Effects of motorcycle exhaust on cytochrome p-450-dependent monooxygenases and glutathione S-transferase in rat tissues

Journal of Toxicology and Environmental Health - Part A

Volumn 54, Issue 7, 1998, Pages 509-527

  Ueng, Tzuu Huei ^a   Hwang, Wen Po ^a   Chen, Ruei Ming ^a   Wang, Hui Wu ^a   Kuo, Min Liang ^a   Park, Sang S ^b   Guengerich, F Peter ^c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b Korea Occupational Safety and Health Agency   (South Korea)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE; BENZO[A]PYRENE; BENZPHETAMINE; CYTOCHROME P450; ERYTHROMYCIN; ETHOXYRESORUFIN; GLUTATHIONE TRANSFERASE; MONOCLONAL ANTIBODY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXHAUST GAS; HYDROXYLATION; IMMUNOBLOTTING; INHALATION; KIDNEY; LIVER; MALE; MICROSOME; MOTORCYCLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT;

ADMINISTRATION, INHALATION; ANIMALS; BENZOPYRENE HYDROXYLASE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE TRANSFERASE; INJECTIONS, INTRAPERITONEAL; KIDNEY; LIVER; LUNG; MALE; MICROSOMES; NADPH-FERRIHEMOPROTEIN REDUCTASE; RATS; RATS, WISTAR; VEHICLE EMISSIONS;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0031681173     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/009841098158674     Document Type: Article

References (48)

1. Alvares, A. P., and Kappas, P. 1977. Heterogeneity of cytochrome P-450s induced by polychlorinated biphenyls. J. Biol. Chem. 25:6373-6378.
2. Brady, J. F., Xiao, F., Ning, S. M., and Yang, C. S. 1990. Metabolism of methyl tertiary-butyl ether by rat hepatic microsomes. Arch. Toxicol. 64:157-160.
3. Chaloupka, K., Santostefano, M., Goldfarb, I. S., Liu, G., Myers, M. J., Tsyrolv, I. B., Gelboin, H. V., Krishnan, V., and Safe, S. 1995. Aryl hydrocarbon (Ah) receptor-independent induction of Cypla2 gene expression by acenaphthylene and related compounds in B6C3F1 mice. Carcinogenesis 15:2835-2840.
4. Chan, C.-C., Lin, S.-H., and Her, G.-R. 1993. Student's exposure to volatile organic compounds while commuting by motorcycle and bus in Taipei City. J. Air Waste Manage. Assoc. 43:1231-1238.
5. Chen, K. C. 1986. Induction of ary hydrocarbon hydroxylase in rat tissue following intratracheal instillation of diesel particulate extract and benzo(a)pyrene. J. Appl. Toxicol. 6:259-262.
6. Chou, M. W., Wang, B., Von Tungeln, L. S., Beland, F. A., and Fu, P. 1987. Induction of rat hepatic cytochromes P-450 by environmental nitropolycyclic aromatic hydrocarbons. Biochem. Pharmacol. 36:2449-2454.
7. Clunies-Ross, C., Stanmore, B. R., and Millar, G. J. 1996. Dioxins in diesel exhaust. Nature 381:3 79.
8. Estabrook, R. W. 1996. The remarkable P450s: A historical overview of these versatile hemeprotein catalysts. FASEB J. 10:202-204.
9. Foy, J. W.-D., Silverman, D. M., and Schatz, R. A. 1996. Low-level m-xylene inhalation alters pulmonary and hepatic cytochrome P-450 activity in the rat. J. Toxicol. Environ. Health 47:135-144.
10. Green, F. H. Y., Boyd, R. L., Danner-Robovsky, J., Fisher, M. J., Moorman, W. J., Ong, T.-M., Tucker, J., Vallyathan, V., Whong, W.-Z., Zoldak, J., and Lewis, T. 1983. Inhalation studies of diesel exhaust and coal dust in rats. Scand. J. Work Environ. Health 9:181-188.
11. Groopman, J. D., and Kensler, T. W. 1993. Molecular markers for human chemical carcinogen exposures. Chem. Res. Toxicol. 6:764-770.
12. Guengerich, F. P., Kim, D.-H., and Iwasaki, M. 1991. Role of human cytochrome P-450IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4:168-179.
13. Gut, I., Terelius, Y., Frantik, E., Unhart, I., Soucek, P., Filipcova, B., and Kluckova, H. 1993. Exposure to various benzene derivatives differently induces cytochromes P450 2B1 and P450 2E1 in rat liver. Arch. Toxicol. 67:237-243.
14. Habig, W. H., Pabst, M. J., and Jakoby, W. B. 1974. Glutathione 5-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249:7130-7139.
15. Hayes, J. D., and Pulford, D. J. 1995. The glutathione 5-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Biol. 30:445-600.
16. Hricko, A. 1994. Toxic Taipei traffic. Environ. Health Perspect. 102:279.
17. 16 hydrocarbons using dual-column capillary GC: Application to exhaust emissions from passenger car and motorcycle engine. J. Chromatogr. Sci. 33:34-48.
18. Jeng, Y.-J., and Peng, F.-J. 1997. Chemical analysis and identification of motorcycle exhaust particulates. 12th Joint Annu. Conf. Biomedical5ciences, 19-20 April, Taipei, Taiwan, p. 234.
19. 4. Nature 227:680-685.
20. Lee, I. P., Suzuki, K., Lee, S. D., and Dixon, R. L. 1980. Aryl hydrocarbon hydroxylase induction in rat lung, liver, and male reproductive organs following inhalation exposure to diesel emission. Toxicol. Appl. Pharmacol. 52:181-184.
21. Lewis, T. R., Moorman, W. J., Yang, Y.-Y., and Stara, J. F. 1974. Long-term exposure to auto exhaust and other pollutant mixtures. Arch. Environ. Health 29:102-106.
22. Lewtas, J. 1993. Airborne carcinogens. Pharmacol. Toxicol. 72(suppl. 1):S55-S63.
23. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein determinations with Folin phenol reagent. J. Biol. Chem. 193:265-275.
24. Lubet, R. A., Mayer, R. T., Cameron, J. W., Nims, R. W., Burke, M. D., Wolff, T., and Guengerich, F. P. 1985. Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics. Arch. Biochem. Biophys. 238:43-48.
25. Maejima, K., Suzuki, T., Numata, H., Maekawa, A., and Nagase, S. 1994. Subchronic (12-week) inhalation toxicity study of methanol-fueled engine exhaust in rats. J. Toxicol. Environ. Health 41:315-327.
26. Mauderly, J. L. 1994. Toxicological and epidemiological evidence for health risks from inhaled engine emissions. Environ. Health Perspect. 102:165-171.
27. Mayer, R. T., Jermyn, J. W., Burke, M. D., and Prough, R. A. 1977. Methoxyresorufin as a substrate for the fluorometric assay of insect microsomal O-dealkylase. Pestic. Biochem. Physiol. 7:349-354.
28. Meister, A. 1994. Glutathione-ascorbic acid antioxidant system in animals. J. Biol. Chem. 269:9397-9400.
29. Nash, T. 1953. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem. J. 55:416-421.
30. Nebert, D. W. 1994. Drug-metabolizing enzymes in ligand-modulated transcription. Biochem. Pharmacol. 47:25-37.
31. Nebert, D. W., and Gelboin, H. V. 1968. Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J. Biol. Chem. 243:6242-6249.
32. Okey, A. B. 1990. Enzyme i nduction i n the cytochrome P-450 system. Pharmacol. Ther. 45:241-298.
33. Omura, T., and Sato, R. 1964. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239:2370-2378.
34. Park, S. S., Fujino, T., Miller, H., Guengerich, F. P., and Gelboin, H. V. 1984. Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450. Biochem. Pharmacol. 33:2071-2081.
35. Park, S. S., Miller, A. V., Klotz, A. V., Klopper-Sams, P. J., Stegeman, J. J., and Gelboin, H. V. 1986a. Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (scup): Cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450. Arch. Biochem. Biophys. 249:339-350.
36. Park, S. S., Waxman, D. J., Miller, H., Robinson, R., Attisano, C., and Gelboin, H. V. 1986b. Preparation and characterization of monoclonal antibodies to pregnenolone 16-a-carbonitrile inducible rat liver cytochrome P-450. Biochem. Pharmacol. 35:2859-2867.
37. Phillips, A. H., and Langdon, R. G. 1962. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: I solation, characterization, and kinetic studies. J. Biol. Chem. 237:2652-2660.
38. Pohl, A. H., and Fouts, J. R. 1980. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal. Biochem. 107:150-155.
39. Quinones, L., and Gil, L. 1995. Induction of rat hepatic P4501 A1 by organic extracts from airborne particulate matter in Santiago, Chile. Xenobiotica 25:81-89.
40. Rabovsky, J., Marion, K. J., Groseclose, R. D., Lewis, T. R., and Petersen, M. 1984. Low-dose chronic inhalation of diesel exhaust and/or coal dust by rats: Effect of age and exposure on lung and liver cytochrome P-450. Xenobiotica 14:595-598.
41. Ryan, D. E., and Levin, W. 1990. Purification and characterization of hepatic microsomal cytochrome P-450. Pharmacol. Ther. 45:153-239.
42. Sagai, M., Furuyamam, A., and Ichinose, T. 1996. Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice. Free Radical Biol. Med. 21:199-209.
43. Tietze, F. 1969. Enzymatic method for qualitative determination of nanogram amounts of total and oxidized glutathione. Anal. Biochem. 27:502-522.
44. Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
45. Tsien, A., Diaz-Sanchez, D., Ma, J., and Saxon, A. 1997. The organic component of diesel exhaust particles and phenanthrene, a major polyaromatic hydrocarbon constituent, enhances IgE production by IgE-secreting EBV-transformed human B cells in vitro. Toxicol. Appl. Pharmacol. 142: 256-263.
46. Ueng, T.-H., Ueng, Y.-F., Chen, T.-L., Park, S. S., Iwasaki, M., and Guengerich, F. P. 1993. Induction of cytochrome P450-dependent monooxygenases in hamster tissues by fasting. Toxicol. Appl. Pharmacol. 119:66-73.
47. Wrighton, S. A., Thomas, P. E., Ryan, D. E., and Levin, W. 1987. Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj. Arch. Biochem. Biophys. 258:292-297.
48. Zhou, W., and Ye, S.-H. 1997. Mutagenicity of scooter exhaust particulate matter. J. Toxicol. Environ. Health 52:35-44.