Are lymph node micrometastases of any clinical significance in Dukes Stages A and B colorectal cancer?

Diseases of the Colon and Rectum

Volumn 41, Issue 10, 1998, Pages 1244-1249

  Öberg, Åke ^a   Stenling, Roger ^a   Tavelin, Björn ^a   Lindmark, Gudrun ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Colonic neoplasms; Cytokeratin; Immunohistochemistry; Lymph nodes; Micrometastases; Rectal neoplasms; Survival; Tumor stage

Indexed keywords

CYTOKERATIN;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; SURVIVAL TIME;

ADULT; AGED; AGED, 80 AND OVER; COLONIC NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; RECTAL NEOPLASMS; SURVIVAL ANALYSIS;

EID: 0031751217     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02258221     Document Type: Article

References (18)

1. Astler VB, Coller F. The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg 1954;139:846-51.
2. Dukes CE, Bussey HJ. The spread of rectal cancer and its effect on prognosis. Br J Surg 1958;12:309-20.
3. Spiessl B, Hermanek P, Scheibe O, Wagner G, eds. UICC TNM-atlas. Berlin: Springer, 1985.
4. Chapuis PH, Dent OF, Fisher R, et al. A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer. Br J Surg 1985;72:698-702.
5. Jass JR, Atkin WS, Cuzick J, et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology 1986;10:437-59.
6. American Joint Committee on Cancer. Manual of staging of cancer. 4th ed. Philadelphia: Lippincott, 1992.
7. Lindmark G, Gerdin B, Påhlman L, Bergström R, Glimelius B. Prognostic predictors in colorectal cancer. Dis Colon Rectum 1994;37:1219-27.
8. Cohen AM, Tremiterra S, Candela F, Thaler HT, Sigurdson ER. Prognosis of node-positive colon cancer. Cancer 1991;67:1859-61.
9. Brodsky JT, Richard GK, Cohen AM, Minsky BD. Variables correlated with the risk of lymph node metastasis in early rectal cancer. Cancer 1992;69:322-6.
10. Davidson BR, Sams VR, Styles J, Deane C, Boulos PB. Detection of occult nodal metastases in patients with colorectal carcinoma. Cancer 1990;65:967-70.
11. Cutait R, Alves VA, Lopes LC, et al. Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratins. Dis Colon Rectum 1991;34: 917-20.
12. Greenson J, Isenhart C, Rice R, Mojzisik C, Houchens D, Martin E. Identification of occult micrometastases in pericolic lymph nodes of Dukes' B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Cancer 1994;73:563-9.
13. Jeffers MD, O'Dowd GM, Mulcahy H, Stagg M, O'Donoghue DF, Toner M. The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma. J Pathol 1994;172: 183-7.
14. Hayashi N, Ito I, Yanagisawa A, et al. Genetic diagnosis of lymph-node metastases in colorectal cancer. Lancet 1995;345:1257-9.
15. Adell G, Boeryd B, Frånlund B, Sjödahl R, Håkansson L. Occurrence and prognostic importance of micrometastases in regional lymph nodes in Dukes' B colorectal carcinoma: an immunohistochemical study. Eur J Surg 1996;162:637-42.
16. Moertel CG, Fleming TR, Macdonald JS, et al. Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med 1996;122:321-6.
17. Lawless JF. Statistical models and methods for life-time data. New York: Wiley & Sons, 1982.
18. Peto R, Pike M, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observations of each patient. II. Analyses and examples. Br J Surg 1977;35:1-39.