Hyperlipidemic subjects have reduced uptake of newly absorbed vitamin E into their plasma lipoproteins, erythrocytee, platelets, and lymphocytes, as studied by deuterium-labeled α-tocopherol biokinetics

Journal of Nutrition

Volumn 135, Issue 1, 2005, Pages 58-63

  Hall, Wendy L ^a   Jeanes, Yvonne M ^a   Lodge, John K ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Biokinetics; Blood cells; Deuterated; Hyperlipidemia; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; CHYLOMICRON; DEUTERIUM; LIPOPROTEIN;

ADULT; BIOAVAILABILITY; BLOOD SAMPLING; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HALF LIFE TIME; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; INGESTION; ISOTOPE LABELING; LIPOPROTEIN BLOOD LEVEL; LIQUID CHROMATOGRAPHY; LYMPHOCYTE; MALE; MASS SPECTROMETRY; NUTRIENT UPTAKE; THROMBOCYTE; VITAMIN BLOOD LEVEL;

EID: 11844292032     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.1.58     Document Type: Conference Paper

References (48)

1. Brigelius-Flohe, R. & Traber, M. G. (1999) Vitamin E: function and metabolism. FASEB J. 13: 1145-1155.
2. Burton, G. W. & Traber, M. G. (1990) Vitamin E: antioxidant activity, biokinetics and bioavailability. Annu. Rev. Nutr. 10: 357-382.
3. Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E., Colditz, G. A. & Willett, W. C. (1993) Vitamin E consumption and the risk of coronary heart disease in men. N. Engl. J. Med. 328: 1450-1456.
4. Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., Rosner, B. & Willet, W. C. (1993) Vitamin E consumption and the risk of coronary disease in women. N. Engl. J. Med. 328: 1444-1449.
5. Bellizzi, M. C., Franklin, M. F., Duthie, G. G. & James, W. P. (1994) Vitamin E and coronary heart disease: the European paradox. Eur. J. Clin. Nutr. 48: 822-831.
6. Gey, K. F. (1991) Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am. J. Clin. Nutr. 53: 326S-334S.
7. Gey, K. F. & Puska, P. (1989) Plasma vitamins E and A inversely correlated to mortality from ischemic heart disease in cross-cultural epidemiology. Ann. N.Y. Acad. Sci. 570: 268-282.
8. Griffin, B. A. (1999) Lipoprotein atherogenicity: an overview of current mechanisms. Proc. Nutr. Soc. 58: 163-169.
9. Stamler, J., Wentworth, D. & Neaton, J. D. (1986) Is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? The Multiple Risk Factor Intervention Trial. J. Am. Med. Assoc. 256: 2823-2828.
10. Hokanson, J. & Austin, M. A. (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high density lipoprotein cholesterol: a meta-analysis of population-based prospective studies. J. Cardiovasc. Risk 3: 213-219.
11. Austin, M. A., King, M.-C., Vranizan, K. M. & Krauss, R. M. (1990) Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation 82: 495-506.
12. Griffin, B. A., Freeman, D. J., Tait, G. W., Thomson, J., Caslake, M. J., Packard, C. J. & Shepherd, J. (1994) Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis 106: 241-253.
13. Davi, G., Gresele, P., Violi, F., Basili, S., Catalano, M., Giammarresi, C., Volpato, R., Nenci, G. G., Ciabattoni, G. & Patrono, C. (1997) Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo. Evidence derived from the study of peripheral arterial disease. Circulation 96: 69-75.
14. de Man, F. H., Nieuwland, R., van der Laarse, A., Romijn, F., Smelt, A. H., Gevers Leuven, J. A. & Sturk, A. (2000) Activated platelets in patients with severe hypertriglyceridemia: effects of triglyceride-lowering therapy. Atherosclerosis 152: 407-414.
15. Stokes, K. Y., Clanton, E. C., Bowles, K. S., Fuseler, J. W., Chervenak, D., Chervenak, R., Jennings, S. R. & Granger, D. N. (2002) The role of T-lymphocytes in hypercholesterolemia-induced leukocyte-endothelial interactions. Microcirculation 9: 407-417.
16. Robertson, A. K., Zhou, X., Strandvik, B. & Hansson, G. K. (2004) Severe hypercholesterolaemia leads to strong Th2 responses to an exogenous antigen. Scand. J. Immunol. 59: 285-293.
17. Calzada, C., Bruckdorfer, K. R. & Rice-Evans, C. A. (1997) The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 128: 97-105.
18. Meydani, S. N., Meydani, M., Blumberg, J. B., Leka, L. S., Siber, G., Loszewski, R., Thompson, C., Pedrosa, M. C., Diamond, R. D. & Stollar, B. D. (1997) Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. J. Am. Med. Assoc. 277: 1380-1386.
19. Meydani, S. N., Barklund, M. P., Liu, S., Meydani, M., Miller, R. A., Cannon, J. G., Morrow, F. D., Rocklin, R. & Blumberg, J. B. (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am. J. Clin. Nutr. 52: 557-563.
20. Brigelius-Flohe, R., Kelly, F. J., Salonen, J. T., Neuzil, J., Zingg, J. M. & Azzi, A. (2002) The European perspective on vitamin E: current knowledge and future research. Am. J. Clin. Nutr. 76: 703-716.
21. Munteanu, A., Zingg, J. M. & Azzi, A. (2004) Anti-atherosclerotic effects of vitamin E-myth or reality? J. Cell. Mol. Med. 8: 59-76.
22. Horwitt, M. K., Harvey, C. C., Dahm, C. H., Jr. & Searcy, M. T. (1972) Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy. Ann. N.Y. Acad. Sci. 203: 223-236.
23. Thurnham, D. I., Davies, J. A., Crump, B. J., Situnayake, R. D. & Davis, M. (1986) The use of different lipids to express serum tocopherol: lipid ratios for the measurement of vitamin E status. Ann. Clin. Biochem. 23 (Pt. 5): 514-520.
24. Simon, E., Paul, J. L., Soni, T., Simon, A. & Moatti, N. (1997) Plasma and erythrocyte vitamin E content in asymptomatic hypercholesterolemic subjects. Clin. Chem. 43: 285-289.
25. Leonhardt, W., Hanefeld, M. & Schaper, F. (1999) Diminished susceptibility to in vitro oxidation of low-density lipoproteins in hypercholesterolemia: key role of alpha-tocopherol content. Atherosclerosis 144: 103-107.
26. Muldoon, M. F., Kritchevsky, S. B., Evans, R. W. & Kagan, V. E. (1996) Serum total antioxidant activity in relative hypo- and hypercholesterolemia. Free Radic. Res. 25: 239-245.
27. van Tits, L. J., Demacker, P. N., de Graaf, J., Hak-Lemmers, H. L. & Stalenhoef, A. F. (2000) Alpha-tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals. Am. J. Clin. Nutr. 71: 458-464.
28. Simon, E., Paul, J. L., Atger, V., Simon, A. & Moatti, N. (1998) Erythrocyte antioxidant status in asymptomatic hypercholesterolemic men. Atherosclerosis 138: 375-381.
29. Jeanes, Y. M., Hall, W. L., Proteggente, A. R. & Lodge, J. K. (2004) Cigarette smokers have decreased lymphocyte and platelet α-tocopherol levels and increased excretion of the γ-tocopherol metabolite γ-carboxyethyl-hydroxy-chroman (γ-CEHC). Free Radic. Res. 38: 861-868.
30. Lehmann, J., Rao, D. D., Canary, J. J. & Judd, J. T. (1988) Vitamin E and relationships among tocopherols in human plasma, platelets, lymphocytes, and red blood cells. Am. J. Clin. Nutr. 47: 470-474.
31. Weintraub, M. S., Eisenberg, S. & Breslow, J. L. (1987) Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil. J. Clin. Invest. 79: 1110-1119.
32. Havel, R. J., Eder, H. A. & Bragdon, J. H. (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34: 1345-1353.
33. Clevidence, B. A. & Ballard-Barbash, R. (1991) Tocopherol contents of lipoproteins from frozen plasma separated by affinity chromatography. Lipids 26: 723-728.
34. Davies, I. G., Graham, J. M. & Griffin, B. A. (2003) Rapid separation of LDL subclasses by iodixanol gradient ultracentrifugation. Clin. Chem. 49: 1865-1872.
35. Burton, G. W., Webb, A. & Ingold, K. U. (1985) A mild, rapid, and efficient method of lipid extraction for use in determining vitamin E/lipid ratios. Lipids 20: 29-39.
36. Hall, W. L., Jeanes, Y. M., Pugh, J. & Lodge, J. K. (2003) Development of a liquid chromatographic time-of-flight mass spectrometric method for the determination of unlabelled and deuterium-labelled alpha-tocopherol in blood components. Rapid Commun. Mass Spectrom. 17: 2797-2803.
37. Traber, M. G., Rader, D., Acuff, R. V., Ramakrishnan, R., Brewer, H. B. & Kayden, H. J. (1998) Vitamin E dose-response studies in humans with use of deuterated RRR-alpha-tocopherol. Am. J. Clin. Nutr. 68: 847-853.
38. Roxborough, H. E., Burton, G. W. & Kelly, F. J. (2000) Inter- and intra-individual variation in plasma and red blood cell vitamin E after supplementation. Free Radic. Res. 33: 437-445.
39. Traber, M. G., Olivecrona, T. & Kayden, H. J. (1985) Bovine milk lipoprotein lipase transfers tocopherol to human fibroblasts during triglyceride hydrolysis in vitro. J. Clin. Invest. 75: 1729-1734.
40. Traber, M. G., Burton, G. W., Hughes, L., Ingold, K. U., Hidaka, H., Malloy, M., Kane, J., Hyams, J. & Kayden, H. J. (1992) Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J. Lipid Res. 33: 1171-1182.
41. Tribble, D. L., Thiel, P. M., van den Berg, J.J.M. & Krauss, R. M. (1995) Differing α-tocopherol oxidative lability and ascorbic acid sparing effects in bouyant and dense LDL. Arterioscler. Thromb. Vasc. Biol. 15: 2025-2031.
42. Tribble, D. L., van den Berg, J.J.M., Motchnik, P., Ames, B. N., Lewis, D., Chait, A. & Krauss, R. M. (1994) Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. Proc. Natl. Acad. Sci. U.S.A. 94: 1183-1187.
43. Tribble, D. L., Holl, L. G., Wood, P. D. & Krauss, R. M. (1992) Variations in oxidative susceptability among six low density lipoprotein subfractions of differing density and particle size. Atherosclerosis 93: 189-199.
44. Kitabchi, A. E. & Wimalasena, J. (1982) Specific binding sites for D-alpha-tocopherol on human erythrocytes. Biochim. Biophys. Acta 684: 200-206.
45. Simon, E., Paul, J. L., Atger, V., Simon, A. & Moatti, N. (2000) Study of vitamin E net mass transfer between alpha-tocopherol-enriched HDL and erythrocytes: application to asymptomatic hypercholesterolemic men. Free Radic. Biol. Med. 28: 815-823.
46. Kaempf, D. E., Miki, M., Ogihara, T., Okamoto, R., Konishi, K. & Mino, M. (1994) Assessment of vitamin E nutritional status in neonates, infants and children-on the basis of alpha-tocopherol levels in blood components and buccal mucosal cells. Int. J. Vitam. Nutr. Res. 64: 185-191.
47. Ye, S. Q. & Kwiterovich, P. O., Jr. (2000) Influence of genetic polymorphisms on responsiveness to dietary fat and cholesterol. Am. J. Clin. Nutr. 72: 1275S-1284S.
48. Relou, I. A., Hackeng, C. M., Akkerman, J. W. & Malle, E. (2003) Low-density lipoprotein and its effect on human blood platelets. Cell. Mol. Life Sci. 60: 961-971.