Histomorphometric analysis of the effects of standard heparin on trabecular bone in vivo

Blood

Volumn 88, Issue 4, 1996, Pages 1314-1320

  Muir, Jeffrey M ^a   Andrew, Maureen ^a   Hirsh, Jack ^a   Weitz, Jeffrey I ^a   Young, Edward ^a   Deschamps, Paula ^a   Shaughnessy, Stephen G ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b HAMILTON HEALTH SCIENCES   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; HEPARIN; PYRIDINOL;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE MINERALIZATION; CONTROLLED STUDY; FEMALE; FEMUR; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TRABECULAR BONE;

EID: 0029838671     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.4.1314.bloodjournal8841314     Document Type: Article

References (35)

1. Avioli LV: Heparin induced osteoporosis: An appraisal. Adv Exp Med Biol 52:375, 1975
2. Griffith CC, Nichols G, Asher JD, Flanagan B: Heparin osteoporosis. JAMA 193:85, 1965
3. Jaffe MD, Willis PW: Multiple fractures associated with long term sodium heparin therapy. JAMA 193:152, 1965
4. Miller WE. DeWolfe VG: Osleoporosis resulting from heparin therapy. Cleve Clin Quart 33:31, 1966
5. Dahlman TC, Sjoberg HE, Ringertz H: Bone mineral density during long-term prophylaxis with heparin in pregnancy. Am J Obstet Gynecol 170:1315, 1994
6. Squires JW, Pinch LWC: Heparin-induced spinal fractures. JAMA 241:2417, 1979
7. Murphy MS, John PR, Mayer AD, Buckels JAC, Kelly DA: Heparin therapy and bone fractures. Lancet 340:1098, 1992
8. Monreal M, Olive A, Lafoz E, Del Rio L: Heparins, coumarin, and bone density. Lancet 338:706, 1991
9. Rupp WM, McCarthy HB, Ronde TD, Blackshear PJ, Goldenberg FJ, Buchwald H: Risk of osteoporosis in patients treated with long-term intravenous heparin. Curr Probl Surg 39:419, 1982
10. Barbour LA, Kick SD, Steiner JF, LoVerde ME, Heddleston LN, Lear JL, Baron AE, Barton PL: A prospective study of heparin-induced osteoporosis in pregnancy using bone densitometry. Am J Obstet Gynecol 170:862, 1994
11. Monreal M, Lafoz E, Olive A, del Rio L, Vedia C: Comparison of subcutaneous unfractionated heparin with a low molecular weight heparin (Fragmin) in patients with venous thromboembolism and contraindications to coumarin. Thromb Haemost 71:7, 1994
12. Dahlman TC: Osteoporotic fractures and the recurrence of thromboembolism during pregnancy and the puerperium in 184 women undergoing thromboprophylaxis with heparin. Am J Obstet Gynecol 168:1265, 1993
13. Hurley MM, Kream BE, Raisz LG: Structural determinants of the capacity of heparin to inhibit collagen synthesis in 21-day fetal rat calvariae. J Bone Miner Res 5:1127, 1990
14. Shibata Y, Abiko Y, Goto K, Moriya Y, Takiguchi H: Heparin stimulates the collagen synthesis in mineralized cultures of the osteoblast-like cell line, MC3T3-E1. Biochem Intern 28:335, 1992
15. Shaughnessy SG, Young E, Deschamps P, Hirsh J: The effects of low molecular weight and standard heparin on calcium loss from fetal rat calvaria. Blood 86:1368, 1995
16. Cochran DL: Glycosaminoglycan stimulation of calcium release from mouse calvariae. Specificity for hyaluronic acid and dermatan sulfate. Calcif Tissue Int 41:79, 1987
17. Lenaers-Claeys G, Vaes G: Collagenase, procollagenase and bone resorption. Effects of heparin. parathyroid hormone and calcitonin. Biochim Biophys Acta 584:375, 1979
18. Goldhaber P: Heparin enhancement of factors stimulating bone resorption in tissue culture. Science 147:407, 1965
19. Fuller K, Chambers TJ, Gallagher AC: Heparin augments osteoclast resorption-stimulating activity in serum. J Cell Physiol 147:208, 1991
20. Chowdhury MH, Hamadu C, Dempster DW: Effects of heparin on osteoclast activity. J Bone Miner Res 7:771, 1992
21. Kostenuik PJ, Orr FW, Suyama K, Singh G: Increased growth rat and tumor burden of spontaneously metastatic walker 256 cancer cells in the skeleton of bisphosphonate-treated rats. Cancer Res 53:5452, 1993
22. Kostenuik PJ, Singh G, Suyama KL, Orr FW: A quantitative model for spontaneous bone metastasis: Evidence for a mitogenic effect of bone on Walker 256 cancer cells. Clin Exp Metastasis 10:403, 1992
23. Kostenuik PJ, Singh G, Suyama KL, Orr FW: Increased bone resorption in vivo is associated with a selective increase in the growth of metastatic Walker 256 cancer cells in bone. Clin Exp Metastasis 10:411, 1992
24. Monreal M, Vinas L, Monreal L, Lavin S, Lafoz E, Angles AM: Heparin-related osteoporosis in rats. Haemostusis 20:204, 1990
25. Matzsch T, Bergqvist D, Hedner U, Nilsson B. Ostergaard P: Effects of low molecular weight heparin and unfragmented heparin on induction of osteoporosis in rats. Thromb Haemost 63:505, 1990
26. Murray WJG, Lindo VS, Kakkar VV, Melissari E: Long-term administration of heparin and heparin fractions and osteoporosis in experimental animals. Blood Coagul Fibrinolysis 6:113, 1995
27. Gospodarowicz D, Cheng J: Heparin protects basic and acidic FGF from inactivation. J Cell Physiol 128:475, 1986
28. Hurley MM, Kessler M, Gronowicz G, Raisz LG: The interaction of heparin and basic fibroblast growth factor on collagen synthesis in 21-day fetal rat calvariae. Endocrinology 130:2675, 1992
29. Crisp AJ, Wright JK, Hazleman BL: Effects of heparin, histamine, and salmon calcitonin on mouse calvarial bone resorption. Ann Rheum Dis 45:422, 1986
30. Van der Wiel HE, Lips P, Huijgens PC, Netelenbos JC: Effects of short-term low-dose heparin administration on biochemical parameters of bone turnover. Bone Mineral 22:27, 1993
31. Rodan GA, Martin TJ: Role of osteoblasts in hormonal control of bone resorption - A hypothesis. Calcif Tissue Int 33:349, 1981
32. Braidman IP, Anderson DC, Jones CJP, Weiss JB: Separation of two bone populations from fetal rat calvaria and a study of their responses to parathyroid hormone and calcitonin. J Endocrinol 99:387, 1983
33. McSheehy PMJ, Chambers TJ: Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone. Endocrinology 118:824, 1986
34. Megard M, Cuche M, Grapeloux A, Bojoly C, Meunier PJ: Osteoporose de l'heparinotherapie. Analyse histomorphometrique de la biopsie osseuse. Une observation. Nouv Presse Med 11:261, 1982
35. Zimran A, Shilo S, Fisher D, Bab I: Histomorphometric Evaluation of reversible heparin-induced osteoporosis in pregnancy. Arch Intern Med 146:386, 1986