Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral α-(4-chloro-phenoxy)alkanoic acids

Farmaco

Volumn 56, Issue 3, 2001, Pages 239-246

  Ferorelli, Savina ^a   Loiodice, Fulvio ^a   Tortorella, Vincenzo ^a   Conte Camerino, Diana ^a   De Luca, Anna Maria ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Absolute configuration; Chiroptical properties; Chloride channel conductance; Enantioselective synthesis; Myotonic inducing effects

Indexed keywords

2 (4 CHLORO 2 METHYLPHENOXY)BUTANOIC ACID; 2 (4 CHLORO 2 METHYLPHENOXY)PROPANOIC ACID; 2 (4 CHLORO 2,6 DIMETHYLPHENOXY)BUTANOIC ACID; 2 (4 CHLORO 2,6 DIMETHYLPHENOXY)PROPANOIC ACID; 2 (4 CHLORO PHENOXY)BUTANOIC ACID; 2 (4 CHLORO PHENOXY)PROPANOIC ACID; BUTYRIC ACID DERIVATIVE; CHLORIDE CHANNEL; CHLORIDE ION; CLOFIBRATE DERIVATIVE; METHYL GROUP; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CHEMICAL MODIFICATION; CHIRALITY; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENANTIOMER; EXTENSOR DIGITORUM LONGUS MUSCLE; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALKANES; ANIMALS; CARBOXYLIC ACIDS; CHLORIDE CHANNELS; CIRCULAR DICHROISM; HYDROLYSIS; MALE; MASS SPECTROMETRY; MUSCLE, SKELETAL; RATS; SPECTROPHOTOMETRY, INFRARED; STEREOISOMERISM;

EID: 0035306599     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01041-2     Document Type: Article

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