A male genital tract-specific carbohydrate epitope on human CD52: Implications for immunocontraception

Tissue Antigens

Volumn 60, Issue 5, 2002, Pages 354-364

  Norton, E J ^a   Diekman, A B ^c   Westbrook, V A ^a   Mullins, D W ^a   Klotz, K L ^a   Gilmer, L L ^a   Thomas, T S ^a   Wright, D C ^b   Brisker, J ^b   Engelhard, V H ^a   Flickinger, C J ^a   Herr, John C ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NOVAVAX INC   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

CD52; Contraception; Epididymis; SAGA 1; Spermatozoa; Tissue specificity

Indexed keywords

ALEMTUZUMAB; ANTIGEN; CARBOHYDRATE; CD52 ANTIGEN; EPITOPE; GLYCOPROTEIN; IMMUNOGLOBULIN G1; LIPOSOME; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY S19; NOVASOME; SPERM AGGLUTINATION ANTIGEN 1; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY REACTION; ARTICLE; CONTRACEPTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ENZYME ACTIVITY; EPIDIDYMIS; EPITHELIUM; FEMALE GENITAL SYSTEM; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCONTRACEPTION; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; MALE GENITAL SYSTEM; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPERMATOZOON; TISSUE SPECIFICITY; VAGINA CONTRACEPTION; VAS DEFERENS; WESTERN BLOTTING;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, NEOPLASM; BLOTTING, WESTERN; CARBOHYDRATES; CONTRACEPTION, IMMUNOLOGIC; EPITOPE MAPPING; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; GENITALIA, MALE; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; ORGAN SPECIFICITY;

MURINAE;

EID: 12244258187     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2002.600502.x     Document Type: Article

References (40)

1. Shetty J, Naaby-Hansen S, Shibihara H, Bronson R, Flickinger CJ, Herr JC. Human sperm proteome. Immunodominant sperm surface antigens identified with sera from infertile men and women. Biol Reprod 1999: 61: 61-9.
2. Diekman AB, Goldberg E. Characterization of a human antigen with sera from infertile patients. Biol Reprod 1994: 50: 1087-93.
3. Naaby-Hansen S, Flickinger CJ, Herr JC. Two-dimensional gel electrophoretic analysis of vectorially labeled surface proteins of human spermatozoa. Biol Reprod 1997: 56: 771-87.
4. Herr JC, Flickinger CJ, Homyk M, Klotz KL, John E. Biochemical and morphological characterization of the intra-acrosomal antigen SP-10 from human sperm. Biol Reprod 1990: 42: 181-93.
5. Diekman AB, Westbrook-Case VA, Naaby-Hansen S, Klotz KL, Flickinger CJ, Herr JC. Biochemical characterization of sperm agglutination antigen-1, a human sperm surface antigen implicated in gamete interactions. Biol Reprod 1997: 57: 1136-44.
6. Anderson DJ, Johnson PM, Alexander NJ, Jones WR, Griffin PD. Monoclonal antibodies to human trophoblast and sperm antigens: Report of two WHO-sponsored workshops, June 30, 1986-Toronto, Canada. J Reprod Immunol 1987: 10: 231-57.
7. Mahoney MC, Fulgham DL, Blackmore PF, Alexander NJ. Evaluation of sperm-zona pellucida tight binding by presence of monoclonal antibodies to sperm antigens. J Reprod Immunol 1991: 19: 269-85.
8. Isojima S, Kameda K, Tsuji Y, Shigeta M, Ikeda Y, Koyama K. Establishment and characterization of a human hybridoma secreting monoclonal antibody with high titers of sperm immobilizing and agglutination activities against human seminal plasma. J Reprod Immunol 1987: 10: 67-78.
9. Diekman AB, Norton EJ, Klotz KL et al. N-linked glycan of a sperm CD52 glycoform associated with human infertility. FASEB J 1999: 13: 1303-13.
10. Kirchoff C. CD52 is the 'major maturation-associated' sperm membrane antigen. Mol Hum Reprod 1996: 2: 9-17.
11. Hale G, Rye PD, Warford A, Lauder I, Brito-Babapulle A. The glycophoshpatidylinositol-anchored lymphocyte antigen CDw52 is associated with the epididymal maturation of human spermatozoa. J Reprod Immunol 1993: 23: 189-205.
12. Hale G, Cobbold S, Waldmann H. T cell depletion with CAMPATH-1 in allogenic bone marrow transplantation. Transplantation 1988: 45: 753-9.
13. Schröter S, Derr P, Conrad HS, Nimtz M, Hale G, Kirchhoff C. Male-specific modification of human CD52. J Biol Chem 1999: 274: 29862-73.
14. Treumann A, Lifely MR, Schneider P, Ferguson MAJ. Primary structure of CD52. J Biol Chem 1995: 270: 6088-99.
15. McCauley TC, Kurth BE, Norton EJ et al. Analysis of a human sperm CD52 glycoform in primates: Identification of an animal model for immunocontraceptive vaccine development. Biol Reprod 2002, in press.
16. Southgate J, Trejdosiewicz LK. Immunolabelling of cells and tissues: Approaches and pitfalls. Hum Reprod 1997: 12: 65-75.
17. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970: 227: 680-5.
18. Towbin H, Staehlin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci U S A 1979: 76: 4350-4.
19. Bronson RA, Fusi F. Evidence that an Arg-Gly-Asp adhesion sequence plays a role in mammalian fertilization. Biol Reprod 1990: 43: 1019-25.
20. Tsuji Y, Clausen H, Nudelman E, Kaizu T, Hakomori S-I, Isojima S. Human sperm carbohydrate antigens defined by an anti-sperm human monoclonal antibody derived from an infertile woman bearing antis-perm antibodies in her serum. J Exp Med 1988: 168: 343-56.
21. Zimmerman DH, Ulrich JT, Wright C, Lloyd JP, Winship MD, Sarin PS. Cross-clade p17 peptide recognition by antisera to HGP-30, a 30-amino acid synthetic peptide antigen from HIV Type 1 p17. AIDS Res Hum Retroviruses 1998: 14: 741-9.
22. Krull N, Ivell R, Osterhoff C, Kirchhoff C. Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue-specific cDNAs. Mol Reprod Dev 1993: 34: 16-24.
23. Yeung CH, Cooper TG, Nieschlag E. Human epididymal secreted protein CD52 on ejaculated spermatozoa: Correlations with semen characteristics and the effect of its antibody. Mol Hum Reprod 1997: 3: 1045-51.
24. Tulsiani DRP, Orgebin-Crist MC, Skudlarek MD. Role of luminal fluid glycosyltransferases and glycosidases in the modification of rat sperm plasma membrane glycoproteins during epididymal maturation. J Reprod Fertil 1998: 53: 85-97.
25. Deng XN, Czymmek K, Martin-DeLeon PA. Biochemical maturation of Spam 1 (PH-20) during epididymal transit of mouse sperm involves modifications of N-linked oligos accharides. Mol Reprod Dev 1999: 52: 196-206.
26. Homyk M, Herr JC. Light and electron microscopic immunolocalization of sperm proteins identified by monoclonal antibodies from the World Health Organization Task Force on Sperm Antigens. J Reprod Immunol 1992: 22: 237-56.
27. Cooper TG. Epididymal proteins and sperm maturation. In: E Nieschlag et al., eds. Spermatogenesis-Fertilization-Contraception. Molecular, Cellular and Endocrine Events in Male Reproduction. Schering Foundation Workshop 4. Berlin: Springer-Verlag, 1992: 285-318.
28. Tulsiani DRP, Yoshida-Komiya H, Araki Y. Mammalian fertilization: A carbohydrate-mediated event. Biol Reprod 1997: 57: 487-94.
29. Fenichel P, Cervoni F, Hofmann P et al. Expression of the complement regulatory protein CD59 on human spermatozoa: Characterization and role in gamete interaction. Mol Reprod Dev 1994: 38: 338-46.
30. Cervoni F, Oglesby TJ, Fenichel P et al. Expression of decay-accelerating factor (CD55) of the complement system on human spermatozoa. J Immunol 1993: 151: 939-48.
31. Kirchhoff C, Hale G. Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation. Mol Hum Reprod 1996: 2: 177-84.
32. Orgebin-Crist MC. Studies on the function of the epididymis. Biol Reprod 1969: 1: 155.
33. Igdoura SA, Herscovics A, Lal A, Moremen KW, Morales CR, Hermo L. Alpha-mannosidases involved in N-glycan processing show cell specificity and distinct subcompartmentalization within the Golgi apparatus of cells in the testis and epididymis. Eur J Cell Biol 1999: 78: 441-52.
34. Kirchhoff C, Carballada R, Harms B, Kascheike I. CD52 mRNA is modulated by androgens and temperature in epididymal cell cultures. Mol Reprod Dev 2000: 56: 26-33.
35. Pera I, Ivell R, Kirchhoff C. Body temperature (37°C) specifically down-regulates the messenger ribonucleic acid for the major sperm surface antigen CD52 in epididymal cell culture. Endocrinology 1996: 137: 4451-9.
36. Foldesy RG, Bedford JM. Biology of the scrotum. I. Temperature and androgen as determinants of the sperm storage capacity of the rat cauda epididymis. Biol Reprod 1982: 26: 673-82.
37. Fukuda M. Cell surface carbohydrates: cell-type specific expression. In: Molecular Glycobiology. M Fukuda, O Hindsgaul, eds. Tokyo: Oxford University Press, 1994: 1-52.
38. Norton EJ, Diekman AB, Westbrook VA, Flickinger CJ, Herr JC. RASA, an anti-sperm ScFv directed against the sperm glycoform of CD52: Implications for novel contraceptives. Hum Reprod 2001: 16: 1854-60.
39. Talwar GP. Vaccines and passive immunological approaches for the control of fertility and hormone-dependant cancers. Immunol Rev 1999: 171: 173-92.
40. Naz RK. Vaccine for contraception targeting sperm. Immunol Rev 1999: 171: 193-202.