Structure-Based Design of Novel Nonpeptide Inhibitors of the Src SH2 Domain: Phosphotyrosine Mimetics Exploiting Multifunctional Group Replacement Chemistry

Biopolymers - Peptide Science Section

Volumn 71, Issue 6, 2003, Pages 717-729

  Sundaramoorthi, Raji ^a   Kawahata, Noriyuki ^a   Yang, Michael G ^a   Shakespeare, William C ^a   Metcalf, Chester A ^a   Wang, Yihan ^a   Merry, Taylor ^a   Eyermann, Charles J ^a   Bohacek, Regine S ^a   Narula, Surinder ^a   Dalgarno, David C ^a   Sawyer, Tomi K ^a  

^a ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

Nonpeptide inhibitor; Phosphotyrosine (pTyr); PTyr mimetic; Src homology 2 (SH2); Src tyrosine kinase

Indexed keywords

COMPLEXATION; MOLECULAR STRUCTURE; PHOSPHORUS COMPOUNDS; X RAY ANALYSIS;

BINDING SITES; MULTIFUNCTIONAL GROUPS;

BIOPOLYMERS;

4' PHOSPHONO 3' CARBOXYMETHYLOXYPHENYLALANINE; 4',3' DICARBOXYMETHYLOXYPHENYLALANINE; 4',3' DIPHOSPHONOPHENYLALANINE; ACETYL 4 TYROSYLGLUTAMYLGLUTAMYLISOLEUCINAMIDE; AP 21979; AP 22408; AP 22650; AP 22674; AP 22684; AP 22918; BENZAMIDE DERIVATIVE; PHENYLALANINE DERIVATIVE; PHOSPHOTYROSINE; PROTEIN SH2; PROTEIN SH2 INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; TETRAPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN DOMAIN; STRUCTURE ANALYSIS; X RAY ANALYSIS;

BINDING SITES; BIOMIMETIC MATERIALS; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; PEPTIDES; PHOSPHOTYROSINE; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12144287207     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10600     Document Type: Article

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