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Volumn 18, Issue 1, 2004, Pages 93-100

Heparin Is Much More Than Just an Anticoagulant

Author keywords

Aldosterone; Endothelium; Heparin; Inflammation; Osteoporosis; Platelets; Thyroid function test

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN III; DELTEPARIN; ENOXAPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; MINIHEP; THROMBIN; TINZAPARIN;

EID: 1242319582     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2003.10.021     Document Type: Review
Times cited : (28)

References (114)
  • 1
    • 0035405584 scopus 로고    scopus 로고
    • AHA Scientific Statement: Guide to anticoagulant therapy: Heparin: A Statement for healthcare professionals from the American Heart Association
    • Hirsh J, Anand SS, Halperin JL, et al: AHA Scientific Statement: Guide to anticoagulant therapy: Heparin: A Statement for healthcare professionals from the American Heart Association. Arterioscler Thromb Vasc Biol 21:e9-e33, 2001
    • (2001) Arterioscler Thromb Vasc Biol , vol.21
    • Hirsh, J.1    Anand, S.S.2    Halperin, J.L.3
  • 2
    • 0036463453 scopus 로고    scopus 로고
    • Novel drug development opportunities for heparin
    • Lever R, Page CP: Novel drug development opportunities for heparin. Nat Rev Drug Discov 1:140-148, 2002
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 140-148
    • Lever, R.1    Page, C.P.2
  • 3
    • 0035253193 scopus 로고    scopus 로고
    • Heparan sulfate: Decoding a dynamic multifunctional cell regulator
    • Turnbull J, Powell A, Guimond S: Heparan sulfate: Decoding a dynamic multifunctional cell regulator. Trends Cell Biol 11:75-82, 2001
    • (2001) Trends Cell Biol , vol.11 , pp. 75-82
    • Turnbull, J.1    Powell, A.2    Guimond, S.3
  • 4
    • 0035125405 scopus 로고    scopus 로고
    • Heparin and low-molecular-weight heparin: Mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety
    • Hirsh J, Warkentin TE, Shaughnessy SG, et al: Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety. Chest 119:64S-94S, 2001 (suppl)
    • (2001) Chest , vol.119 , Issue.SUPPL.
    • Hirsh, J.1    Warkentin, T.E.2    Shaughnessy, S.G.3
  • 5
    • 0018647312 scopus 로고
    • Molecular weight dependency of the heparin-potentiated inhibition of thrombin and activated factor X. Effect of heparin neutralization in plasma
    • Andersson LO, Barrowcliffe TW, Holmer E, et al: Molecular weight dependency of the heparin-potentiated inhibition of thrombin and activated factor X. Effect of heparin neutralization in plasma. Thromb Res 15:531-541, 1979
    • (1979) Thromb Res , vol.15 , pp. 531-541
    • Andersson, L.O.1    Barrowcliffe, T.W.2    Holmer, E.3
  • 7
    • 0026337077 scopus 로고
    • The coagulation cascade: Initiation, maintenance, and regulation
    • Davie EW, Fujikawa K, Kisiel W: The coagulation cascade: Initiation, maintenance, and regulation. Biochemistry 30:10363-10370, 1991
    • (1991) Biochemistry , vol.30 , pp. 10363-10370
    • Davie, E.W.1    Fujikawa, K.2    Kisiel, W.3
  • 8
    • 0018195842 scopus 로고
    • Human alpha2-macroglobulin and its antitrypsin and antithrombin activities in serum and plasma
    • de Vonne TL, Mouray H: Human alpha2-macroglobulin and its antitrypsin and antithrombin activities in serum and plasma. Clin Chim Acta 90:83-85, 1978
    • (1978) Clin Chim Acta , vol.90 , pp. 83-85
    • De Vonne, T.L.1    Mouray, H.2
  • 9
    • 0023374585 scopus 로고
    • Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation
    • Suzuki K, Kusumoto H, Deyashiki Y, et al: Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J 6:1891-1897, 1987
    • (1987) EMBO J , vol.6 , pp. 1891-1897
    • Suzuki, K.1    Kusumoto, H.2    Deyashiki, Y.3
  • 10
    • 0023755722 scopus 로고
    • Physiologic inhibition of human activated protein C by alpha 1-antitrypsin
    • Heeb MI, Griffin JH: Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. J Biol Chem 263:11613-11616, 1988
    • (1988) J Biol Chem , vol.263 , pp. 11613-11616
    • Heeb, M.I.1    Griffin, J.H.2
  • 11
    • 0020321012 scopus 로고
    • Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma
    • Tollefsen DM, Majerus DW, Blank MK: Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma. J Biol Chem 257:2162-2169, 1982
    • (1982) J Biol Chem , vol.257 , pp. 2162-2169
    • Tollefsen, D.M.1    Majerus, D.W.2    Blank, M.K.3
  • 12
    • 0015821564 scopus 로고
    • The purification and mechanism of action of human antithrombin-heparin cofactor
    • Rosenberg RD, Damus PS: The purification and mechanism of action of human antithrombin-heparin cofactor. J Biol Chem 248:6490-6505, 1973
    • (1973) J Biol Chem , vol.248 , pp. 6490-6505
    • Rosenberg, R.D.1    Damus, P.S.2
  • 13
    • 0021054526 scopus 로고
    • Antithrombin in vertebrate species: Conservation of the heparin-dependent anticoagulant mechanism
    • Jordan RE: Antithrombin in vertebrate species: Conservation of the heparin-dependent anticoagulant mechanism. Arch Biochem Biophys 227:587-595, 1983
    • (1983) Arch Biochem Biophys , vol.227 , pp. 587-595
    • Jordan, R.E.1
  • 14
    • 0026690347 scopus 로고
    • Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement
    • Olson ST, Bjork I, Sheffer R, et al: Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. J Biol Chem 267:12528-12538, 1992
    • (1992) J Biol Chem , vol.267 , pp. 12528-12538
    • Olson, S.T.1    Bjork, I.2    Sheffer, R.3
  • 15
    • 0001668795 scopus 로고
    • Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin
    • Lindahl U, Backstrom G, Thunberg L, et al: Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin. Proc Natl Acad Sci U S A 77:6551-6555, 1980
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 6551-6555
    • Lindahl, U.1    Backstrom, G.2    Thunberg, L.3
  • 16
    • 0019801543 scopus 로고
    • The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence. Chemical and 13C nuclear-magnetic-resonance studies
    • Casu B, Oreste P, Torri G, et al: The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence. Chemical and 13C nuclear-magnetic-resonance studies. Biochem J 197:599-609, 1981
    • (1981) Biochem J , vol.197 , pp. 599-609
    • Casu, B.1    Oreste, P.2    Torri, G.3
  • 17
    • 0023154734 scopus 로고
    • Hypothermia-induced reversible platelet dysfunction
    • Valeri CR, Feingold H, Cassidy G, et al: Hypothermia-induced reversible platelet dysfunction. Ann Surg 205:175-181, 1987
    • (1987) Ann Surg , vol.205 , pp. 175-181
    • Valeri, C.R.1    Feingold, H.2    Cassidy, G.3
  • 18
    • 0028118792 scopus 로고
    • Aspirin, platelets, and thrombosis: Theory and practice
    • Roth GJ, Calverley DC: Aspirin, platelets, and thrombosis: Theory and practice. Blood 83:885-898, 1994
    • (1994) Blood , vol.83 , pp. 885-898
    • Roth, G.J.1    Calverley, D.C.2
  • 19
    • 33750716927 scopus 로고    scopus 로고
    • Effect of heparin on fibrinolytic activity and platelet function in vivo
    • Upchurch GR, Valeri CR, Khuri SF, et al: Effect of heparin on fibrinolytic activity and platelet function in vivo. Am J Physiol 271: H528-H534, 1996
    • (1996) Am J Physiol , vol.271
    • Upchurch, G.R.1    Valeri, C.R.2    Khuri, S.F.3
  • 20
    • 0021808560 scopus 로고
    • Studies on the profibrinolytic actions of heparin and its fractions
    • Fareed J, Walenga JM, Hoppensteadt DA, et al: Studies on the profibrinolytic actions of heparin and its fractions. Semin Thromb Hemost 11:199-207, 1985
    • (1985) Semin Thromb Hemost , vol.11 , pp. 199-207
    • Fareed, J.1    Walenga, J.M.2    Hoppensteadt, D.A.3
  • 21
    • 0345487533 scopus 로고    scopus 로고
    • Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor
    • Xiao Z, Theroux P: Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor. Circulation 97:251-256, 1998
    • (1998) Circulation , vol.97 , pp. 251-256
    • Xiao, Z.1    Theroux, P.2
  • 22
    • 0026764079 scopus 로고
    • High-dose heparin suppresses platelet alpha granule secretion
    • Rohrer MJ, Kestin AS, Ellis PA, et al: High-dose heparin suppresses platelet alpha granule secretion. J Vasc Surg 15:1000-1008, 1992
    • (1992) J Vasc Surg , vol.15 , pp. 1000-1008
    • Rohrer, M.J.1    Kestin, A.S.2    Ellis, P.A.3
  • 23
    • 0015186126 scopus 로고
    • Inhibition of thrombin-induced aggregation of human platelets by heparin and antithrombin 3
    • Eika C: Inhibition of thrombin-induced aggregation of human platelets by heparin and antithrombin 3. Scand J Haematol 8:250-256, 1971
    • (1971) Scand J Haematol , vol.8 , pp. 250-256
    • Eika, C.1
  • 24
    • 0029053225 scopus 로고
    • Platelet GPIb-V-IX complex. Structure, function, physiology, and pathology
    • Clemetson KJ, Clemetson JM: Platelet GPIb-V-IX complex. Structure, function, physiology, and pathology. Semin Thromb Hemost 21:130-136, 1995
    • (1995) Semin Thromb Hemost , vol.21 , pp. 130-136
    • Clemetson, K.J.1    Clemetson, J.M.2
  • 25
    • 0025812017 scopus 로고
    • Identification of the disulphide bonds in human platelet glycocalicin
    • Hess D, Schaller J, Rickli EE, et al: Identification of the disulphide bonds in human platelet glycocalicin. Eur J Biochem 199:389-393, 1991
    • (1991) Eur J Biochem , vol.199 , pp. 389-393
    • Hess, D.1    Schaller, J.2    Rickli, E.E.3
  • 26
    • 0028047501 scopus 로고
    • Glycocalicin: A new assay-The normal plasma levels and its potential usefulness in selected diseases
    • Beer JH, Buchi L, Steiner B: Glycocalicin: A new assay-The normal plasma levels and its potential usefulness in selected diseases. Blood 83:691-702, 1994
    • (1994) Blood , vol.83 , pp. 691-702
    • Beer, J.H.1    Buchi, L.2    Steiner, B.3
  • 27
    • 0033614851 scopus 로고    scopus 로고
    • Thrombin-induced platelet activation is inhibited by high- and low-molecular-weight heparin
    • De Candia E, De Cristofaro R, Landolfi R: Thrombin-induced platelet activation is inhibited by high- and low-molecular-weight heparin. Circulation 99:3308-3314, 1999
    • (1999) Circulation , vol.99 , pp. 3308-3314
    • De Candia, E.1    De Cristofaro, R.2    Landolfi, R.3
  • 28
    • 0035467607 scopus 로고    scopus 로고
    • Drug-induced and drug dependent immune thrombocytopenias
    • Greinacher A, Eichler P, Lubenow N, et al: Drug-induced and drug dependent immune thrombocytopenias. Rev Clin Exp Hematol 5:166-200, 2001
    • (2001) Rev Clin Exp Hematol , vol.5 , pp. 166-200
    • Greinacher, A.1    Eichler, P.2    Lubenow, N.3
  • 29
    • 0018747096 scopus 로고
    • Heparin-induced thrombocytopenia: Association with a platelet aggregating factor and arterial thromboses
    • Cimo PL, Moake JL, Weinger RS, et al: Heparin-induced thrombocytopenia: association with a platelet aggregating factor and arterial thromboses. Am J Hematol 6:125-133, 1979
    • (1979) Am J Hematol , vol.6 , pp. 125-133
    • Cimo, P.L.1    Moake, J.L.2    Weinger, R.S.3
  • 30
    • 0026844620 scopus 로고
    • Heparin-induced thrombocytopenia
    • Chong BH: Heparin-induced thrombocytopenia. Aust N Z J Med 22:145-152, 1992
    • (1992) Aust N Z J Med , vol.22 , pp. 145-152
    • Chong, B.H.1
  • 31
    • 0018231089 scopus 로고
    • Thrombocytopenia associated with antiheparin antibody
    • Wahl TO, Lipschitz DA, Stechschulte DJ: Thrombocytopenia associated with antiheparin antibody. JAMA 240:2560-2562, 1978
    • (1978) JAMA , vol.240 , pp. 2560-2562
    • Wahl, T.O.1    Lipschitz, D.A.2    Stechschulte, D.J.3
  • 32
    • 0018696343 scopus 로고
    • Heparin-induced thrombocytopenia, thrombosis, and hemorrhage
    • Kapsch DN, Adelstein EH, Rhodes GR, et al: Heparin-induced thrombocytopenia, thrombosis, and hemorrhage. Surgery 86:148-155, 1979
    • (1979) Surgery , vol.86 , pp. 148-155
    • Kapsch, D.N.1    Adelstein, E.H.2    Rhodes, G.R.3
  • 33
    • 0029878458 scopus 로고    scopus 로고
    • Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia
    • Amiral J, Wolf M, Fischer A, et al: Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia. Br J Haematol 92:954-959, 1996
    • (1996) Br J Haematol , vol.92 , pp. 954-959
    • Amiral, J.1    Wolf, M.2    Fischer, A.3
  • 34
    • 0026638091 scopus 로고
    • Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia
    • Amiral J, Bridey F, Dreyfus M, et al: Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 68:95-96, 1992
    • (1992) Thromb Haemost , vol.68 , pp. 95-96
    • Amiral, J.1    Bridey, F.2    Dreyfus, M.3
  • 35
    • 0032211182 scopus 로고    scopus 로고
    • Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia
    • Ziporen L, Li ZQ, Park KS, et al: Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. Blood 92:3250-3259, 1998
    • (1998) Blood , vol.92 , pp. 3250-3259
    • Ziporen, L.1    Li, Z.Q.2    Park, K.S.3
  • 36
    • 0002205476 scopus 로고    scopus 로고
    • The platelet Fc receptor in heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (eds). New York, Marcel Dekker
    • Denomme GA: The platelet Fc receptor in heparin-induced thrombocytopenia, in Warkentin TE, Greinacher A (eds): Heparin-Induced Thrombocytopenia (ed 2). New York, Marcel Dekker, 2001, pp 189-214
    • (2001) Heparin-Induced Thrombocytopenia (Ed 2) , pp. 189-214
    • Denomme, G.A.1
  • 37
    • 0024449410 scopus 로고
    • The mechanism of heparin-induced platelet aggregation
    • Chong BH, Ismail F: The mechanism of heparin-induced platelet aggregation. Eur J Haematol 43:245-251, 1989
    • (1989) Eur J Haematol , vol.43 , pp. 245-251
    • Chong, B.H.1    Ismail, F.2
  • 38
    • 8944247264 scopus 로고    scopus 로고
    • Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia
    • Amiral J, Marfaing-Koka A, Wolf M, et al: Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. Blood 88:410-416, 1996
    • (1996) Blood , vol.88 , pp. 410-416
    • Amiral, J.1    Marfaing-Koka, A.2    Wolf, M.3
  • 39
    • 0019223160 scopus 로고
    • Heparin-induced thrombocytopenia and recurrent thromboembolism
    • Ansell J, Deykin D: Heparin-induced thrombocytopenia and recurrent thromboembolism. Am J Hematol 8:325-332, 1980
    • (1980) Am J Hematol , vol.8 , pp. 325-332
    • Ansell, J.1    Deykin, D.2
  • 40
    • 0027971564 scopus 로고
    • Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: An explanation for the thrombotic complications of heparin-induced thrombocytopenia
    • Warkentin TE, Hayward CP, Boshkov LK, et al: Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: An explanation for the thrombotic complications of heparin-induced thrombocytopenia. Blood 84:3691-3699, 1994
    • (1994) Blood , vol.84 , pp. 3691-3699
    • Warkentin, T.E.1    Hayward, C.P.2    Boshkov, L.K.3
  • 41
    • 0028009642 scopus 로고
    • Antibodies from patients with heparin-induced thrombocytopenia/ thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells
    • Visentin GP, Ford SE, Scott JP, et al: Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest 93:81-88, 1994
    • (1994) J Clin Invest , vol.93 , pp. 81-88
    • Visentin, G.P.1    Ford, S.E.2    Scott, J.P.3
  • 42
    • 0023706045 scopus 로고
    • Characterization of platelet binding of heparins and other glycosaminoglycans
    • Sobel M, Adelman B: Characterization of platelet binding of heparins and other glycosaminoglycans. Thromb Res 50:815-826, 1988
    • (1988) Thromb Res , vol.50 , pp. 815-826
    • Sobel, M.1    Adelman, B.2
  • 43
    • 0027169166 scopus 로고
    • Heparin-associated thrombocytopenia: Immune complexes are attached to the platelet membrane by the negative charge of highly sulphated oligosaccharrides
    • Greinacher A, Michels I, Liebenhoff U, et al: Heparin-associated thrombocytopenia: Immune complexes are attached to the platelet membrane by the negative charge of highly sulphated oligosaccharrides. Br J Hematol 84:711-716, 1993
    • (1993) Br J Hematol , vol.84 , pp. 711-716
    • Greinacher, A.1    Michels, I.2    Liebenhoff, U.3
  • 44
    • 0025255513 scopus 로고
    • The effect of molecular weight on heparin binding to platelet
    • Horne MK III, Chao ES: The effect of molecular weight on heparin binding to platelet. Br J Haematol 74:306-312, 1990
    • (1990) Br J Haematol , vol.74 , pp. 306-312
    • Horne III, M.K.1    Chao, E.S.2
  • 45
    • 0034254793 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia with thromboembolic complications: Meta-analysis of 2 prospective trials to assess in value of parenteral treatment with lepirudin and its therapeutic aPTT range
    • Greinacher A, Eichler P, Lubenow N, et al: Heparin-induced thrombocytopenia with thromboembolic complications: Meta-analysis of 2 prospective trials to assess in value of parenteral treatment with lepirudin and its therapeutic aPTT range. Blood 96:846-851, 2000
    • (2000) Blood , vol.96 , pp. 846-851
    • Greinacher, A.1    Eichler, P.2    Lubenow, N.3
  • 46
    • 0030611555 scopus 로고    scopus 로고
    • Anticoagulation with Novastan (argatroban) in patients with heparin-induced thrombocytopenia and heparin induced thrombocytopenia and thrombosis syndrome
    • Lewis BE, Walenga JM, Wallis DE: Anticoagulation with Novastan (argatroban) in patients with heparin-induced thrombocytopenia and heparin induced thrombocytopenia and thrombosis syndrome. Semin Thromb Hemost 23:197-202, 1997
    • (1997) Semin Thromb Hemost , vol.23 , pp. 197-202
    • Lewis, B.E.1    Walenga, J.M.2    Wallis, D.E.3
  • 47
    • 0031793581 scopus 로고    scopus 로고
    • New treatment options for heparin-induced thrombocytopenia
    • Ortel TL, Chong BH: New treatment options for heparin-induced thrombocytopenia. Semin Hematol 35:26-34, 1998 (suppl)
    • (1998) Semin Hematol , vol.35 , Issue.SUPPL. , pp. 26-34
    • Ortel, T.L.1    Chong, B.H.2
  • 48
    • 0031850163 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross-reactivity with low-molecular-weight heparin and heparinoid
    • Newman PM, Swanson RL, Chong BH: Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross-reactivity with low-molecular-weight heparin and heparinoid. Thromb Haemost 80:292-297, 1998
    • (1998) Thromb Haemost , vol.80 , pp. 292-297
    • Newman, P.M.1    Swanson, R.L.2    Chong, B.H.3
  • 49
    • 0029852157 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: IgG-mediated platelet activation, platelet microparticle generation, and altered procoagulant/anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-induced thrombocytopenia
    • Warkentin TE: Heparin-induced thrombocytopenia: IgG-mediated platelet activation, platelet microparticle generation, and altered procoagulant/anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-induced thrombocytopenia. Transfus Med Rev 10:249-258, 1996
    • (1996) Transfus Med Rev , vol.10 , pp. 249-258
    • Warkentin, T.E.1
  • 50
    • 84870858023 scopus 로고
    • Cardiopulmonary bypass with a low molecular-weight heparin fraction
    • Gouault-Heilmann M, Huet Y, Contant G, et al: Cardiopulmonary bypass with a low molecular-weight heparin fraction. Lancet 2:1374, 1983
    • (1983) Lancet , vol.2 , pp. 1374
    • Gouault-Heilmann, M.1    Huet, Y.2    Contant, G.3
  • 51
    • 0033783136 scopus 로고    scopus 로고
    • Cardiopulmonary bypass in humans: Bypassing unfractionated heparin
    • Frederiksen JW: Cardiopulmonary bypass in humans: Bypassing unfractionated heparin. Ann Thorac Surg 70:1434-1443, 2000
    • (2000) Ann Thorac Surg , vol.70 , pp. 1434-1443
    • Frederiksen, J.W.1
  • 52
    • 0029942038 scopus 로고    scopus 로고
    • The interaction between heparin and polylysine: A circular dichroism and molecular modelling study
    • Mulloy B, Crane DT, Drake AF, et al: The interaction between heparin and polylysine: A circular dichroism and molecular modelling study. Braz J Med Biol Res 29:721-729, 1996
    • (1996) Braz J Med Biol Res , vol.29 , pp. 721-729
    • Mulloy, B.1    Crane, D.T.2    Drake, A.F.3
  • 53
    • 0025974938 scopus 로고
    • One explanation of the asthma paradox: Inhibition of natural anti-inflammatory mechanism by beta 2-agonists
    • Page CP: One explanation of the asthma paradox: Inhibition of natural anti-inflammatory mechanism by beta 2-agonists. Lancet 337:717-720, 1991
    • (1991) Lancet , vol.337 , pp. 717-720
    • Page, C.P.1
  • 54
    • 0027434514 scopus 로고
    • Heparin inhibits the immediate response in antigen in the skin and lungs of allergic subjects
    • Bowler SD, Smith SM, Lavercombe PS: Heparin inhibits the immediate response in antigen in the skin and lungs of allergic subjects. Am Rev Respir Dis 147:160-163, 1993
    • (1993) Am Rev Respir Dis , vol.147 , pp. 160-163
    • Bowler, S.D.1    Smith, S.M.2    Lavercombe, P.S.3
  • 55
    • 0032975985 scopus 로고    scopus 로고
    • Unfractioned heparin in the therapy of patients with highly active inflammatory bowel disease
    • Folwaczny C, Wiebecke B, Loeschke K: Unfractioned heparin in the therapy of patients with highly active inflammatory bowel disease. Am J Gastroenterol 94:1551-1555, 1999
    • (1999) Am J Gastroenterol , vol.94 , pp. 1551-1555
    • Folwaczny, C.1    Wiebecke, B.2    Loeschke, K.3
  • 56
    • 0031001403 scopus 로고    scopus 로고
    • Epithelial coating techniques in the treatment of interstitial cystitis
    • Parsons CL: Epithelial coating techniques in the treatment of interstitial cystitis. Urology 49:100-104, 1997 (suppl)
    • (1997) Urology , vol.49 , Issue.SUPPL. , pp. 100-104
    • Parsons, C.L.1
  • 57
    • 0031744024 scopus 로고    scopus 로고
    • Low-dose low-molecular-weight heparin is anti-inflammatory during venous thrombosis
    • Downing LJ, Strieter RM, Kadell AM, et al: Low-dose low-molecular-weight heparin is anti-inflammatory during venous thrombosis. J Vasc Surg 28:848-854, 1998
    • (1998) J Vasc Surg , vol.28 , pp. 848-854
    • Downing, L.J.1    Strieter, R.M.2    Kadell, A.M.3
  • 58
  • 59
    • 0026737738 scopus 로고
    • Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils
    • Klein NJ, Shennan GI, Heyderman RS, et al: Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils. J Cell Sci 102:821-832, 1992
    • (1992) J Cell Sci , vol.102 , pp. 821-832
    • Klein, N.J.1    Shennan, G.I.2    Heyderman, R.S.3
  • 60
    • 0017273853 scopus 로고
    • The observation of heparin on endothelium after injection
    • Hiebert LM, Jaques LB: The observation of heparin on endothelium after injection. Thromb Res 8:195-204, 1976
    • (1976) Thromb Res , vol.8 , pp. 195-204
    • Hiebert, L.M.1    Jaques, L.B.2
  • 61
    • 0017705237 scopus 로고
    • Heparin releases heparan sulfate from the cell surface
    • Kraemer PM: Heparin releases heparan sulfate from the cell surface. Biochem Biophys Res Commun 78:1334-1340, 1977
    • (1977) Biochem Biophys Res Commun , vol.78 , pp. 1334-1340
    • Kraemer, P.M.1
  • 62
    • 0033950082 scopus 로고    scopus 로고
    • The effects of heparin and related molecules upon the adhesion of human polymorphonuclear leucocytes to vascular endothelium in vitro
    • Lever R, Hoult JR, Page CP: The effects of heparin and related molecules upon the adhesion of human polymorphonuclear leucocytes to vascular endothelium in vitro. Br J Pharmacol 129:533-540, 2000
    • (2000) Br J Pharmacol , vol.129 , pp. 533-540
    • Lever, R.1    Hoult, J.R.2    Page, C.P.3
  • 63
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
    • Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76:301-314, 1994
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 64
    • 0024109978 scopus 로고
    • Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen
    • Altieri DC, Bader R, Mannucci PM, et al: Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen. J Cell Biol 107:1893-1900, 1988
    • (1988) J Cell Biol , vol.107 , pp. 1893-1900
    • Altieri, D.C.1    Bader, R.2    Mannucci, P.M.3
  • 65
    • 0012008473 scopus 로고
    • Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: An alternative initiation of the coagulation protease cascade
    • Altieri DC, Morrissey JH, Edgington TS: Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: An alternative initiation of the coagulation protease cascade. Proc Natl Acad Sci U S A 85:7462-7466, 1988
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 7462-7466
    • Altieri, D.C.1    Morrissey, J.H.2    Edgington, T.S.3
  • 66
    • 0029166397 scopus 로고
    • Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1)
    • Diamond MS, Alon R, Parkos CA, et al: Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1). J Cell Biol 130:1473-1482, 1995
    • (1995) J Cell Biol , vol.130 , pp. 1473-1482
    • Diamond, M.S.1    Alon, R.2    Parkos, C.A.3
  • 67
    • 0033527375 scopus 로고    scopus 로고
    • Heparin inhibits ligand binding to the leukocyte integrin Mac-1 (CD11b/CD18)
    • Peter K, Schwarz M, Conradt C, et al: Heparin inhibits ligand binding to the leukocyte integrin Mac-1 (CD11b/CD18). Circulation 100:1533-1539, 1999
    • (1999) Circulation , vol.100 , pp. 1533-1539
    • Peter, K.1    Schwarz, M.2    Conradt, C.3
  • 68
    • 0026581798 scopus 로고
    • Cardiopulmonary bypass induces leukocyte-platelet adhesion
    • Rinder CS, Bonan JL, Rinder HM, et al: Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 79:1201-1205, 1992
    • (1992) Blood , vol.79 , pp. 1201-1205
    • Rinder, C.S.1    Bonan, J.L.2    Rinder, H.M.3
  • 69
    • 0028130314 scopus 로고
    • Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18)
    • Ueda T, Rieu P, Brayer J, et al: Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18). Proc Natl Acad Sci U S A 91:10680-10684, 1994
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10680-10684
    • Ueda, T.1    Rieu, P.2    Brayer, J.3
  • 70
    • 0036024085 scopus 로고    scopus 로고
    • Selectins: Critical mediators of leukocyte recruitment
    • Patel KD, Cuvelier SL, Wiehler S: Selectins: Critical mediators of leukocyte recruitment. Semin Immunol 14:73-81, 2002
    • (2002) Semin Immunol , vol.14 , pp. 73-81
    • Patel, K.D.1    Cuvelier, S.L.2    Wiehler, S.3
  • 71
    • 0029758146 scopus 로고    scopus 로고
    • Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro
    • Walcheck B, Moore KL, McEver RP, et al: Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro. J Clin Invest 98:1081-1087, 1996
    • (1996) J Clin Invest , vol.98 , pp. 1081-1087
    • Walcheck, B.1    Moore, K.L.2    McEver, R.P.3
  • 72
    • 0027209421 scopus 로고
    • Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
    • Mayadas TN, Johnson RC, Rayburn H, et al: Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74:541-554, 1993
    • (1993) Cell , vol.74 , pp. 541-554
    • Mayadas, T.N.1    Johnson, R.C.2    Rayburn, H.3
  • 73
    • 0028464674 scopus 로고
    • Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
    • Arbones ML, Ord DC, Ley K, et al: Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1:247-260, 1994
    • (1994) Immunity , vol.1 , pp. 247-260
    • Arbones, M.L.1    Ord, D.C.2    Ley, K.3
  • 74
    • 0028534657 scopus 로고
    • Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins
    • Labow MA, Norton CR, Rumberger JM, et al: Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins. Immunity 1:709-720, 1994
    • (1994) Immunity , vol.1 , pp. 709-720
    • Labow, M.A.1    Norton, C.R.2    Rumberger, J.M.3
  • 75
    • 0027484507 scopus 로고
    • Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation
    • Nelson RM, Cecconi O, Roberts WG, et al: Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood 82:3253-3258, 1993
    • (1993) Blood , vol.82 , pp. 3253-3258
    • Nelson, R.M.1    Cecconi, O.2    Roberts, W.G.3
  • 76
    • 0029857294 scopus 로고    scopus 로고
    • Reduction of brain injury using heparin to inhibit leukocyte accumulation in rat model of transient focal cerebral ischemia. I. Protective mechanism
    • Yanak K, Spellman SR, McCarthy JB, et al: Reduction of brain injury using heparin to inhibit leukocyte accumulation in rat model of transient focal cerebral ischemia. I. Protective mechanism. J Neurosurg 85:1102-1107, 1996
    • (1996) J Neurosurg , vol.85 , pp. 1102-1107
    • Yanak, K.1    Spellman, S.R.2    McCarthy, J.B.3
  • 77
    • 0027493797 scopus 로고
    • The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B lymphoid cell phenotypes
    • Watt SM, Williamson J, Genevier H, et al: The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B lymphoid cell phenotypes. Blood 82:2649-2663, 1993
    • (1993) Blood , vol.82 , pp. 2649-2663
    • Watt, S.M.1    Williamson, J.2    Genevier, H.3
  • 78
    • 0033385653 scopus 로고    scopus 로고
    • The use of heparin for treating human malignancies
    • Ornstein DL, Zacharski LR: The use of heparin for treating human malignancies. Haemostasis 29:48-60, 1999 (suppl)
    • (1999) Haemostasis , vol.29 , Issue.SUPPL. , pp. 48-60
    • Ornstein, D.L.1    Zacharski, L.R.2
  • 79
    • 0019820999 scopus 로고
    • Role of platelets in tumor cell metastases
    • Karpatkin S, Pearlstein E: Role of platelets in tumor cell metastases. Ann Intern Med 95:636-641, 1981
    • (1981) Ann Intern Med , vol.95 , pp. 636-641
    • Karpatkin, S.1    Pearlstein, E.2
  • 80
    • 0030748084 scopus 로고    scopus 로고
    • Selectin-carbohydrate interactions during inflammation and metastasis
    • McEver RP: Selectin-carbohydrate interactions during inflammation and metastasis. Glycoconj J 14:585-591, 1997
    • (1997) Glycoconj J , vol.14 , pp. 585-591
    • McEver, R.P.1
  • 81
    • 0027398098 scopus 로고
    • Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium
    • Takada A, Ohmori K, Yoneda T, et al: Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res 53:354-361, 1993
    • (1993) Cancer Res , vol.53 , pp. 354-361
    • Takada, A.1    Ohmori, K.2    Yoneda, T.3
  • 82
    • 0034952423 scopus 로고    scopus 로고
    • P-selectin, carcinoma metastasis and heparin: Novel mechanistic connections with therapeutic implications
    • Varki A, Varki NM: P-selectin, carcinoma metastasis and heparin: Novel mechanistic connections with therapeutic implications. Braz J Med Biol Res 34:711-717, 2001
    • (2001) Braz J Med Biol Res , vol.34 , pp. 711-717
    • Varki, A.1    Varki, N.M.2
  • 83
    • 0023720810 scopus 로고
    • Role of fibrin coagulation in protection of murine tumor cells from destruction by cytotoxic cells
    • Gunji Y, Gorelik E: Role of fibrin coagulation in protection of murine tumor cells from destruction by cytotoxic cells. Cancer Res 48:5216-5221, 1988
    • (1988) Cancer Res , vol.48 , pp. 5216-5221
    • Gunji, Y.1    Gorelik, E.2
  • 84
    • 0027935431 scopus 로고
    • Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice
    • Zhang Y, Deng Y, Luther T, et al: Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest 94:1320-1327, 1994
    • (1994) J Clin Invest , vol.94 , pp. 1320-1327
    • Zhang, Y.1    Deng, Y.2    Luther, T.3
  • 85
    • 0029973399 scopus 로고    scopus 로고
    • Actions of heparin in the atherosclerotic process
    • Engelberg H: Actions of heparin in the atherosclerotic process. Pharmacol Rev 48:327-352, 1996
    • (1996) Pharmacol Rev , vol.48 , pp. 327-352
    • Engelberg, H.1
  • 87
    • 0027535914 scopus 로고
    • Biology and biochemistry of proteinases in tumor invasion
    • Mignatti P, Rifkin DB: Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 73:161-195, 1993
    • (1993) Physiol Rev , vol.73 , pp. 161-195
    • Mignatti, P.1    Rifkin, D.B.2
  • 88
    • 0032941869 scopus 로고    scopus 로고
    • Actions of heparin that may affect the malignant process
    • Engelberg H: Actions of heparin that may affect the malignant process. Cancer 85:257-272, 1999
    • (1999) Cancer , vol.85 , pp. 257-272
    • Engelberg, H.1
  • 89
    • 0026762840 scopus 로고
    • Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptide
    • Drake SL, Klein DJ, Mickelson DJ, et al: Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptide. J Cell Biol 117:1331-1341, 1992
    • (1992) J Cell Biol , vol.117 , pp. 1331-1341
    • Drake, S.L.1    Klein, D.J.2    Mickelson, D.J.3
  • 90
    • 0021678302 scopus 로고
    • Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor
    • Cochran BH, Zullo J, Verma IM, et al: Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science 226:1080-1082, 1984
    • (1984) Science , vol.226 , pp. 1080-1082
    • Cochran, B.H.1    Zullo, J.2    Verma, I.M.3
  • 91
    • 0345070015 scopus 로고
    • The PDGF A-chain contains an amino acid sequence that specifically binds to heparin causing inactivation of the growth factor
    • Fager G: The PDGF A-chain contains an amino acid sequence that specifically binds to heparin causing inactivation of the growth factor. Scand J Clin Invest 199:33-36, 1990
    • (1990) Scand J Clin Invest , vol.199 , pp. 33-36
    • Fager, G.1
  • 92
    • 0036840597 scopus 로고    scopus 로고
    • Heparin-induced hyperkalemia after cardiac surgery
    • Day JRS, Chaudhry AN, Hunt I, et al: Heparin-induced hyperkalemia after cardiac surgery. Ann Thorac Surg 74:1698-1700, 2002
    • (2002) Ann Thorac Surg , vol.74 , pp. 1698-1700
    • Day, J.R.S.1    Chaudhry, A.N.2    Hunt, I.3
  • 93
    • 0025970264 scopus 로고
    • Effects of routine heparin therapy on plasma aldosterone concentration
    • Kageyama Y, Suzuki H, Saruta T: Effects of routine heparin therapy on plasma aldosterone concentration. Acta Endocrinol (Copenh) 124:267-270, 1991
    • (1991) Acta Endocrinol (Copenh) , vol.124 , pp. 267-270
    • Kageyama, Y.1    Suzuki, H.2    Saruta, T.3
  • 94
    • 0026703707 scopus 로고
    • Dose-dependent suppression of mineralocorticoid metabolism by different heparin fractions
    • Siebels M, Andrassy K, Vecsei P, et al: Dose-dependent suppression of mineralocorticoid metabolism by different heparin fractions. Thromb Res 66:467-473, 1992
    • (1992) Thromb Res , vol.66 , pp. 467-473
    • Siebels, M.1    Andrassy, K.2    Vecsei, P.3
  • 95
    • 0025254073 scopus 로고
    • Heparin-induced hyperkalemia
    • Aull L, Chao H, Coy K: Heparin-induced hyperkalemia. DICP 24:244-246, 1990
    • (1990) DICP , vol.24 , pp. 244-246
    • Aull, L.1    Chao, H.2    Coy, K.3
  • 96
    • 0024082159 scopus 로고
    • Inducing hyperkalemia by converting enzyme inhibitors and heparin
    • Durand D, Ader JL, Rey JP, et al: Inducing hyperkalemia by converting enzyme inhibitors and heparin. Kidney Int Suppl 25:S196-S197, 1988
    • (1988) Kidney Int Suppl , vol.25
    • Durand, D.1    Ader, J.L.2    Rey, J.P.3
  • 97
    • 0022909027 scopus 로고
    • Suppression of aldosterone production by low-dose heparin
    • Sherman RA, Ruddy MC: Suppression of aldosterone production by low-dose heparin. Am J Nephrol 6:165-168, 1986
    • (1986) Am J Nephrol , vol.6 , pp. 165-168
    • Sherman, R.A.1    Ruddy, M.C.2
  • 98
    • 0029000397 scopus 로고
    • Heparin-induced aldosterone suppression and hyperkalemia
    • Oster JR, Singer I, Fishman LM: Heparin-induced aldosterone suppression and hyperkalemia. Am J Med 98:575-586, 1995
    • (1995) Am J Med , vol.98 , pp. 575-586
    • Oster, J.R.1    Singer, I.2    Fishman, L.M.3
  • 99
    • 0023679426 scopus 로고
    • Lipoprotein lipase, hepatic lipase and plasma lipolytic activity. Effects of heparin and a low-molecular-weight heparin fragment (Fragmin)
    • Persson E: Lipoprotein lipase, hepatic lipase and plasma lipolytic activity. Effects of heparin and a low-molecular-weight heparin fragment (Fragmin). Acta Med Scand Suppl 724:1-56, 1988
    • (1988) Acta Med Scand Suppl , vol.724 , pp. 1-56
    • Persson, E.1
  • 100
    • 0029075830 scopus 로고
    • Triglyceride lipases and atherosclerosis
    • Olivecrona G, Olivecrona T: Triglyceride lipases and atherosclerosis. Curr Opin Lipidol 6:291-305, 1995
    • (1995) Curr Opin Lipidol , vol.6 , pp. 291-305
    • Olivecrona, G.1    Olivecrona, T.2
  • 101
    • 0020071216 scopus 로고
    • The role of heparin in the changes of lipid patterns during a single hemodialysis
    • Teraoka J, Matsui N, Nakagawa S, et al: The role of heparin in the changes of lipid patterns during a single hemodialysis. Clin Nephrol 17:96-99, 1982
    • (1982) Clin Nephrol , vol.17 , pp. 96-99
    • Teraoka, J.1    Matsui, N.2    Nakagawa, S.3
  • 102
    • 0035955618 scopus 로고    scopus 로고
    • Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis
    • Fan J, Unoki H, Kojima N, et al: Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 276:40071-40079, 2001
    • (2001) J Biol Chem , vol.276 , pp. 40071-40079
    • Fan, J.1    Unoki, H.2    Kojima, N.3
  • 103
    • 0025260564 scopus 로고
    • Lipolytic effects of heparin and low-molecular-weight heparin and their importance in hemodialysis
    • Schrader J, Andersson LO, Armstrong VW, et al: Lipolytic effects of heparin and low-molecular-weight heparin and their importance in hemodialysis. Semin Thromb Hemost 16:41-45, 1990 (suppl)
    • (1990) Semin Thromb Hemost , vol.16 , Issue.SUPPL. , pp. 41-45
    • Schrader, J.1    Andersson, L.O.2    Armstrong, V.W.3
  • 104
    • 0029879190 scopus 로고    scopus 로고
    • Extremely low doses of heparin release lipase activity into the plasma and can thereby cause artifactual elevations in the serum-free thyroxine concentration as measured by equilibrium dialysis
    • Jaume JC, Mendel CM, Frost PH, et al: Extremely low doses of heparin release lipase activity into the plasma and can thereby cause artifactual elevations in the serum-free thyroxine concentration as measured by equilibrium dialysis. Thyroid 6:79-83, 1996
    • (1996) Thyroid , vol.6 , pp. 79-83
    • Jaume, J.C.1    Mendel, C.M.2    Frost, P.H.3
  • 105
    • 0034821307 scopus 로고    scopus 로고
    • Abnormal serum free thyroid hormone levels due to heparin administration
    • Laji K, Rhidha B, John R, et al: Abnormal serum free thyroid hormone levels due to heparin administration. Q J Med 94:471-473, 2001
    • (2001) Q J Med , vol.94 , pp. 471-473
    • Laji, K.1    Rhidha, B.2    John, R.3
  • 106
    • 0022999002 scopus 로고
    • Effect of free fatty acids on the concentration of free thyroxine in human serum: The note of albumin
    • Mendel CM, Frost PH, Cavalieri RR: Effect of free fatty acids on the concentration of free thyroxine in human serum: The note of albumin. J Clin Endocrinol Metab 63:1394-1399, 1986
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 1394-1399
    • Mendel, C.M.1    Frost, P.H.2    Cavalieri, R.R.3
  • 107
    • 0023578378 scopus 로고
    • Mechanism of the heparin-induced increase in the concentration of free thyroxine in plasma
    • Mendel CM, Frost PH, Kunitake ST, et al: Mechanism of the heparin-induced increase in the concentration of free thyroxine in plasma. J Clin Endocrinol Metab 65:1259-1264, 1987
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 1259-1264
    • Mendel, C.M.1    Frost, P.H.2    Kunitake, S.T.3
  • 109
    • 0018605698 scopus 로고
    • Heparin: An old drug with a new paradigm
    • Jaques BL: Heparin: An old drug with a new paradigm. Science 206:528-533, 1979
    • (1979) Science , vol.206 , pp. 528-533
    • Jaques, B.L.1
  • 110
    • 0016420988 scopus 로고
    • Heparin-induced osteopenia: An appraisal
    • Avioli LV: Heparin-induced osteopenia: An appraisal. Adv Exp Med Biol 52:375-387, 1975
    • (1975) Adv Exp Med Biol , vol.52 , pp. 375-387
    • Avioli, L.V.1
  • 111
    • 0029092536 scopus 로고
    • The effects of low-molecular-weight and standard heparin on calcium loss from fetal rat calvaria
    • Shaughnessy SG, Young E, Deschamps P, et al: The effects of low-molecular-weight and standard heparin on calcium loss from fetal rat calvaria. Blood 86:1368-1373, 1995
    • (1995) Blood , vol.86 , pp. 1368-1373
    • Shaughnessy, S.G.1    Young, E.2    Deschamps, P.3
  • 112
    • 0030881464 scopus 로고    scopus 로고
    • Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung
    • Fryer A, Huang YC, Rao G, et al: Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung. J Pharmacol Exp Ther 282:208-219, 1997
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 208-219
    • Fryer, A.1    Huang, Y.C.2    Rao, G.3
  • 113
    • 0033583465 scopus 로고    scopus 로고
    • Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics
    • Petitou M, Driguez PA, Duchaussoy P, et al: Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics. Bioorg Med Chem Lett 9:1161-1166, 1999
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 1161-1166
    • Petitou, M.1    Driguez, P.A.2    Duchaussoy, P.3
  • 114
    • 0034612268 scopus 로고    scopus 로고
    • Orally administered unfractionated heparin with carrier agent is therapeutic for deep venous thrombosis
    • Gonze MD, Salartash K, Sternbergh WC III, et al: Orally administered unfractionated heparin with carrier agent is therapeutic for deep venous thrombosis. Circulation 101:2658-2661, 2000
    • (2000) Circulation , vol.101 , pp. 2658-2661
    • Gonze, M.D.1    Salartash, K.2    Sternbergh III, W.C.3


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