Cardiorespiratory and renal responses to arterial chemoreceptor stimulation in early hypertension

International Journal of Clinical Pharmacology and Therapeutics

Volumn 34, Issue 11, 1996, Pages 470-476

  Ledderhos, C ^a   Brauer, H ^a   Gens, A ^a   Sanchez, R ^a   Quies, W ^a   Schuster, R ^a   Honig, A ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Almitrine bismesylate; Arterial chemoreceptors; Cardiovascular system; External ventilation; Kidney function; Primary systemic hypertension

Indexed keywords

ALMITRINE DIMESILATE; LITHIUM; SODIUM;

ADULT; ARTERIOLE; ARTERY; ARTICLE; BLOOD VESSEL REACTIVITY; BORDERLINE HYPERTENSION; CARDIOVASCULAR SYSTEM; CHEMORECEPTOR; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; GLOMERULUS FILTRATION; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; KIDNEY; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY NERVE; KIDNEY VASCULAR RESISTANCE; LATENT PERIOD; LUNG MINUTE VOLUME; MALE; NORMAL HUMAN; RESPIRATORY SYSTEM; SODIUM ABSORPTION; SODIUM URINE LEVEL; SYSTOLIC BLOOD PRESSURE; URINARY EXCRETION;

ADULT; ALMITRINE; ARTERIES; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CHEMORECEPTORS; ELECTROLYTES; HEART RATE; HUMANS; HYPERTENSION; KIDNEY; MALE; RENAL CIRCULATION; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM AGENTS; STIMULATION, CHEMICAL; URINE;

EID: 0029853951     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Bardsley PA, Johnson BF, Stewart AG, Barer GB 1991 Natriuresis secondary to carotid chemoreceptor stimulation with almitrine bismesylate in the rat: The effect on kidney function and the response to renal denervation and deficiency of antidiuretic hormone. Biomed Biochim Acta 50: 175-182
2. Brauer H, Gens A, Ledderhos C, Sanchez R, Schuster R, Quies W. Honig A 1996 Cardiorespiratory and renal responses to whole-body hypoxic hypoxia and to pharmacological stimulation of the peripheral arterial chemoreceptors in young normotensive men. Clin Exp Pharmacol Physiol, accepted for publication
3. DeBacker W, Vermeire P, Bogaert E, Janssens E, Van Maele R 1985 Almitrine has no effect on gas exchange after bilateral carotid body resection in severe chronic airflow obstruction. Bull Eur Physiopathol Respir 21: 427-432
4. Fukuda Y, Sato A, Trzebski A 1987 Carotid chemoreceptor discharge responses to hypoxia and hypercapnia in normotensive and spontaneously hypertensive rats. J Autonom Nerve Syst 19: 1-11
5. Habeck J-O 1991 Peripheral arterial chemoreceptors and hypertension. J Autonom Nerve Syst 34: 1-8
6. Heath D, Smith P 1992 Diseases of the human carotid body. Chapter 14: The carotid bodies in systemic hypertension. Springer, London, pp 119-126
7. Honig A 1989 Peripheral arterial chemoreceptors and reflex control of sodium and water homeostasis. Am J Physiol 257: 1282-1302
8. Karim F, Poucher SM, Summerill RA 1987 The effects of stimulating carotid chemoreceptors on renal hemodynamics and function in dogs. J Physiol (Lond) 392: 451-462
9. Karim F, Al-Obaidi M 1993 Modification of carotid chemoreceptor-induced changes in renal hemodynamics and function by carotid baroreflex in dogs. J Physiol (Lond) 466:599-610
10. Koller EA. Schopen M, Keller M, Lang RE, Valloton MB 1989 Ventilatory, circulatory, endocrine and renal effects of almitrine infusion in man: A contribution to high-altitude physiology. Eur J Appl Physiol 58: 419-425
11. Laubie M, Schnitt H 1980 Long-lasting hyperventilation induced by almitrine: Evidence for a specific effect on carotid and thoracic chemoreceptors. Eur J Pharmacol 61: 125-136
12. Ledderhos C, Quies W, Schuster R, Peters R 1987 Renal hemodynamics and excretory function of healthy young men during stimulation of their peripheral arterial chemoreceptors by almitrine bismesylate. Biomed Biochim Acta 46: 1035-1042
13. Ledderhos C, Sanchez R, Quies W, Schuster R 1990 Does the stimulation of the peripheral arterial chemoreceptors in humans by almitrine bismesylate inhibit proximal tubular sodium reabsorplion? In: Acker H, Trzebski A, O'Regan RG (eds) Chemoreceptors and Chemoreceptor Reflexes. Plenum Press, New York, pp 293-302
14. Matsumoto H, Osanai S, Nakano H, Akiba Y, Onodera S 1991 Ventilatory responses in patients with essential hypertension. Jpn J Physiol 41: 831-842
15. O'Regan RG 1981 Responses of carotid body chemosensory activity and blood flow to stimulation of sympathetic nerves in the cat. J Physiol (Lond)315: 81-98
16. Peers C, O'Donnell J 1990 Potassium currents recorded in type I carotid body cells from the neonatal rat and their modulation by chemoexcitatory agents. Brain Res 522: 259-266
17. Przybylski J, Trzebski A, Czycewski T, Jodkowski J 1982 Responses to hyperoxia, hypoxia, hypercapnia and almitrine in spontaneously hypertensive rats, Bull Eur Physiopathol Respir 16 (Suppl 4): 145-154
18. Quies W, Claus T, Honig A 1983 Die Hyperventilation der Hypertoniker -Eine Pilotstudie zum Verhalten der Reflexe der arteriellen Chemoreceptoren bei hypertensiven Erkrankungen. Dtsch Gesundheitswesen 38: 612-617
19. Schmidt M, Kretschmann B, Schuster R, Honig A 1990 Influence of sorbitol and mannitol on the reactions of kidney excretory function evoked by arterial chemoreceptor stimulation with almitrine in anaesthetized and artificially ventilated cats. Biomed Biochim Acta 49: 1067-1080