Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor

Journal of Medicinal Chemistry

Volumn 42, Issue 25, 1999, Pages 5224-5234

  Strømgaard, Kristian ^a   Brierley, Matthew J ^b   Andersen, Kim ^c   Sløk, Frank A ^a   Mellor, Ian R ^b   Usherwood, Peter N R ^b   Krogsgaard Larsen, Povl ^a   Jaroszewski, Jerzy W ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

IONOTROPIC RECEPTOR; N (12 AMINODODECYL) 4 HYDROXY ALPHA [(1 OXOBUTYL)AMINO]BENZENEPROPANAMIDE; NICOTINIC RECEPTOR; PHILANTHOTOXIN 343; POLYAMINE; UNCLASSIFIED DRUG; WASP VENOM;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; POLYAMINE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; GRASSHOPPERS; MAGNETIC RESONANCE SPECTROSCOPY; MUSCLES; NICOTINIC ANTAGONISTS; PHENOLS; POLYAMINES; RECEPTORS, NICOTINIC; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 0033576734     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9903747     Document Type: Article

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