Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by 1H/ 13C NMR spectroscopy

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 13, 2001, Pages 1665-1669

  Sundaramoorthi, Raji ^a   Siedem, Chris ^a   Vu, Chi B ^a   Dalgarno, David C ^a   Laird, Ellen C ^a   Botfield, Martyn C ^a   Combs, Amanda B ^a   Adams, Susan E ^a   Yuan, Ruth W ^a   Weigele, Manfred ^a   Narula, Surinder S ^a  

^a ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 ALPHA,BETA DIKETOESTER; BENZOIC ACID; CYSTEINE; GLYOXYLIC ACID; PROTEIN TYROSINE KINASE; THIOL DERIVATIVE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CARBON ISOTOPES; ENZYME INHIBITORS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTONS; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES; SULFHYDRYL COMPOUNDS;

EID: 0035833022     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00269-4     Document Type: Article

References (26)