Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 tesla

Magnetic Resonance in Medicine

Volumn 36, Issue 1, 1996, Pages 1-6

  Gruetter, Rolf ^b   Garwood, Michael ^b   Ugurbil, Kâmil ^b   Seaquist, Elizabeth R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

1H NMR; brain; glucose; human; in vivo

Indexed keywords

BRAIN; GLUCOSE; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

1H-NMR SPECTRA; D-GLUCOSE; HUMAN; HUMAN BRAIN; IN-VIVO; PEAK INTENSITY; SPECTRAL OVERLAP; WATER SIGNALS;

NUCLEAR MAGNETIC RESONANCE;

GLUCOSE;

ARTICLE; BRAIN; GLUCOSE BRAIN LEVEL; HUMAN; HUMAN EXPERIMENT; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0029884561     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910360102     Document Type: Article

References (48)

1. W. M. Pardridge, Brain metabolism: a perspective from the bloodbrain barrier. Physiol. Rev. 63, 1481-1535 (1983).
2. M. E. Raichle, Circulatory and metabolic correlates of brain function in normal humans, in "Handbook of Physiology - The Nervous System V," Williams & Wilkins, Baltimore, pp. 643-674, 1983.
3. H. Lund-Andersen, Transport of glucose from blood to brain. Physiol. Rev. 59, 305-352 (1979).
4. A. Gjedde, Blood-brain glucose transfer, in "Handbook of Experimental Pharmacology, vol. 103, Physiology and Pharmacology of the Blood-Brain" M. W. B. Bradbury, Ed.), pp. 65-117, Springer Verlag. New York, 1992.
5. A. Carruthers, Facilitated diffusion of glucose. Physiol. Rev. 70, 1135-1176 (1990).
6. R. N. Kalaria, S. A. Gravina, J. W. Schmidley, G. Perry, S. I. Harik, The glucose transporter of the human brain and blood-brain barrier. Ann. Neurol. 24, 757-764 (1988).
7. D. A. Pelligrino, J. C. LaManna, R. B. Duckrow, R. M. Bryan, S. I. Harik, Hyperglycemia and blood-brain barrier glucose transport. J. Cereb. Blood Flow Metab. 12, 887-899 (1992).
8. R. N. Kalaria, S. I. Harik, Reduced glucose transporter at the bloodbrain barrier and in cerebral cortex in Alzheimer's disease. J. Neurochem. 53, 1083-1088 (1989).
9. D. C. DeVivo, R. R. Trifiletti, R. I. Jacobson, G. M. Ronen, R. A. Behmand, S. I. Harik, Defective glucose transport across the bloodbrain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay. N. Engl. J. Med. 325, 703-709 (1991).
10. J. E. Holden. K. Mori, G. A. Dienel, N. F. Cruz, T. Nelson, L. Sokoloff, Modeling the dependence of hexose distribution volumes in brain on plasma glucose concentration: implications for estimation of the local 2-deoxyglucose lumped constant. J. Cereb. Blood Flow Metab, 11, 171-182 (1991).
11. J. L. Tyler, S. C. Strother, R. J. Zatorre, B. Alivisatos. K. J. Worsley, M. Diksic, Y. L. Yamamoto, Stability of regional cerebral glucose metabolism in tho normal human brain measured by positron emission tomography. J. Nucl. Mad. 29, 631-B42 (1988).
12. L. E. Feinendegen, H. Herzog, H. Wieler, D. D. Patton, A. Schmid, Glucose transport and utilization in the human brain: model using carbon-11 methylglucose and positron omission tomography. J. Nucl. Med. 27, 1867-1877 (1986).
13. G. Blomqvist, A. Gjedde, M. Gutniak, V. Grill, L. Widén. S. Stono-Elander, E. Hellstrand, Facilitated transport of glucose from blond to brain in man and the effect of moderato hypoglycemia on cerebral glucose utilization. Bur. J. Nucl. Med. 18, 834-837 (1991).
14. 13C] glucose. J. Neurochem. 63, 1377-1385 (1994).
15. 13C] glucose. Magn. Roson. Med. 3, 911-920 (1986).
16. 13C NMR for the assessment of human brain glucose metabolism in vivo. Biocheinistiy 30, 6362-6366 (1991).
17. G. F. Mason, K. L. Behar, D. L. Rothman, R. G. Shulman, NMR dotermination of intracerebral glucose concentration and transport kinetics in rat brain. J. Cereb. Blood Flow Metabol. 12, 448-455 (1992).
18. 13C NMR spectroscopy. Proc. Natl. Acad. Sci. USA 89, 1109-1112 (1992). Erratum appears in vol. 89, 12208.
19. T. Michaolis, K. D. Merboldt, W. Hänicke, M. L. Gyngell, J. Frahm, On the identification of cerebral metabolites in localized 1H NMR spectra of human brain in vivo. NMB Biomed. 5, 90-98 (1991).
20. 1H NMR difference spectra of the human brain. Magn. Reson. Med. 27, 183-188 (1992).
21. R. Kreis, B. D. Ross, Gerebral metabolic disturbances in patients with subacuto and chronic diabetes mollitus: detection with proton MR spoctroscopy. Radiology 184, 123-130 (1992).
22. K. D. Merboldt, H. Bruhn, W. Hänicke, T. Michaelis, J. Frahm, Decrease of glucose in the human visual cortex during photic stimulation. Magn. Reson. Med. 25, 187-194 (1992).
23. S. W. Provoncher, W. Hanicke, T. Michaelis, Automated quantitation of localized 1H MR spectra in vivo: capabilities and limitations, in "Proc., SMR, 3rd Annual Meeting, Nice, 1995," p, 1952.
24. R. Gruetter, D. L. Rothman, E. J. Novotny, G. I. Shulman, J. W. Prichard, R. G. Shulman, Detection of glucose by 1H NMR spectroscopy of the human brain during acute hyperglycemia, in "Proc., SMRM, 10th Annual Meeting, San Francisco, 1991," p. 1014.
25. 13C]-glucose and its metabolic products. Magn. Reson. Med. 30. 544-551 (1993).
26. 13C-glucose. Biochem. Biophys. Res. Commun. 191, 866-872 (1993).
27. 1H NMR spectra of human brain. Magn. Reson. Med. 32, 294-302 (1994).
28. 1H NMR spectra of the human brain, in "Proc., SMR. 3rd Annual Meeting, Nice, 1995." p. 523.
29. E. R. Soaquist, R. P. Robertson, Effects of hemipancreatectomy on pancreatic: alpha and beta cell function in healthy human donors. J. Clin. Invest. 89, 1761-1766 (1992).
30. R. A. DeFronzo, J. D. Tobin. R. Andres, Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237, E214-223 (1979).
31. H. Merkle, M. Garwood, K. Ugurbil, Dedicated circularly polarized surface coil assembly for brain studies at 4T, in "Proc., SMRM, 12th Annual Meeting, New York, 1993," p. 1358.
32. J. H. Lee, M. Garwood, R. Menon, G. Adrianyi, P. Andersen, G. L. Truwit, K. Ugurbil, High contrast and fast three-dimensional imaging at high fields. Magn. Reson. Med. 34, 308-312 (1995).
33. C. T. W. Moonen, P. C. M. van Zijl, Highly effective water suppression for in vivo proton NMR spectroscopy (DRYSTEAM). J. Magn. Reson. 88, 28-41 (1990).
34. J. Granot, Selected volume excitation using stimulated echoes (VEST). Applications to spatially localized spectroscopy and imaging. J. Magn. Reson. 70, 488-492 (1986).
35. R. Kimmich, D. Hoepfel, Volume-selective multipulse spin-echo spectroscopy. J. Magn. Reson. 72, 379-384 (1987).
36. J. Frahm, K. D. Merboldt, W. Hänicke, Localized proton spectroscopy using stimulated echoes. J. Magn. Reson. 72, 502-508 (1987).
37. Y. Luo, A. Tannus, M. Garwood, Frequency-selective elimination of coherent signal with B1 insensitivity: an improved outer volume, suppression method (BISTRO), in "Proc., SMR, 3rd Annual Meeting. Nice, 1995," p. 1017.
38. R. Gruotter, Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn. Reson. Med. 29, 804-811 (1993).
39. R. Gruetter. K. Uguibil, A fast, automatic shimming technique by mapping along projections (FASTMAP) at 4 Tesla, in "Proc., SMR, 3rd Annual Meeting, Nice, 1995," p. 698.
40. 1H NMR studies of glucose transport in the human brain. J. Cereb. Blood Flow Metab. 16, 427-438 (1996).
41. 1H spectroscopy in human brain at 4 Tesla. Magn. Reson. Med. 33, 246-252 (1995).
42. G. F. Mason, J. W. Pan, S. L. Ponder, D. B. Twieg. G. M. Pohost, H. P. Hetherington, Detection of brain glutamate and glutamine in spectroscopic images at 4.1T. Magn. Reson. Med. 32, 142-145 (1994).
43. O. A. C. Potroff, D. D. Spencer, J. R. Alger, J. W. Prichard, High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy. Neurology 39, 1197-1202 (1989).
44. 1H magnetic resonance spectroscopy of extracts of human epileptic: neocortex and hippocampus. Neurology 43, 589-594 (1993).
45. 13C magnetic resonance, in "Frontiers in Gerebral Vascular Biology: Transport and its Regulation" (L. R. Drewes. A. L. Betz, eds.), Adv. Exp. Med. Biol. 331, pp. 35-40, Plenum Press, New York (1993).
46. C. T. W. Moonen, M. von Kienlin, P. C. M. van Zijl, J. Cohen. J. Gillen, P. Daly, G. Wolf, Comparison of single-shot localization methods (STEAM and PRESS) for in vivo proton NMR spectroscopy. NMR Biomed. 2, 201-208 (1989).
47. R. J. Ordidge, A. Connelly, J. A. B. Lohman, Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J. Magn. Reson. 66, 283-294 (1986).
48. R. J. Ordidge, M. R. Bendall, R. E. Gordon, A. Connelly, Volume selection for in-vivo biological spectroscopy, in "Magnetic Resonance in Biology and Medicine" (G. Govil, C. L. Khetrapal, A. Saran, Tata, eds.), McGraw-Hill, New Delhi, pp. 387-397, 1985.