Genetic variation at the hormone sensitive lipase: Gender-specific association with plasma lipid and glucose concentrations

Clinical Genetics

Volumn 65, Issue 2, 2004, Pages 93-100

  Qi, L ^a   Shen, H ^a   Larson, I ^a   Barnard, J R ^a   Schaefer, E J ^a   Ordovas, Jose M ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Alcohol drinking; Apolipoprotein E; Genetic polymorphisms; Glucose; Lipases; Lipoproteins; Obesity

Indexed keywords

ANTIDIABETIC AGENT; CHOLESTEROL; CHOLESTEROL ESTER; GLUCOSE; HORMONE; HORMONE SENSITIVE LIPASE; HYPOCHOLESTEROLEMIC AGENT; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; ALCOHOL CONSUMPTION; ALLELE; ANTHROPOMETRY; ARTICLE; BODY FAT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE LOCUS; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HORMONE SENSITIVITY; HORMONE SUBSTITUTION; HUMAN; HYDROLYSIS; INSULIN RELEASE; LIPID BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; SEX DIFFERENTIATION; SINGLE NUCLEOTIDE POLYMORPHISM; STEROIDOGENESIS;

BASE SEQUENCE; BLOOD GLUCOSE; CHOLESTEROL ESTERASE; DNA PRIMERS; FEMALE; HAPLOTYPES; HETEROZYGOTE DETECTION; HUMANS; LINKAGE DISEQUILIBRIUM; LIPIDS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS; VARIATION (GENETICS);

EID: 1242341223     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0009-9163.2004.00196.x     Document Type: Article

References (35)

1. Langin D, Holm C, Lafontan M. Adipocyte hormone-sensitive lipase: a major regulator of lipid metabolism. Proc Nutr Soc 1996: 55: 93-109.
2. Escary JL, Choy HA, Reue K et al. Hormone-sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophage foam cells. Arterioscler Thromb Vasc Biol 1998: 18: 991-998.
3. Frayn KN. Visceral fat and insulin resistance - causative or correlative? Br J Nutr 2000: 83 (Suppl. 1): S71-S77.
4. Lavebratt C, Ryden M, Schalling M et al. The hormone-sensitive lipase i6 gene polymorphism and body fat accumulation. Eur J Clin Invest 2002: 32: 938-942.
5. Talmud PJ, Palmen J, Nicaud V et al. Association of the hormone sensitive lipase -60C>G variant with fasting insulin levels in healthy young men. Nutr Metab Cardiovasc Dis 2002: 12: 173-177.
6. Hoffstedt J, Arner P, Schalling M et al. A common hormone-sensitive lipase i6 gene polymorphism is associated with decreased human adipocyte lipolytic function. Diabetes 2001: 50: 2410-2413.
7. Pihlajamaki J, Valve R, Karjalainen L et al. The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance. Eur J Clin Invest 2001: 31: 302-308.
8. Shimada F, Makino H, Hashimoto N et al. Detection of an amino acid polymorphism in hormone-sensitive lipase in Japanese subjects. Metabolism 1996: 45: 862-864.
9. Talmud PJ, Palmen J, Luan J et al. Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study. Biochim Biophys Acta 2001: 1537: 239-244.
10. Talmud PJ, Palmen J, Walker M. Identification of genetic variation in the human hormone-sensitive lipase gene and 5′ sequences: homology of 5′ sequences with mouse promoter and identification of potential regulatory elements. Biochem Biophys Res Commun 1998: 252: 661-668.
11. Garenc C, Perusse L, Chagnon YC et al. The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study. Int J Obes Relat Metab Disord 2002: 26: 220-227.
12. Barnard RJ. Effects of life-style modification on serum lipids. Arch Intern Med 1991: 151: 1389-1394.
13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972: 18: 499-502.
14. Larson IA, Ordovas JM, DeLuca C et al. Association of apolipoprotein (Apo) E genotype with plasma apo E levels. Atherosclerosis 2000: 148: 327-335.
15. Larson IA, Ordovas JM, Barnard JR et al. Effects of apolipoprotein A-I genetic variations on plasma apolipoprotein, serum lipoprotein and glucose levels. Clin Genet 2002: 61: 176-184.
16. Greenberg AS, Shen WJ, Muliro K et al. Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. J Biol Chem 2001: 276: 45456-45461.
17. Osuga J, Ishibashi S, Oka T et al. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc Natl Acad Sci USA 2000: 97: 787-792.
18. Lucas S, Tavernier G, Tiraby C et al. Expression of human hormone-sensitive lipase in white adipose tissue of transgenic mice increases lipase activity but does not enhance in vitro lipolysis. J Lipid Res 2003: 44: 154-163.
19. Haemmerle G, Zimmermann R, Strauss JG et al. Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle. J Biol Chem 2002: 277: 12946-12952.
20. Contreras JA, Holm C, Martin A et al. Presence of hormone-sensitive lipase mRNA in J774 macrophages. Isr J Med Sci 1994: 30: 778-781.
21. Grober J, Lucas S, Sorhede-Winzell M et al. Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa. J Biol Chem 2003: 278: 6510-6515.
22. Holm C, Belfrage P, Fredrikson G. Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue. Biochem Biophys Res Commun 1987: 148: 99-105.
23. Langfort J, Ploug T, Ihlemann J et al. Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle. Adv Exp Med Biol 1998: 441: 219-228.
24. Mulder H, Holst LS, Svensson H et al. Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells. Diabetes 1999: 48: 228-232.
25. Fredrikson G, Stralfors P, Nilsson NO et al. Hormone-sensitive lipase of rat adipose tissue. Purification and some properties. J Biol Chem 1981: 256: 6311-6320.
26. Jepson CA, Harrison JA, Kraemer FB et al. Downregulation of hormone-sensitive lipase in sterol ester-laden J774.2 macrophages. Biochem J 1996: 318 (1): 173-177.
27. Zilkens RR, Burke V, Watts G et al. The effect of alcohol intake on insulin sensitivity in men: a randomized controlled trial. Diabetes Care 2003: 26: 608-612.
28. Zilkens RR, Puddey IB. Alcohol and type 2 diabetes - another paradox? J Cardiovasc Risk 2003: 10: 25-30.
29. Ajani UA, Hennekens CH, Spelsberg A et al. Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians. Arch Intern Med 2000: 160: 1025-1030.
30. Facchini F, Chen YD, Reaven GM. Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care 1994: 17: 115-119.
31. Lazarus R, Sparrow D, Weiss ST. Alcohol intake and insulin levels. The Normative Aging Study. Am J Epidemiol 1997: 145: 909-916.
32. al Qatari M, Shih MF, Taberner PV. Chronic ethanol consumption ameliorates the maturity-onset diabetes-obesity syndrome in CBA mice. Alcohol Alcohol 1996: 31: 89-99.
33. Shih MF, Taberner PV. Dose-dependent effects of chronic ethanol on mouse adipose tissue lipase activity and cyclic AMP accumulation. Br J Pharmacol 1997: 120: 721-727.
34. Shih MF, Taberner PV. Changes in adipose tissue hormone-sensitive lipase activity and cAMP during ethanol withdrawal. Eur J Pharmacol 2000: 409: 223-231.
35. Shih MF, Taberner PV. Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha (2)-adrenoceptor activation bu UK 14304. Alcohol 2001: 36: 381-387.