Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice

Regulatory Peptides

Volumn 113, Issue 1-3, 2003, Pages 89-94

  Wong, H Y ^a   Ahren B ^b   Lips, C J M ^a   Hoppener J W M ^a   Sundler, F ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b LUND UNIVERSITY   (Sweden)

Author keywords

"ob mutation" in the leptin gene; Amylin; Glucagon; HIAPP; Human IAPP; IAPP; Immunoreactive; IR; Islet amyloid polypeptide; Islet development; Islets of Langerhans; Ob; cell distribution

Indexed keywords

AMYLIN; GLUCAGON; MESSENGER RNA; SOMATOSTATIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOARCHITECTURE; EMBRYO; IMMUNOCOMPETENT CELL; IN SITU HYBRIDIZATION; MOUSE; NEWBORN; NEWBORN PERIOD; NONHUMAN; PANCREAS ISLET DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 12444263414     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(02)00298-7     Document Type: Article

References (23)

1. Bonner-Weir S. Anatomy of the islets of Langerhans. Samols E. The endocrine pancreas. 1991;15-27 Raven Press, New York.
2. Cooper G.J. Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease. Endocr. Rev. 15:1994;163-202.
3. Westermark P., Wernstedt C., Wilander E., Sletten K.A. Novel peptide in the calcitonine gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem. Biophys. Res. Commun. 140:1986;827-831.
4. Johnson K.H., O'Brien T.D., Betsholtz C., Westermark P. Islet amyloid, islet-amyloid polypeptide, and diabetes mellitus. N. Engl. J. Med. 321:1989;513-518.
5. Clark A., Chargé S.B.P., Badman M.K., MacArthur D.A., de Koning E.J.P. Islet amyloid polypeptide: actions and role in the pathogenesis of diabetes. Biochem. Soc. Trans. 24:1996;594-599.
6. Kahn S.E., Andrikopoulos S., Verchere C.B. Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes. Diabetes. 48:1999;241-253.
7. Höppener J.W.M., Ahrén B., Lips C.J.M. Islet amyloid and type 2 diabetes mellitus. N. Engl. J. Med. 343:2000;411-419.
8. Höppener J.W.M., Verbeek J.S., De Koning E.J.P., Oosterwijk C., Van Hulst K.L., Visser-Vernooy H.J.et al. Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localisation of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia. Diabetologia. 36:1993;1258-1265.
9. Westermark P., Engström U., Johnson K.H., Westermark G.T., Betsholtz C. Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc. Natl. Acad. Sci. U. S. A. 87:1990;5036-5040.
10. Ahrén B., Oosterwijk C., Lips C.J.M., Höppener J.W.M. Transgenic overexpression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice. Diabetologia. 41:1998;1374-1380.
11. Petrik J., Pell J.M., Arany E., McDonald T.J., Dean W.L., Reik W.et al. Overexpression of insulin-like growth factor-II in transgenic mice associated with pancreatic islet cell hyperplasia. Endocrinology. 140:1999;2353-2363.
12. Devedjian J.-C., George M., Casellas A., Pujol A., Visa J., Pelegrín M.et al. Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes. J. Clin. Invest. 105:2000;731-740.
13. Ahlgren U., Jonsson J., Jonsson L., Simu K., Edlund H. β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev. 12:1998;1763-1768.
14. Janson J., Soeller W.C., Roche P.C., Nelson R.T., Torchia A.J., Kreutter D.K.et al. Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc. Natl. Acad. Sci. U. S. A. 93:1996;7283-7288.
15. vy/a mice expressing human islet amyloid polypeptide. Diabetes. 47:1998;743-750.
16. Mulder H., Ahrén B., Stridsberg M., Sundler F. Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rat islets following dexamethasone treatment. Diabetologia. 38:1995;395-402.
17. Mosselman S., Höppener J.W.M., Lips C.J.M., Jansz H.S. The complete islet amyloid polypeptide precursor is encoded by two exons. FEBS Lett. 247:1989;154-158.
18. Harris P.J., Cooper M.E., Hiranyachattada S., Berka J.L., Kelly D.J., Nobes M.et al. Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney. Am. J. Physiol. 272:1997;F13-F21.
19. Wookey P.J., Tikellis C., Nobes M., Casley D., Cooper M.E., Darby I.A. Amylin as a growth factor during fetal and postnatal development of the rat kidney. Kidney Int. 53:1998;25-30.
20. Karlsson E., Sandler S. Islet amyloid polypeptide promotes beta-cell proliferation in neonatal rat pancreatic islets. Diabetologia. 44:2001;1015-1018.
21. Gebre-Medhin S., Mulder H., Pekny M., Westermark G., Törnell J., Westermark P.et al. Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin). Biochem. Biophys. Res. Commun. 250:1998;271-277.
22. Janson J., Ashley R.H., Harrison D., McIntyre S., Butler P.C. The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes. 48:1999;491-498.
23. Kapurniotu A. Amyloidogenicity and cytotoxicity of islet amyloid polypeptide. Biopolymers. 60:2001;438-459.