic instability. Costs and benefits of genomic instability are discussed.
-
(2003)
Cancer Res
, vol.63
, pp. 6635-6642
-
-
Komarova, N.L.1
Wodarz, D.2
-
50
-
-
1542374198
-
Problems of somatic mutation and cancer
-
Frank SA, Nowak MA: Problems of somatic mutation and cancer. Bioessays 2004, 26:291-299. A comprehensive review of the research of the Frank and Nowak group on cancer as a process of somatic evolution.
-
(2004)
Bioessays
, vol.26
, pp. 291-299
-
-
Frank, S.A.1
Nowak, M.A.2
-
51
-
-
0141639747
-
Stochastic elimination of cancer cells
-
Michor F, Nowak MA, Frank SA, et al.: Stochastic elimination of cancer cells. Proc R Soc Lond B Biol Sci 2003, 270:2017-2024. This article presents a stochastic model of accumulation of mutations and talks about design principles capable of reducing the risk of cancer.
-
(2003)
Proc R Soc Lond B Biol Sci
, vol.270
, pp. 2017-2024
-
-
Michor, F.1
Nowak, M.A.2
Frank, S.A.3
-
52
-
-
0242298209
-
Somatic selection for and against cancer
-
Michor F, Frank SA, May RM, et al.: Somatic selection for and against cancer. J Theor Biol 2003, 225:377-382. This article discusses how tissue compartment size may influence the rate at which mutations are accumulated.
-
(2003)
J Theor Biol
, vol.225
, pp. 377-382
-
-
Michor, F.1
Frank, S.A.2
May, R.M.3
-
53
-
-
10944225680
-
Linear model of colon cancer initiation
-
Michor F, Iwasa Y, Rajagopalan H, et al.: Linear model of colon cancer initiation. Cell Cycle 2004, 3:358-362.
-
(2004)
Cell Cycle
, vol.3
, pp. 358-362
-
-
Michor, F.1
Iwasa, Y.2
Rajagopalan, H.3
-
54
-
-
0344736666
-
The linear process of somatic evolution
-
Nowak MA, Michor F, Iwasa Y: The linear process of somatic evolution. Proc Natl Acad Sci U S A 2003, 100:14966-14969. This article presents a stochastic model of tissue renewal and discusses implications for cancer.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14966-14969
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Nowak, M.A.1
Michor, F.2
Iwasa, Y.3
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55
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1642292422
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Pretumor progression: Clonal evolution of human stem cell populations
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Calabrese P, Tavare S, Shibata D: Pretumor progression: clonal evolution of human stem cell populations. Am J Pathol 2004, 164:1337-1346. This article presents a model of neutral evolution inside colon stem niches and relates this to the multistage carcinogenesis hypothesis.
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(2004)
Am J Pathol
, vol.164
, pp. 1337-1346
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Calabrese, P.1
Tavare, S.2
Shibata, D.3
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56
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1642396519
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Enhanced stem cell survival in familial adenomatous polyposis
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Kim KM, Calabrese P, Tavare S, et al.: Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol 2004, 164:1369-1377. This article uses the stem niche dynamical model to explain the experimentally observed methylation pattern diversity in people with and without FAP.
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(2004)
Am J Pathol
, vol.164
, pp. 1369-1377
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Kim, K.M.1
Calabrese, P.2
Tavare, S.3
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