-
3
-
-
0029761702
-
Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling
-
D.T. Denhardt Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling Biochem. J. 318 Pt 3 1996 729 747
-
(1996)
Biochem. J.
, vol.318
, Issue.3
, pp. 729-747
-
-
Denhardt, D.T.1
-
4
-
-
0036803602
-
In the cellular garden of forking paths: How p38 MAPKs signal for downstream assistance
-
Y. Shi, and M. Gaestel In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance Biol. Chem. 383 2002 1519 1536
-
(2002)
Biol. Chem.
, vol.383
, pp. 1519-1536
-
-
Shi, Y.1
Gaestel, M.2
-
5
-
-
0034671847
-
The p38 pathway provides negative feedback for Ras proliferative signaling
-
G. Chen, M. Hitomi, J. Han, and D.W. Stacey The p38 pathway provides negative feedback for Ras proliferative signaling J. Biol. Chem. 275 2000 38973 38980
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 38973-38980
-
-
Chen, G.1
Hitomi, M.2
Han, J.3
Stacey, D.W.4
-
6
-
-
0021184853
-
Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein
-
D.W. Stacey, and H.F. Kung Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein Nature 310 1984 508 511
-
(1984)
Nature
, vol.310
, pp. 508-511
-
-
Stacey, D.W.1
Kung, H.F.2
-
7
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
J. Downward Targeting RAS signalling pathways in cancer therapy Nat. Rev., Cancer 3 2003 11 22
-
(2003)
Nat. Rev., Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
9
-
-
0026483206
-
Fibroblasts transformed by different ras oncogenes show dissimilar patterns of protease gene expression and regulation
-
J.Y. Zhang, and R.M. Schultz Fibroblasts transformed by different ras oncogenes show dissimilar patterns of protease gene expression and regulation Cancer Res. 52 1992 6682 6689
-
(1992)
Cancer Res.
, vol.52
, pp. 6682-6689
-
-
Zhang, J.Y.1
Schultz, R.M.2
-
10
-
-
0033534611
-
Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts
-
M. Janulis, S. Silberman, A. Ambegaokar, J.S. Gutkind, and R.M. Schultz Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts J. Biol. Chem. 274 1999 801 813
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 801-813
-
-
Janulis, M.1
Silberman, S.2
Ambegaokar, A.3
Gutkind, J.S.4
Schultz, R.M.5
-
11
-
-
0034697159
-
Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity
-
S. Huang, L. New, Z. Pan, J. Han, and G.R. Nemerow Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity J. Biol. Chem. 275 2000 12266 12272
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12266-12272
-
-
Huang, S.1
New, L.2
Pan, Z.3
Han, J.4
Nemerow, G.R.5
-
12
-
-
2242463086
-
Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells
-
Q. Han, J. Leng, D. Bian, C. Mahanivong, K.A. Carpenter, Z.K. Pan, J. Han, and S. Huang Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells J. Biol. Chem. 277 2002 48379 48385
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48379-48385
-
-
Han, Q.1
Leng, J.2
Bian, D.3
Mahanivong, C.4
Carpenter, K.A.5
Pan, Z.K.6
Han, J.7
Huang, S.8
-
13
-
-
0141482096
-
P38 Kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells
-
M.S. Kim, E.J. Lee, H.R. Kim, and A. Moon p38 Kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells Cancer Res. 63 2003 5454 5461
-
(2003)
Cancer Res.
, vol.63
, pp. 5454-5461
-
-
Kim, M.S.1
Lee, E.J.2
Kim, H.R.3
Moon, A.4
-
14
-
-
0030581626
-
The primary structure of p38g: A new member of p38 group of MAP kinases
-
Z. Li, Y. Jiang, R.J. Ulevitch, and J. Han The primary structure of p38g: a new member of p38 group of MAP kinases Biochem. Biophys. Res. Commun. 228 1996 334 340
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.228
, pp. 334-340
-
-
Li, Z.1
Jiang, Y.2
Ulevitch, R.J.3
Han, J.4
-
15
-
-
0033625759
-
Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest
-
X. Wang, C.H. McGowan, M. Zhao, L. He, J.S. Downey, C. Fearns, Y. Wang, S. Huang, and J. Han Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest Mol. Cell. Biol. 20 2000 4543 4552
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 4543-4552
-
-
Wang, X.1
McGowan, C.H.2
Zhao, M.3
He, L.4
Downey, J.S.5
Fearns, C.6
Wang, Y.7
Huang, S.8
Han, J.9
-
16
-
-
0025311186
-
Lack of correlation between intercellular junctional communication, p21rasEJ expression, and spontaneous metastatic properties of rat mammary cells after transfection with c-H-rasEJ or neo genes
-
G.L. Nicolson, G.E. Gallick, K.M. Dulski, W.H. Spohn, T.M. Lembo, and M.A. Tainsky Lack of correlation between intercellular junctional communication, p21rasEJ expression, and spontaneous metastatic properties of rat mammary cells after transfection with c-H-rasEJ or neo genes Oncogene 5 1990 747 753
-
(1990)
Oncogene
, vol.5
, pp. 747-753
-
-
Nicolson, G.L.1
Gallick, G.E.2
Dulski, K.M.3
Spohn, W.H.4
Lembo, T.M.5
Tainsky, M.A.6
-
17
-
-
0026469664
-
A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells
-
C. Nerlov, D. De Cesare, F. Pergola, A. Caracciolo, F. Blasi, M. Johnsen, and P. Verde A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells EMBO J. 11 1992 4573 4582
-
(1992)
EMBO J.
, vol.11
, pp. 4573-4582
-
-
Nerlov, C.1
De Cesare, D.2
Pergola, F.3
Caracciolo, A.4
Blasi, F.5
Johnsen, M.6
Verde, P.7
-
18
-
-
0033154928
-
Quantification of VP22-GFP spread by direct fluorescence in 15 commonly used cell lines
-
W.A. Wybranietz, F. Prinz, M. Spiegel, A. Schenk, M. Bitzer, M. Gregor, and U.M. Lauer Quantification of VP22-GFP spread by direct fluorescence in 15 commonly used cell lines J. Gene Med. 1 1999 265 274
-
(1999)
J. Gene Med.
, vol.1
, pp. 265-274
-
-
Wybranietz, W.A.1
Prinz, F.2
Spiegel, M.3
Schenk, A.4
Bitzer, M.5
Gregor, M.6
Lauer, U.M.7
-
19
-
-
0033537853
-
An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes
-
G. Sweeney, R. Somwar, T. Ramlal, A. Volchuk, A. Ueyama, and A. Klip An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes J. Biol. Chem. 274 1999 10071 10078
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10071-10078
-
-
Sweeney, G.1
Somwar, R.2
Ramlal, T.3
Volchuk, A.4
Ueyama, A.5
Klip, A.6
-
20
-
-
0032530336
-
Structural basis of inhibitor selectivity in MAP kinases
-
Z. Wang, B.J. Canagarajah, J.C. Boehm, S. Kassisa, M.H. Cobb, P.R. Young, S. Abdel-Meguid, J.L. Adams, and E.J. Goldsmith Structural basis of inhibitor selectivity in MAP kinases Structure 6 1998 1117 1128
-
(1998)
Structure
, vol.6
, pp. 1117-1128
-
-
Wang, Z.1
Canagarajah, B.J.2
Boehm, J.C.3
Kassisa, S.4
Cobb, M.H.5
Young, P.R.6
Abdel-Meguid, S.7
Adams, J.L.8
Goldsmith, E.J.9
-
21
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
J.C. Lee, J.T. Laydon, P.C. McDonnell, T.F. Gallagher, S. Kumar, D. Green, D. McNulty, M.J. Blumenthal, J.R. Heys, and S.W. Landvatter A protein kinase involved in the regulation of inflammatory cytokine biosynthesis Nature 372 1994 739 746
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
-
22
-
-
0032564311
-
Molecular basis for p38 protein kinase inhibitor specificity
-
J. Lisnock, A. Tebben, B. Frantz, E.A. O'Neill, G. Croft, S.J. O'Keefe, B. Li, C. Hacker, S. de Laszlo, A. Smith, B. Libby, N. Liverton, J. Hermes, and P. LoGrasso Molecular basis for p38 protein kinase inhibitor specificity Biochemistry 37 1998 16573 16581
-
(1998)
Biochemistry
, vol.37
, pp. 16573-16581
-
-
Lisnock, J.1
Tebben, A.2
Frantz, B.3
O'Neill, E.A.4
Croft, G.5
O'Keefe, S.J.6
Li, B.7
Hacker, C.8
De Laszlo, S.9
Smith, A.10
Libby, B.11
Liverton, N.12
Hermes, J.13
Lograsso, P.14
-
23
-
-
0038363324
-
P38 Isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity
-
R. Pramanik, X. Qi, S. Borowicz, D. Choubey, R.M. Schultz, J. Han, and G. Chen p38 Isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity J. Biol. Chem. 278 2003 4831 4839
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4831-4839
-
-
Pramanik, R.1
Qi, X.2
Borowicz, S.3
Choubey, D.4
Schultz, R.M.5
Han, J.6
Chen, G.7
-
24
-
-
0040958791
-
Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor
-
S. Ried, C. Jager, M. Jeffers, G.F. Vande Woude, H. Graeff, M. Schmitt, and E. Lengyel Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor J. Biol. Chem. 274 1999 16377 16386
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16377-16386
-
-
Ried, S.1
Jager, C.2
Jeffers, M.3
Vande Woude, G.F.4
Graeff, H.5
Schmitt, M.6
Lengyel, E.7
-
25
-
-
0029583938
-
Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene
-
E. Lengye, B. Singh, R. Gum, C. Nerlov, A. Sabichi, M. Birrer, and D. Boyd Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene Oncogene 11 1995 2639 2648
-
(1995)
Oncogene
, vol.11
, pp. 2639-2648
-
-
Lengye, E.1
Singh, B.2
Gum, R.3
Nerlov, C.4
Sabichi, A.5
Birrer, M.6
Boyd, D.7
-
26
-
-
0031857536
-
UV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: Requirement of an AP1 enhancer element
-
F. Miralles, M. Parra, C. Caelles, Y. Nagamine, J. Felez, and P. Munoz-Canoves UV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: requirement of an AP1 enhancer element Mol. Cell. Biol. 18 1998 4537 4547
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 4537-4547
-
-
Miralles, F.1
Parra, M.2
Caelles, C.3
Nagamine, Y.4
Felez, J.5
Munoz-Canoves, P.6
-
27
-
-
0030977398
-
Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases
-
C. Zhang, R.A. Baumgartner, K. Yamada, and M.A. Beaven Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases J. Biol. Chem. 272 1997 13397 13402
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 13397-13402
-
-
Zhang, C.1
Baumgartner, R.A.2
Yamada, K.3
Beaven, M.A.4
-
28
-
-
0033625759
-
Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest
-
Jul. 20
-
X. Wang, C.H. McGowan, M. Zhao, L. He, J.S. Downey, C. Fearns, Y. Wang, S. Huang, and J. Han Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest Mol. Cell. Biol. 13 2000 (Jul. 20) 4543 4552
-
(2000)
Mol. Cell. Biol.
, vol.13
, pp. 4543-4552
-
-
Wang, X.1
McGowan, C.H.2
Zhao, M.3
He, L.4
Downey, J.S.5
Fearns, C.6
Wang, Y.7
Huang, S.8
Han, J.9
-
29
-
-
0342758711
-
P38 MAPK signalling cascades: Ancient roles and new functions
-
E. Martin-Blanco p38 MAPK signalling cascades: ancient roles and new functions Bioessays 22 2000 637 645
-
(2000)
Bioessays
, vol.22
, pp. 637-645
-
-
Martin-Blanco, E.1
-
30
-
-
0037020067
-
P38 and activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose
-
M. Zayzafoon, S. Botolin, and L.R. McCabe p38 And activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose J. Biol. Chem. 277 2002 37212 37218
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 37212-37218
-
-
Zayzafoon, M.1
Botolin, S.2
McCabe, L.R.3
-
31
-
-
0032793301
-
Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
-
G. Cirillo, L. Casalino, D. Vallone, A. Caracciolo, D. De Cesare, and P. Verde Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate Mol. Cell. Biol. 19 1999 6240 6252
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 6240-6252
-
-
Cirillo, G.1
Casalino, L.2
Vallone, D.3
Caracciolo, A.4
De Cesare, D.5
Verde, P.6
-
32
-
-
9144267697
-
Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma
-
F.J. Esteva, A.A. Sahin, T.L. Smith, Y. Yang, L. Pusztai, R. Nahta, T.A. Buchholz, A.U. Buzdar, G.N. Hortobagyi, and S.S. Bacus Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma Cancer 100 2004 499 506
-
(2004)
Cancer
, vol.100
, pp. 499-506
-
-
Esteva, F.J.1
Sahin, A.A.2
Smith, T.L.3
Yang, Y.4
Pusztai, L.5
Nahta, R.6
Buchholz, T.A.7
Buzdar, A.U.8
Hortobagyi, G.N.9
Bacus, S.S.10
-
33
-
-
0036731380
-
Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence
-
R. Haq, J.D. Brenton, M. Takahashi, D. Finan, A. Finkielsztein, S. Damaraju, R. Rottapel, and B. Zanke Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence Cancer Res. 62 2002 5076 5082
-
(2002)
Cancer Res.
, vol.62
, pp. 5076-5082
-
-
Haq, R.1
Brenton, J.D.2
Takahashi, M.3
Finan, D.4
Finkielsztein, A.5
Damaraju, S.6
Rottapel, R.7
Zanke, B.8
-
34
-
-
0346463059
-
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
-
Q. Deng, R. Liao, B.L. Wu, and P. Sun High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts J. Biol. Chem. 279 2004 1050 1059
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1050-1059
-
-
Deng, Q.1
Liao, R.2
Wu, B.L.3
Sun, P.4
-
35
-
-
0038246249
-
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a
-
D.V. Bulavin, O. Kovalsky, M.C. Hollander, and A.J. Fornace Jr. Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a Mol. Cell Biol. 23 2003 3859 3871
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 3859-3871
-
-
Bulavin, D.V.1
Kovalsky, O.2
Hollander, M.C.3
Fornace Jr., A.J.4
-
36
-
-
0036242247
-
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
-
W. Wang, J.X. Chen, R. Liao, Q. Deng, J.J. Zhou, S. Huang, and P. Sun Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence Mol. Cell. Biol. 22 2002 3389 3403
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3389-3403
-
-
Wang, W.1
Chen, J.X.2
Liao, R.3
Deng, Q.4
Zhou, J.J.5
Huang, S.6
Sun, P.7
-
37
-
-
0033061063
-
PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma
-
C. Simon, M.J. Hicks, A.J. Nemechek, R. Mehta, B.W. O'Malley Jr., H. Goepfert, C.M. Flaitz, and D. Boyd PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma Br. J Cancer 80 1999 1412 1419
-
(1999)
Br. J Cancer
, vol.80
, pp. 1412-1419
-
-
Simon, C.1
Hicks, M.J.2
Nemechek, A.J.3
Mehta, R.4
O'Malley Jr., B.W.5
Goepfert, H.6
Flaitz, C.M.7
Boyd, D.8
-
38
-
-
0026733002
-
PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity
-
M.S. Qui, and S.H. Green PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity Neuron 9 1992 705 717
-
(1992)
Neuron
, vol.9
, pp. 705-717
-
-
Qui, M.S.1
Green, S.H.2
|