A pilot study of fatty acid metabolism in oral squamous cell carcinoma

International Journal of Oral and Maxillofacial Surgery

Volumn 34, Issue 1, 2005, Pages 78-81

  Zhang, Yie ^a   Guo, C ^a   Yu, G ^a  

^a PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

Author keywords

Apoptosis; Cerulenin; Fatty acid synthesis; Squamous cell carcinoma

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETIC ACID; C 75; CELL DNA; CERULENIN; FATTY ACID SYNTHASE INHIBITOR; LIPID; TRITIUM; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CARCINOMA CELL; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG TARGETING; ELECTROPHORESIS; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; FIBROBLAST; GINGIVA; HUMAN; HUMAN CELL; MOUTH CARCINOMA; PILOT STUDY; SQUAMOUS CELL CARCINOMA;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CERULENIN; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; HUMANS; MOUTH NEOPLASMS; PILOT PROJECTS;

EID: 11844283960     PISSN: 09015027     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijom.2004.03.001     Document Type: Article

References (26)

1. Chalbos D. Joyeux C. Galtier F. Escot C. Chambo M. Maudelonde T. Rochefort H. Progestin-induced fatty acid synthetase in human mammary tumors: From molecular to clinical studies J. Steroid Biochem. Mol. Biol. 43 1992 223-228
2. Chen B.A. Huang P.L. Dai Z.S. Lin G.W. Proliferation inhibition and apoptosis induction of K562 cells by fatty acid synthase inhibitor-cerulenin Chin. J. Henatol. 21 2000 244-246
3. Funabashi H. Kawaguchi A. Tomoda H. Omura S. Okuda S. Iwasaki S. Binding site of cerulenin in fatty acid synthetase J. Biochem. 105 1989 751-755
4. Fuyuya Y. Akimoto S. Yasuda K. Ito H. Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis Anticancer Res. 17 1997 4589-4594
5. Gansler T.S. Hardman W. III Hunt D.A. Schaffel S. Hennigar R.A. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival Hum. Pathol. 28 1997 686-692
6. Guo C.B. Cui L.H. Yu G.Y. Liu D.X. Meng S.C. Song Q. Endogenous fatty acid synthesis in squamous cell carcinomas of the oral cavity Brit. J. Oral Maxillofac. Surg. 38 2000 506-508
7. Herrmann M. Lorenz H.M. Voll R. Grünke M. Woith W. Kalden J.R. A rapid and simple method for the isolation of apoptotic DNA fragments Nucleic Acids Res. 22 1994 5506-5507
8. Krontiras H. Roye G.D. Beenken S.E. Myers R.B. Peters G.E. Grezzle W.E. Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue Head Neck 21 1999 325-329
9. Kuhajda F.P. Jenner K. Wood F.D. Hennigar R.A. Jacobs L.B. Dick J.D. Pasternack G.R. Fatty acid synthesis: A potential selective target for antineoplastic therapy Proc. Natl. Acad. Sci. USA 91 1994 6379-6383
10. Kuhajda F.P. Piantadosi S. Pasternack G.R. Haptoglobin-related protein epitopes in breast cancer as a predictor of recurrence of the disease N. Engl. J. Med. 321 1989 636-641
11. Kuhajda F.P. Pizer E.S. Li J.N. Mani N.S. Frehywot G.L. Townsend C.A. Synthesis and antitumor activity of an inhibitor of fatty acid synthase Proc. Natl. Acad. Sci. USA 97 2000 3450-3454
12. Lawrence D.S. Zilfou J.T. Smith C.D. Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors J. Med. Chem. 42 1999 4932-4941
13. Pedersen P.L. Tumor mitochondria and the bioenergetics of cancer cells Prog. Exp. Tumor Res. 22 1978 190-274
14. Ookhtens M. Kanna R. Lyon I. Baker N. Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor Am. J. Physiol. 247 1984 R146-R153
15. Pizer E.S. Chrest F.J. DiGiuseppe J.A. Han W.F. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines Cancer Res. 58 1998 4611-4615
16. Pizer E.S. Jackisch C. Wood F.D. Pasternack G.R. Davidson N.E. Kuhajda F.P. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells Cancer Res. 56 1996 2745-2747
17. Pizer E.S. Lax S. Kuhajda F.P. Pasternack G.R. Kurman R.J. Fatty acid synthase expression in endometrial carcinoma: Correlation with cell proliferation and hormone receptors Cancer 83 1998 528-537
18. Pizer E.S. Thupari J. Han W.F. Pinn M.L. Chrest F.J. Frehywot G.L. Townsend C.A. Kuhajda F.P. Malonyl-Coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and Xenografts Cancer Res. 60 2000 213-218
19. Pizer E.S. Wood F.D. Heine H.S. Romantsev F.E. Pasternack G.R. Kuhajda F.P. Inhibition of fatty acid synthesis delays disease progression in a Xenograft model of ovarian cancer Cancer Res. 56 1996 1189-1193
20. Pizer E.S. Wood F.D. Pasternack G.R. Kuhajda F.P. Fatty acid synthase (FAS): A target for cytotoxic antimetabolites in HL60 premyelocytic leukemia cell Cancer Res. 56 1996 745-751
21. Rashid A. Pizer E.S. Moga M. Milgraum L.Z. Zahurok M. Pasternack G.R. Kuhajda F.P. Hamilton S.R. Elevated expression of fatty acid synthase and fatty acid syhthetic activity in colorectal neoplasia Am. J. Pathol. 150 1997 201-208
22. Reston M.S. Kern S.E. Vogelstein B. Hamilton S.R. Expression of OA-519 (haptoglobin-related protein episodes) in colorectal cancers: Comparison with molecular genetic alterations and metastasis Lab. Incest. 66 1992 47A
23. Shurbaji M.S. Kalbfleisch J.H. Thurmond T.S. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of prostate cancer Hum. Pathol. 27 1996 917-921
24. Swinnen J. Esquenet M. Goossens K. Heyns W. Verhoeven G. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP Cancer Res. 57 1997 1086-1090
25. Tyagi R.K. Azrad A. Degani H. Yoram SalomonSimultaneous extraction of cellular lipids and water-soluble metabolites: Evaluation by NMR spectroscopy Magn. Reson. Med. 35 1996 194-200
26. Weiss L. Hoffmann G.E. Schreiber R. Andres H. Fuchs E. Körber E. Kolb H.J. Fatty-acid biosynthesis in man, a pathway of minor importance Biol. Chem. Hoppe-Seylwe 367 1986 905-912