The interaction between heparin and polylysine: A circular dichroism and molecular modelling study

Brazilian Journal of Medical and Biological Research

Volumn 29, Issue 6, 1996, Pages 721-729

  Mulloy, B ^a   Crane, D T ^a   Drake, A F ^b   Davies, D B ^b  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

circular dichroism; heparin; polylysine

Indexed keywords

HEPARIN; HEPARIN DERIVATIVE; OLIGOSACCHARIDE; POLYLYSINE;

ARTICLE; CIRCULAR DICHROISM; DRUG INTERACTION; DRUG STRUCTURE; SPECTROSCOPY;

CIRCULAR DICHROISM; DRUG INTERACTIONS; HEPARIN; MODELS, MOLECULAR; OLIGOSACCHARIDES; POLYLYSINE;

EID: 0029942038     PISSN: 0100879X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Jackson RL, Busch SJ & Cardin AD (1991). Glycosaminoglycans: Molecular properties, protein interactions, and role in physiological processes. Physiological Reviews, 71:481-539.
2. Cardin AD & Weintraub HJR (1989). Molecular modeling of protein-glycosaminoglycan interactions. Arteriosclerosis, 9: 21-32.
3. Margalit H, Fischer N & Ben-Sasson SA (1993). Comparative analysis of structurally defined heparin binding sequences reveals a distinct spatial distribution of basic residues. Journal of Biological Chemistry, 268: 19228-19231.
4. Spillmann D & Lindahl U (1994). Glycosaminoglycan-protein interactions: a question of specificity. Current Opinion in Structural Biology, 4: 677-682.
5. Choay J, Lormeau JC, Petitou M, Sinäy P, Casu B, Oreste P, Torri G & Gatti G (1980). Anti-Xa active heparin oligosaccharides. Thrombosis Research, 18: 573-578.
6. Gelman RA & Blackwell J (1973). Heparin-polypeptide interactions in aqueous solution. Archives of Biochemistry and Biophysics, 159: 427-433.
7. Blackwell J, Schodt KP & Gelman RA (1977). Polysaccharide-polypeptide systems as models for heparin interactions. Federation Proceedings, 36: 98-101.
8. Mulloy B, Forster MJ, Jones C & Davies DB (1993). NMR and molecular modelling studies of the solution conformation of heparin. Biochemical Journal, 293:849-858.
9. Mulloy B, Forster MJ, Jones C, Johnson EA & Davies DB (1994). The effect of variation of substitution on the solution conformation of heparin: a spectroscopic and molecular modelling study. Carbohydrate Research, 255: 1-26.
10. Bangham DR & Mussett MV (1959). The Second International Standard for Heparin. Bulletin of the World Health Organization, 20: 1201-1208.
11. Nielsen J-I (1992). A convenient method for molecular mass determination of heparin. Thrombosis and Haemostasis, 68: 478-480.
12. Drake AF, Siligardi G & Gibbons WA (1988). Reassessment of the electronic circular dichroism criteria for random coil conformations of poly(L-lysine) and the implications for protein folding and denaturation studies. Biophysical Chemistry, 31: 143-146.
13. Siligardi G & Drake AF (1995). The importance of extended conformations and in particular of the PII conformation for the molecular recognition of peptides. Biopolymers (Peptide Science), 37: 281-292.
14. Morttishire-Smith RJ, Drake AF, Nutkins JC & Williams DH (1991). Left-handed α-helix formation by a bacterial peptide. FEBS Letters, 278: 244-246.
15. Nieduszynski IA & Atkins EDT (1975). Crystalline structure of heparin. In: Bradshaw RA & Wessier S (Editors), Heparin: Structure, Function, and Clinical Implications. 1st edn. Plenum Press, New York.
16. Gelman RA, Rippon WB & Blackwell J (1972). Interactions between chondroitin sulfate and poly-L-lysine: preliminary report. Biochemical and Biophysical Research Communications, 48: 708-711.
17. Gelman RA & Blackwell J (1973). Interactions between mucopolysaccharides and cationic polypeptides in aqueous solution: chondroitin 4-sulfate and dermatan sulfate. Biopolymers, 12: 1959-1974.
18. Gelman RA & Blackwell J (1973). Mucopolysaccharide-polypeptide interactions: effect of the position of the sulfate group. Biochimica et Biophysics Acta, 297: 452-455.
19. Bystricky S & Malovlková A (1994). Conformation presumption for polysaccharide-polylysine complexation. In: Dubin P, Bock K, Davis RM, Schultz DN & Thies C (Editors), Macromolecular Complexes in Chemistry and Biology. Springer-Verlag, Berlin.
20. Ferran DS, Sobel M & Harris RB (1992). Design and synthesis of a helix heparin-binding peptide. Biochemistry, 31: 5010-5016.
21. van Boeckel CAA, Grootenhuis PDJ & Visser A (1994). A mechanism for heparin-induced potentiation of antithrombin III. Structural Biology, 1: 423-425.