메뉴 건너뛰기




Volumn 21, Issue 4, 2003, Pages 320-325

Molecular Detection of Circulating Cancer Cells: Role in Diagnosis, Prognosis and Follow-Up of Colon Cancer Patients

Author keywords

Chemosensitivity; Circulating cancer cells; Circulating tumor cells; Colon cancer; Colorectal cancer; Molecular biology

Indexed keywords

BLOOD ANALYSIS; BONE MARROW; CANCER CELL; CELL COUNT; COLORECTAL CANCER; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; HUMAN; LYMPH NODE; MOLECULAR BIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

EID: 1142310557     PISSN: 02572753     EISSN: None     Source Type: Journal    
DOI: 10.1159/000075355     Document Type: Review
Times cited : (56)

References (48)
  • 2
    • 50549121134 scopus 로고
    • Distribution of secondary growths in cancer of the breast
    • Paget S: Distribution of secondary growths in cancer of the breast. Lancet 1889;i:571-573.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 3
    • 0017234894 scopus 로고
    • The significance of hematogenous tumour cell clumps in the metastatic process
    • Liotta LA, Kleinerman J, Saifedel GM: The significance of hematogenous tumour cell clumps in the metastatic process. Cancer Res 1976;36:889-894.
    • (1976) Cancer Res , vol.36 , pp. 889-894
    • Liotta, L.A.1    Kleinerman, J.2    Saifedel, G.M.3
  • 4
    • 0021213017 scopus 로고
    • Correlation between circulating tumour cancer cells and incidence of metastases
    • Glaves D: Correlation between circulating tumour cancer cells and incidence of metastases. Br J Cancer 1984;50:159-166.
    • (1984) Br J Cancer , vol.50 , pp. 159-166
    • Glaves, D.1
  • 5
    • 0026806148 scopus 로고
    • Prognostic significance of micrometastasic tumour cells in bone marrow of colorectal cancer patients
    • Lindemann F, Schlimok G, Dirschedl G, et al: Prognostic significance of micrometastasic tumour cells in bone marrow of colorectal cancer patients. Lancet 1992;41:685-689.
    • (1992) Lancet , vol.41 , pp. 685-689
    • Lindemann, F.1    Schlimok, G.2    Dirschedl, G.3
  • 6
    • 0030743467 scopus 로고    scopus 로고
    • Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR
    • Soeth E, Vogel I, Röder C, et al: Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR. Cancer Res 1997;57:3106-3110.
    • (1997) Cancer Res , vol.57 , pp. 3106-3110
    • Soeth, E.1    Vogel, I.2    Röder, C.3
  • 7
    • 0031931742 scopus 로고    scopus 로고
    • Immunomagnetic enrichment of disseminated epithelial tumour cells from peripheral blood by MACS
    • Martin VM, Siewert C, Scharl A, et al: Immunomagnetic enrichment of disseminated epithelial tumour cells from peripheral blood by MACS. Exp Hematol 1998;26:252-264.
    • (1998) Exp Hematol , vol.26 , pp. 252-264
    • Martin, V.M.1    Siewert, C.2    Scharl, A.3
  • 8
    • 0032516046 scopus 로고    scopus 로고
    • Detection and characterization of carcinoma cells in the blood
    • Racila E, Euhus D, Wiess A, et al: Detection and characterization of carcinoma cells in the blood. Proc Natl Acad Sci USA 1998;95:4589-4594.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4589-4594
    • Racila, E.1    Euhus, D.2    Wiess, A.3
  • 9
    • 0025897011 scopus 로고
    • Detection of cancer in regional lymph nodes: Comparative histological and immunohistological investigations with the broad range anticytokeratin monoclonal antibody A45-B/b3
    • Stosiek P, Kasper M, Karsten U, et al: Detection of cancer in regional lymph nodes: Comparative histological and immunohistological investigations with the broad range anticytokeratin monoclonal antibody A45-B/b3. Neoplasma 1991;38:43-47.
    • (1991) Neoplasma , vol.38 , pp. 43-47
    • Stosiek, P.1    Kasper, M.2    Karsten, U.3
  • 10
    • 0029838788 scopus 로고    scopus 로고
    • The detection of disseminated tumor cells in bone marrow from colorectal-cancer patients by a cytokeratin-20-specific nested reverse-transcriptasepyolmerase-chain reaction is related to the stage of the disease
    • Soeth E, Röder C, Juhl H, et al: The detection of disseminated tumor cells in bone marrow from colorectal-cancer patients by a cytokeratin-20-specific nested reverse-transcriptasepyolmerase-chain reaction is related to the stage of the disease. Int J Cancer 1996;69:278-282.
    • (1996) Int J Cancer , vol.69 , pp. 278-282
    • Soeth, E.1    Röder, C.2    Juhl, H.3
  • 11
    • 0035678088 scopus 로고    scopus 로고
    • Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients
    • Molnar B, Ladányi A, Tanko L, et al: Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients. Clin Cancer Res 2001;7:4080-4085.
    • (2001) Clin Cancer Res , vol.7 , pp. 4080-4085
    • Molnar, B.1    Ladányi, A.2    Tanko, L.3
  • 12
    • 0028010876 scopus 로고
    • Identification of occult micrometastases in pericolic lymph nodes of Dukes' B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49
    • Greenson JK, Craig EI, Rice R, et al: Identification of occult micrometastases in pericolic lymph nodes of Dukes' B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Cancer 1994;73:563-569.
    • (1994) Cancer , vol.73 , pp. 563-569
    • Greenson, J.K.1    Craig, E.I.2    Rice, R.3
  • 13
    • 0037083251 scopus 로고    scopus 로고
    • Prognostic significance of cytokeratin-20 reverse transcriptase polymerase chain reaction in lymph nodes of node negative colorectal cancer patients
    • Rosenberg R, Hoos A, Mueller J, Baier P, et al: Prognostic significance of cytokeratin-20 reverse transcriptase polymerase chain reaction in lymph nodes of node negative colorectal cancer patients. J Clin Oncol 2003;20:1049-1055.
    • (2003) J Clin Oncol , vol.20 , pp. 1049-1055
    • Rosenberg, R.1    Hoos, A.2    Mueller, J.3    Baier, P.4
  • 14
    • 0025216585 scopus 로고
    • High gradient magnetic cell separation with MACS
    • Miltenyi S, Müller W, Weichel W, et al: High gradient magnetic cell separation with MACS. Cytometry 1990;11:231-240.
    • (1990) Cytometry , vol.11 , pp. 231-240
    • Miltenyi, S.1    Müller, W.2    Weichel, W.3
  • 15
    • 0020467073 scopus 로고
    • The catalogue of human cytokeratins: Pattern of expression in normal epithelia, tumors and cultured cells
    • Moll R, Franke WW, Schiller DL, et al: The catalogue of human cytokeratins: Pattern of expression in normal epithelia, tumors and cultured cells. Cell 1982;31:11-24.
    • (1982) Cell , vol.31 , pp. 11-24
    • Moll, R.1    Franke, W.W.2    Schiller, D.L.3
  • 16
    • 0031745479 scopus 로고    scopus 로고
    • Detection of colorectal cancer cells in peripheral blood by reverse-transcriptase polymerase chain reaction for cytokeratin 20
    • Wyld DK, Selby P, Perren TJ, et al: Detection of colorectal cancer cells in peripheral blood by reverse-transcriptase polymerase chain reaction for cytokeratin 20. Int J Cancer 1998;79:288-294.
    • (1998) Int J Cancer , vol.79 , pp. 288-294
    • Wyld, D.K.1    Selby, P.2    Perren, T.J.3
  • 17
    • 0036282415 scopus 로고    scopus 로고
    • Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells
    • Silva JM, Rodriguez R, Garcia JM, Munoz C, Silva J, Dominguez G, Provencio M, Espana P, Bonilla F: Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut 2002;50:530-534.
    • (2002) Gut , vol.50 , pp. 530-534
    • Silva, J.M.1    Rodriguez, R.2    Garcia, J.M.3    Munoz, C.4    Silva, J.5    Dominguez, G.6    Provencio, M.7    Espana, P.8    Bonilla, F.9
  • 18
    • 0034688316 scopus 로고    scopus 로고
    • Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease
    • Hardingham JE, Hewett PJ, Sage RE, et al: Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease. Int J Cancer 2000;89:8-13.
    • (2000) Int J Cancer , vol.89 , pp. 8-13
    • Hardingham, J.E.1    Hewett, P.J.2    Sage, R.E.3
  • 19
    • 0029856172 scopus 로고    scopus 로고
    • Guanylil cyclase C is a selective marker for metastatic colorectal tumors in human gastrointestinal tissues
    • Carrithers SL, Barber MT, Biswas S, et al: Guanylil cyclase C is a selective marker for metastatic colorectal tumors in human gastrointestinal tissues. Proc Natl Acad Sci USA 1996;93:13827-14832.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13827-14832
    • Carrithers, S.L.1    Barber, M.T.2    Biswas, S.3
  • 20
    • 0037562837 scopus 로고    scopus 로고
    • Realtime PCR (TaqMan PCR) quantification of carcinoembryonic antigen (CEA) mRNA in the peripheral blood of colorectal cancer patients
    • Miura M, Ichikawa Y, Tanaka K, et al: Realtime PCR (TaqMan PCR) quantification of carcinoembryonic antigen (CEA) mRNA in the peripheral blood of colorectal cancer patients. Anticancer Res 2003;23:1271-1276.
    • (2003) Anticancer Res , vol.23 , pp. 1271-1276
    • Miura, M.1    Ichikawa, Y.2    Tanaka, K.3
  • 21
    • 0034912560 scopus 로고    scopus 로고
    • Immunobead RT-PCR versus regular RT-PCR amplification of CEA mRNA in peripheral blood
    • Park S, Lee B, Kim I, et al: Immunobead RT-PCR versus regular RT-PCR amplification of CEA mRNA in peripheral blood. J Cancer Res Clin Oncol 2001;127:489-494.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 489-494
    • Park, S.1    Lee, B.2    Kim, I.3
  • 22
    • 0032926781 scopus 로고    scopus 로고
    • Molecular detection of telomerase positive circulating epithelial cells in metastatic breast cancer patients
    • Soria JC, Guthier LR, Raymond E, et al: Molecular detection of telomerase positive circulating epithelial cells in metastatic breast cancer patients. Clin Cancer Res 1999;5:971-975.
    • (1999) Clin Cancer Res , vol.5 , pp. 971-975
    • Soria, J.C.1    Guthier, L.R.2    Raymond, E.3
  • 23
    • 0034834309 scopus 로고    scopus 로고
    • Quantitative reverse transcription-PCR: Comparison of tumor cell enrichment methods
    • Ladányi A, Soong R, Tabiti K, et al: Quantitative reverse transcription-PCR: Comparison of tumor cell enrichment methods. Clin Chem 2001;47:1860-1863.
    • (2001) Clin Chem , vol.47 , pp. 1860-1863
    • Ladányi, A.1    Soong, R.2    Tabiti, K.3
  • 24
    • 0035207656 scopus 로고    scopus 로고
    • Detecting disseminated solid tumor cells in hematopoietic samples: Methodological aspects
    • Mehes G, Ambros PF, Gadner H: Detecting disseminated solid tumor cells in hematopoietic samples: Methodological aspects. Hematologia 2001;31:91-109.
    • (2001) Hematologia , vol.31 , pp. 91-109
    • Mehes, G.1    Ambros, P.F.2    Gadner, H.3
  • 25
    • 0033970143 scopus 로고    scopus 로고
    • Detection and analysis of cancer cells in blood and bone marrow using a rare event imaging system
    • Kraeft S, Sutherland R, Gravelin L, et al: Detection and analysis of cancer cells in blood and bone marrow using a rare event imaging system. Clin Cancer Res 2000;6:434-442.
    • (2000) Clin Cancer Res , vol.6 , pp. 434-442
    • Kraeft, S.1    Sutherland, R.2    Gravelin, L.3
  • 26
    • 0035478543 scopus 로고    scopus 로고
    • Ectopic expression of guanylil cyclase C in C D34+ progenitor cells in peripheral blood
    • Fava TA, Desnuyers R, Schulz S, et al: Ectopic expression of guanylil cyclase C in C D34+ progenitor cells in peripheral blood. J Clin Oncol 2001;19:3951-3959.
    • (2001) J Clin Oncol , vol.19 , pp. 3951-3959
    • Fava, T.A.1    Desnuyers, R.2    Schulz, S.3
  • 27
    • 0343628846 scopus 로고    scopus 로고
    • High percentage of false positive results of cytokeratin 20 RT-PCR in blood: A model for the analysis of illegitimate gene expression
    • Ko Y, Grünewald E, Totzke G, et al: High percentage of false positive results of cytokeratin 20 RT-PCR in blood: A model for the analysis of illegitimate gene expression. Oncology 2000;59:81-88.
    • (2000) Oncology , vol.59 , pp. 81-88
    • Ko, Y.1    Grünewald, E.2    Totzke, G.3
  • 28
    • 0034769730 scopus 로고    scopus 로고
    • Transcription of cytokeratins 8,18,19 in bone marrow and limited expression of cytokeratins 7 and 20 by carcinoma cells: Inherent limitations for RT-PCR in the detection of isolated tumor cells
    • Dimmler A, Gerhards R, Betz C, et al: Transcription of cytokeratins 8,18,19 in bone marrow and limited expression of cytokeratins 7 and 20 by carcinoma cells: Inherent limitations for RT-PCR in the detection of isolated tumor cells. Lab Invest 2001;81:1351-1361.
    • (2001) Lab Invest , vol.81 , pp. 1351-1361
    • Dimmler, A.1    Gerhards, R.2    Betz, C.3
  • 29
    • 1142303999 scopus 로고    scopus 로고
    • Correspondence re: Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients
    • Molnar B, Ladányi A, Tanko L, et al: Correspondence re: Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients. Clin Cancer Res 2002;8:2016-2017.
    • (2002) Clin Cancer Res , vol.8 , pp. 2016-2017
    • Molnar, B.1    Ladányi, A.2    Tanko, L.3
  • 30
    • 0033372437 scopus 로고    scopus 로고
    • Increased detection of circulating tumor cells in the blood of colorectal carcinoma patients using two reverse transcription-PCR assays and multiple blood samples
    • Wharton RQ, Jonas SK, Glover C, et al: Increased detection of circulating tumor cells in the blood of colorectal carcinoma patients using two reverse transcription-PCR assays and multiple blood samples. Clin Cancer Res 1999;5:4158-4163.
    • (1999) Clin Cancer Res , vol.5 , pp. 4158-4163
    • Wharton, R.Q.1    Jonas, S.K.2    Glover, C.3
  • 31
    • 0036114433 scopus 로고    scopus 로고
    • Effect of blood sample handling and RT-PCR assay sensitivity on detection of cytokeratin 20 expression in healthy donor blood
    • Vlems F, Soong R, Diepstra H, et al: Effect of blood sample handling and RT-PCR assay sensitivity on detection of cytokeratin 20 expression in healthy donor blood. Diagnostic Mol Pathol 2002;11:90-97.
    • (2002) Diagnostic Mol Pathol , vol.11 , pp. 90-97
    • Vlems, F.1    Soong, R.2    Diepstra, H.3
  • 32
    • 0037305814 scopus 로고    scopus 로고
    • Reliability of quantitative RT-PCR based detection of tumor cells in the blood between different laboratories using a standardized protocol
    • Vlems F, Ladányi A, Gertler R, et al: Reliability of quantitative RT-PCR based detection of tumor cells in the blood between different laboratories using a standardized protocol. Eur J Cancer 2003;39:388-396.
    • (2003) Eur J Cancer , vol.39 , pp. 388-396
    • Vlems, F.1    Ladányi, A.2    Gertler, R.3
  • 33
    • 0037900694 scopus 로고    scopus 로고
    • Comparison of the expression profile of metastasis associated genes between primary and circulating cancer cells on oral squamous cell carcinoma
    • Ito H, Hatori M, Kinugasa Y, Irie T, et al: Comparison of the expression profile of metastasis associated genes between primary and circulating cancer cells on oral squamous cell carcinoma. Anticancer Res 2003;23:1425-1431.
    • (2003) Anticancer Res , vol.23 , pp. 1425-1431
    • Ito, H.1    Hatori, M.2    Kinugasa, Y.3    Irie, T.4
  • 34
    • 0038420045 scopus 로고    scopus 로고
    • Detection of p16 promoter hypermethylation in serum of gastric cancer patients
    • Kanyama Y, Hibi K, Nakayama H, et al: Detection of p16 promoter hypermethylation in serum of gastric cancer patients. Cancer Sci 2003;94:418-420.
    • (2003) Cancer Sci , vol.94 , pp. 418-420
    • Kanyama, Y.1    Hibi, K.2    Nakayama, H.3
  • 35
    • 0035654288 scopus 로고    scopus 로고
    • Methylation profiling of human cancers in blood: Molecular monitoring and prognostication
    • Wong IHN: Methylation profiling of human cancers in blood: Molecular monitoring and prognostication. Intl J Oncol 2001;19:1319-1324.
    • (2001) Intl J Oncol , vol.19 , pp. 1319-1324
    • Wong, I.H.N.1
  • 36
    • 0036145156 scopus 로고    scopus 로고
    • Cancer as an epigenetic disease: DNa methylation and chromatin alterations in human tumours
    • Esteller M, Herman JG: Cancer as an epigenetic disease: DNa methylation and chromatin alterations in human tumours. J Pathol 2002;196:1-7.
    • (2002) J Pathol , vol.196 , pp. 1-7
    • Esteller, M.1    Herman, J.G.2
  • 37
  • 38
    • 0036275835 scopus 로고    scopus 로고
    • Incidence and prognostic implications of isolated tumor cells in lymph nodes from patients with Dukes B colorectal carcinoma
    • Choi H, Choi Y, Hong S: Incidence and prognostic implications of isolated tumor cells in lymph nodes from patients with Dukes B colorectal carcinoma. Dis Colon Rectum 2003;45:750-756.
    • (2003) Dis Colon Rectum , vol.45 , pp. 750-756
    • Choi, H.1    Choi, Y.2    Hong, S.3
  • 39
    • 0031751217 scopus 로고    scopus 로고
    • Are lymph node micrometastases of any clinical significance in Dukes stage A and B colorectal cancer?
    • Öberg A, Stenling R, Tavelin B, Lindmark G: Are lymph node micrometastases of any clinical significance in Dukes stage A and B colorectal cancer? Dis Colon Rectum 1998;41:1244-1249.
    • (1998) Dis Colon Rectum , vol.41 , pp. 1244-1249
    • Öberg, A.1    Stenling, R.2    Tavelin, B.3    Lindmark, G.4
  • 40
    • 0035181336 scopus 로고    scopus 로고
    • Quanitative reverse transcription-polymerase chain reaction detection of cytokeratin 20 in noncolorectal lymph nodes
    • Soong R, Beyser K, Basten O, et al: Quanitative reverse transcription-polymerase chain reaction detection of cytokeratin 20 in noncolorectal lymph nodes. Clin Cancer Res 2001;7:3423-3429.
    • (2001) Clin Cancer Res , vol.7 , pp. 3423-3429
    • Soong, R.1    Beyser, K.2    Basten, O.3
  • 41
    • 0342507974 scopus 로고
    • Micrometastatic cancer cells in bone marrow: In vitro detection with anticytokeratin and invivo labeling with anti17-1A monoclonal antibodies
    • Schlimok G, Funke I, Holzmann B, et al: Micrometastatic cancer cells in bone marrow: In vitro detection with anticytokeratin and invivo labeling with anti17-1A monoclonal antibodies. Proc Natl Acad Sci USA 1987;84:8672-8676.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8672-8676
    • Schlimok, G.1    Funke, I.2    Holzmann, B.3
  • 42
    • 0036185115 scopus 로고    scopus 로고
    • Cytokeratin-positive cells in preoperative peripheral blood and bone marrow aspirates of patients with colorectal cancer
    • Werther K, Normark M, Vrunner N, et al: Cytokeratin-positive cells in preoperative peripheral blood and bone marrow aspirates of patients with colorectal cancer. Scand J Lab Invest 2002;62:49-58.
    • (2002) Scand J Lab Invest , vol.62 , pp. 49-58
    • Werther, K.1    Normark, M.2    Vrunner, N.3
  • 43
    • 0036843957 scopus 로고    scopus 로고
    • Immunomagnetic enrichment and detection of micrometastases in colorectal cancer: Correlation with established clinical parameters
    • Weihrauch MR, Skibowski E, Koslowsky TC, et al: Immunomagnetic enrichment and detection of micrometastases in colorectal cancer: Correlation with established clinical parameters. J Clin Oncol 2003;21:4338-4343.
    • (2003) J Clin Oncol , vol.21 , pp. 4338-4343
    • Weihrauch, M.R.1    Skibowski, E.2    Koslowsky, T.C.3
  • 44
    • 0027310175 scopus 로고
    • Detection and enumeration of circulating tumour cells in colorectal cancer
    • Leather AJM, Gallegos NC, Kocjan G, et al: Detection and enumeration of circulating tumour cells in colorectal cancer. Br J Surg 1993;80:777-780.
    • (1993) Br J Surg , vol.80 , pp. 777-780
    • Leather, A.J.M.1    Gallegos, N.C.2    Kocjan, G.3
  • 45
    • 0036152794 scopus 로고    scopus 로고
    • Clearance of circulating tumor cells after excision of primary colorectal cancer
    • Patel H, Le Marer N, Wharton R, et al: Clearance of circulating tumor cells after excision of primary colorectal cancer. Ann Surg 2002;235:226-231.
    • (2002) Ann Surg , vol.235 , pp. 226-231
    • Patel, H.1    Le Marer, N.2    Wharton, R.3
  • 46
    • 0036693979 scopus 로고    scopus 로고
    • A novel method for monitoring response to chemotherapy based on the detection of circulating tumor cells: A case report
    • Aquino A, Prete SP, Balduzzi A, et al: A novel method for monitoring response to chemotherapy based on the detection of circulating tumor cells: A case report. J Chemother 2002;14:412-416.
    • (2002) J Chemother , vol.14 , pp. 412-416
    • Aquino, A.1    Prete, S.P.2    Balduzzi, A.3
  • 47
    • 0037501264 scopus 로고    scopus 로고
    • Effects of whole body hyperthermia (41.8 degrees C) on the frequency of tumor cells in the peripheral blood of patients with advanced malignancies
    • Hegewisch-Becker S, Braun K, Otte M, et al: Effects of whole body hyperthermia (41.8 degrees C) on the frequency of tumor cells in the peripheral blood of patients with advanced malignancies. Clin Cancer Res 2003;9:2079-2084.
    • (2003) Clin Cancer Res , vol.9 , pp. 2079-2084
    • Hegewisch-Becker, S.1    Braun, K.2    Otte, M.3
  • 48
    • 0037613266 scopus 로고    scopus 로고
    • Gastrointestinal cancer: Towards a tailored tumour therapy
    • Seufferlein T, Adler G: Gastrointestinal cancer: Towards a tailored tumour therapy. Scand J Gastroenterol 2003;38:22-25.
    • (2003) Scand J Gastroenterol , vol.38 , pp. 22-25
    • Seufferlein, T.1    Adler, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.