Alcohol and type 2 diabetes - Another paradox?

Journal of Cardiovascular Risk

Volumn 10, Issue 1, 2003, Pages 25-30

  Zilkens, Renate R ^a   Puddey, Ian B ^b  

^a Box X 2213 GPO   (Australia)

^b NONE

Author keywords

Alcohol; Insulin sensitivity; Type 2 diabetes

Indexed keywords

ACUTE DRUG ADMINISTRATION; ALCOHOL CONSUMPTION; CHRONIC DRUG ADMINISTRATION; HEART PROTECTION; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; ISCHEMIC HEART DISEASE; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; REVIEW; RISK; CORONARY ARTERY DISEASE; DRINKING BEHAVIOR; FRANCE; GLUCOSE BLOOD LEVEL; INCIDENCE; RISK FACTOR;

ALCOHOL DRINKING; BLOOD GLUCOSE; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; FRANCE; HUMANS; INCIDENCE; INSULIN RESISTANCE; RISK FACTORS;

EID: 0037292873     PISSN: 13506277     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043798-200302000-00006     Document Type: Review

References (54)

1. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339:1523-1526.
2. Law M, Wald N. Why heart disease mortality is low in France: the time lag explanation. BMJ 1999; 318:1471-1476.
3. Barker DJ. Why heart disease mortality is low in France. Commentary: intrauterine nutrition may be important. BMJ 1999; 318:1477-1478.
4. Dornhorst A, Ouyang A. Effect of alcohol on glucose tolerance. Lancet 1971; ii(7731):957-959.
5. McMonagle J, Felig P. Effects of ethanol ingestion on glucose tolerance and insulin secretion in normal and diabetic subjects. Metabolism 1975; 24:625-632.
6. Nikkila EA, Taskinen MR. Ethanol-induced alterations of glucose tolerance, post glucose hypoglycemia, and insulin secretion in normal, obese, and diabetic subjects. Diabetes 1975; 24:933-943.
7. Metz R, Berger S, Mako M. Potentiation of the plasma insulin response to glucose by prior administration of alcohol. An apparent islet-priming effect. Diabetes 1969; 18:517-522.
8. Yki-Jarvinen H, Nikkila EA. Ethanol decreases glucose utilization in healthy man. J Clin Endocrinol Metab 1985; 61:941-945.
9. Avogaro A, Fontana P, Valerio A, Trevisan R, Riccio A, Del Prato S, et al. Alcohol impairs insulin sensitivity in normal subjects. Diabetes Res 1987; 5:23-27.
10. Shah JH. Alcohol decreases insulin sensitivity in healthy subjects. Alcohol and Alcoholism 1988; 23:103-109.
11. Shelmet JJ, Reichard GA, Skutches CL, Hoeldtke RD, Owen OE, Boden G. Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance. J Clin Investigation 1988; 81:1137-1145.
12. Boden G, Chen X, DeSantis RA, Kendrick Z. Ethanol inhibits insulin action on lipolysis and on insulin release in elderly men. Am J Physiol 1993; 265:E197-E202.
13. Knip M, Ekman AC, Ekman M, Leppaluoto J, Vakkuri O. Ethanol induces a paradoxical simultaneous inprease in circulating concentrations of insulin-like growth factor binding protein-1 and insulin. Metabolism 1995; 44:1356-1359.
14. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 1981; 30:1000-1007.
15. *Yki-Jarvinen H, Koivisto VA, Ylikahri R, Taskinen MR. Acute effects of ethanol and acetate on glucose kinetics in normal subjects. Am J Physiol 1988; 254:E175-E180. The basal rates of both glucose production and utilization are maximally inhibited by small doses of ethanol(4 mmol/l), whereas inhibition of insulin stimulated glucose disposal requires a moderate ethanol dose (14 mmol/l). Ethanol-induced insulin resistance is not mediated by acetate.
16. Avogaro A, Valerio A, Miola M, Crepaldi C, Pavan P, Tiengo A, et al. Ethanol impairs insulin-mediated glucose uptake by an indirect mechanism. J Clin Endocrinol Metab 1996; 81:2285-2290.
17. Spolarics Z, Bagby GJ, Pekala PH, Dobrescu C, Skrepnik N, Spitzer JJ. Acute alcohol administration attenuates insulin-mediated glucose use by skeletal muscle. Am J Physiol 1994; 267:E886-E891.
18. Goodyear LJ, Hirshman MF, Napoli R, Calles J, Markuns JF, Ljungqvist O, et al. Glucose ingestion causes GLUT4 translocation in human skeletal muscle. Diabetes 1996; 45:1051-1056.
19. Kreisberg RA, Siegal AM, Owen WC. Glucose-lactate interrelationships: effect of ethanol. J Clin Investigation 1971; 50:175-185.
20. Kolaczynski JW, Ylikahri R, Harkonen M, Koivfsto VA. The acute effect of ethanol on counterregulatory response and recovery from insulin-induced hypoglycemia. J Clin Endocrinol Metab 1988; 67:384-388.
21. Razay G, Heaton KW, Bolton CH, Hughes AO. Alcohol consumption and its relation to cardiovascular risk factors in British women. BMJ 1992; 304:80-83.
22. Razay G, Heaton KW. Alcohol consumption and cardiovascular risk factors in middle-aged men. Cardiovascular Risk Factor 1995; 5:200-205.
23. Hodge AM, Dowse GK, Collins VR, Zimmet PZ. Abnormal glucose tolerance and alcohol consumption in three populations at high risk of non-insulin-dependent diabetes mellitus. Am J Epidemiol 1993; 137:178-189.
24. Mayer EJ, Newman B, Quesenberry CP, Jr., Friedman GD, Selby JV. Alcohol consumption and insulin concentrations. Role of insulin in associations of alcohol intake with high-density lipoprotein cholesterol and triglycerides. Circulation 1993; 88:2190-2197.
25. Kiechl S, Willeit J, Poewe W, Egger G, Oberhollenzer F, Muggeo M, et al. Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study). BMJ 1996; 313:1040-1044.
26. Facchini F, Chen YD, Reaven GM. Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care 1994; 17:115-119.
27. Bell RA, Mayer-Davis EJ, Martin MA, D'Agostino RB, Jr., Haffner SM. Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors: the Insulin Resistance and Atherosclerosis Study. Diabetes Care 2000; 23:1630-1636.
28. Godsland IF, Leyva F, Walton C, Worthington M, Stevenson JC. Associations of smoking, alcohol and physical activity with risk factors for coronary heart disease and diabetes in the first follow-up cohort of the Heart Disease and Diabetes Risk Indicators in a Screened Cohort study (H DDRISC-1). J Intern Med 1998; 244:33-41.
29. Lazarus R, Sparrow D, Weiss ST. Alcohol intake and insulin levels. The Normative Aging Study. Am J Epidemiol 1997; 145:909-916.
30. Mooy JM, Grootenhuis PA, de Vries H, Bouter LM, Kostense PJ, et al. Determinants of specific serum insulin concentrations in a general Caucasian population aged 50 to 74 years (the Hoorn Study). Diabetic Med 1998; 18:45-52.
31. Cordain L, Melby CL, Hamamoto AE, O'Neill DS, Cornier MA, Barakat HA, et al. Influence of moderate chronic wine consumption on insulin sensitivity and other correlates of syndrome X in moderately obese women. Metabolism 2000; 49:1473-1478.
32. Davies MJ, Baer DJ, Judd JT, Brown ED, Campbell WS, Taylor PR. Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA 2002; 287:2559-2562.
33. Flanagan DE, Pratt E, Murphy J, Vaile JC, Petley GW, Godsland IF, et al. Alcohol consumption alters insulin secretion and cardiac autonomic activity. Eur J Cfin Invest 2002; 32:187-192.
34. *Perry IJ, Wannamethee SG, Walker MK, Thomson AG, Whincup PH, et al. Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men. BMJ 1995; 310:560-564. Large prospective study (n = 7 735) which had the advantage of having a reasonable number of subjects (> 10%) that consumed alcohol at the higher end of the drinking spectrum (i.e. > 48 g/day). Used occasional drinkers as the reference group to identify a nonlinear relation between alcohol intake and diabetes, with the lower risk among moderate drinkers (18-48 g/day).
35. *Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC. Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men. BMJ 1995; 310:555-559. Prospective study (n = 1429) which had 3.5% of subjects drinking more than 50 g alcohol per day. Compared with abstainers, men who drank 30-49.9 g of alcohol per day had a reduced risk of diabetes. Trend for inverse association between alcohol and diabetes was maintained when ex-drinkers that had dramatically reduced their alcohol intake were excluded from the reference group.
36. *Wei M, Gibbons LW, Mitchell TL, Kampert JB, Blair SN. Alcohol intake and incidence of type 2 diabetes in men. Diabetes Care 2000; 23:18-22. Large prospective study (n = 8633) which had 20% of subjects drinking more than 40 g/day. After adjusting for 10 diabetes risk factors the greatest protection against incident diabetes was seen in men that drank 9-18 g alcohol per day.
37. Tsumura K, Hayashi T, Suematsu C, Endo G, Fujii S, Okada K. Daily alcohol consumption and the risk of type 2 diabetes in Japanese men: the Osaka Health Survey. Diabetes Care 1999; 22:1432-1437.
38. Shaper AG, Wannamethee G, Walker M. Alcohol and mortality in British men: explaining the U-shaped curve. Lancet 1988; ii:1267-1273.
39. Holbrook TL, Barrett-Connor E, Wingard DL. A prospective population-based study of alcohol use and non-insulin-dependent diabetes mellitus. Am J Epidemiol 1990; 132:902-909.
40. Ajani UA, Hennekens CH, Spelsberg A, Manson JE. Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians. Arch Intern Med 2000; 160:1025-1030.
41. *Kao WH, Puddey IB, Boland LL, Watson RL, Brancati FL. Alcohol consumption and the risk of type 2 diabetes mellitus: atherosclerosis risk in communities study. Am J Epidemiol 2001; 154:748-757. A large prospective study (n = 12261) that used occasional drinkers as the reference group and which had 8% of subjects drinking more than 36 g/day. After adjusting for 10 diabetes risk factors the subjects with a high alcohol intake (i.e. 36 g/day) have an increased diabetes risk among middle aged men.
42. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Arky RA, Hennekens CH, et al. A prospective study of moderate alcohol drinking and risk of diabetes in women. Am J Epidemiol 1988; 128:549-558.
43. Christiansen C, Thomsen C, Rasmussen O, Glerup H, Berthelsen J, Hansen C, et al. Acute effects of graded alcohol intake on glucose, insulin and free fatty acid levels in non-insulin-dependent diabetic subjects. Eur J Clin Nutr 1993; 47:648-652.
44. Valmadrid CT, Klein R, Moss SE, Klein BE, Cruickshanks KJ. Alcohol intake and the risk of coronary heart disease mortality in persons with older-onset diabetes mellitus. JAMA 1999; 282:239-246.
45. Solomon CG, Hu FB, Stampfer MJ, Colditz GA, Speizer FE, Rimm EB, et al. Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. Circulation 2000; 102:494-499.
46. Ajani UA, Gaziano JM, Lotufo PA, Liu S, Hennekens CH, Buring JE, et al. Alcohol consumption and risk of coronary heart disease by diabetes status. Circulation 2000; 102:500-505.
47. Kohner EM, Aldington SJ, Stratton IM, Manley SE, Holman RR, Matthews DR, et al. United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors. Arch Ophthalmol 1998; 116:297-303.
48. Young RJ, McCulloch DK, Prescott RJ, Clarke BF. Alcohol: another risk factor for diabetic retinopathy? BMJ (Clin Res Ed) 1984; 288:1035-1037.
49. Moss SE, Klein R, Klein BE. The association of alcohol consumption with the incidence and progression of diabetic retinopathy. Ophthalmology 1994; 101:1962-1968.
50. McKay R, McCarty CA, Taylor HR. Diabetic retinopathy in Victoria, Australia: the Visual Impairment Project. Br J Ophthalmol 2000; 84:865-870.
51. Adler AI, Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, Smith DG. Risk factors for diabetic peripheral sensory neuropathy. Results of the Seattle Prospective Diabetic Foot Study. Diabetes Care 1997; 20:1162-1167.
52. Mantey I, Foster AV, Spencer S, Edmonds ME. Why do foot ulcers recur in diabetic patients? Diabet Med 1999; 16:245-249.
53. Masarei JR, Puddey IB, Rouse IL, Lynch WJ, Vandongen R, Beilin LJ. Effects of alcohol consumption on serum lipoprotein-lipid and apolipoprotein concentrations. Results from an intervention study in healthy subjects. Atherosclerosis 1986; 60:79-87.
54. Dimmitt SB, Rakic V, Puddey IB, Baker R, Oostryck R, Adams MJ, et al. The effects of alcohol on coagulation and fibrinolytic factors: a controlled trial. Blood Coagul Fibrinolysis 1998; 9:39-45.