Peripheral chemoreceptor contributions to cardiovascular regulation

HeartDrug

Volumn 4, Issue 4, 2004, Pages 190-200

  Shoemaker, J Kevin ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Blood pressure; Cardiovascular system; Hypoxia; Peripheral chemoreflex; Sympathetic nerve activity

Indexed keywords

AORTA CHEMORECEPTOR; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE MONITORING; CHEMORECEPTOR REFLEX; CHEMOSENSITIVITY; CORRELATION ANALYSIS; CROSS COUPLING REACTION; CROSS LINKING; HEART DISEASE; HEART FAILURE; HEART FUNCTION; HEART MUSCLE EXCITABILITY; HUMAN; HUMAN GENOME; HYPERTENSION; INFORMATION PROCESSING; LUNG VENTILATION PERFUSION RATIO; MOLECULAR MECHANICS; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; REVIEW; SENSITIVITY ANALYSIS; SLEEP APNEA SYNDROME; STATISTICAL SIGNIFICANCE; SYMPATHETIC TONE;

EID: 11444270116     PISSN: 14229528     EISSN: None     Source Type: Journal    
DOI: 10.1159/000082190     Document Type: Review

References (85)

1. Daly MDB, Ungar A: Comparison of the reflex responses elicited by stimulation of the separately perfused carotid and aortic body chemoreceptors in the dog. J Physiol 1966;182:379-403.
2. Marshall JM: Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev 1994;74:543-594.
3. Neubauer JA, Sunderram J: Oxygen-sensing neurons in the central nervous system. J Appl Physiol 2004;96:367-374.
4. Lugliani R, Whipp BJ, Wasserman K: A role for the carotid body in cardiovascular control in man. Chest 1973;63:744-750.
5. Lugliani R, Whipp BJ, Seard C, Wasserman K: Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man. N Engl J Med 1971;285:1105-1111.
6. West JB: Respiratory Physiology, ed 4. Baltimore, Williams & Wilkins, 1990.
7. Cunningham DJ: Studies on arterial chemoreceptors in man. J Physiol 1987;384:1-26.
8. Prabhakar NR: Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol 2000;88:2287-2295.
9. Eckberg DL: The human respiratory gate. J Physiol 2003;548(pt 2):339-352.
10. Lopes OU, Palmer JF: Proposed respiratory 'gating' mechanism for cardiac slowing. Nature 1976;264:454-456.
11. Delp MD, Brown M, Laughlin MH, Hasser EM: Rat aortic vasoreactivity is altered by old age and hindlimb unloading. J Appl Physiol 1995;78:2079-2086.
12. Katona PG, Jih F: Respiratory sinus arrhythmia: Noninvasive measure of parasympathetic cardiac control. J Appl Physiol 1975;39:801-805.
13. Barman SM, Gebber GL: Basis for synchronization of sympathetic and phrenic nerve discharges. Am J Physiol 1976;231:1601-1607.
14. Kollai M, Mizsei G: Respiratory sinus arrhythmia is a limited measure of cardiac parasympathetic control in man. J Physiol 1990;424:329-342.
15. Eckberg DL: Human sinus arrhythmia as an index of vagal cardiac outflow. J Appl Physiol 1983;54:961-966.
16. Daly MDB: Peripheral Arterial Chemoreceptors and Respiratory- Cardiovascular Integration. Oxford, Clarendon Press, 1997.
17. Guyenet PG: Neural structures that mediate sympathoexcitation during hypoxia. Respir Physiol 2000;121:147-162.
18. Seals DR, Suwarno NO, Dempsey JA: Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 1990;67:130-141.
19. Seals DR, Suwarno NO, Joyner MJ, Iber C, Copeland JG, Dempsey JA: Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circ Res 1993;72:440-454.
20. Dempsey JA, Sheel AW, St Croix CM, Morgan BJ: Respiratory influences on sympathetic vasomotor outflow in humans. Respir Physiol Neurobiol 2002;130:3-20.
21. De Burgh DM, Hazzledine JL, Ungar A: The reflex effects of alterations in lung volume on systemic vascular resistance in the dog. J Physiol 1967;188:331-351.
22. Cooke WH, Hoag JB, Crossman AA, Kuusela TA, Tahvanainen KU, Eckberg DL: Human responses to upright tilt: A window on central autonomic integration. J Physiol 1999;517:617-628.
23. Daly MDB, Scott MJ: The effects of stimulation of the carotid body chemoreceptors on heart rate in the dog. J Physiol 1958;144:148-166.
24. Daly MDB, Scott MJ: The cardiovascular responses to stimulation of the carotid body chemoreceptors in the dog. J Physiol 1963;165:179-197.
25. Marshall JM, Metcalfe JD: Analysis of factors that contribute to cardiovascular changes induced in the cat by graded levels of systemic hypoxia. J Physiol 1989;412:429-448.
26. Shoemaker JK, Vovk A, Cunningham DA: Peripheral chemoreceptor contributions to sympathetic and cardiovascular responses during hypercapnia. Can J Physiol Pharmacol 2002;80:1136-1144.
27. Leuenberger UA, Hardy JC, Herr MD, Gray KS, Sinoway LI: Hypoxia augments apneainduced peripheral vasoconstriction in humans. J Appl Physiol 2001;90:1516-1522.
28. Somers VK, Mark AL, Zavala DC, Abboud FM: Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol 1989;67:2095-2100.
29. Halliwill JR, Morgan BJ, Charkoudian N: Peripheral chemoreflex and baroreflex interactions in cardiovascular regulation in humans. J Physiol 2003;552:295-302.
30. Rowell LB, Johnson DG, Chase PB, Comess KA, Seals DR: Hypoxemia raises muscle sympathetic activity but not norepinephrine in resting humans. J Appl Physiol 1989;66:1736-1743.
31. Leuenberger U, Gleeson K, Wroblewski K, Prophet S, Zelis R, Zwillich C, et al: Norepinephrine clearance is increased during acute hypoxemia in humans. Am J Physiol 1991;261:H1659-H1664.
32. Ledderhos C, Quies W, Schuster R, Peters R: Renal hemodynamics and excretory function of healthy young men during stimulation of their peripheral arterial chemoreceptors by almitrine bismesylate. Biomed Biochim Acta 1987;46:1035-1042.
33. Honig A, Wedler B, Zingler C, Ledderhos C, Schmidt M: Kidney function during arterial chemoreceptor stimulation. 3. Long-lasting inhibition of renal tubular sodium reabsorption due to pharmacologic stimulation of the peripheral arterial chemoreceptors with almitrine bismesylate. Biomed Biochim Acta 1985;44:1659-1672.
34. Rowell LB, Blackmon JR: Human cardiovascular adjustments to acute hypoxaemia. Clin Physiol 1987;7:349-376.
35. Morgan BJ, Crabtree DC, Palta M, Skatrud JB: Combined hypoxia and hypercapnia evokes long-lasting sympathetic activation in humans. J Appl Physiol 1995;79:205-213.
36. Cutler MJ, Swift NM, Keller DM, Wasmund WL, Smith ML: Hypoxia-mediated prolonged elevation of sympathetic nerve activity after periods of intermittent hypoxic apnea. J Appl Physiol 2004;96:754-761.
37. Hansen J, Sander M: Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol 2003;546:921-929.
38. Izzo JL Jr, Taylor AA: The sympathetic nervous system and baroreflexes in hypertension and hypotension. Curr Hypertens Rep 1999;1:254-263.
39. Izzo JL Jr: Sympathoadrenal activity, catecholamines, and the pathogenesis of vasculopathic hypertensive target-organ damage. Am J Hypertens 1989;2:305S-312S.
40. Mancia G, di Rienzo M, Parati G, Grassi G: Sympathetic activity, blood pressure variability and end organ damage in hypertension. J Hum Hypertens 1997;11(suppl 1):S3-S8.
41. Koshiya N, Guyenet PG: Role of the pons in the carotid sympathetic chemoreflex. Am J Physiol 1994;267:R508-R518.
42. Koshiya N, Guyenet PG: NTS neurons with carotid chemoreceptor inputs arborize in the rostral ventrolateral medulla. Am J Physiol 1996;270:R1273- R1278.
43. St Croix CM, Satoh M, Morgan BJ, Skatrud JB, Dempsey JA: Role of respiratory motor output in within-breath modulation of muscle sympathetic nerve activity in humans. Circ Res 1999;85:457-469.
44. Kimmerly DS, Tutungi E, Wilson TD, Serrador JM, Gelb AW, Hughson RL, et al: Circulating norepinephrine and cerebrovascular control in conscious humans. Clin Physiol Funct Imaging 2003;23:314-319.
45. O'Regan RG, Majcherczyk S: Role of peripheral chemoreceptors and central chemosensitivity in the regulation of respiration and circulation. J Exp Biol 1982;100:23-40.
46. O'Regan RG: Responses of carotid body chemosensory activity and blood flow to stimulation of sympathetic nerves in the cat. J Physiol 1981;315:81-98.
47. Mancia G, Shepherd JT, Donald DE: Interplay among carotid sinus, cardiopulmonary, and carotid body reflexes in dogs. Am J Physiol 1976;230:19-24.
48. Somers VK, Mark AL, Abboud FM: Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 1991;87:1953-1957.
49. Pauletto P, Scannapieco G, Pessina AC: Sympathetic drive and vascular damage in hypertension and atherosclerosis. Hypertension 1991;17(suppl 4):III75-III81.
50. Cechetto DF: Experimental cerebral ischemic lesions and autonomic and cardiac effects in cats and rats. Stroke 1993;24(suppl 12):I6-I9.
51. Du X, Cox HS, Dart AM, Esler MD: Sympathetic activation triggers ventricular arrhythmias in rat heart with chronic infarction and failure. Cardiovasc Res 1999;43:919-929.
52. Kaye DM, Lefkovits J, Jennings GL, Bergin P, Broughton A, Esler MD: Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol 1995;26:1257-1263.
53. Benarroch EE: The central autonomic network: Functional organization, dysfunction, and perspective. Mayo Clin Proc 1993;68:988-1001.
54. Stoney C, Davis M, Matthews K: Sex differences in physiological responses to stress and in coronary heart disease: A causal link? Psychophysiology 1987;24:127-131.
55. Hachinski VC, Smith KE, Silver MD, Gibson CJ, Ciriello J: Acute myocardial and plasma catecholamine changes in experimental stroke. Stroke 1986;17:387-390.
56. Hachinski VC, Wilson JX, Tichenoff L, Smith KE, Cechetto DF: Effect of age on autonomic and cardiac responses in a rat stroke model. Arch Neurol 1992;49:690-696.
57. Grassi G, Seravalle G, Bertinieri G, Turri C, Dell'Oro R, Stella ML, Mancia G: Sympathetic and reflex alterations in systo-diastolic and systolic hypertension of the elderly. J Hypertens 2000;18:587-593.
58. Doyle AE, Donnan GA: Stroke as a clinical problem in hypertension. J Cardiovasc Pharmacol 1990;15(suppl 1):S34-S37.
59. Grassi G, Seravalle G, Cattaneo BM, Lanfranchi A, Vailati S, Giannattasio C, et al: Sympathetic activation and loss of reflex sympathetic control in mild congestive heart failure. Circulation 1995;92:3206-3211.
60. Middlekauff HR: Mechanisms and implications of autonomic nervous system dysfunction in heart failure. Curr Opin Cardiol 1997;12:265-275.
61. Narkiewicz K, Pesek CA, van de Borne P, Kato M, Somers V: Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure. Circulation 1999;100:262-267.
62. 2 in hyperoxia and hypoxia in older aged humans. J Appl Physiol 1993;75:2209-2216.
63. Kregel KC: Alterations in autonomic adjustments to acute hypoxia in conscious rats with aging. J Appl Physiol 1996;80:540-546.
64. Franchini KG, Moreira ED, Ida F, Krieger EM: Alterations in the cardiovascular control by the chemoreflex and the baroreflex in old rats. Am J Physiol 1996;270(pt 2):R310-R313.
65. Mancia G, Cleroux J, Daffonchio A, Ferrari AU, Giannattasio C, Grassi G: Reflex control of circulation in the elderly. Cardiovasc Drugs Ther 1991;4(suppl 6):1223-1228.
66. Tanaka H, Davy KP, Seals DR: Cardiopulmonary baroreflex inhibition of sympathetic nerve activity is preserved with age in healthy humans. J Physiol 1999;515:249-254.
67. Leuenberger U, Jacob E, Sweer L, Waravdekar N, Zwillich C, Sinoway L: Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia. J Appl Physiol 1995;79:581-588.
68. Narkiewicz K, van de Borne PJ, Pesek CA, Dyken ME, Montano N, Somers VK: Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation 1999;99:1183-1189.
69. Imadojemu VA, Gleeson K, Gray KS, Sinoway LI, Leuenberger UA: Obstructive apnea during sleep is associated with peripheral vasoconstriction. Am J Respir Crit Care Med 2002;165:61-66.
70. Narkiewicz K, van de Borne PJ, Montano N, Dyken ME, Phillips BG, Somers VK: Contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea. Circulation 1998;97:943-945.
71. Grassi G: Role of the sympathetic nervous system in human hypertension. J Hypertens 1998;616:1979-1987.
72. Somers V, Mark AL, Abboud FM: Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension 1988;11:608-612.
73. Trzebski A, Tafil M, Zoltowski M, Przybylski J: Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc Res 1982;16:163-172.
74. Ledderhos C, Brauer H, Gens A, Sanchez R, Quies W, Schuster R, et al: Cardiorespiratory and renal responses to arterial chemoreceptor stimulation in early hypertension. Int J Clin Pharmacol Ther 1996;34:470-476.
75. Francis GS: Neuroendocrine manifestations of congestive heart failure. Am J Cardiol 1988;62:9A-13A.
76. Grassi G, Seravalle G, Cattaneo BM, Lanfranchi A, Vailati S, Giannattasio C, Del Bo A, et al: Sympathetic activation and loss of reflex sympathetic control in mild congestive heart failure. Circulation 1995;92:3206-3211.
77. Zucker IH, Wang W, Brandle M, Schultz HD, Patel KP: Neural regulation of sympathetic nerve activity in heart failure. Prog Cardiovasc Dis 1995;37:397-414.
78. Murakami H, Liu JL, Zucker IH: Blockade of AT(1) receptors enhances baroreflex control of heart rate in conscious rabbits with heart failure. Am J Physiol Regul Integr Comp Physiol 1996;40:R303-R309.
79. Sun SY, Wang W, Zucker IH, Schultz HD: Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure. J Appl Physiol 1999;86:1264-1272.
80. Chua TP, Ponikowski P, Webb-Peploe K, Harrington D, Anker SD, Piepoli M, et al: Clinical characteristics of chronic heart failure patients with an augmented peripheral chemoreflex. Eur Heart J 1997;18:480-486.
81. Ponikowski P, Chua TP, Anker SD, Francis DP, Doehner W, Banasiak W, et al: Peripheral chemoreceptor hypersensitivity: An ominous sign in patients with chronic heart failure. Circulation 2001;104:544-549.
82. van de Borne P, Oren RM, Andersen EA, Mark AL, Somers V: Tonic chemoreflex activation does not contribute to elevated muscle sympathetic nerve activity in heart failure. Circulation 1996;94:1325-1328.
83. Goso Y, Asanoi H, Ishise H, Kameyama T, Hirai T, Nozawa T, et al: Respiratory modulation of muscle sympathetic nerve activity in patients with chronic heart failure. Circulation 2001;104:418-423.
84. Pinna GD, Maestri R, Mortara A, La Rovere MT, Fanfulla F, Sleight P: Periodic breathing in heart failure patients: Testing the hypothesis of instability of the chemoreflex loop. J Appl Physiol 2000;89:2147-2157.
85. Griffith TM, Edwards DH, Davies RL, Harrison TJ, Evans KT: EDRF coordinates the behaviour of vascular resistance vessels. Nature 1987;329:442-445.