Adipocyte hormone-sensitive lipase: A major regulator of lipid metabolism

Proceedings of the Nutrition Society

Volumn 55, Issue 1, 1996, Pages 93-109

  Langin, Dominique ^a   Holm, Cecilia ^b   Lafontan, Max ^a  

^a INSERM   (France)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTERASE;

ADIPOCYTE; AMINO ACID SEQUENCE; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIPID METABOLISM; METABOLISM; MOLECULAR GENETICS; REVIEW;

ADIPOCYTES; AMINO ACID SEQUENCE; CHOLESTEROL ESTERASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPID METABOLISM; LIPID METABOLISM, INBORN ERRORS; MOLECULAR SEQUENCE DATA;

EID: 0030093040     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS19960013     Document Type: Article

References (83)

1. Ailhaud, G., Grimaldi, P. & Négrel, R. (1992). Cellular and molecular aspects of adipose tissue development. Animal Review of Nutrition 12, 207-233.
2. Au-Young, J. & Fielding, C. J. (1992). Synthesis and secretion of wild-type and mutant human plasma cholesteryl ester transfer protein in baculovirus-transfected insect cells: the carboxyl-terminal region is required for both lipoprotein binding and catalysis of transfer. Proceedings of the National Academy of Sciences, USA 89, 4094-4098.
3. Berlan, M. & Lafontan, M. (1985). Evidence that epinephrine acts preferentially as an antilipolytic agent in abdominal human subcutaneous fat cells: assessment by analysis of beta- and alpha-2-adrenoceptors properties. European Journal of Clinical Investigation 15, 341-346.
4. Björntorp, P. (1990). 'Portal' adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 10, 493-496.
5. Chowdhary, B. P., Thomsen, P. D., Harbitz, I., Landset, M. & Gustavsson, I. (1994). Precise localization of the genes for glucose phosphate isomerase (GPI), calcium release channel (CRC), hormone-sensitive lipase (LIPE), and growth hormone (GH) in pigs, using nonradioactive in situ hybridization. Cytogenctics and Cell Genetics 67, 211-214.
6. Corton, J., Gillespie, J., Hawley, S. & Hardie, D. (1995). 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? European Journal of Biochemistry 229, 558-565.
7. Degerman, E., Smith, C. J., Tornquist, H., Vasta, V., Belfrage, P. & Manganiello, V. C. (1990). Evidence that insulin and isoprenaline activate the cGMP-inhibited low Km cAMP-phosphodiesterase in rat fat cells by phosphorylation. Proceedings of the National Academy of Sciences, USA 87, 533-537.
8. Derewenda, Z. S. (1994). Structure and function of lipases. Advances in Protein Chemistry 45, 1-52.
9. Egan, J. J., Greenberg, A. S., Chang, M.-K., Wek, S. A., Moos, M. C. Jr & Londos, C. (1992). Mechanism of hormone-stimulated lipolysis in adipocytes: Translocation of hormone-sensitive lipase to the lipid storage droplet. Proceedings of the National Academy of Sciences, USA 89, 8537-8541.
10. Eriksson, H., Ridderstråle, M., Degerman, E., Ekholm, D., Smith, C. J., Manganiello, V. C., Belfrage, P. & Tornqvist, H. (1995). Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin. Biochimica et Biophysica Acta 1266, 101-107.
11. Fain, J. N. & Garcia-Sainz, J. A. (1983). Adrenergic regulation of adipocyte metabolism. Journal of Lipid Research 24, 945-966.
12. Frayn, K. & Coppack, S. (1993). Insulin resistance, adipose tissue and coronary heart disease. Clinical Science 82, 1-8.
13. Frayn, K. N., Coppack, S. W., Fielding, B. A. & Humphreys, S. M. (1995). Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Advances in Enzyme Regulation 35, 163-178.
14. Frayn, K. N., Langin, D., Holm, C. & Belfrage, P. (1993). Hormone-sensitive lipase: quantitation of enzyme activity and mRNA level in small biopsies of human adipose tissue. Clinica Chimica Acta 216, 183-189.
15. Fredrikson, G., Tornqvist, H. & Belfrage, P. (1986). Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol. Biochimica et Biophysica Acta 876, 288-293.
16. Fujii, J., Otsu, K., Zorzato, F., De Leon, S., Khanna, V. K., Weiler, J. E., O'Brien, P. J. & MacLennan, D. H. (1991). Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science 253, 448-451.
17. Garton, A. J., Campbell, D. G., Carling, D., Hardie, D. G., Colbran, R. J. & Yeaman, S. J. (1989). Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. European Journal of Biochemistry 179, 249-254.
18. Garton, A. J. & Yeaman, S. J. (1990). Identification and role of the basal phosphorylation site on hormone-sensitive lipase. European Journal of Biochemistry 191, 245-250.
19. Gettys, T. W., Rohlfs, E. M., Prpic, V., Daniel, K. W., Taylor, I. L. & Collins, S. (1995). Age-dependent changes in β-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats. Endocrinology 136, 2022-2032.
20. Greenberg, A., Egan, J. J., Wek, S. A., Garty, N. B., Blanchette-Mackie, E. J. & Londos, C. (1991). Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. Journal of Biological Chemistry 266, 11341-11346.
21. Greenberg, A. S., Egan, J. J., Wek, S. A., Moos, M. C. Jr, Londos, C. & Kimmel, A. R. (1993). Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proceedings of the National Academy of Sciences, USA 90, 12035-12039.
22. Gu, F., Harbitz, I., Chowdhary, B. P., Bosnes, M. & Gustavsson, I. (1992). Chromosomal localization of the hormone sensitive lipase (LIFE) and insulin receptor (INSR) genes in pigs. Hereditas 117, 231-236.
23. Hardie, D. & McIntosh, R. (1992). AMP-activated protein kinase: an archetypal protein kinase cascade. BioEssays 14, 699-704.
24. Hare, J. F., Taylor, K. & Holocher, A. (1994). Energy-dependent protein-triacylglycerol interaction in a cell-free system from 3T3-L1 adipocytes. Journal of Biological Chemistry 269, 771-776.
25. Hemilä, H., Koivula, T. T. & Palva, I. (1994). Hormone-sensitive lipase is closely related to several bacterial proteins, and distantly related to acetylcholinesterase and protein lipase: identification of a superfamily of esterases and lipases. Biochimica et Biophysics Acta 1210, 249-253.
26. Hirsch, A. H. & Rosen, O. M. (1984). Lipolytic stimulation modulates the subcellular distribution of hormone-sensitive lipase in 3T3-L1 cells. Journal of Lipid Research 25, 665-677.
27. Holm, C., Belfrage, P. & Fredrikson, G. (1987). Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue. Biochemical and Biophysical Research Communications 148, 99-105.
28. Holm, C., Belfrage, P., Østerlund, T., Davis, R. C., Schotz, M. C. & Langin, D. (1994). Hormone-sensitive lipase: structure, function, evolution and overproduction in insect cells using the baculovirus expression system. Protein Engineering 7, 537-541.
29. Holm, C., Davis, R. C., Østerlund, T., Schotz, M. C. & Fredrikson, G. (1994). Identification of the active serine of hormone-sensitive lipase by site-directed mutagenesis. FEBS Letters 344, 234-238.
30. Holm, C., Fredrikson, G. & Belfrage, P. (1986). Demonstration of the amphiphilic character of hormone-sensitive lipase by temperature-induced phase separation in triton X-114 and charge-shift electrophoresis. Journal of Biological Chemistry 261, 15659-15661.
31. Holm, C., Kirchgessner, T. G., Svensson, K. L., Fredrikson, G., Nilsson, S., Miller, C. G., Shively, J. E., Heinzmann, C., Sparkes, R. S., Mohandas, T., Lusis, A. J., Belfrage, P. & Schotz, M. C. (1988). Hormone-sensitive lipase: sequence, expression and chromosomal localization to 19 cent q13.3. Science 241 1503-1506.
32. Honnor, R. C., Dhillon, G. S. & Londos, C. (1985). cAMP-dependent protein kinase and lipolysis in rat adipocytes. II. Definition of steady-state relationship with lipolytic and antilipolytic modulators. Journal of Biological Chemistry 260, 15130-15138.
33. Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L. & Spiegelman, B. M. (1995). Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. Journal of Clinical Investigation 95, 2409-2415.
34. Jedlicka, A. E., Taylor, E. W., Meyers, D. A., Liu, Z. & Levitt, R. C. (1994). Localization of the highly polymorphic locus D19S120 to 19p13.3 by linkage. Cytogenetics and Cell Genetics 65, 140.
35. Jepson, C. A. & Yeaman, S. J. (1992). Inhibition of hormone-sensitive lipase by intermediary lipid metabolites. FEBS Letters 310, 197-200.
36. Kawakami, M., Murase, T., Igawa, H., Ishibashi, S., Mori, N., Takagu, F. & Shibata, S. (1987). Human recombinant TNF suppresses lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells. Journal of Biochemistry 101, 331-338.
37. Kawamura, M., Jensen, D. F., Wancewicz, E. V., Joy, L. L., Khoo, J. C. & Steinberg, D. (1981). Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase. Proceedings of the National Academy of Sciences, USA 78, 732-736.
38. Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R. & Simsolo, R. B. (1995). The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. Journal of Clinical Investigation 95, 2111-2119.
39. Kraemer, F., Patel, S., Saedi, M. & Sztalryd, C. (1993). Detection of hormone-sensitive lipase in various tissues. I. Expression of an HSL/bacterial fusion protein and generation of anti-HSL antibodies. Journal of Lipid Research 34, 663-671.
40. Kraemer, F. B., Tavanger, K. & Hoffman, A. R. (1991). Developmental regulation of hormone-sensitive lipase mRNA in the rat: changes in steroidogenic tissues. Journal of Lipid Research 32, 1303-1310.
41. Lafontan, M. & Berlan, M. (1993). Fat cell adrenergic receptors and the control of white and brown fat cell function. Journal of Lipid Research 34, 1057-1091.
42. Lafontan, M. & Langin, D. (1995). Cellular aspects of fuel mobilization and selection in white adipocytes. Proceedings of the Nutrition Society 54, 49-63.
43. Langin, D. & Holm, C. (1993). Sequence similarities between hormone-sensitive lipase and five prokaryotic enzymes. Trends in Biochemical Sciences 18, 466-467.
44. Langin, D., Laurell, H., Holst, L. S., Belfrage, P. & Holm, C. (1993). Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moràxella TA144, an antarctic bacterium. Proceedings of the National Academy of Sciences, USA 90, 4897-4901.
45. Laurell, H., Grober, J., Holst, L. S., Holm, C., Mohrenwieser, H. & Langin, D. (1995). The hormone-sensitive lipase (LIPE) gene located on chromosome 19q13.1-13.2 is not duplicated on 19p13.3. International Journal of Obesity 19, 590-592.
46. Levitt, R. C., Jedlicka, A. E. & Nouri, N. (1992). Dinucleotide repeat polymorphism at the hormone sensitive lipase (LIPE) locus. Human Molecular Genetics 1, 139.
47. Levitt, R. C., McKusick, V. A., Fletcher, J. E. & Rosenberg, H. (1990). Gene candidate. Nature 345, 297-298.
48. Levitt, R., Liu, Z., Nouri, N., Meyers, D., Brandriff, B. & Mohrenwieser, H. (1995). Mapping of the gene for hormone-sensitive lipase (LIPE) to chromosome 19q13.1-13.2. Cytogenetics and Cell Genetics 69, 211-214.
49. Li, Z., Sumida, M., Birchbauer, A., Schotz, M. C. & Reue, K. (1994). Isolation and characterization of the gene for mouse hormone-sensitive lipase. Genomics 24, 259-265.
50. Lönnqvist, F., Nyberg, B., Wahrenberg, H. & Arner, P. (1990). Catecholamine-induced lipolysis in adipose tissue of the elderly. Journal of Clinical Investigation 85, 1614-1621.
51. Lopez-Aparicio, P., Belfrage, P., Manganiello, V. C., Kono, T. & Degerman, E. (1993). Stimulation by insulin of the serine kinase in human platelets that phosphorylates and activates the cGMP-inhibited cAMP phosphodiesterase. Biochemical and Biophysical Research Communications 193, 1137-1144.
52. Manganiello, V. C., Degerman, E., Smith, C. J., Vasta, V., Tornqvist, H. & Belfrage, P. (1992). Mechanisms for activation of the rat adipocyte paniculate cyclic-GMP-inhibited cyclic AMP phosphodiesterase and its importance in the antilipolytic action of insulin. In Advances in Second Messenger and Phosphoprotein Research [S. J. Strada and H. Hidaka, editors]. New York: Raven Press Ltd.
53. Martin-Hidalgo, A., Holm, C., Belfrage, P., Schotz, M. C. & Herrera, E. (1994). Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy. American Journal of Physiology 266, E930-E935.
54. Mauriège, P., Galitzky, J., Berlan, M. & Lafontan, M. (1987). Heterogeneous distribution of beta- and alpha-2-adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. European Journal of Clinical Investigation 17, 156-165.
55. Olsson, H. & Belfrage, P. (1988). Phosphorylation and dephosphorylation of hormone-sensitive lipase. Interactions between the regulatory and basal phosphorylation sites. FEBS Letters 232, 78-82.
56. Patton, J., Shepard, H., Wilking, H., Lewis, G., Aggarwal, B., Eessalu, T., Gavin, L. & Grunfeld, C. (1986). Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. Proceedings of the National Academy of Sciences, USA 83, 8313-8317.
57. Probst, M. R., Beer, M., Beer, D., Jenö, P., Meyer, U. A. & Gasser, R. (1994). Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. Journal of Biological Chemistry 269, 21650-21656.
58. Reaven, G. (1988). Role of insulin resistance in human disease. Diabetes 37, 1595-1607.
59. Reynisdottir, S., Ellerfeldt, K., Wahrenberg, H., Lithell, H. & Amer, P. (1994). Multiple lipolysis defects in the insulin resistance (metabolic) syndrome. Journal of Clinical Investigation 93, 2590-2599.
60. Reynisdottir, S., Eriksson, M., Angelin, B. & Arner, P. (1995a). Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia. Journal of Clinical Investigation 95, 2161-2169.
61. Reynisdottir, S., Langin, D., Carlström, K., Holm, C., Rössner, S. & Arner, P. (1995b). Effects of weight reduction on the regulation of lipolysis in adipocytes of women with upper-body obesity. Clinical Science 89, 421-429.
62. Ron, D., Brasier, A. R., McGehee, R. E. & Habener, J. F. (1992). Tumor necrosis factor-induced reversal of adipocyte phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). Journal of Clinical Investigation 89, 223-233.
63. Schonk, D., Van Dijk, P., Riegmann, P., Trapman, J., Holm, C., Willcocks, T. C., Sillekens, P., Van Venrooij, W., Wimmer, E., Van Kessel, A. G., Ropers, H. H. & Wieringa, B. (1990). Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region. Cytogenetics and Cell Genetics 54, 15-19.
64. Slavin, B. G., Ong, J. M. & Kern, P. A. (1994). Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. Journal of Lipid Research 35, 1535-1541.
65. Smith, C. & Manganiello, V. (1988). Role of hormone-sensitive low Km cAMP phosphodiesterase in regulation of cAMP-dependent protein kinase and lipolysis in rat adipocytes. Molecular Pharmacology 35, 381-386.
66. Smith, C. J., Vasta, V., Degerman, E., Belfrage, P. & Manganiello, V. C. (1991). Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation. Journal of Biological Chemistry 266, 13385-13390.
67. Spiegelman, B. M. & Hotamisligil, G. S. (1993). Through thick and thin: wasting, obesity, and TNFa. Cell 73, 625-627.
68. Strålfors, P. & Belfrage, P. (1983). Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinase. Journal of Biological Chemistry 258, 15146-15152.
69. Strålfors, P., Olsson, H. & Belfrage, P. (1987). Hormone-sensitive lipase. In The Enzymes, pp. 147-177 [P. D. Boyer and E. G. Krebs, editors]. New York: Academic Press.
70. Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D. & Beri, R. K. (1994). Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Letters 353, 33-36.
71. Sumida, M., Sekiya, K., Okuda, H., Tanaka, Y. & Shiosaka, T. (1990). Inhibitory effect of tumor necrosis factor on gene expression of hormone sensitive lipase in 3T3-L1 adipocytes. Journal of Biochemistry 107, 1-2.
72. Sztalryd, C., Komaromy, M. & Kraemer, F. (1995). Overexpression of hormone-sensitive lipase prevents triglyceride accumulation in adipocytes. Journal of Clinical Investigation 95, 2652-2661.
73. Sztalryd, C. & Kraemer, F. B. (1994). Differences in hormone-sensitive lipase expression in white adipose tissue from various anatomic locations of the rat. Metabolism 43, 241-247.
74. Sztalryd, C. & Kraemer, F. B. (1994). Regulation of hormone-sensitive lipase during fasting. American Journal of Physiology 266, E179-E185.
75. Tavernier, G., Galitzky, J., Valet, P., Remaury, A., Bouloumié, A., Lafontan, M. & Langin, D. (1995). Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes. American Journal of Physiology 268, E1135-E1142.
76. Thompson, M. P., Cooper, S. T., Parry, B. R. &Tuckey, J. A. (1993). Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients. Biochimica et Biopliysica Acta 1180, 236-242.
77. Wang, S., Lapierre, P., Robert, M.-F., Nadeau, J. H. & Mitchell, G. A. (1994). Hormone-sensitive lipase maps to proximal chromosome 7 in mice and is genetically distinct from the Ad and Tub loci. Genomics 24, 416-417.
78. Warden, C. H., Davis, R. C., Yoon, M. Y., Hui, D. Y., Svenson, K., Xia, Y. R., Diep, A., He, K. Y. & Lusis, A. J. (1993). Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase. Journal of Lipid Research 34, 1451-1455.
79. Warden, C. H., Fisler, J. S., Shoemaker, S. M., Wen, P.-Z., Svenson, K. L., Pace, M. J. & Lusis, A. J. (1995). Identification of four chromosomal loci determining obesity in a multifactorial mouse model. Journal of Clinical Investigation 95, 1545-1552.
80. Wesslau, C., Eriksson, J. & Smith, U. (1993). Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness. Evidence against a significant role of Gi in insulin signal transduction. Biochemical and Biophysical Research Communications 196, 287-293.
81. Wilson, B. E., Deeb, S. & Florant, G. L. (1992). Seasonal changes in hormone-sensitive and lipoprotein lipase mRNA concentrations in marmot white adipose tissue. American Journal of Physiology 262, R177-R181.
82. Wise, L. & Jungas, R. (1978). Evidence for a dual mechanism of lipolysis activation by epinephrine in rat adipose tissue. Journal of Biological Chemistry 253, 2624-2627.
83. Wood, S. L., Emmison, N., Borthwick, A. C. & Yeaman, S. J. (1993). The protein phosphatases responsible for dephosphorylation of hormone-sensitive lipase in isolated rat adipocytes. Biochemical Journal 295, 531-535.