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Volumn 271, Issue 1-2, 2004, Pages 125-135

Influence of the co-encapsulation of different excipients on the properties of polyester microparticle-based vaccine against brucellosis

Author keywords

Brucellosis; Microparticles; Phagocytosis; Poly(lactide co glycolide); Poly( caprolactone); Vaccine

Indexed keywords

BRUCELLA VACCINE; EXCIPIENT; HYDROGEN PEROXIDE; NITRIC OXIDE; POLOXAMER; POLYCAPROLACTONE; POLYESTER; POLYGLACTIN; POLYMER; POLYSORBATE 20; POVIDONE;

EID: 1142285522     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.11.008     Document Type: Article
Times cited : (15)

References (46)
  • 1
    • 0037133126 scopus 로고    scopus 로고
    • Targeting to macrophages: Role of physicochemical properties of particulate carriers - Liposomes and microspheres - On the phagocytosis by macrophages
    • Ahsan F., Rivas I.P., Khan M., Torres Suárez A.I. Targeting to macrophages: role of physicochemical properties of particulate carriers - liposomes and microspheres - on the phagocytosis by macrophages. J. Control. Release. 79:2002;29-40.
    • (2002) J. Control. Release , vol.79 , pp. 29-40
    • Ahsan, F.1    Rivas, I.P.2    Khan, M.3    Torres Suárez, A.I.4
  • 2
    • 0023096025 scopus 로고    scopus 로고
    • Biodegradable microspheres. V: Stimulation of macrophages with microparticles made of various polysaccharides
    • Artursson P., Arro E., Edman P., Ericsson J.L.E., Sjöholm I. Biodegradable microspheres. V: stimulation of macrophages with microparticles made of various polysaccharides. J. Pharm. Sci. 76:1997;127-133.
    • (1997) J. Pharm. Sci. , vol.76 , pp. 127-133
    • Artursson, P.1    Arro, E.2    Edman, P.3    Ericsson, J.L.E.4    Sjöholm, I.5
  • 3
    • 0021332202 scopus 로고
    • The respiratory burst of phagocytes
    • Babior B.M. The respiratory burst of phagocytes. J. Clin. Invest. 73:1983;599-601.
    • (1983) J. Clin. Invest. , vol.73 , pp. 599-601
    • Babior, B.M.1
  • 4
    • 0032991916 scopus 로고    scopus 로고
    • Preparation and characterization of protein-loaded poly(e-caprolactone) microparticles for oral vaccine delivery
    • Benoit M.A., Baras B., Guillard J. Preparation and characterization of protein-loaded poly(e-caprolactone) microparticles for oral vaccine delivery. Int. J. Pharm. 184:1999;73-84.
    • (1999) Int. J. Pharm. , vol.184 , pp. 73-84
    • Benoit, M.A.1    Baras, B.2    Guillard, J.3
  • 5
    • 0032078351 scopus 로고    scopus 로고
    • Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: Effect of the protein and polymer properties and of the co-encapsulation of surfactants
    • Blanco D., Alonso M.J. Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. Eur. J. Pharm. Biopharm. 45:1998;285-294.
    • (1998) Eur. J. Pharm. Biopharm. , vol.45 , pp. 285-294
    • Blanco, D.1    Alonso, M.J.2
  • 7
    • 0027169629 scopus 로고
    • Brucella melitensis Rev.1 vaccine as a cause of human brucellosis
    • Blasco J.M., Diaz R. Brucella melitensis Rev.1 vaccine as a cause of human brucellosis. Lancet. 342:1993;805.
    • (1993) Lancet , vol.342 , pp. 805
    • Blasco, J.M.1    Diaz, R.2
  • 8
    • 0034080025 scopus 로고    scopus 로고
    • Identification of protective outer membrane antigens of Brucella ovis by passive immunisation of mice with monoclonal antibodies
    • Bowden R.A., Estein S.M., Zygmunt M.S., Dubray G., Cloeckaert A. Identification of protective outer membrane antigens of Brucella ovis by passive immunisation of mice with monoclonal antibodies. Microbes. Infect. 2:2000;481-488.
    • (2000) Microbes. Infect. , vol.2 , pp. 481-488
    • Bowden, R.A.1    Estein, S.M.2    Zygmunt, M.S.3    Dubray, G.4    Cloeckaert, A.5
  • 9
    • 0033081516 scopus 로고    scopus 로고
    • Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders
    • Cao X., Schoichet M.S. Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders. Biomaterials. 20:1999;329-339.
    • (1999) Biomaterials , vol.20 , pp. 329-339
    • Cao, X.1    Schoichet, M.S.2
  • 10
    • 0030589072 scopus 로고    scopus 로고
    • Molecular and immunological characterization of the major outer membrane proteins of Brucella
    • Cloeckaert A., Verger J.M., Grayon M., Vizcaino N. Molecular and immunological characterization of the major outer membrane proteins of Brucella. FEMS Microbiol. Lett. 15:1996;1-8.
    • (1996) FEMS Microbiol. Lett. , vol.15 , pp. 1-8
    • Cloeckaert, A.1    Verger, J.M.2    Grayon, M.3    Vizcaino, N.4
  • 11
    • 0035961506 scopus 로고    scopus 로고
    • Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: Effect of formulation and route of immunization on induction of Th1 and Th2 cells
    • Conway M.A., Madrigal-Esteban L., McClean S., Brayden D.J., Mills K.H.G. Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells. Vaccine. 19:2001;1940-1950.
    • (2001) Vaccine , vol.19 , pp. 1940-1950
    • Conway, M.A.1    Madrigal-Esteban, L.2    McClean, S.3    Brayden, D.J.4    Mills, K.H.G.5
  • 12
    • 0019785108 scopus 로고
    • Persistence of Brucella abortus strain 19 infection in adult cattle vaccinated with reduced doses
    • Corner L.A., Alton G.G. Persistence of Brucella abortus strain 19 infection in adult cattle vaccinated with reduced doses. Res. Vet. Sci. 31:1981;342-344.
    • (1981) Res. Vet. Sci. , vol.31 , pp. 342-344
    • Corner, L.A.1    Alton, G.G.2
  • 13
    • 0034602127 scopus 로고    scopus 로고
    • Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres
    • De Rosa G.D., Iommelli R., La Rotonda M.I., Miro A., Quaglia F. Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres. J. Control. Release. 69:2000;283-295.
    • (2000) J. Control. Release , vol.69 , pp. 283-295
    • De Rosa, G.D.1    Iommelli, R.2    La Rotonda, M.I.3    Miro, A.4    Quaglia, F.5
  • 14
    • 0023706894 scopus 로고    scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production
    • Ding A.H., Nathan C.F., Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:1998;2407-2412.
    • (1998) J. Immunol. , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Stuehr, D.J.3
  • 15
    • 0024517697 scopus 로고
    • Comparative analysis of proteins extracted by hot saline or release spontaneously into outer membrane blebs from field strains of Brucella ovis and Brucella melitensis
    • Gamazo C., Winter A.J., Moriyón I., Riezu-Boj J.I., Blasco J.M., Díaz R. Comparative analysis of proteins extracted by hot saline or release spontaneously into outer membrane blebs from field strains of Brucella ovis and Brucella melitensis. Infect. Immun. 57:1989;1419-1426.
    • (1989) Infect. Immun. , vol.57 , pp. 1419-1426
    • Gamazo, C.1    Winter, A.J.2    Moriyón, I.3    Riezu-Boj, J.I.4    Blasco, J.M.5    Díaz, R.6
  • 16
    • 0032036428 scopus 로고    scopus 로고
    • Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages
    • Gross A., Spiesser S., Terraza A., Rouot B., Caron E., Dornand J. Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages. Infect. Immun. 66:1998;1309-1316.
    • (1998) Infect. Immun. , vol.66 , pp. 1309-1316
    • Gross, A.1    Spiesser, S.2    Terraza, A.3    Rouot, B.4    Caron, E.5    Dornand, J.6
  • 17
    • 0033525798 scopus 로고    scopus 로고
    • Biodegradable microspheres containing influenza a vaccine: Immune response in mice
    • Hilbert A.K., Fritzsche U., Kissel T. Biodegradable microspheres containing influenza A vaccine: immune response in mice. Vaccine. 17:1999;1065-1073.
    • (1999) Vaccine , vol.17 , pp. 1065-1073
    • Hilbert, A.K.1    Fritzsche, U.2    Kissel, T.3
  • 18
    • 0034055487 scopus 로고    scopus 로고
    • Neutrophil activation by plasma opsonized polymeric microspheres: Inhibitory effect of Pluronic F127
    • Jackson J.K., Springate C.M.K., Hunter W.L., Burt H.M. Neutrophil activation by plasma opsonized polymeric microspheres: inhibitory effect of Pluronic F127. Biomaterials. 21:2000;1483-1491.
    • (2000) Biomaterials , vol.21 , pp. 1483-1491
    • Jackson, J.K.1    Springate, C.M.K.2    Hunter, W.L.3    Burt, H.M.4
  • 19
    • 0028039981 scopus 로고
    • Protective immunity to Brucella ovis in BALB/c mice following recovery from primary infection or immunization with subcellular vaccines
    • Jiménez de Bagués M.P., Elzer P.H., Blasco J.M., Marén C.M., Gamazo C., Winter A.J. Protective immunity to Brucella ovis in BALB/c mice following recovery from primary infection or immunization with subcellular vaccines. Infect. Immun. 62:1994;632-638.
    • (1994) Infect. Immun. , vol.62 , pp. 632-638
    • Jiménez De Bagués, M.P.1    Elzer, P.H.2    Blasco, J.M.3    Marén, C.M.4    Gamazo, C.5    Winter, A.J.6
  • 20
    • 0028965193 scopus 로고
    • The Brucella abortus RB51 vaccine does not confer protection against Brucella ovis in rams
    • Jiménez de Bagüés M.P., Barberán M., Marín C.M., Blasco J.M. The Brucella abortus RB51 vaccine does not confer protection against Brucella ovis in rams. Vaccine. 13:1995;301-304.
    • (1995) Vaccine , vol.13 , pp. 301-304
    • Jiménez De Bagüés, M.P.1    Barberán, M.2    Marín, C.M.3    Blasco, J.M.4
  • 22
    • 0036357041 scopus 로고    scopus 로고
    • Brucella abortus strain RB51 vaccination in elk. II. Failure of high dosage to prevent abortion
    • Kreeger T.J., Cook W.E., Edwards W.H., Elzer P.H., Olsen S.C. Brucella abortus strain RB51 vaccination in elk. II. Failure of high dosage to prevent abortion. J. Wildl. Dis. 38:2002;27-31.
    • (2002) J. Wildl. Dis. , vol.38 , pp. 27-31
    • Kreeger, T.J.1    Cook, W.E.2    Edwards, W.H.3    Elzer, P.H.4    Olsen, S.C.5
  • 23
    • 0035112496 scopus 로고    scopus 로고
    • Influence of pluronics on protein-loaded poly(epsilon-caprolactone) microparticles
    • Lin W.J., Huang L.I. Influence of pluronics on protein-loaded poly(epsilon-caprolactone) microparticles. J. Microencapsulation. 18:2001;191-197.
    • (2001) J. Microencapsulation , vol.18 , pp. 191-197
    • Lin, W.J.1    Huang, L.I.2
  • 24
    • 0343920708 scopus 로고    scopus 로고
    • Lipopolysaccharides of Brucella abortus and Brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
    • Lopez-Urrutia L., Alonso A., Nieto M.L., Bayon Y., Orduña A., Sanchez Crespo M. Lipopolysaccharides of Brucella abortus and Brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages. Infect. Immun. 68:2000;1740-1745.
    • (2000) Infect. Immun. , vol.68 , pp. 1740-1745
    • Lopez-Urrutia, L.1    Alonso, A.2    Nieto, M.L.3    Bayon, Y.4    Orduña, A.5    Sanchez Crespo, M.6
  • 25
    • 0024967459 scopus 로고
    • Comparison of three serological tests for Brucella ovis infection of rams using different antigenic extracts
    • Marín C.M., Jiménez de Bagués M.P., Blasco J.M., Gamazo C., Moriyón I., Díaz R. Comparison of three serological tests for Brucella ovis infection of rams using different antigenic extracts. Vet. Rec. 11:1989;504-508.
    • (1989) Vet. Rec. , vol.11 , pp. 504-508
    • Marín, C.M.1    Jiménez De Bagués, M.P.2    Blasco, J.M.3    Gamazo, C.4    Moriyón, I.5    Díaz, R.6
  • 26
    • 0033525913 scopus 로고    scopus 로고
    • MHC class I- and class II-restricted processing and presentation of microencapsulated antigens
    • Men Y., Audran R., Thomasin C., Eberl G., Demotz H.P., Gander B., Corradin G. MHC class I- and class II-restricted processing and presentation of microencapsulated antigens. Vaccine. 17:1999;1047-1056.
    • (1999) Vaccine , vol.17 , pp. 1047-1056
    • Men, Y.1    Audran, R.2    Thomasin, C.3    Eberl, G.4    Demotz, H.P.5    Gander, B.6    Corradin, G.7
  • 27
    • 0029558085 scopus 로고
    • Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic lymphocytes and CD4+ Th1 cells
    • Moore A., McGuirk P., Adams S., Jones W.C., McGee J.P., O'Hagan D.T., Mills K.H. Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic lymphocytes and CD4+ Th1 cells. Vaccine. 13:1995;1741-1749.
    • (1995) Vaccine , vol.13 , pp. 1741-1749
    • Moore, A.1    McGuirk, P.2    Adams, S.3    Jones, W.C.4    McGee, J.P.5    O'Hagan, D.T.6    Mills, K.H.7
  • 28
    • 0035158059 scopus 로고    scopus 로고
    • Applicability of various amphiphilic polymers to the modification of protein release kinetics from biodegradable reservoir-type microspheres
    • Morita T., Sakamura Y., Horikiri Y., Suzuki T., Yoshino H. Applicability of various amphiphilic polymers to the modification of protein release kinetics from biodegradable reservoir-type microspheres. Eur. J. Pharm. Biopharm. 51:2001;45-53.
    • (2001) Eur. J. Pharm. Biopharm. , vol.51 , pp. 45-53
    • Morita, T.1    Sakamura, Y.2    Horikiri, Y.3    Suzuki, T.4    Yoshino, H.5
  • 29
    • 0031051814 scopus 로고    scopus 로고
    • Influence of fluorescent labelling of polystyrene particles on phagocytic uptake, surface hydrophobicity, and plasma protein adsorption
    • Müller R.H., Rühl D., Paulke B.R. Influence of fluorescent labelling of polystyrene particles on phagocytic uptake, surface hydrophobicity, and plasma protein adsorption. Pharm. Res. 14:1997;18-24.
    • (1997) Pharm. Res. , vol.14 , pp. 18-24
    • Müller, R.H.1    Rühl, D.2    Paulke, B.R.3
  • 30
    • 0035919548 scopus 로고    scopus 로고
    • A Brucella ovis antigenic complex bearing poly-epsilon-caprolactone microparticles confer protection against experimental brucellosis in mice
    • Murillo M., Grilló M.J., Reñé J., Marín C.M., Barberán M., Goñi M.M., Blasco J.M., Irache J.M., Gamazo C. A Brucella ovis antigenic complex bearing poly-epsilon-caprolactone microparticles confer protection against experimental brucellosis in mice. Vaccine. 19:2001;4099-4106.
    • (2001) Vaccine , vol.19 , pp. 4099-4106
    • Murillo, M.1    Grilló, M.J.2    Reñé, J.3    Marín, C.M.4    Barberán, M.5    Goñi, M.M.6    Blasco, J.M.7    Irache, J.M.8    Gamazo, C.9
  • 31
    • 0036254831 scopus 로고    scopus 로고
    • Polyester microparticles as a vaccine delivery system for brucellosis: Influence of the polymer on release, phagocytosis and toxicity
    • Murillo M., Gamazo C., Irache J.M., Goñi M.M. Polyester microparticles as a vaccine delivery system for brucellosis: influence of the polymer on release, phagocytosis and toxicity. J. Drug Target. 10:2002a;211-219.
    • (2002) J. Drug Target. , vol.10 , pp. 211-219
    • Murillo, M.1    Gamazo, C.2    Irache, J.M.3    Goñi, M.M.4
  • 32
    • 0037073640 scopus 로고    scopus 로고
    • Modulation of the cellular immune response after oral or subcutaneous immunization with microparticles containing Brucella ovis antigens
    • Murillo M., Goñi M.M., Irache J.M., Arangoa M.A., Blasco J.M., Gamazo C. Modulation of the cellular immune response after oral or subcutaneous immunization with microparticles containing Brucella ovis antigens. J. Control. Release. 85:2002b;237-246.
    • (2002) J. Control. Release , vol.85 , pp. 237-246
    • Murillo, M.1    Goñi, M.M.2    Irache, J.M.3    Arangoa, M.A.4    Blasco, J.M.5    Gamazo, C.6
  • 33
    • 0002924925 scopus 로고
    • Controlled protein release from polyethyleneimine-coated poly(L-lactic acid)/pluronic blend matrices
    • Park T.G., Cohen S., Langer R. Controlled protein release from polyethyleneimine-coated poly(L-lactic acid)/pluronic blend matrices. Pharm. Res. 9:1992;37-39.
    • (1992) Pharm. Res. , vol.9 , pp. 37-39
    • Park, T.G.1    Cohen, S.2    Langer, R.3
  • 34
    • 0036181321 scopus 로고    scopus 로고
    • In vitro phagocytosis and monocyte activation with poly(lactide) and poly(lactide-co-glycolide) microspheres
    • Prior S., Gander B., Blarer N., Merkle H.P., Subirá M.L., Irache J.M., Gamazo C. In vitro phagocytosis and monocyte activation with poly(lactide) and poly(lactide-co-glycolide) microspheres. Eur. J. Pharm. Sci. 15:2002;197-207.
    • (2002) Eur. J. Pharm. Sci. , vol.15 , pp. 197-207
    • Prior, S.1    Gander, B.2    Blarer, N.3    Merkle, H.P.4    Subirá, M.L.5    Irache, J.M.6    Gamazo, C.7
  • 35
    • 0022723966 scopus 로고
    • Comparison of lipopolysaccharide and outer membrane protein- lipopolysaccharide extracts in an enzyme-linked immunosorbent assay for the diagnosis of Brucella ovis infection
    • Riezu-Boj J.I., Moriyón I., Blasco J.M., Marín C.M., Díaz R. Comparison of lipopolysaccharide and outer membrane protein-lipopolysaccharide extracts in an enzyme-linked immunosorbent assay for the diagnosis of Brucella ovis infection. J. Clin. Microbiol. 23:1986;938-942.
    • (1986) J. Clin. Microbiol. , vol.23 , pp. 938-942
    • Riezu-Boj, J.I.1    Moriyón, I.2    Blasco, J.M.3    Marín, C.M.4    Díaz, R.5
  • 36
    • 0025022360 scopus 로고
    • Antibody response to Brucella ovis outer membrane proteins in ovine brucellosis
    • Riezu-Boj J.I., Moriyón I., Blasco J.M., Gamazo C., Díaz R. Antibody response to Brucella ovis outer membrane proteins in ovine brucellosis. Infect. Immun. 58:1990;489-494.
    • (1990) Infect. Immun. , vol.58 , pp. 489-494
    • Riezu-Boj, J.I.1    Moriyón, I.2    Blasco, J.M.3    Gamazo, C.4    Díaz, R.5
  • 37
    • 0033030477 scopus 로고    scopus 로고
    • Optimization of the encapsulation and release of β-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres
    • Rojas J., Pinto-Alphandary H., Leo S., Pecquet E., Couvreur P., Fattal E. Optimization of the encapsulation and release of β-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres. Int. J. Pharm. 183:1999a;67-71.
    • (1999) Int. J. Pharm. , vol.183 , pp. 67-71
    • Rojas, J.1    Pinto-Alphandary, H.2    Leo, S.3    Pecquet, E.4    Couvreur, P.5    Fattal, E.6
  • 38
    • 0033051381 scopus 로고    scopus 로고
    • A polysorbate-based non-ionic surfactant can modulate loading and release of β-lactoglobulin entrapped in multiphase poly(DL-lactide-co- glycolide) microspheres
    • Rojas J., Alphandary H.P., Leo E., Pecquet S., Couvreur P., Gulik A., Fattal E. A polysorbate-based non-ionic surfactant can modulate loading and release of β-lactoglobulin entrapped in multiphase poly(DL-lactide-co- glycolide) microspheres. Pharm. Res. 16:1999b;255-260.
    • (1999) Pharm. Res. , vol.16 , pp. 255-260
    • Rojas, J.1    Alphandary, H.P.2    Leo, E.3    Pecquet, S.4    Couvreur, P.5    Gulik, A.6    Fattal, E.7
  • 39
    • 0345493887 scopus 로고    scopus 로고
    • Formulation strategies for the stabilisation of tetanus toxoid in poly(lactide-co-glycolide) microspheres
    • Sanchez A., Villamayor B., Guo Y., McIver J., Alonso M.J. Formulation strategies for the stabilisation of tetanus toxoid in poly(lactide-co-glycolide) microspheres. Int. J. Pharm. 185:1999;255-266.
    • (1999) Int. J. Pharm. , vol.185 , pp. 255-266
    • Sanchez, A.1    Villamayor, B.2    Guo, Y.3    McIver, J.4    Alonso, M.J.5
  • 40
    • 0032773958 scopus 로고    scopus 로고
    • Outer membtane proteins Omp10, Omp16, and Omp19 of Brucella spp. are lipoproteins
    • Tibor A., Decelle B., Letesson J.J. Outer membtane proteins Omp10, Omp16, and Omp19 of Brucella spp. are lipoproteins. Infect. Immun. 67:1999;4960-4962.
    • (1999) Infect. Immun. , vol.67 , pp. 4960-4962
    • Tibor, A.1    Decelle, B.2    Letesson, J.J.3
  • 41
    • 0032956055 scopus 로고    scopus 로고
    • A novel system based on a poloxamer/PLGA blend as a tetanus toxoid delivery vehicle
    • Tobio M., Nolley J., Guo Y., McIver J., Alonso M.J. A novel system based on a poloxamer/PLGA blend as a tetanus toxoid delivery vehicle. Pharm. Res. 16:1999;682-688.
    • (1999) Pharm. Res. , vol.16 , pp. 682-688
    • Tobio, M.1    Nolley, J.2    Guo, Y.3    McIver, J.4    Alonso, M.J.5
  • 42
    • 0034063912 scopus 로고    scopus 로고
    • PLGA microspheres phagocytosis by pig alveolar macrophages: Influence of poly(vinyl alcohol) concentration, nature of loaded-protein and copolymer nature
    • Torché A.M., Le Corre P., Albina E., Jestin A., Le Verge R. PLGA microspheres phagocytosis by pig alveolar macrophages: influence of poly(vinyl alcohol) concentration, nature of loaded-protein and copolymer nature. J. Drug Target. 7:2000;343-354.
    • (2000) J. Drug Target. , vol.7 , pp. 343-354
    • Torché, A.M.1    Le Corre, P.2    Albina, E.3    Jestin, A.4    Le Verge, R.5
  • 43
    • 0029757276 scopus 로고    scopus 로고
    • Cloning, nucleotide sequence, and expression of the Brucella melitensis omp31 gene coding for an imunogenic major outer membrane protein
    • Vizcaino N., Cloeckaert A., Zygmunt M.S., Dubray G. Cloning, nucleotide sequence, and expression of the Brucella melitensis omp31 gene coding for an imunogenic major outer membrane protein. Infect. Immun. 64:1996;3744-3751.
    • (1996) Infect. Immun. , vol.64 , pp. 3744-3751
    • Vizcaino, N.1    Cloeckaert, A.2    Zygmunt, M.S.3    Dubray, G.4
  • 44
    • 0030453147 scopus 로고    scopus 로고
    • Improving protein delivery from microparticles using blends of poly(DL lactide co-glycolide) and poly(ethylene oxide)-poly(propylene oxide) copolymers
    • Yeh M.K., Davis S.S., Coombes A.G.A. Improving protein delivery from microparticles using blends of poly(DL lactide co-glycolide) and poly(ethylene oxide)-poly(propylene oxide) copolymers. Pharm. Res. 13:1996;1693-1698.
    • (1996) Pharm. Res. , vol.13 , pp. 1693-1698
    • Yeh, M.K.1    Davis, S.S.2    Coombes, A.G.A.3
  • 45
    • 0037151317 scopus 로고    scopus 로고
    • Oral immunogenicity of the inactivated Vibrio cholerae whole-cell vaccine encapsulated in biodegradable microparticles
    • Yeh M.K., Liu Y.T., Chen J.L., Chiang C.H. Oral immunogenicity of the inactivated Vibrio cholerae whole-cell vaccine encapsulated in biodegradable microparticles. J Control. Release. 82:2002;237-247.
    • (2002) J Control. Release , vol.82 , pp. 237-247
    • Yeh, M.K.1    Liu, Y.T.2    Chen, J.L.3    Chiang, C.H.4
  • 46
    • 0028110815 scopus 로고
    • Brucella melitensis cell envelope protein and lipopolysaccharide epitopes involved in humoral immune responses of naturally and experimentally infected sheep
    • Zygmunt M.S., Cloeckaert A., Dubray G. Brucella melitensis cell envelope protein and lipopolysaccharide epitopes involved in humoral immune responses of naturally and experimentally infected sheep. J. Clin. Microbiol. 32:1994;2514-2522.
    • (1994) J. Clin. Microbiol. , vol.32 , pp. 2514-2522
    • Zygmunt, M.S.1    Cloeckaert, A.2    Dubray, G.3


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