Brain glucose concentrations in patients with type 1 diabetes and hypoglycemia unawareness

Journal of Neuroscience Research

Volumn 79, Issue 1-2, 2005, Pages 42-47

  Criego, Amy B ^a,c   Tkac, Ivan ^a   Kumar, Anjali ^a   Thomas, William ^b   Gruetter, Rolf ^a   Seaquist, Elizabeth R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c MMC 404 ^*  (United States)

Author keywords

Brain glucose; Hypoglycemia unawareness; Magnetic resonance spectroscopy; Type 1 diabetes

Indexed keywords

ADRENALIN; GLUCAGON; GLUCOSE; HEMOGLOBIN A1C; INSULIN; NORADRENALIN; SOMATOSTATIN;

ADULT; BODY MASS; BRAIN METABOLISM; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEADY STATE;

ADULT; AGED; BLOOD GLUCOSE; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, TYPE 1; EPINEPHRINE; FEMALE; GLUCAGON; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPOGLYCEMIA; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NOREPINEPHRINE; RADIOIMMUNOASSAY; RECURRENCE; TRITIUM;

EID: 12244284625     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20296     Document Type: Conference Paper

References (38)

1. Adriany G, Gruetter R. 1997. A half-volume coil for efficient proton decoupling in humans at 4 tesla. J Magn Reson 125:178-184.
2. Amiel S, Sherwin R, Simonson D. 1988. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 37:901-907.
3. Boado R, Pardridge W. 1993. Glucose deprivation causes posttranscriptional enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization. J Neurochem 60:2290-2296.
4. Boyle P, Kempers S, O'Connor AM, Nagy R. 1995. Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus. N Engl J Med 333:1726-1731.
5. Boyle P, Nagy R, O'Connor A, Kempers S, Yeo R, Qualls C. 1994. Adaption in brain glucose uptake following recurrent hypoglycemia. Proc Natl Acad Sci USA 91:9352-9356.
6. Choi I, Lee S, Kim S, Gruetter R. 2001. In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia. J Cereb Blood Flow Metab 21:653-663.
7. Choi I, Lei H, Gruetter R. 2002. Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total glucose consumption with glutamatergic action. J Cereb Blood Flow Metab 22:1343-1351.
8. Clarke W, Cox D, Gonder-Frederick L, Julian D, Schlundt D, Polonsky W. 1995. Reduced awareness of hypoglycemia in adults with IDDM. A prospective study of hypoglycemic frequency and associated symptoms. Diabetes Care 18:517-522.
9. Cranston I, Marsden P, Matyka K, Evans M, Lomas J, Sonksen P, Maisey M, Amiel SA. 1998. Regional differences in cerebral blood flow and glucose utilization in diabetic man: the effect of insulin. J Cereb Blood Flow Metab 18:130-140.
10. Cryer P. 1994. Hypoglycemia: the limiting factor in the management of IDDM. Diabetes 43:1378-1388.
11. Dagogo-Jack S, Craft S, Cryer P. 1993. Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. J Clin Invest 91:819-828.
12. DCCT Research Group. 1987. Feasibility of centralized measurements of glycated hemoglobin in the Diabetes Control and Complications Trial: a multicenter study. Clin Chem 33:2267-2271.
13. DCCT Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:978-986.
14. de Graaf R, Pan J, Telang F, Lee J, Brown P, Novotny E, Hertherington H, Rothman D. 2001. Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab 21:483-492.
15. Evans M, Halter J, Porte D. 1978. Comparison of double and single isotope enzymatic derivative methods of measurement of catecholamines in human plasma. Clin Chem 24:567-570.
16. Gruetter R. 1993. Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn Reson Med 29:804-811.
17. 1H NMR spectra of the human brain at 4 Tesla. Magn Reson Med 36:1-6.
18. Gruetter R, Tkac I. 2000. Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 43:319-323.
19. Gruetter R, Ugurbil K, Seaquist E. 1998a. Steady-state cerebral glucose concentration and transport in the human brain. J Neurochem 70:397-408.
20. 1H-NMR spectra with increased magnetic field strength. J Magn Reson 135:260-264.
21. Harris V, Faloona G, Unger R. 1979. In: Jaffe B, Behrman H, editors. Methods of hormone radioimmunoassay (2nd ed). New York: Academic Press, p 643.
22. Hasselbach S, Knudsen G, Videbaek C, Pinborg L, Schmidt J, Holm S, Paulson O. 1999. No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 48:1915-1921.
23. Koranyi L, Bourey R, James D, Mueckler M, Fiedorek F, Permutt A. 1991. Glucose transporter gene expression in rat brain: pretranslational changes associated with chronic insulin-induced hypoglycemia, fasting and diabetes. Mol Cell Neurosci 2:244-252.
24. Kumagai A, Kang Y-S, Boado R, Pardridge W. 1995. Upregulation of blood-brain barrier GLUT-1 glucose transporter protein and mRNA in experimental chronic hypoglycemia. Diabetes 44:1399-1404.
25. Lee JH, Garwood M, Menon R, Adriany G, Andersen P, Truwit CL, Ugurbil K. 1995. High contrast and fast three-dimensional imaging at high fields. Magn Reson Med 34:308-312.
26. McCall A, Millington W, Wurtman R. 1982. Metabolic fuel and amino acid transport into the brain in experimental diabetes mellitus. Proc Natl Acad Sci USA 79:5406-5410.
27. McCrimmon R, Jacob R, Fan X, McNay E, Sherwin R. 2003. Effects of recurrent antecedent hypoglycemia and chronic hyperglycaemia on brain-stem extra-cellular glucose concentrations during acute hypoglycaemia in conscious diabetic BB rats. Diabetologia 46:1658-1661.
28. Pardridge W. 1983. Brain metabolism: a perspective from the blood-brain barrier. Physiol Rev 63:1481-1535.
29. Pardridge W, Boado R, Farrell C. 1990. Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier: studies with quantitative Western blotting and in situ hybridization. J Biol Chem 265:18035-18040.
30. Petroff O, Spencer D, Alger J, Prichard J. 1989. High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy. Neurology 39:1197-1201.
31. 1H NMR measurements of GABA levels in human brain in vivo. Proc Natl Acad Sci USA 90:5662-5666.
32. Seaquist E. 1997. Comparison of arterialized venous sampling from the hand and foot in the assessment of in vivo glucose metabolism. Metabolism 46:1364-1366.
33. Seaquist E, Damberg G, Tkac I, Gruetter R. 2001. The effect of insulin on in vivo cerebral glucose concentrations and rate of glucose transport/metabolism in humans. Diabetes 50:2203-2209.
34. Segel S, Fanelli C, Dence C, Markham J, Videen T, Paramore D, Powers W, Cryer P. 2001. Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. Diabetes 50:1911-1917.
35. Simpson IA, Appel NM, Hokari M, Oki J, Holman GD, Maher F, Koehler-Stec EM, Vannucci SJ, Smith QR. 1999. Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited. J Neurochem 72:238-247.
36. Terpstra M, Ugurbil K, Gruetter R. 2002. Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla. Magn Reson Med 47:1009-1012.
37. 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 41:649-656.
38. Yen S, Siler T, DeVane G. 1974. Effect of somatostatin in patients with acromegaly: suppression of growth hormone, prolactin, insulin and glucose levels. N Engl J Med 290:935-938.