Overexpression of GAP-43 induces prolonged sprouting and causes death of adult motoneurons

European Journal of Neuroscience

Volumn 11, Issue 7, 1999, Pages 2237-2242

  Harding, D I ^a   Greensmith, L ^a   Mason, M ^a   Anderson, P N ^a   Vrbova, G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Motoneuron death; Nerve injury; Neurodegenerative disorders; Transgenic mice

Indexed keywords

GROWTH ASSOCIATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE OVEREXPRESSION; MOTONEURON; MOUSE; NERVE FIBER TRANSECTION; NERVE SPROUTING; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; SCIATIC NERVE; TRANSGENIC MOUSE;

EID: 0033046893     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00640.x     Document Type: Article

References (14)

1. Aigner, L., Arber, S., Kapfhammer, J.P., Laux, T., Schneider, C., Botteri, F., Brenner, H.R., Caroni, P. 1995 Overexpression of the neural growth‐associated protein GAP‐43 induces nerve sprouting in the adult nervous system of transgenic mice. Cell, 83, 269 278.
2. Aigner, L. & Caroni, P. 1995 Absence of persistent spreading, branching, and adhesion in GAP‐43‐depleted growth cones. J. Cell. Biol., 128, 647 660.
3. Benowitz, L.I. & Routtenberg, A. 1997 GAP‐43: an intrinsic determinant of neuronal development and plasticity. TINS, 20, 84 91.
4. Buffo, A., Holtmaat, A.J.D.G., Savio, T., Verbeek, J.S., Oberdick, J., Oestreicher, A.B., Gispen, W.H., Verhaagen, J., Rossi, F., Strata, P. 1997 Targeted overexpression of the neurite growth‐associated protein B‐50/GAP‐43 in cerebellar Purkinje cells induces sprouting after axotomy but not axon regeneration into growth‐permissive transplants. J. Neurosci., 17, 8778 8791.
5. Greensmith, L. & Vrbová, G. 1996 Motoneurone survival: a functional approach. Trends Neurosci., 19, 450 455.
6. Hanker, J.S., Yates, P.E., Metz, C.B., Rustioni, A. 1977 A new specific, sensitive and non‐carcinogenic reagent for the demonstration of horseradish peroxidase. Histochem. J., 9, 789 792.
7. Harding, D.I., Greensmith, L., Anderson, P.N., Vrbová, G. 1998 Motoneurons innervating partially denervated rat hindlimb muscles remain susceptible to axotomy‐induced cell death. Neuroscience, 86, 291 299.
8. Nachlas, M.M., Tsou, K.C., De Souza, E., Chang, C.H., Seligman, A.M. 1957 Cytochemical demonstration of succinate dehydrogenase by the use of a new, p‐nitrophenyl substituted ditetrazole. J. Histochem. Cytochem., 5, 420 436.
9. Namba, T., Nakamura, T., Grob, D. 1967 Staining for nerve fibre and cholinesterase activity in fresh frozen sections. Am. J. Clin. Path., 47, 74 77.
10. Skene, J.H. 1989 Axonal growth‐associated proteins. Annu. Rev. Neurosci., 12, 127 156.
11. Skene, J.H. & Willard, M. 1981 Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems. J. Cell. Biol., 89, 96 103.
12. Stålberg, E. & Grimby, G. 1995 Dynamic electromyography and muscle biopsy changes in a 4‐year follow up: study of patients with history of polio. Muscle-Nerve, 18, 699 707.
13. Stålberg, E. & Sanders, D.B. 1984 The motor unit in ALS studied with different neurophysiological techniques. In: Rose, C, ed. Research Progress in Motor Neuron Disease. Pitman, London, pp. 105 201.
14. Vaudano, E., Campbell, G., Anderson, P.N., Davies, A.P., Woolhead, C., Schreyer, D.J., Lieberman, A.R. 1995 The effects of a lesion or a peripheral nerve graft on GAP‐43 upregulation in the adult rat brain: an in situ hybridization and immunocytochemical study. J. Neurosci., 15, 3594 3611.