Mechanisms of action of CHF3381 in the forebrain

British Journal of Pharmacology

Volumn 139, Issue 7, 2003, Pages 1333-1341

  Barbieri, Mario ^a   Bregola, Gianni ^a   Buzzi, Andrea ^a   Marino, Silvia ^a   Zucchini, Silvia ^a   Stables, James P ^b   Bergamaschi, Marco ^c   Pietra, Claudio ^c   Villetti, Gino ^c   Simonato, Michele ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c CHIESI FARMACEUTICI S P A   (Italy)

Author keywords

CHF3381; Cortex; Glutamate; Hippocampus; N methyl D aspartate (NMDA); Na + channel

Indexed keywords

ANTICONVULSIVE AGENT; CHF 3381; DIZOCILPINE; GLUTAMIC ACID; LAMOTRIGINE; MESSENGER RNA; N (2 INDANYL)GLYCINAMIDE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; PROTEIN C FOS; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ELECTRIC POTENTIAL; ELECTROSTIMULATION; EVOKED RESPONSE; FOREBRAIN; GENE EXPRESSION; HIPPOCAMPUS; MALE; NEUROTRANSMISSION; NEWBORN; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SODIUM CURRENT;

ANIMALS; ANTICONVULSANTS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GLYCINE; HIPPOCAMPUS; INDANS; INJECTIONS, INTRAPERITONEAL; ION CHANNEL GATING; MALE; N-METHYLASPARTATE; NEURONS; PROSENCEPHALON; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SODIUM CHANNELS;

EID: 12444329963     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705381     Document Type: Article

References (27)

1. BEANI, L., BIANCHI, C., GIACOMELLI, A. & TAMBERI, F. (1978). Noradrenaline inhibition of acetylcholine release from guinea-pig brain. Eur. J. Pharmacol., 48, 179-193.
2. GANDOLFI, O., BONFANTE, V., VOLTATTORNI, M., DALL'OLIO, R., POLI, A., PIETRA, C. & VILLETTI, G. (2001). Anficonvulsant preclinical profile of CHF 3381: dopaminergic and glutamatergic mechanisms. Pharmacol. Biochem. Behav. 70, 157-166.
3. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch., 391, 85-100.
4. HOSFORD, D.A., SIMONATO, M., CAO, Z., GARCIA-CAIRASCO, N., SILVER, J.M., BUTLER, L., SHIN, C. & MCNAMARA, J.O. (1995). Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development. J. Neurosci., 15, 2513-2523.
5. HUGHES, P.E., ALEXI, T., WALTON, M., WILLIAMS, C.E., DRAGUNOW, M., CLARK, R.G. & GLUCKMAN, P.D. (1999). Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system. Prog. Neurobiol., 57, 421-450.
6. KOHL, B.K. & DANNHARDT, G. (2001). The NMDA receptor complex: a promising target for novel antiepileptic strategies. Curr. Med. Chem., 8, 1275-1289.
7. LABINER, D.M., BUTLER, L.S., CAO, Z., HOSFORD, D.A., SHIN, C. & MCNAMARA, J.O. (1993). Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. J. Neurosci., 13, 744-751.
8. LEACH, M.J., MARDEN, C.M. & MILLER, A.A. (1986). Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia, 27, 490-497.
9. LEREA, L.S., BUTLER, L.S. & MCNAMARA, J.O (1992). NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes. J. Neurosci., 12, 2973-2981.
10. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A. & RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
11. MCNAMARA, J.O. (2001). Drugs effective in the treatment of the epilepsies. In: The Pharmacological Basis of Therapeutics 10th edn., ed. Hardman, J.G., Limbird, L.E. & Goodman Gilman, A. pp. 521-547. New York: McGraw-Hill.
12. MORGAN, J.I., COHEN, D.R., HEMPSTEAD, J.L. & CURRAN, T. (1987). Mapping patterns of c-fos expression in the central nervous system after seizure. Science, 237, 192-197.
13. 3H]D-aspartate outflow from various in vitro preparations of the rat hippocampus. Neurochem. Int., 31, 113-124.
14. PALMER, G.C. (2001). Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies. Curr. Drug Targets, 2, 241-271.
15. PARSONS, C.G. (2001). NMDA receptors as targets for drug action in neuropathic pain. Eur. J. Pharmacol., 429, 71-78.
16. PARSONS, C.G., GRUNER, R., ROZENTAL, J., MILLAR, J. & LODGE, D. (1993). Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology, 32, 1337-1350.
17. PELLEGRINO, L.J., PELLEGRINO, A.S. & CUSHMAN, A.J. (1979). A Stereotaxic Atlas of the Rat Brain, New York: Plenum Press.
18. SAFFEN, D.W., COLE, A.J., WORLEY, P.F., CHRISTY, B.A., RYDER, K. & BARABAN, J.M. (1988). Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc. Natl. Acad. Sci. U.S.A., 85, 7795-7799.
19. SHIN, C., MCNAMARA, J.O., MORGAN, J.I., CURRAN, T. & COHEN, D.R. (1990). Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. J. Neurochem., 55, 1050-1055.
20. SIMONATO, M., BREGOLA, G., DONATINI, A., BIANCHI, C., BEANI, L., FERRI, S. & ROMUALDI, P. (1996). Kindled seizure-induced c-fos and prodynorphin mRNA expressions are unrelated in the rat brain. Eur. J. Neurosci., 8, 2064-2067.
21. SIMONATO, M., HOSFORD, D.A., LABINER, D.M., SHIN, C., MANSBACH, H.H. & MCNAMARA, J.O. (1991). Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy. Mol. Brain Res., 11, 115-124.
22. SOBOLEVSKY, A.I. & YELSHANSKY, M.V. (2000). The trapping block of NMDA receptor channels in acutely isolated rat hippocampal neurones. J. Physiol., 526, 493-506.
23. VILLETTI, G., BREGOLA, G., BASSANI, F., BERGAMASCHI, M., RONDELLI, I., PIETRA, C. & SIMONATO, M. (2001). Preclinical evaluation of CHF3381 as a novel antiepileptic agent. Neuropharmacology, 40, 866-878.
24. 3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol. Pharmacol., 22, 627-635.
25. WILLOW, M., GONOI, T. & CATTERALL, W.A. (1985). Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. Mol. Pharmacol., 27, 549-558.
26. WILLOW, M., KUENZEL, E.A. & CATTERALL, W.A. (1984). Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol. Pharmacol., 25, 228-234.
27. ZUCCHINI, S., BUZZI, A., BERGAMASCHI, M., PIETRA, C., VILLETTI, G. & SIMONATO, M. (2002). Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist. NeuroReport, 13, 2071-2074.