The use of biologically based cancer risk models in radiation epidemiology

Radiation Protection Dosimetry

Volumn 104, Issue 4, 2003, Pages 367-376

  Krewski, D ^a   Zielinski, J M ^a,b   Hazelton, W D ^c   Garner, M J ^a   Moolgavkar, S H ^c  

^a UNIVERSITY OF OTTAWA   (Canada)

^b Environmental Health Center   (Canada)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TIN; URANIUM;

ANALYTICAL PARAMETERS; ATOMIC BOMB SURVIVOR; BIOLOGICAL MODEL; CANADA; CANCER CELL; CANCER EPIDEMIOLOGY; CANCER RISK; CELL TRANSFORMATION; CHINESE; CLONAL VARIATION; COHORT ANALYSIS; DATA ANALYSIS; EPIDEMIOLOGICAL DATA; HUMAN; JAPAN; LIFESPAN; MALIGNANT TRANSFORMATION; MATHEMATICAL MODEL; MINER; RADIATION CARCINOGENESIS; RADIATION DOSE; RADIATION EXPOSURE; REGISTER; REVIEW; RISK ASSESSMENT; SOMATIC CELL; UNITED STATES; VALIDATION PROCESS; WORKER;

EID: 0142093085     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.rpd.a006200     Document Type: Review

References (37)

1. Moolgavkar, S. H. and Knudson, A. G. Jr. Mutation and cancer: a model for human carcinogenesis. J. Natl. Cancer Inst. 66, 1037-1052 (1981).
2. Armitage, P. and Doll, R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br. J. Cancer 8, 1-12 (1954).
3. Armitage, P. Multistage models of carcinogenesis. Environ. Health Perspect. 63, 195-201 (1985).
4. Armitage, P. and Doll, R. Stochastic models for carcinogenesis. Proceedings of the Fourth Berkeley Symposium on Mathematical Statistics and Probability, Vol. IV. (Berkeley and Los Angeles: University of California Press) pp. 19-38 (1961).
5. Whittemore, A. S. Quantitative theories of oncogenesis. Adv. Cancer Res. 27, 55-88 (1978).
6. Cook, P. J., Doll, R. and Fellingham, S. A. A mathematical model for the age distribution of cancer in man. Int. J. Cancer 4, 93-112 (1969).
7. Armitage, P. and Doll, R. A two-stage theory of carcinogenesis in relation to the age distribution of human cancer. Br. J. Cancer 11, 161-169 (1957).
8. Hazelton, W. D., Luebeck, E. G., Heidenreich, W. F. and Moolgavkar, S. H. Analysis of a historical cohort of Chinese tin miners with arsenic, radon, cigarette smoke, and pipe smoke exposures using the biologically based two-stage clonal expansion model. Radiat. Res. 156, 78-94 (2001).
9. Fisher, J. C. Multiple mutation theory of carcinogenesis. Nature 181, 651-652 (1958).
10. Luebeck, E. G., Curtis, S. B., Cross, F. T. and Moolgavkar, S. H. Two-stage model of radon-induced malignant lung tumors in rats: effects of cell killing. Radiat. Res. 145, 163-173 (1996).
11. Moolgavkar, S. H. The Neyman-Scott carcinogenesis model for low-dosage extrapolation. Math. Biosci. 50, 155-156 (2002).
12. Heidenreich, W. F., Jacob, P., Paretzke, H. G., Cross, F. T. and Dagle, G. E. Two-step model for the risk of fatal and incidental lung tumors in rats exposed to radon. Radiat. Res. 151, 209-217 (1999).
13. Heidenreich, W. F., Wellmann, J., Jacob, P. and Wichmann, H. E. Mechanistic modelling in large case-control studies of lung cancer risk from smoking. Stat. Med. 21, 3055-3070 (2002).
14. Moolgavkar, S. H. Carcinogenesis models: an overview. Basic Life Sci. 58, 387-396 (1991).
15. Sielken, R. L. Jr., Bretzlaff, R. S. and Stevenson, D. E. Incorporating additional biological phenomena into two-stage cancer models. Prog. Clin. Biol. Res. 387, 237-260 (1994).
16. Moolgavkar, S., Krewski, D. and Schwarz, M. Mechanisms of carcinogenesis and biologically based models for estimation and prediction of risk. IARC Sci. Publ. 131, 179-237 (1999).
17. Heidenreich, W. F. and Paretzke, H. G. The two-stage clonal expansion model as an example of a biologically based model of radiation-induced cancer. Radiat. Res. 156, 678-681 (2001).
18. Moolgavkar, S. H. and Luebeck, G. Two-event model for carcinogenesis: biological, mathematical, and statistical considerations. Risk Anal. 10, 323-341 (1990).
19. Kai, M., Luebeck, E. G. and Moolgavkar, S. H. Analysis of the incidence of solid cancer among atomic bomb survivors using a two-stage model of carcinogenesis. Radiat. Res. 148, 348-358 (1997).
20. Moolgavkar, S. H., Dewanji, A. and Venzon, D. J. A stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor. Risk Anal. 8, 383-392 (1988).
21. Heidenreich, W. F., Luebeck, E. G. and Moolgavkar, S. H. Some properties of the hazard function of the two-mutation clonal expansion model. Risk Anal. 17, 391-399 (1997).
22. Luebeck, E. G. and Hazelton, W. D. Multistage carcinogenesis and radiation. J. Radiol. Prot. 22, A43-A49 (2002).
23. Zheng, Q., Lutz, W. K. and Gaylor, D. W. A carcinogenesis model describing mutational events at the DNA adduct level. Math. Biosci. 144, 23-44 (1997).
24. Luebeck, E. G. and Moolgavkar, S. H. Multistage carcinogenesis and the incidence of colorectal cancer. Proc. Natl. Acad. Sci. USA 99, 15095-15100 (2002).
25. Hazelton, W. D., Moolgavkar, S. H., Curtus, S. B., Zielinski, J. M., Ashmore, J. P., and Krewski, D. Biologically based analysis of lung cancer incidence in a large Canadian occupational cohort with low-dose ionizing radiation exposure, and comparison with Japanese atomic bomb survivors. Submitted.
26. Heidenreich, W. F., Brugmans, M. J., Little, M. P., Leenhouts, H. P., Paretzke, H. G., Morin, M., and Lafuma, J. Analysis of lung tumour risk in radon-exposed rats: tin intercomparison of multi-step modelling. Radiat. Environ. Biophys. 39, 253-264 (2000).
27. Krewski, D. and Thomas, R. D. Carcinogenic mixtures. Risk Anal. 12, 105-113 (1992).
28. Zielinski, J., Kodell, R. and Krewski, D. Interaction between two carcinogens in the two-stage clonal expansion model of carcinogenesis. J. Epidemiol. Biostat. 6, 219-228 (2001).
29. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and Effects of Ionizing Radiation: United Nations Scientific Committee on the Effects of Atomic Radiation UNSCEAR 2000 Report to the General Assembly with Scientific Annexes. Annex H. (Vienna: UNSCEAR) (2000).
30. Kodell, R. L., Krewski, D. and Zielinski, J. M. Additive and multiplicative relative risk in the two-stage clonal expansion model of carcinogenesis. Risk Anal. 11, 483-490 (1991).
31. Luebeck, E. G., Heidenreich, W. F., Hazelton, W. D., Paretzke, H. G. and Moolgavkar, S. H. Biologically based analysis of the data for the Colorado uranium miners cohort: age, dose and dose-rate effects. Radiat. Res. 152, 339-351 (1999).
32. Moolgavkar, S. H., Luebeck, E. G., Krewski, D. and Zielinski, J. M. Radon, cigarette smoke, and lung cancer: a re-analysis of the Colorado Plateau uranium miners' data. Epidemiology 4, 204-217 (1993).
33. Shimizu, Y., Schull, W. J. and Kato, H. Cancer risk among atomic bomb survivors. The RERF Life Span Study. Radiation Effects Research Foundation. J. Am. Med. Assoc. 264, 601-604 (1990).
34. Heidenreich, W., Jacob, P. and Paretzke, H. G. Exact solutions of the clonal expansion model and their application to the incidence of solid tumors of the atomic bomb survivors. Radiat. Environ. Biophys. 36, 45-58 (1997).
35. Heidenreich, W. F., Luebeck, E. G., Hazelton, W. D., Paretzke, H. G. and Moolgavkar, S. H. Multistage models and the incidence of cancer in the cohort of atomic bomb survivors. Radiat. Res. 158, 607-614 (2002).
36. Sont, W. N., Zielinski, J. M., Ashmore, J. P., Jiang, H., Krewski, D., Fair, M. E., Band, P. R. and Letourneau, E. G. First analysis of cancer incidence and occupational radiation exposure based on the National Dose Registry of Canada. Am. J. Epidemiol. 153, 309-318 (2001).
37. Ashmore, J. P., Krewski, D., Zielinski, J. M., Jiang, H., Semenciw, R. and Band, P. R. First analysis of mortality and occupational radiation exposure based on the National Dose Registry of Canada. Am. J. Epidemiol. 148, 564-574 (1998).