Dietary iron concentration alters LDL oxidatively the effect of antioxidants

Research Communications in Molecular Pathology and Pharmacology

Volumn 99, Issue 1, 1998, Pages 69-80

  Van Jaarsveld, H ^a   Pool, G F ^a   Barnard, H C ^a  

^a UNIVERSITY OF THE FREE STATE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; RETINOL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CONCENTRATION RESPONSE; IRON INTAKE; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN MODIFICATION; RAT;

ANIMALS; ANTIOXIDANTS; BETA CAROTENE; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; IRON, DIETARY; LIPID PEROXIDATION; MALE; OXIDATION-REDUCTION; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; VITAMIN E;

EID: 0031886064     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Esterbauer, H., Wäg, G., Puhl, H. (1993). Lipid peroxidation and its role in atherosclerosis. Br. Med. Bull. 49: 566-576.
2. Frei, B., Keaney, J.F., Retsky, K.I., Chen, K. (1996). Vitamin C and E and LDL oxidation. In: Vitamins and Hormones, volume 52. Edited by Litwack G. Academic Press, San Diego, pp1-34.
3. Fuhrman, B., Judith, O., Keidar, S., Been-Yaish, L., Kaplan, M., Aviram, M. (1997). Increased uptake of LDL by oxidized macrophages is the result of an initial enhanced LDL receptor activity and of a further progressive oxidation of LDL. Free Radical Biol. Med. 23: 334-346.
4. Gokce, N., Frei, B. (1996). Basic research in antioxidant inhibition of steps in atherogenesis. J. Cardiovasc. Risk 3: 352-357.
5. Hunter, G.C., Dubick, M.A., Keen, C.L., Eskelson, C.D. (1991). Effects of hypertension on aortic antioxidant status in human abdominal aneurysmal and occlusive disease. Proc. Soc. Exp. Biol. Med. 196: 273-279.
6. Janero, D.R. and Burghard, B. (1989). Thiobarbituric acid-reactive malondialdehyde formation during superoxide-dependent, iron-catalyzed lipid peroxidation: Influence of peroxidation conditions. Lipids 24: 125-131.
7. Jiang, Z.Y., Hunt, J.V., Wolff, S.P. (1992). Ferrous ion oxidation in the presence of xylonol orange for detection of lipid hydroperoxide in low-density lipoprotein. Anal. Biochem. 202: 384-389.
8. Kiechl, S., Aichner, F., Gerstenbrand, F., Egger, G., Mair, A., Rungger, G., Spögler, F., Jarosch, E., Oberhollenzer, F., Willeit, J. (1994). Body iron stores and presence of carotid atherosclerosis. Results from the Bruneck study. Arterioscler. Thromb. 14: 1625-1630.
9. Lowry, O.H., Rosenbrough, N.J., Farr, A.L., Randall, R.J. (1951). Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-275.
10. Morel, D.W. and Chisolm, G.M. (1989). Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytoxicity. J. Lipid Res. 30: 1827-1834.
11. Ohkawa, H., Ohishi, N., Yaki, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351-359.
12. Palamada, J.R. and Kehrer, J.P. (1992). Inhibition of protein carbonyl formation and lipid peroxidation by gluthathione in rat liver microsomes. Arch. Biochem. Biophys. 293:103-109.
13. Pang, J.H.S., Jiang, M.J., Chen, Y.L., Wang, F.W., Wang, D.L., Chu, S.H. (1996). Increased ferritin gene expression in atherosclerotic lesions. J. Clin. Invest. 97: 2204-2212.
14. Raal, F.J., Areias, A.J., Pilcher, G.J., Joffe, B.I., Seftel, H.C. (1994). Lack of effect of high dose vitamin E on xanthoma regression in homozygous familial hypercholesterolaemia. Atherosclerosis 107: 213-219.
15. Rosenfeld, M.E., Tsukada, T., Gown, A.M., Ross, R. (1987). Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis 7: 9-23.
16. Salonen, J.T., Nyssönen, K., Korpela, H., Tuomilehto, J., Seppänen. R., Salonen, R. (1992). High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men. Circulation 86: 803-811.
17. Salonen, J.T., Nyssönen, K., Salonen, R. (1994). Body iron stores and the risk of coronary heart disease. N. Eng. J. Med. 331: 1159.
18. Smith, C., Mitchinson, J.J., Aruaoma, O.I., Halliwell, B. (1992). Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions. Biochem. J. 286: 901-905.
19. Stadtman, E.R. and Oliver, C.N. (1991). Metal-catalyzed oxidation of proteins. Physiological consequences. J. Biol. Chem. 266: 2005-2008.
20. Staprans, I., Rapp, J.H., Feingold, K.R. (1993). The effect of oxidised lipids in the diet on serum lipoprotein peroxides in control and diabetic rats. J. Clin. Invest. 92: 638-643.
21. Steinberg, D., Parthasarathy, S., Carew, I.E., Khoo, J.C., Witsum, J. (1989). Beyond cholesterol. Modifications of low density lipoprotein that increase its atherogenecity. N. Eng. J. Med. 320: 915-924.
22. Steinbrecher, U.P., Zhang, H., Lougheed, M. (1990). Role of oxidatively modified LDL in Atherosclerosis. Free Radic. Biol. Med. 9: 155-168.
23. Terpstra, A.H.M., Woodward, C.J.H., Sanchez-Muniz, F.J. (1981). Improved techniques for the separation of serum lipoproteins by density gradient ultracentrifugation: Visualization by prestaining and rapid separation of serum lipoproteins from small volumes of serum. Anal. Biochem. 111: 149-157.
24. Witztum, J.L., Steinberg, D. (1991). Role of oxidized low density lipoprotein in Atherosclerosis. J. Clin. Invest. 88: 1785-1792.
25. Yan, L.J., Lodge, J.K., Traber, M.G., Packer, L. (1997). Apolipoprotein B carbonyl formation is enhanced by lipid peroxidation during copper-mediated oxidation of human low-density lipoproteins. Arch. Biochem. Biophys. 339: 165-171.
26. Yuan, X.M., Anders, Li, W. Olsson, A.G., Brunk, U.T. (1996). Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis. Atherosclerosis 124: 61-73.