Modulation of the discriminative stimulus effects of mu opioid agonists in rats: I. Effects of dopamine D2/3 antagonists

Behavioural Pharmacology

Volumn 15, Issue 1, 2004, Pages 65-74

  Cook, C D ^a   Beardsley, P M ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

BP897; Drug discrimination; Heroin training dose; Methadone; Morphine; Nafadotride; Nalbuphine; Rat

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BP 897; DIAMORPHINE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE 3 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR STIMULATING AGENT; ETICLOPRIDE; FLUPENTIXOL; METHADONE; MORPHINE; MU OPIATE RECEPTOR AGONIST; NAFADOTRIDE; NALBUPHINE; WATER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATION LEARNING; DISCRIMINATIVE STIMULUS; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; MALE; NONHUMAN; RAT; TRAINING;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; BRAIN; DOPAMINE; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FLUPENTHIXOL; HEROIN; METHADONE; MORPHINE; MOTIVATION; NALBUPHINE; NAPHTHALENES; PIPERAZINES; PYRROLIDINES; RATS; RATS, LONG-EVANS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, OPIOID, MU; SALICYLAMIDES;

EID: 1242317091     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200402000-00008     Document Type: Article

References (47)

1. Altier N, Stewart J (1998). Dopamine receptor antagonists in the nucleus accumbens attenuate analgesia induced by ventral tegmental area substance P or morphine and by nucleus accumbens amphetamine. J Pharmacol Exp Ther 285:208-215.
2. Aretha CW, Sinha A, Galloway MP (1995). Dopamine D3-preferring ligands act at synthesis modulating autoreceptors. J Pharmacol Exp Ther 274:609-613.
3. Ashby CR Jr, Paul M, Gardner EL, Heidbreder CA, Hagan JJ (2003). Acute administration of the selective D3 receptor antagonist SB-277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats. Synapse 48:154-156.
4. Audinot V, Newman-Tancredi A, Gobert A, Rivet JM, Brocco M, Lejeune F, et al. (1998). A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther 287:187-197.
5. Baker LE, Miller ME, Svensson KA (1997). Assessment of the discriminative stimulus effects of the D3 dopamine antagonist PNU-99194A in rats: comparison with psychomotor stimulants. Behav Pharmacol 8:243-252.
6. Colpaert FC, Niemegeers CJ, Janssen PA (1976). Fentanyl and apomorphine: asymmetrical generalization of discriminative stimulus properties. Neuropharmacology 15:541-545.
7. Colpaert FC, Niemegeers JE, Janssen PA (1977). Differential haloperidol effect on two indices of fentanyl-saline discrimination. Psychopharmacology (Berl) 53:169-173.
8. Cook CD, Beardsley PM (2003). The modulatory actions of dopamine D2/3 agonists and antagonists on the locomotor activating effects of morphine and caffeine in mice. Pharmacol Biochem Behav 75:363-371.
9. 2/3 agonists. Behav Pharmacol 15:75-83.
10. Corrigall WA, Coen KM (1990). Selective D1 and D2 dopamine antagonists decrease response rates of food-maintained behavior and reduce the discriminative stimulus produced by heroin. Pharmacol Biochem Behav 35:351-355.
11. Costanza RM, Barber DJ, Terry P (2001). Antagonism of the discriminative stimulus effects of cocaine at two training doses by dopamine D2-like receptor antagonists. Psychopharmacology (Berl) 158:146-153.
12. David V, Durkin TP, Cazala P (2002). Differential effects of the dopamine D2/D3 receptor antagonist sulpiride on self-administration of morphine into the ventral tegmental area or the nucleus accumbens. Psychopharmacology (Berl) 160:307-317.
13. Di Chiara G, Imperato A (1988). Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther 244:1067-1080.
14. Franklin SR, Baker LE, Svensson KA (1998). Discriminative stimulus properties of the dopamine D3 antagonist PNU-99194A. Psychopharmacology (Berl) 138:40-46.
15. Gainetdinov RR, Sotnikova TD, Grekhova TV, Rayevsky KS (1996). In vivo evidence for preferential role of dopamine D3 receptor in the presynaptic regulation of dopamine release but not synthesis. Eur J Pharmacol 308:61-269.
16. Gauvin DV, Young AM (1989). Evidence for perceptual masking of the discriminative morphine stimulus. Psychopharmacology (Berl) 98:212-221.
17. Gerrits M, Ramsey NF, Wolterink G, van Ree JM (1994). Lack of evidence for an involvement of nucleus accumbens dopamine D1 receptors in the initiation of heroin self-administration in the rat. Psychopharmacology (Berl) 114:486-494.
18. 3 autoreceptors control synthesis and release in mesolimbic, mesocortical and nigrostriatal pathways. J Pharmacol Exp Ther 275:899-913.
19. Griffon N, Pilon C, Sautel F, Schwartz JC, Sokoloff P (1996). Antipsychotics with inverse agonist activity at the dopamine D3 receptor. J Neural Transm 103:1163-1175.
20. Haile CN, Kosten TA (2001). Differential effects of D1- and D2-like compounds on cocaine serf-administration in Lewis and Fischer 344 inbred rats. J Pharmacol Exp Ther 299:509-518.
21. Hemby SE, Smith JE, Dworkin SI (1996). The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats. J Pharmacol Exp Ther 277:1247-1258.
22. Institute of Laboratory Animal Resources (1996). Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press.
23. Koeltzow TE, Xu M, Cooper DC, Hu X-T, Tonegawa S, Wolf ME, White FJ (1998). Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J Neurosci 18:2231-2238.
24. Levant B (1997). The D3 dopamine receptor: neurobiology and potential clinical relevance. Pharmacol Rev 49:231-252.
25. 2 dopamine receptors by nafadotride. Neuropsychopharmacology 17:67-71.
26. McCarten MD, Lal H (1979). Attenuation of the discriminative stimulus strength of morphine by haloperidol. Neuropharmacology 18:465-467.
27. Morgan MJ, Franklin KBJ (1991). Dopamine receptor subtypes and formalin test analgesia. Pharmacol Biochem Behav 40:317-322.
28. Newman JL, Vann RE, May EL, Beardsley PM (2002). Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats. Psychopharmacology (Berl) 164:108-114.
29. Overton DA (1982). Comparison of the degree of discriminability of various drugs using the T-maze drug discrimination paradigm. Psychopharmacology (Berl) 76:385-395.
30. Picker MJ, Dykstra LA (1989). Discriminative stimulus effects of mu and kappa opioids in the pigeon: Analysis of the effects of full and partial mu and kappa agonists. J Pharmacol Exp Ther 249:557-566.
31. Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, et al. (1999). Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. Nature 400:371-375.
32. Rezayof A, Zarrindast MR, Sahraei H, Haeri-Rohani AH (2002). Involvement of dopamine D2 receptors of the central amygdala on the acquisition and expression of morphine-induced place preference in rat. Pharmacol Biochem Behav 74:1 87-197.
33. Sautel F, Griffon N, Sokoloff R, Schwartz J-C, Launay C, Simon P, et al. (1995). Nafadotride, a potent dopamine D3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther 275:1239-1246.
34. Shaham Y, Stewart J (1996). Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats. Psychopharmacology (Berl) 125:385-391.
35. Shippenberg TS, Herz A (1988). Motivational effects of opioids: influence of D-1 versus D-2 receptor antagonists. Eur J Pharmacol 151:233-242.
36. Shippenberg TS, Bals-Kubik R, Herz A (1993). Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors. J Pharmacol Exp Ther 265:53-59.
37. Sotnikova TD, Gainetdinov RR, Grekhova TV, Rayevsky KS (2001). Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study). Pharmacol Res 43:283-290.
38. Ukai M, Hiraiwa E, Kameyama T (1991). Pentazocine-like discriminative stimulus effects of morphine are blocked by the dopamine D-1 antagonist SCH 23390, but not by the dopamine D-2 antagonist sulpiride. Brain Res 541:146-148.
39. Wicke K, Garcia-Ladona J (2001). The dopamine D3 receptor partial agonist, BP 897, is an antagonist at human dopamine D3 receptors and at rat somatodendritic dopamine D3 receptors. Eur J Pharmacol 424:85-90.
40. Winger G, France CP, Woods JH, Smith CB, Medzihradsky F, Iorio MA (1992). Opioid and non-opioid effects of novel butyrophenone analogues. Neuropsychopharmacology 7:177-187.
41. Wise RA, Leone P, Rivest R, Leeb K (1995). Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration. Synapse 21:140-148.
42. Wood MD, Boyfield I, Nash DJ, Jewitt FR, Avenell KY, Riley GJ (2000). Evidence for antagonist activity of the dopamine D3 receptor partial agonist, BP 897, at human dopamine D3 receptor. Eur J Pharmacol 407:47-51.
43. Wood PL, McQuade P, Richard JW, Thakur M (1983). Agonist/antagonist analgesics and nigrostiatal dopamine metabolism in the rat: evidence of receptor dualism. Life Sci 33:759-762.
44. Young AM, Stephens KR, Hein DW, Woods JH (1984). Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids. J Pharmacol Exp Ther 229:118-126.
45. Young AM, Masaki MA, Geula C (1992). Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids. J Pharmacol Exp Ther 261:246-257.
46. Zarrindast MR, Zarghi A (1992). Morphine stimulates locomotor activity by an indirect dopaminergic mechanism: possible D-1 and D-2 receptor involvement. Gen Pharmacol 23:1221-1225.
47. Zhang L, Walker EA, Sutherland J, Young AM (2000). Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids. Psychopharmacology (Berl) 148:136-145.