Sequential cytotoxicity: A theory evaluated using novel 2-[4-(3-aryl-2-propenoyloxy)phenylmethylene]cyclohexanones and related compounds

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3933-3940

  Dimmock, J R ^a   Kandepu, N M ^a   Nazarali, A J ^a   Motaganahalli, N L ^a   Kowalchuk, T P ^a   Pugazhenthi, U ^a   Prisciak, J S ^a   Quail, J W ^a   Allen, T M ^b   LeClerc, R ^b   Santos, C L ^b   De Clercq, E ^c   Balzarini, J ^c  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 PROPENOYLOXY)PHENYLMETHYLENE]CYCLOHEXANONE DERIVATIVE; CYCLOHEXANE DERIVATIVE; CYCLOHEXIMIDE; CYTOTOXIC AGENT; DACTINOMYCIN; FLUOROURACIL; HELENALIN; MANNICH BASE; MELPHALAN; PROTEIN; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCULATION; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR MODEL; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RNA SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANONES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MANNICH BASES; MICE; MODELS, MOLECULAR; NEOPLASM PROTEINS; RNA, NEOPLASM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034687246     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000058o     Document Type: Article

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