Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 2, 2005, Pages 227-232

  Ueng, Yune Fang ^a,b   Tsai, Tung Hu ^a   Don, Ming Jaw ^a   Chen, Ruei Ming ^b,c   Chen, Ta Liang ^b,d  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d Jen Ai Municipal Hospital   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 1A2; ETHOXYRESORUFIN DEETHYLASE; METHOXYRESORUFIN; RESORUFIN DERIVATIVE; RUTAECARPINE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CONTROLLED STUDY; DEMETHYLATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG METABOLISM; ENZYME ACTIVITY; EVODIA RUTAECARPA; HERB; KIDNEY; MALE; MEAN RESIDENCE TIME; MICRODIALYSIS; NONHUMAN; RAT;

ALKALOIDS; ANIMALS; AREA UNDER CURVE; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; ENZYME INDUCTION; EVODIA; HALF-LIFE; INTUBATION, GASTROINTESTINAL; KIDNEY; LUNG; MALE; MICRODIALYSIS; MICROSOMES, LIVER; OXAZINES; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; THEOPHYLLINE; TIME FACTORS;

EID: 12344326617     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357055489     Document Type: Article

References (29)

1. Alexandrov, K., Cascorbi, I., Rojas, M., Bouvier, G., Kriek, E., Bartsch, H. (2002) CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation. Carcinogenesis 23: 1969-1977
2. Alvares, A. P., Mannering, G. J. (1970) Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes. Mol. Pharmacol. 6: 206-211
3. Barnes, P. J. (2003) Therapy of chronic obstructive pulmonary disease. Pharmacol. Ther. 97: 87-94
4. Don, M.-J, Lewis, D. F. V., Wang, S.-Y., Tsai, M.-W., Ueng, Y.-F. (2003) Effects of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1. Bioorg. Med. Chem. Lett. 13: 2535-2538
5. Gabrielsson, J., Weiner, D. (1994) Non-compartmental analysis. In: Pharmacokinetic and pharmacodynamic data analysis concepts and applications. Swedish Pharm. Press, Stockholm, pp 621-626
6. Gillner, M., Bergman, J., Cambillau, C., Gustafsson, J. A. (1989) Interactions of rutaecarpine alkaloids with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Carcinogenesis 10: 651-654
7. Greenlee, W. F., Poland, A. (1978) An improved assay of 7-ethoxycoumarin deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p- dioxin. J. Pharmacol. Exp. Ther. 205: 596-605
8. Ha, H. R., Chen, J., Freiburghaus, A. U., Follath, F. (1995) Metabolism of theophylline by cDNA-expressed human cytochrome P-450. Br. J. Clin. Pharmacol. 39: 321-326
9. Hendeles, L., Iafrate, R. P., Weinberger, M. (1984) A clinical and pharmacokinetic basis for the selection and use of slow release theophylline products. Clin. Pharmacokinet. 9: 95-135
10. Lowry, O. H., Roseborough, N. J., Farr, A. L., Randall, R. L. (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-275
11. Nebert, D. W., Puga, A., Vasiliou, V. (1993) Role of the Ah receptor and the dioxine-inducible [Ah] gene battery in toxicity, cancer, and signal transduction. Ann. N. Y. Acad. Sci. 685: 624-640
12. Omura, T., Sato, R. (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemeprotein nature. J. Biol. Chem. 239: 2370-2379
13. Pohl, R. J., Fouts, J. R. (1980) A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal. Biochem. 107: 150-155
14. Robson, R. A., Miners, J. O., Matthews, A. P., Stupans, I., Meller, D., McManus, M. E., Birkett, D. J. (1988) Characterization of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies. Biochem. Pharmacol. 37: 1651-1659
15. Salyers, K. L., Barr, J., Sipes, I. G. (1994) In vitro metabolism of theophylline by rat and human liver tissue. Xenobiotica 24: 389-399
16. Tang, W., Eisenbrand, G. (1992) Evodia rutaecarpa (Juss) Benth. In: Tang, W., Eisenbrand, G. (eds) Chinese drugs of plant origin. Springer-Verlag, Berlin, pp 509-514
17. Telting-Diaz, M., Scott, D. O., Lunte, C. E. (1992) Intravenous microdialysis sampling in awake, freely-moving rats. Anal. Chem. 64: 806-810
18. Teunissen, M. W., Brorens, I. O., Geerlings, J. M., Breimer, D. D. (1985) Dose-dependent elimination of theophylline in rats. Xenobiotica 15: 165-171
19. Tjia, J. F., Colbert, J., Back, D. J. (1996) Theophylline metabolism in human liver microsomes: inhibition studies. J. Pharmacol. Exp. Ther. 276: 912-917
20. Tsai, T. H., Chen, Y. F., Chen, I. F., Chen, C. F. (1999) Measurement of unbound caffeic acid in rat blood by on-line microdialysis coupled with liquid chromatography and its application to pharmacokinetic studies. J. Chromatogr. B 729: 119-125
21. Ueng, T.-H., Hwang, W.-P., Chen, R.-M., Wang, H.-W., Kuo, M.-L., Park, S. S., Guengerich, F. P. (1998) Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues. J. Toxicol. Environ. Health A 54: 509-527
22. Ueng, Y.-F., Wang, J.-J., Lin, L.-C., Park, S. S., Chen, C.-F. (2001) Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa. Life Sci. 70: 207-217
23. Ueng, Y.-F., Ko, H.-C., Chen, C.-F., Wang, J.-J., Chen, K.-T. (2002a) Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice. Life Sci. 71: 1267-1277
24. Ueng, Y.-F., Jan, W.-C., Lin, L.-C., Chen, T.-L., Guengerich, F. P., Chen, C.-F. (2002b) The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Drug Metab. Dispos. 30: 349-353
25. Wang, H.-W., Ueng, T.-H., Chen, T.-L., Yang, P.-C. (2003) Effect of frying-meat emission particulate on 17beta-estradiol 2- and 4-hydroxylation in human lung adenocarcinoma CL5 cells. J. Toxicol. Environ. Health A 66: 1175-1188
26. Weinberger, M., Hendeles, L. (1996) Theophylline in asthma. N. Engl. J. Med. 334: 1380-1388
27. Williams, J. F., Lowitt, S., Szentivanyi, A. (1979) Effects of phenobarbital and 3-methylcholanthrene pretreatment on the plasma half-life and urinary excretion profile of theophylline and its metabolites in rats. Biochem. Pharmacol. 28: 2935-2940
28. Zhang, Z.-Y., Kaminsky, L. S. (1995) Characterization of human cytochrome P450 involved in theophylline 8-hydroxylation. Biochem. Pharmacol. 50: 205-211
29. Zhu, Y.-P. (1998) Chinese materia medica: chemistry, pharmacology and applications. Harwood Academic publishers, Amsterdam, The Netherlands, pp 356-360