Bcl-2 protection of axotomized Purkinje cells in organotypic culture is age dependent and not associated with an enhancement of axonal regeneration

Progress in Brain Research

Volumn 148, Issue , 2005, Pages 37-44

  Ghoumari, A M ^a,b   Wehrle R ^a,c   Sotelo, C ^a,c   Dusart, I ^a,c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

axonal regeneration; axotomy; Bcl 2; cerebellum; neuronal death; Purkinje cell

Indexed keywords

PROTEIN BCL 2;

APOPTOSIS; CELL CULTURE; CELL DEATH; CELL SURVIVAL; HUMAN; NERVE FIBER REGENERATION; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; REVIEW;

EID: 12344284590     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(04)48004-2     Document Type: Review

References (46)

1. Barmack N.H., Simpson J.I. Effects of microlesions of dorsal cap of inferior olive of rabbits on optokinetic and vestibuloocular reflexes. J. Neurophysiol. 43:1980;182-206
2. Benowitz L.I., Routtenberg A. GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci. 20:1997;84-91
3. Bernard R., Farlie P., Bernard O. NSE-bcl-2 transgenic mice, a model system for studying neuronal death and survival. Dev. Neurosci. 19:1997;79-85
4. Bonfanti L., Strettoi E., Chierzi S., Cenni M.C., Liu X.H., Martinou J.C., Maffei L., Rabacchi S.A. Protection of retinal ganglion cells from natural and axotomy induced cell death in neonatal transgenic mice overexpressing bcl-2. J. Neurosci. 16:1996;4186-4194
5. Bouslama-Oueghlani L., Wehrlé R., Sotelo C., Dusart I. The developmental loss of Purkinje Cell ability to regenerate their axons occurs in the absence of myelin: an in vitro model to prevent myelination. J. Neurosci. 23:2003;8318-8329
6. Bravin M., Savio T., Strata P., Rossi F. Olivocerebellar axon regeneration and target reinnervation following dissociated Schwann cell grafts in surgically injured cerebella of adult rats. Eur. J. Neuroscience. 9:1997;2634-2649
7. Buffo A., Holtmaat A.J., Savio T., Verbeek J.S., Oberdick J., Oestreicher A.B., Gispen W.H., Verhaagen J., Rossi F., Strata P. Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting after axotomy but not axon regeneration into growth-permissive transplants. J. Neurosci. 17:1997;8778-8791
8. Buffo A., Fronte M., Oestreicher A., Rossi F. Degenerative phenomena and reactive modifications of the adult rat inferior olivary neurons following axotomy and disconnection from their targets. Neuroscience. 85:1998;587-604
9. Caleo M., Cenni M.C., Costa M., Menna E., Zentilin L., Giadrossi S., Giacca M., Maffei L. Expression of Bcl-2 via adeno-associated virus vectors rescues thalamic neurons after visual cortex lesion in the adult rat. Eur. J. Neurosci. 15:2002;1271-1277
10. Cenni M.C., Bonfanti L., Martinou J.C., Ratto G.M., Strettoi E., Maffei L. Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice. Eur. J. Neurosci. 8:1996;1735-1745
11. Chen D.F., Schneider G.E., Martinou J.C., Tonegawa S. Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature. 385:1997;434-439
12. Chierzi S., Cenni M.C., Maffei L., Pizzorusso T., Porciatti V., Ratto G.M., Strettoi E. Protection of retinal ganglion cells and preservation of function after optic nerve lesion in bcl-2 transgenic mice. Vision Res. 38:1998;1537-1543
13. Chierzi S., Strettoi E., Cenni M.C., Maffei L. Optic nerve crush: axonal responses in wild type and bcl-2 transgenic mice. J. Neurosci. 19:1999;8367-8376
14. De Bilbao F., Dubois-Dauphin M. Time course of axotomy-induced apoptotic cell death in facial motoneurons of neonatal wild type and bcl-2 transgenic mice. Neuroscience. 71:1996;1111-1119
15. Doster S.K., Lozano A.M., Aguayo A.J., Willard M.B. Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury. Neuron. 6:1991;635-647
16. Dubois-Dauphin M., Frankowski H., Tsujimoto Y., Huarte J., Martinou J.C. Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc. Natl. Acad. Sci. USA. 91:1994;3309-3313
17. Dusart I., Airaksinen M.S., Sotelo C. Purkinje cell survival and regeneration are age dependent: an in vitro study. J. Neurosci. 17:1997;3710-3726
18. Fan H., Favero M., Vogel M.W. Elimination of Bax expression in mice increases cerebellar purkinje cell numbers but not the number of granule cells. J. Comp. Neurol. 436:2001;82-91
19. Farlie P.G., Dringen R., Rees S.M., Kannourakis G., Bernard O. Bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc. Natl. Acad. Sci. USA. 92:1995;4397-4401
20. Gagliardini V., Dusart I., Fankhauser C. Absence of GAP-43 can protect neurons from death. Mol. Cell Neurosci. 16:2000;27-33
21. Ghoumari A.M., Wehrlé R., Bernard O., Sotelo C., Dusart I. Implication of Bcl-2 and Caspase-3 in the age-related Purkinje cell death in murine organotypic culture: An in vitro model to study apoptosis. Eur. J. Neurosci. 12:2000;2935-2949
22. Ghoumari A.M., Wehrle R., De Zeeuw C.I., Sotelo C., Dusart I. Inhibition of protein kinase C prevents Purkinje cell death but does not affect axonal regeneration. J. Neurosci. 22:2002;3531-3542
23. Ghoumari A.M., Dusart I., Tronche F., El-Etr M., Sotelo C., Schumacher M., Baulieu E.E. Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum. Proc. Natl. Acad. Sci. USA. 86:2003;848
24. Harding D.I., Greensmith L., Mason M., Anderson P.N., Vrbova G. Overexpression of GAP-43 induces prolonged sprouting and causes death of adult motoneurons. Eur. J. Neurosci. 11:1999;2237-2242
25. Heaton M.B., Moore D.B., Paiva M., Gibbs T., Bernard O. Bcl-2 overexpression protects the neonatal cerebellum from ethanol neurotoxicity. Brain Res. 817:1999;13-18
26. Herdegen T., Skene P., Baehr M. The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 20:1997;227-231
27. Inoue T., Hosokawa M., Morigiwa K., Ohashi Y., Fukuda Y. Bcl-2 overexpression does not enhance in vivo axonal regneration of retinal ganglion cells after peripheral nerve transplantation in adult mice. J. Neurosci. 22:2002;. 4486-4477
28. Ito M., Jastreboff P.J., Miyashita Y. Retrograde influence of surgical and chemical flocculectomy upon dorsal cap neurons of the inferior olive. Neurosci. Lett. 20:1980;45-48
29. Lodovichi C., Di Cristo G., Cenni M.C., Maffei L. Bcl-2 overexpression per se does not promote regeneration of neonatal crushed optic fibers. Eur. J. Neurosci. 13:2001;833-838
30. Marin-Teva J.L., Dusart I., Colin C., Gervais A., van Rooijen N., Mallat M. Microglia promote the death of developing Purkinje cells. Neuron. 41:2004;535-547
31. Martinou J.C., Dubois-Dauphin M., Staple J.K., Rodriguez I., Frankowski H., Missotten M., Albertini P., Talabot D., Catsicas S., Pietra C., Huarte J. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron. 13:1994;1017-1030
32. Misantone L.J., Gershenbaum M., Murray M. Viability of retinal ganglion cells after optic nerve crush in adult rats. J. Neurocytol. 13:1984;449-465
33. Nakamura M., Raghupathi R., Merry D.E., Scherbel U., Saatman K.E., McIntosh T.K. Overexpression of bcl-2 is neuroprotective after experimental brain injury in transgenic mice. J. Comp. Neurol. 412:1999;681-692
34. Offen D., Beart P.M., Cheung N.S., Pascoe C.J., Hochman A., Gorodin S., Melamed E., Bernard R., Bernard O. Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity. Proc. Natl. Acad. Sci. USA. 95:1998;5789-5794
35. Richardson P.M., McGuinness U.M., Aguayo A.J. Peripheral nerve autografts to the rat spinal cord: studies with axonal tracing methods. Brain Res. 237:1982;147-162
36. Rossi F., Jankovski A., Sotelo C. Differential regenerative response of Purkinje cell and inferior olivary axons confronted with embryonic grafts: environmental cues versus intrinsic neuronal determinants. J. Comp. Neurol. 359:1995;663-677
37. Shibata M., Murray M., Tessier A., Ljubetic C., Connors T., Saavedra R.A. Single injections of a DNA plasmid that contains the human Bcl-2 gene prevent loss and atrophy of distinct neuronal populations after spinal cord injury in adult rats. Neurorehabil. Neural Repair. 14:2000;319-330
38. Stoppini L., Buchs P.A., Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Meth. 37:1991;173-182
39. Takahashi K., Schwarz E., Ljubetic C., Murray M., Tessier A., Saavedra R.A. DNA plasmid that codes for human Bcl-2 gene preserves axotomized Clarke's nucleus and reduces atrophy after spinal cord hemisection in adult rats. J. Comp. Neurol. 404:1999;159-171
40. Tetzlaff W., Alexander S.W., Miller F.D., Bisby M.A. Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43. J. Neurosci. 11:1991;2528-2544
41. Villegas-Pérez M.P., Vidal-Sanz M., Bray G.M., Aguayo A.J. Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats. J. Neurosci. 8:1988;265-280
42. Wassef M., Zanetta J.P., Brehier A., Sotelo C. Transient biochemical compartmentalization of Purkinje cells during early cerebellar development. Dev. Biol. 111:1985;129-137
43. Wehrlé R., Caroni P., Sotelo C., Dusart I. Role of GAP-43 in mediating the responsiveness of cerebellar neurons to axotomy. Eur. J. Neurosci. 13:2001;857-870
44. Winter C., Weiss C., Martin-Villalba A., Zimmermann M., Schenkel J. JunB and Bcl-2 overexpression results in protection against cell death of nigral neurons following axotomy. Mol. Brain Res. 104:2002;194-202
45. Zanjani H.S., Vogel M.W., Delhaye-Bouchaud N., Martinou J.C., Mariani J. Increased cerebellar Purkinje cell numbers in mice overexpressing a human bcl-2 transgene. J. Comp. Neurol. 374:1996;332-341
46. Zhou L., Connors T., Chen D.F., Murray M., Tessier A., Kambin P., Saavedra R.A. Red nucleus neurons of Bcl-2 over-expressing mice are protected from cell death induced axotomy. Neuroreport. 10:1999;3417-3421