Frequent deletion and 5' CpG island methylation of the p16 gene in primary malignant lymphoma of the brain

Cancer Research

Volumn 58, Issue 6, 1998, Pages 1231-1237

  Zhang, Shu Jing ^a   Endo, Sumio ^a   Ichikawa, Tomio ^a   Washiyama, Kazuo ^a   Kumanishi, Toshiro ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16;

ARTICLE; BRAIN LYMPHOMA; CONTROLLED STUDY; GENE ACTIVATION; GENE DELETION; GENE LOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; METHYLATION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

BRAIN NEOPLASMS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA, NEOPLASM; GENE DELETION; GENES, P16; HUMANS; LYMPHOMA, B-CELL; LYMPHOMA, LARGE-CELL, DIFFUSE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TUMOR SUPPRESSOR PROTEINS;

EID: 0032521170     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., III, Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC) 264: 436-440, 1994.
2. Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., and Carson, D. A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers Nature (Lond.), 368: 753-756, 1994.
3. Serrano, M., Hannon, G. J., and Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366: 704-707, 1993.
4. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature (Lond.), 371: 257-261, 1994.
5. INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev., 8: 2939-2952, 1994.
6. Lo, K-W., Huang, D. P., and Lau, K-M. p16 gene alterations in nasopharyngeal carcinoma. Cancer Res., 55: 2039-2043, 1995.
7. INK4B/ MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res., 55: 1448-1451, 1995.
8. INK4B/MTS2 in human leukemias and lymphomas. Cancer Res., 55: 1436-1440, 1995.
9. Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., and Kern, S. E. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat. Genet., 8: 27-32, 1994.
10. INK4A characterize the major types of hematological malignancies. Cancer Res., 57: 837-841, 1997.
11. INK4b/MTS2 in pediatric acute lymphoblastic leukemia. Blood, 85: 2321-2330, 1995.
12. Ogawa, S., Hirano, N., Sato, N., Takahashi, T., Hangaishi, A., Tanaka, K., Kurokawa, M., Tanaka, T., Mitani, K., Yazaki, Y., and Hirai, H. Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood, 84: 2431-2435, 1994.
13. INK4B) display frequent homozygous deletions in primary cells from T-but not form B-cell lineage acute lymphoblastic leukemias. Blood, 84: 4038-4044, 1994.
14. Ueki, K., Ono, Y., Henson, J. W., Efird, J. T., von Deimling, A., and Louis, D. N. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res., 56: 150-153, 1996.
15. Merlo. A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., and Sidransky, D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med., 1: 686-692, 1995.
16. Gonzalez-Zulueta, M., Bender, C. M., Yang, A. S., Nguyen, T-D., Beart, R. W., Van Tornout, J. M., and Jones, P. A. Methylation of 5′ CpG island of p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55: 4531-4535, 1995.
17. Herman, J. G., Merlo, A., Mao, L., Lapidus, R. G., Issa, J-P. J., Davidson, N. E., Sidransky, D., and Baylin, S. B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers Cancer Res., 55: 4525-4530, 1995.
18. Maesawa, C., Tamura, G., Nishizuka, S., Ogasawara, S., Ishida, K., Terashima, M., Sakata, K., Sato, N., Saito, K., and Satodate, R. Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma. Cancer Res., 56: 3875-3878, 1996.
19. Lo, K-W., Cheung, S-T., Leung, S-F., van Hasselt, A., Tsang, Y-S., Mak, K-F., Chung, Y-F., Woo, J. K. S., Lee, J. C. K., and Huang, D. P. Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res. 56: 2721-2725, 1996.
20. Fueyo, J., Gomez-Manzano, C., Bruner, J. M., Saito, Y., Zhang, B-H., Zhang, W., Levin, V. A., Yung, WK. A., and Kyrtisis, A. P. Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas. Oncogene, 13: 1615-1619, 1996.
21. Russell, D. S., and Rubinstein, L. J. Pathology of the Tumours of the Nervous System, 5th Ed., pp. 590-638. London: Edward Arnold, 1989.
22. Hayakawa, T., Takakura, K., Abe, H., Yoshimoto, T., Tanaka, R., Sugita, K., Kikuchi, H., Uozumi, T., Hori, T., Fukui, H., Ushio, Y., Nomura, K., Matsutani, M., Mohri, N., Kumanishi, T., Aozasa, K., and Nagashima, K. Primary central nervous system lymphoma in Japan-A retrospective, co-operative study by CNS-Lymphoma Study Group in Japan. J. Neuro-oncol., 19: 197-215, 1994.
23. Kumanishi, T., Washiyama, K., Nishiyama, A., Abe, S., Saito, T., and Ichikawa, T. Primary malignant lymphoma of the brain: demonstration of immunoglobulin gene rearrangements in four cases by the Southern blot hybridization technique. Acta Neuropathol., 79: 23-26, 1989.
24. Suci, T., Tajima, K., Nanba, K., Wakasa, H., Mikata, A., Kikuchi, M., Mori, S., Watanabe, S., Mohri, N., Shamoto, M., Harigaya, K., Itagaki, T., Matsuda, M., Kirino, Y., Takagi, K., and Fukunaga, S. Some problems on the histopathological diagnosis of non-Hodgkin's malignant lymphoma-A proposal of a new type. Acta Pathol. Jpn., 29: 755-776,1979.
25. The non-Hodgkin's lymphoma pathologic classification project. National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. Cancer (Phila.), 49: 2112-2135, 1982.
26. Blin, N., and Stafford, D. W. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res., 3: 2303-2308, 1976.
27. Zhang, S-J., Endo, S., Koga, H., Ichikawa, T., Feng, X-L., Onda, K., Washiyama, K., and Kumanishi, T. A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations. Jpn. J. Cancer Res., 87: 900-907, 1996.
28. Kumanishi, T., Zhang, S-J., Ichikawa, T., Endo, S., and Washiyama, K. Primary malignant lymphoma of the brain: demonstration of frequent p16 and p15 gene deletions. Jpn. J. Cancer Res., 87: 691-695, 1996.
29. Morii, K., Tanaka, R., Takahashi, Y., Minoshima, S., Fukuyama, R., Shimizu, N., and Kuwano, R. Structure and chromosome assignment of human S100 α and β subunit genes. Biochem. Biophys. Res. Commun., 175: 185-191, 1991.
30. Clark, S. J., Harrison, J., Paul, C. L., and Frommer, M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res., 22: 2990-2997, 1994.
31. Rodenhiser, D., Chakraborty, P., Andrews, J., Ainsworth, P., Mancini, D., Lopes, E., and Singh, S. Heterogeneous point mutations in the BRCA1 breast cancer susceptibility gene occur in high frequency at the site of homonucleotide tracts, short repeats and methylatable CpG/CpNpG motifs. Oncogene, 12: 2623-2629, 1996.
32. Jen, J., Harper, J. W., Bigner, S. H., Bigner, D. D., Papadopoulos, N., Markowitz, S., Willson, J. K. V., Kinzler, K. W., and Vogelstein, B. Deletion of p16 and p15 genes in brain tumors. Cancer Res., 54: 6353-6358, 1994.
33. INK4B. Cancer Res. 56: 722-727, 1996.
34. INK4 in human cancer. Proc. Natl. Acad. Sci. USA, 91: 11045-11049, 1994.
35. Mori, T., Miura, K., Aoki, T., Nishihira, T., Mori, S., and Nakamura, Y. Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res., 54: 3396-3397, 1994.
36. Zhang, S-Y., Klein-Szanto, A. J. P., Sauter, E. R., Shafarenko, M., Mitsunaga, S., Nobori, T., Carson, D. A., Ridge, J. A., and Goodrow, T. L. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res., 54: 5050-5053, 1994.
37. Ink4B/MTS2 genes in biliary tract cancers. Cancer Res., 55: 2756-2760, 1995.
38. Ng, M. H. L., Chung, Y. F., Lo, K. W., Wickham, N. W. R., Lee, J. C. K., and Huang, D. P. Frequent hypermethylation of p16 and p15 genes in multiple myeloma. Blood, 89: 2500-2506, 1997.
39. Clark, S. J., Harrison, J., and Frommer, M. CpNpG methylation in mammalian cells. Nat. Genet., 10: 20-27, 1995.
40. Selker, E. U., Fritz, D. Y., and Singer, M. J. Dense nonsymmetrical DNA methylation resulting from repeat-induced point mutation in Neurospora. Science (Washington DC), 262: 1724-1728, 1993.
41. Toth, M., Müller, U., and Doerfler, W. Establishment of de novo DNA methylation patterns: transcription factor binding and deoxycytidine methylation at CpG and non-CpG sequences in an integrated adenovirus promoter. Mol. Biol., 214: 673-683, 1990.
42. Tasheva, E. S., and Roufa, D. J. Densely methylated DNA islands in mammalian chromosomal replication origins. Mol. Cell. Biol., 14: 5636-5644, 1994.
43. ink4A) gene in primary B-cell lymphomas. Blood, 86: 2724-2731, 1995.
44. INK4B in non-Hodgkin's lymphomas. Blood, 86: 1534-1539, 1995.
45. Ogawa, S., Hangaishi, A., Miyawaki, S., Hirosawa, S., Miura, Y., Takeyama, K., Kamada, N., Ohtake, S., Uike, N., Shimazaki, C., Toyama, K., Hirano, M., Mizoguchi, H., Kobayashi, Y., Furusawa, S., Saito, M., Emi, N., Yazaki, Y., Ueda, R., and Hirai, H. Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies. Blood, 86: 1548-1556, 1995.
46. Koduru, P. R. K., Zariwala, M., Soni, M., Gong, J. Z., Xiong, Y., and Broome, J. D. Deletion of cyclin-dependent kinase 4 inhibitor genes p15 and p16 in non-Hodgkin's lymphoma. Blood, 86: 2900-2905, 1995.