Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1

British Journal of Pharmacology

Volumn 139, Issue 7, 2003, Pages 1255-1264

  Liantonio, Antonella ^a   De Luca, Annamaria ^a   Pierno, Sabata ^a   Didonna, Maria Paola ^a   Loiodice, Fulvio ^a   Fracchiolla, Giuseppe ^a   Tortorella, Paolo ^a   Laghezza, Antonio ^a   Bonerba, Elisabetta ^a   Traverso, Sonia ^b   Elia, Laura ^b   Picollo, Alessandra ^b   Pusch, Michael ^b   Camerino, Diana Conte ^a  

^a UNIVERSITY OF BARI   (Italy)

^b CNR   (Italy)

Author keywords

Chloride conductance; CLC 1 chloride channel; Clofibric acid analogues; Skeletal muscle

Indexed keywords

2 (4 CHLOROPHENOXY)PROPIONIC ACID; 2 (4 CHLOROPHENOXY)PROPIONIC ACID DERIVATIVE; CARBON; CARBOXYLIC ACID; CELL PROTEIN; CHLORIDE CHANNEL; CLOFIBRIC ACID; OXYGEN; PHOSPHONIC ACID DERIVATIVE; PROTEIN CLC 1; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL MODIFICATION; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTRICAL PARAMETERS; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; XENOPUS LAEVIS;

2-METHYL-4-CHLOROPHENOXYACETIC ACID; ANIMALS; BINDING SITES; CHLORIDE CHANNELS; HUMANS; MALE; MUSCLE, SKELETAL; OOCYTES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, WISTAR; STEREOISOMERISM; XENOPUS LAEVIS;

EID: 12444272240     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705364     Document Type: Article

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