Investigation of the CNS penetration of a potent 5-HT(2a) receptor antagonist (MDL 100,907) and an active metabolite (MDL 105,725) using in vivo microdialysis sampling in the rat

Journal of Pharmaceutical and Biomedical Analysis

Volumn 17, Issue 1, 1998, Pages 17-25

  Scott, Dennis O ^a   Heath, Timothy G ^a  

^a SANOFI   (France)

Author keywords

5 HT(2a) receptor antagonist; Blood brain barrier; Microdialysis; Schizophrenia

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; DRUG METABOLITE; MDL 105725; SEROTONIN 2A ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG METABOLISM; DRUG PENETRATION; DRUG PROTEIN BINDING; EXTRACELLULAR FLUID; INTRAVENOUS DRUG ADMINISTRATION; MICRODIALYSIS; NONHUMAN; ORAL DRUG ADMINISTRATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BLOOD-BRAIN BARRIER; BRAIN; DOGS; EXTRACELLULAR SPACE; FLUOROBENZENES; INJECTIONS, INTRAVENOUS; MALE; MICRODIALYSIS; PIPERIDINES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0032080844     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(97)00144-1     Document Type: Article

References (6)

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3. Schmidt C.J., Fadayel G.M., Sullivan C.K., Taylor V.L. Eur. J. Pharmacol. 223:1992;65.
4. Sorensen S.M., Kehne J.H., Fadayel G.M., Humphreys T.M., Ketteler H.J., Sullivan C.K., Taylor V.L., Schmidt C.J. J. Pharmacol. Exp. Ther. 266:1993;684.
5. Schmidt C.J. Eur. J. Pharmacol. 223:1992;65-74.
6. Heath T.G., Scott D.O. J. Am. Soc. Mass Spectrom. 8:1997;371-379.