Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-Thia and 9β-haloPG derivatives with improved stability

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 15, 2001, Pages 2033-2035

  Maruyama, Toru ^a   Asada, Masaki ^a   Shiraishi, Tai ^a   Sakata, Kiyoto ^a   Seki, Akiteru ^a   Yoshida, Hideyuki ^a   Shinagawa, Yoshiyuki ^a   Maruyama, Takayuki ^a   Ohuchida, Shuichi ^a   Nakai, Hisao ^a   Kondo, Kigen ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 THIAPROSTAGLANDIN E1 RECEPTOR STIMULATING AGENT; 9 BETA CHLOROPROSTAGLANDIN F2 RECEPTOR STIMULATING AGENT; EP4 RECEPTOR AGONIST; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; REACTION ANALYSIS; RECEPTOR BINDING; RECEPTOR SENSITIVITY;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CYCLIC AMP; CYCLOPENTANES; DRUG DESIGN; HALOGENS; HUMANS; LIGANDS; MICE; RECEPTORS, PROSTAGLANDIN E; SENSITIVITY AND SPECIFICITY; SULFUR; SULFUR COMPOUNDS; THIOPHENES;

THIA;

EID: 0035817366     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00365-1     Document Type: Article

References (8)