Langerhans cells derived from genetically modified human CD34+ hemopoietic progenitors are more potent than peptide-pulsed Langerhans cells for inducing antigen-specific CD8+ cytolytic T lymphocyte responses

Journal of Immunology

Volumn 174, Issue 2, 2005, Pages 758-766

  Yuan, Jianda ^a,c,f   Latouche, Jean Baptiste ^c,e,f,h   Reagan, John L ^a,c,f   Heller, Glenn ^d,f,g   Riviere, Isabelle ^c,e,f,g   Sadelain, Michel ^c,e,f,g   Young, James W ^a,b,c,f,g  

^a Laboratory of Cellular Immunobiology   (United States)

^b Memorial Sloan Kettering   (United States)

^c Division of Hematology/Oncology   (United States)

^d Biostatistics Service   (United States)

^e Immunology Program   (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD8 ANTIGEN; EPITOPE; FIBRONECTIN; FLT3 LIGAND; GAMMA INTERFERON; HLA A ANTIGEN; RETROVIRUS VECTOR; STEM CELL FACTOR; THROMBOPOIETIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; DNA MODIFICATION; GENE EXPRESSION; GENETIC TRANSDUCTION; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOGENICITY; INFLUENZA VACCINATION; LANGERHANS CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN PROCESSING; T LYMPHOCYTE;

EID: 11844304390     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.2.758     Document Type: Article

References (51)

1. Schuler, G., B. Schuler-Thurner, and R. M. Steinman. 2003. The use of dendritic cells in cancer immunotherapy. Curr. Opin. Immunol. 15:138.
2. Steinman, R. M., and M. Pope. 2002. Exploiting dendritic cells to improve vaccine efficacy. J. Clin. Invest. 109:1519.
3. Mellman, I., and R. M. Steinman. 2001. Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255.
4. Naldini, L., U. Blomer, F. H. Gage, D. Trono, and I. M. Verma. 1996. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl. Acad. Sci. USA 93:11382.
5. Naldini, L., U. Blomer, P. Gallay, D. Ory, R. Mulligan, F. H. Gage, I. M. Verma, and D. Trono. 1996. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263.
6. Frank, I., L. Kacani, H. Stoiber, H. Stossel, M. Spruth, F. Steindl, N. Romani, and M. P. Dierich. 1999. Human immunodeficiency virus type 1 derived from co-cultures of immature dendritic cells with autologous T cells carries T-cell-specific molecules on its surface and is highly infectious. J. Virol. 73:3449.
7. Cavazzana-Calvo, M., S. Hacein-Bey, G. de Saint Basile, F. Gross, E. Yvon, P. Nusbaum, F. Selz, C. Hue, S. Certain, J. L. Casanova, et al. 2000. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288:669.
8. Szabolcs, P., H. F. Gallardo, D. Ciocon, M. Sadelain, and J. W. Young. 1997. Retrovirally transduced human dendritic cells express a normal phenotype and potent T cell stimulatory capacity. Blood 90:2160.
9. Arthur, J. F., L. H. Butterfield, M. D. Roth, L. A. Bui, S. M. Kiertscher, R. Lau, S. Dubinett, J. Glaspy, W. H. McBride, and J. S. Economou. 1997. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther. 4:17.
10. + T cells: implications for an efficient vaccination strategy. Gene Ther. 10:243.
11. Manickan, E., S. Kanangat, R. J. Rouse, Z. Yu, and B. T. Rouse. 1997. Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells. J. Leukocyte Biol. 61:125.
12. Casares, S., K. Inaba, T. D. Brumeanu, R. M. Steinman, and C. A. Bona. 1997. Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope. J. Exp. Med. 186:1481.
13. Fong, C. L., and K.M. Hui. 2002. Generation of potent and specific cellular immune responses via in vivo stimulation of dendritic cells by pNGVL3-hFLex plasmid DNA and immunogenic peptides. Gene Ther. 9:1127.
14. Weber, L. W., W. B. Bowne, J. D. Wolchok, R. Srinivasan, J. Qin, Y. Moroi, R. Clynes, P. Song, J. J. Lewis, and A. N. Houghton. 1998. Tumor immunity and autoimmunity induced by immunization with homologous DNA. J. Clin. Invest. 102:1258.
15. Hawkins, W. G., J. S. Gold, R. Dyall, J. D. Wolchok, A. Hoos, W. B. Bowne, R. Srinivasan, A. N. Houghton, and J. J. Lewis. 2000. Immunization with DNA coding for gp100 results in CD4 T-cell independent antitumor immunity. Surgery 128:273.
16. Albert, M. L., B. Sauter, and N. Bhardwaj. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86.
17. 5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188:1359.
18. Albert, M. L., J. C. Darnell, A. Bender, L. M. Francisco, N. Bhardwaj, and R. B. Darnell. 1998. Tumor-specific and anti-neuronal killer cells in paraneoplastic cerebellar degeneration. Nat. Med. 4:1321.
19. + killer T cells. J. Exp. Med. 193:405.
20. Nouri-Shirazi, M., J. Banchereau, D. Bell, S. Burkeholder, E. T. Kraus, J. Davoust, and K. A. Palucka. 2000. Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. J. Immunol. 165:3797.
21. Berard, F., P. Blanco, J. Davoust, E.-M. Neidhart-Berard, M. Nouri-Shirazi, N. Taquet, D. Rimoldi, J. C. Cerottini, J. Banchereau, and A. K. Palucka. 2000. Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. J. Exp. Med. 192:1535.
22. Hoffmann, T. K., N. Meidenbauer, G. Dworacki, H. Kanaya, and T. L. Whiteside. 2000. Generation of tumor-specific T lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells. Cancer Res. 60:3542.
23. + hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells. J. Immunol. 173:2780.
24. Dhodapkar, K. M., J. Krasovsky, B. Williamson, and M. V. Dhodapkar. 2002. Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific killer T cells by dendritic cells. J. Exp. Med. 195:125.
25. + T cell help to elicit antitumor immunity: implications for the clinical use of dendritic cells. J. Immunol. 164:1243.
26. Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CDS T cell memory. Science 300:337.
27. Sun, J. C., and M. J. Bevan. 2003. Defective CDS T cell memory following acute infection without CD4 T cell help. Science 300:339.
28. + T lymphocytes. Nature 421:852.
29. + T cells. J. Immunol. 163:3597.
30. Ferlazzo, G., M. L. Tsang, L. Moretta, G. Melioli, R. M. Steinman, and C. Munz. 2002. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp. Med. 195:343.
31. Munz, C., T. Dao, G. Ferlazzo, M. A. de Cos, K. Goodman, and J. W. Young. Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells. Blood. In press.
32. Riviere, I., K. Brose, and R. C. Mulligan. 1995. Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells. Proc. Natl. Acad. Sci. USA 92:6733.
33. Latouche, J. B., and M. Sadelain. 2000. Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells. Nat. Biotechnol. 18:405.
34. Gallardo, H. F., C. Tan, D. Dry, and M. Sadelain. 1997. Recombinant retroviruses pseudotyped with the vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytes. Blood 90:952.
35. Jordan, C. T., G. Yamasaki, and D. Minamoto. 1996. High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations. Exp. Hematol. 24:1347.
36. + T lymphocytes in IFN-γ ELISPOT assays. J. Immunol. Methods 259:95.
37. + bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-α. J. Immunol. 154:5851.
38. Szabolcs, P., D. Avigan, S. Gezelter, D. H. Ciocon, M. A. S. Moore, R. M. Steinman, and J. W. Young. 1996. Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-CPU intermediate. Blood 87:4520.
39. + cells into rapid division. Exp. Hematol. 27:1019.
40. Murray, L., K. Luens, R. Tushinski, L. Jin, M. Burton, J. Chen, S. Forestell, and B. Hill. 1999. Optimization of retroviral gene transduction of mobilized primitive hematopoietic progenitors by using thrombopoietin, Flt3, and Kit ligands and RetroNectin culture. Hum. Gene Ther. 10:1743.
41. - cells with preserved ability to engraft SCID-hu bone. Blood 91:1206.
42. Jonuleit, H., U. Kuhn, G. Muller, K. Steinbrink, L. Paragnik, E. Schmitt, J. Knop, and A. H. Enk. 1997. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27:3135.
43. Zhou, L.-J., R. Schwarting, H. M. Smith, and T. F. Tedder. 1992. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. J. Immunol. 149:735.
44. Zhou, L.-J., and T. F. Tedder. 1995. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154:3811.
45. Zhou, L.-J., and T. F. Tedder. 1995. HB15, a specific marker for human blood dendritic cells. In Leukocyte Typing V, White Cell Differentiation Antigens, Vol. I. S. F. Schlossman, L. Boumsell, W. Gilks, J. F. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, et al., eds. Oxford University Press, Oxford, p. 695.
46. Hennemann, B., J. Y. Chuo, P. D. Schley, K. Lambie, R. K. Humphries, and C. J. Eaves. 2000. High-efficiency retroviral transduction of mammalian cells on positively charged surfaces. Hum. Gene Ther. 11:43.
47. + cells on fibronectin fragment CH-296 is inhibited by high concentrations of vector containing medium. J. Gene Med. 3:207.
48. + bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor α. J. Exp. Med. 182:1111.
49. Kavanaugh, M. P., D. G. Miller, W. Zhang, W. Law, S. K. Kozak, D. Kabat, and A. D. Miller. 1994. Cell surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate transporters. Proc. Natl. Acad. Sci. USA 91:7071.
50. van Zeijl, M., S. V. Johann, E. Closs, J. Cunningham, R. Eddy, T. B. Shows, and B. O'Hara. 1994. A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family. Proc. Nat. Acad. Sci. USA 91:1168.
51. + cord blood-derived dendritic cells. Gene Ther. 9:1551.