CD1 assembly and the formation of CD1-antigen complexes

Current Opinion in Immunology

Volumn 17, Issue 1, 2005, Pages 88-94

  Hava, David L ^a   Brigl, Manfred ^a   Elzen, Peter Van Den ^a,b   Zajonc, Dirk M ^c   Wilson, Ian A ^c   Brenner, Michael B ^a  

^a Lymphocyte Biology Section   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN;

ALPHA HELIX; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN STRUCTURE; COMPLEX FORMATION; ENDOPLASMIC RETICULUM; HUMAN; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN BINDING; REVIEW; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS; ANTIGENS, CD1; HUMANS; LIPIDS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; T-LYMPHOCYTES;

EID: 11844286843     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.12.003     Document Type: Review

References (52)

1. M. Sugita, M. Cernadas, and M.B. Brenner New insights into pathways for CD1-mediated antigen presentation Curr Opin Immunol 16 2004 90 95
2. D.B. Moody, and S.A. Porcelli Intracellular pathways of CD1 antigen presentation Nat Rev Immunol 3 2003 11 22
3. M. Brigl, and M.B. Brenner CD1: Antigen Presentation and T Cell Function Annu Rev Immunol 22 2004 817 890
4. M. Sugita, S.A. Porcelli, and M.B. Brenner Assembly and retention of CD1b heavy chains in the endoplasmic reticulum J Immunol 159 1997 2358 2365
5. R. Huttinger, G. Staffler, O. Majdic, and H. Stockinger Analysis of the early biogenesis of CD1b: involvement of the chaperones calnexin and calreticulin, the proteasome and beta(2)-microglobulin Int Immunol 11 1999 1615 1623
6. S.J. Kang, and P. Cresswell Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain J Biol Chem 277 2002 44838 44844
7. S.P. Balk, S. Burke, J.E. Polischuk, M.E. Frantz, L. Yang, S. Porcelli, S.P. Colgan, and R.S. Blumberg Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium Science 265 1994 259 262
8. H.S. Kim, J. Garcia, M. Exley, K.W. Johnson, S.P. Balk, and R.S. Blumberg Biochemical characterization of CD1d expression in the absence of beta2-microglobulin J Biol Chem 274 1999 9289 9295
9. M. Amano, N. Baumgarth, M.D. Dick, L. Brossay, M. Kronenberg, L.A. Herzenberg, and S. Strober CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms J Immunol 161 1998 1710 1717
10. S. Cardell, S. Tangri, S. Chan, M. Kronenberg, C. Benoist, and D. Mathis CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice J Exp Med 182 1995 993 1004
11. J.J. Park, S.J. Kang, A.D. De Silva, A.K. Stanic, G. Casorati, D.L. Hachey, P. Cresswell, and S. Joyce Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved Proc Natl Acad Sci USA 101 2004 1022 1026
12. A.D. De Silva, J.J. Park, N. Matsuki, A.K. Stanic, R.R. Brutkiewicz, M.E. Medof, and S. Joyce Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum J Immunol 168 2002 723 733
13. V. Briken, R.M. Jackman, S. Dasgupta, S. Hoening, and S.A. Porcelli Intracellular trafficking pathway of newly synthesized CD1b molecules EMBO J 21 2002 825 834
14. J. Jayawardena-Wolf, K. Benlagha, Y.H. Chiu, R. Mehr, and A. Bendelac CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain Immunity 15 2001 897 908
15. M. Sugita, R.M. Jackman, E. van Donselaar, S.M. Behar, R.A. Rogers, P.J. Peters, M.B. Brenner, and S.A. Porcelli Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs Science 273 1996 349 352
16. M. Sugita, X. Cao, G.F. Watts, R.A. Rogers, J.S. Bonifacino, and M.B. Brenner Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells Immunity 16 2002 697 706
17. M. Cernadas, M. Sugita, N. Van Der Wel, X. Cao, J.E. Gumperz, S. Maltsev, G.S. Besra, S.M. Behar, P.J. Peters, and M.B. Brenner Lysosomal Localization of Murine CD1d Mediated by AP-3 Is Necessary for NK T Cell Development J Immunol 171 2003 4149 4155
18. D. Elewaut, A.P. Lawton, N.A. Nagarajan, E. Maverakis, A. Khurana, S. Honing, C.A. Benedict, E. Sercarz, O. Bakke, and M. Kronenberg The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells J Exp Med 198 2003 1133 1146
19. R.M. Jackman, S. Stenger, A. Lee, D.B. Moody, R.A. Rogers, K.R. Niazi, M. Sugita, R.L. Modlin, P.J. Peters, and S.A. Porcelli The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens Immunity 8 1998 341 351
20. Y.H. Chiu, J. Jayawardena, A. Weiss, D. Lee, S.H. Park, A. Dautry-Varsat, and A. Bendelac Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments J Exp Med 189 1999 103 110
21. Y.H. Chiu, S.H. Park, K. Benlagha, C. Forestier, J. Jayawardena-Wolf, P.B. Savage, L. Teyton, and A. Bendelac Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d Nat Immunol 3 2002 55 60
22. T.J. Roberts, V. Sriram, P.M. Spence, M. Gui, K. Hayakawa, I. Bacik, J.R. Bennink, J.W. Yewdell, and R.R. Brutkiewicz Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells J Immunol 168 2002 5409 5414
23. M. Exley, J. Garcia, S.P. Balk, and S. Porcelli Requirements for CD1d recognition by human invariant Valpha24+ CD4-CD8- T cells J Exp Med 186 1997 109 120
24. S. Brozovic, T. Nagaishi, M. Yoshida, S. Betz, A. Salas, D. Chen, A. Kaser, J. Glickman, T. Kuo, and A. Little CD1d function is regulated by microsomal triglyceride transfer protein Nat Med 10 2004 535 539 An important role for MTP in CD1d function is shown using conditionally deleted MTP mice. Mouse hepatocytes from these mice were used to demonstrate that CD1d expression and trafficking are altered in the absence of MTP. Consistent with this, MTP is required for the activation of both αGalCer reactive and self-reactive CD1d-restricted T cells.
25. M.M. Hussain, J. Shi, and P. Dreizen Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly J Lipid Res 44 2003 22 32
26. •].
27. •].
28. •], suggesting that saposins might be involved in lipid transfer to CD1 in vivo.
29. C.G. Schuette, B. Pierstorff, S. Huettler, and K. Sandhoff Sphingolipid activator proteins: proteins with complex functions in lipid degradation and skin biogenesis Glycobiology 11 2001 81R 90R
30. G. Wilkening, T. Linke, and K. Sandhoff Lysosomal degradation on vesicular membrane surfaces. Enhanced glucosylceramide degradation by lysosomal anionic lipids and activators J Biol Chem 273 1998 30271 30278
31. U.E. Schaible, K. Hagens, K. Fischer, H.L. Collins, and S.H. Kaufmann Intersection of group I CD1 molecules and mycobacteria in different intracellular compartments of dendritic cells J Immunol 164 2000 4843 4852
32. W.L. Beatty, E.R. Rhoades, H.J. Ullrich, D. Chatterjee, J.E. Heuser, and D.G. Russell Trafficking and release of mycobacterial lipids from infected macrophages Traffic 1 2000 235 247
33. T.I. Prigozy, P.A. Sieling, D. Clemens, P.L. Stewart, S.M. Behar, S.A. Porcelli, M.B. Brenner, R.L. Modlin, and M. Kronenberg The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules Immunity 6 1997 187 197
34. A. Engering, T.B. Geijtenbeek, S.J. van Vliet, M. Wijers, E. van Liempt, N. Demaurex, A. Lanzavecchia, J. Fransen, C.G. Figdor, and V. Piguet The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells J Immunol 168 2002 2118 2126
35. L. Tailleux, O. Schwartz, J.L. Herrmann, E. Pivert, M. Jackson, A. Amara, L. Legres, D. Dreher, L.P. Nicod, and J.C. Gluckman DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells J Exp Med 197 2003 121 127
36. T.B. Geijtenbeek, S.J. Van Vliet, E.A. Koppel, M. Sanchez-Hernandez, C.M. Vandenbroucke-Grauls, B. Appelmelk, and Y. Van Kooyk Mycobacteria target DC-SIGN to suppress dendritic cell function J Exp Med 197 2003 7 17
37. U.E. Schaible, F. Winau, P.A. Sieling, K. Fischer, H.L. Collins, K. Hagens, R.L. Modlin, V. Brinkmann, and S.H. Kaufmann Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis Nat Med 9 2003 1039 1046
38. S. Mukherjee, T.T. Soe, and F.R. Maxfield Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails J Cell Biol 144 1999 1271 1284
39. D.B. Moody, V. Briken, T.Y. Cheng, C. Roura-Mir, M.R. Guy, D.H. Geho, M.L. Tykocinski, G.S. Besra, and S.A. Porcelli Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation Nat Immunol 3 2002 435 442
40. Z. Zeng, A.R. Castano, B.W. Segelke, E.A. Stura, P.A. Peterson, and I.A. Wilson Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove Science 277 1997 339 345
41. •].
42. S.D. Gadola, N.R. Zaccai, K. Harlos, D. Shepherd, J.C. Castro-Palomino, G. Ritter, R.R. Schmidt, E.Y. Jones, and V. Cerundolo Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains Nat Immunol 3 2002 721 726
43. •] have determined the structure of CD1 bound to natural self and foreign lipid antigens, respectively. These studies, together with comparative analysis of the CD1 antigen-binding groove, have revealed the structural basis of the recognition of foreign and self-lipids by CD1, as well as an understanding of how CD1 is able to bind an array of lipids with differing structures.
44. S. Oki, A. Chiba, T. Yamamura, and S. Miyake The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells J Clin Invest 113 2004 1631 1640
45. L. Brossay, O. Naidenko, N. Burdin, J. Matsuda, T. Sakai, and M. Kronenberg Structural requirements for galactosylceramide recognition by CD1-restricted NK T cells J Immunol 161 1998 5124 5128
46. D.B. Moody, D.C. Young, T.Y. Cheng, J.P. Rosat, C. Roura-Mir, P.B. O'Connor, D.M. Zajonc, A. Walz, M.J. Miller, and S.B. Levery T cell activation by lipopeptide antigens Science 303 2004 527 531 This work describes the first structure of a CD1a-presented antigen to be determined, which is a lipopeptide derived from M. tuberculosis. From this work, our knowledge of the pool of potential antigens that can be bound and presented by CD1 is vastly expanded.
47. M. Kronenberg, and L. Gapin The unconventional lifestyle of NKT cells Nat Rev Immunol 2 2002 557 568
48. M. Skold, and S.M. Behar Role of CD1d-restricted NKT cells in microbial immunity Infect Immun 71 2003 5447 5455
49. H.J. Van Der Vliet, J.W. Molling, B.M. Von Blomberg, N. Nishi, W. Kolgen, A.J. Van Den Eertwegh, H.M. Pinedo, G. Giaccone, and R.J. Scheper The immunoregulatory role of CD1d-restricted natural killer T cells in disease Clin Immunol 112 2004 8 23
50. A. Nicholls, K.A. Sharp, and B. Honig Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons Proteins 11 1991 281 296
51. P.J. Kraulis MOLSCRIPT: a program to produce both detailed and schematic plots of proteins J Appl Crystallogr 24 1991 946 950
52. E.A. Merritt, and D.J. Bacon Raster3D: Photorealistic Molecular Graphics Meth Enzymol 277 1997 505 524