5-Aminoisoquinolinone, a novel inhibitor of poly(adenosine disphosphate-ribose) polymerase, reduces microvascular liver injury but not mortality rate after hepatic ischemia-reperfusion

Critical Care Medicine

Volumn 32, Issue 2, 2004, Pages 472-477

  Khandoga, Andrej ^a   Biberthaler, Peter ^a   Enders, Georg ^a   Krombach, Fritz ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Apoptosis; Leukocytes; Liver; Microcirculation; Necrosis; Perfusion failure; Platelets

Indexed keywords

5 AMINOISOQUINOLINONE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; CELL COUNT; CELL DEATH; CELL INTERACTION; CONTROLLED STUDY; DRUG POTENCY; DRUG SOLUBILITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; FEMALE; FLUORESCENCE MICROSCOPY; LEUKOCYTE ADHERENCE; LIPID PEROXIDATION; LIVER CELL DAMAGE; LIVER CIRCULATION; LIVER ISCHEMIA; LIVER SINUSOID; MICROVASCULAR ISCHEMIA; MICROVASCULATURE; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; SURVIVAL TIME; THROMBOCYTE ADHESION;

ANIMALS; APOPTOSIS; FEMALE; ISOQUINOLINES; LIVER; MICE; MICE, INBRED BALB C; NECROSIS; POLY(ADP-RIBOSE) POLYMERASES; RANDOM ALLOCATION; REPERFUSION INJURY;

EID: 1242320043     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000109448.51468.E3     Document Type: Article

References (32)

1. Bilzer M, Gerbes AL: Preservation injury of the liver: Mechanisms and novel therapeutic strategies. J Hepatol 2000; 32:508-515
2. Jaeschke H: Reactive oxygen and mechanisms of inflammatory liver injury. J Gastroenterol Hepatol 2000; 15:718-724
3. Menger MD, Vollmar B: Role of microcirculation in transplantation. Microcirculation 2000; 7:291-306
4. Virag L, Szabo C: The therapeutic potential of poly(ADP-Ribose) polymerase inhibitors. Pharmacol Rev 2002; 54:375-429
5. Virag L, Salzman AL, Szabo C: Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J Immunol 1998; 161:3753-3759
6. Szabo C, Dawson VL: Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 1998; 19:287-298
7. Szabo C: Role of poly(ADP-ribose)synthetase in inflammation. Eur J Pharmacol 1998; 350:1-19
8. Thiemermann C, Bowes J, Myint FP, et al: Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci U S A 1997; 94:679-683
9. McDonald MC, Filipe HM, Thiemermann C: Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock. Br J Pharmacol 1999; 128:1339-1345
10. Chen CF, Wang D, Hwang CP, et al: The protective effect of niacinamide on ischemia-reperfusion-induced liver injury. J Biomed Sci 2001; 8:446-452
11. Khandoga A, Enders G, Biberthaler P, et al: Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2002; 283:G553-G560
12. Rankin PW, Jacobson EL, Benjamin RC, et al: Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo. J Biol Chem 1989; 264:4312-4317
13. Milam KM, Cleaver JE: Inhibitors of poly(adenosine diphosphate-ribose) synthesis: Effect on other metabolic processes. Science 1984; 223:589-591
14. McDonald MC, Mota-Filipe H, Wright JA, et al: Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. Br J Pharmacol 2000; 130:843-850
15. Thiemermann C: Development of novel, water-soluble inhibitors of poly (adenosine 5′-diphosphate ribose) synthetase activity for use in shock and ischemia-reperfusion injury. Crit Care Med 2002; 30:1163-1165
16. Wayman N, McDonald MC, Thompson AS, et al: 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5′-diphosphate ribose) polymerase, reduces myocardial infarct size. Eur J Pharmacol 2001; 430:93-100
17. Cuzzocrea S, McDonald MC, Mazzon E, et al: Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem Pharmacol 2002; 63:293-304
18. Mota-Filipe H, Sepodes B, McDonald MC, et al: The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat. Med Sci Monit 2002; 8:BR444-BR453
19. Biberthaler P, Luchting B, Massberg S, et al: The influence of organ temperature on hepatic ischemia-reperfusion injury. Transplantation 2001; 72:1486-1490
20. Khandoga A, Biberthaler P, Enders G, et al: P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in vivo. Shock 2002; 18:529-535
21. Khandoga A, Biberthaler P, Enders G, et al: Platelet adhesion mediated by fibrinogen-intercellular adhesion molecule-1 binding induces tissue injury in the postischemic liver in vivo. Transplantation 2002; 74:681-688
22. Massberg S, Enders G, Leiderer R, et al: Platelet-endothelial cell interactions during ischemia/reperfusion: The role of P-selectin. Blood 1998; 92:507-515
23. Menger MD, Vollmar B, Glasz J, et al: Microcirculatory manifestations of hepatic ischemia/reperfusion injury. Prog Appl Microcirc 1993; 19:106-124
24. Zingarelli B, Salzman AL, Szabo C: Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res 1998; 83:85-94
25. Zingarelli B, Szabo C, Salzman AL: Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis. Gastroenterology 1999; 116:335-345
26. Menger MD, Richter S, Yamauchi J, et al: Role of microcirculation in hepatic ischemia/reperfusion injury. Hepatogastroenterology 1999; 46(Suppl 2):1452-1457
27. Khandoga A, Biberthaler P, Messmer K, et al: Platelet-endothelial cell interactions during hepatic ischemia-reperfusion in vivo: A systematic analysis. Microvasc Res 2003; 65:71-77
28. Bilzer M, Lauterburg BH: Oxidant stress and potentiation of ischemia/reperfusion injury to the perfused rat liver by human polymorphonuclear leukocytes. J Hepatol 1994; 20:473-477
29. Weyrich AS, Elstad MR, McEver RP, et al: Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest 1996; 97:1525-1534
30. Bubel S, Wilhelm D, Entelmann M, et al: Chemokines in stored platelet concentrates. Transfusion 1996; 36:445-449
31. Sindram D, Porte RJ, Hoffman MR, et al: Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: A Kupffer cell-mediated injury. FASEB J 2001; 15: 1230-1232
32. Yu SW, Wang H, Poitras MF, et al: Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002; 297:259-263