A polysorbate-based non-ionic surfactant can modulate loading and release of β-lactoglobulin entrapped in multiphase poly(DL-lactide-co- glycolide) microspheres

Pharmaceutical Research

Volumn 16, Issue 2, 1999, Pages 255-260

  Rojas, Judith ^a   Pinto Alphandary, Huguette ^a   Leo, Eliana ^b   Pecquet, Sophie ^c   Couvreur, Patrick ^a   Gulik, Annette ^d   Fattal, Elias ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

^d CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

Author keywords

Biodegradable microspheres; Encapsulation; Poly(DL lactide co glycolide); Protein aggregation; Tween 20; lactoglobulin

Indexed keywords

BETA LACTOGLOBULIN; MICROSPHERE; POLYSORBATE 20; PROTEIN; SURFACTANT;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; EMULSION; ENCAPSULATION; FREEZE FRACTURE; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; VISCOSITY;

EID: 0033051381     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018880409254     Document Type: Article

References (24)

1. 1. D. Gilding and A. M. Reed. Biodegradable polymers for use in surgery polyglycolic/poly (lactic acid) homo and copolymers. Polymer. 20:14529-1464 (1979).
2. 2. S. J. Challacombe, D. Jeffrey, S. S. Davis, and D. T. O'Hagan. Enhanced secretory IgA and IgG antibody responses after oral immunization with biodegradable microparticles containing antigen. Immunology 76:164-168 (1992).
3. 3. M. J. Alonso, R. K. Gupta, C. Min, J. R. Siber, and R. Langer. Biodegradable microspheres as controlled-release tetanus toxoid delivery systems. Vaccine 12:299-306 (1994).
4. 4. K. Allaoui-Attarki, S. Pecquet, E. Fattal, E. Chachaty, P. Couvreur, and A. Andremont. Protective immunity against S. typhimurium elecited in mice by oral vaccination with phosphorylcholine encapsulated in poly(D, L-lactide-co-glycolide) microspheres. Infect. Immun. 65:853-857 (1997).
5. 5. Y. Ogawa, M. Yamamoto, H. Okada, T. Yashiki, and T. Shimamoto. A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly (lactic/glycolic) acid. Chem. Pharm. Bull. 36:1095-1103 (1988).
6. 6. M. Iwata and J. McGinity. Dissolution; stability and morphological properties of conventional and multiphase poly(DL-lactic-co-glycolic acid) microspheres containing water-soluble compounds. Pharm. Res. 10:8, 1219-1227 (1993).
7. 7. M. J. Blanco-Prieto, F. Delie, E. Fattal, A. Tartar, F. Puisieux, and P. Couvreur. Characterization of V3 BRU peptide-loaded small PLGA microparticles prepared by a (W/O/W) emulsion solvent evaporation method. Int. J. Pharm. 111:137-145 (1994).
8. 8. R. Alex and Bodmeier. Encapsulation of water soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on the drug entrapment. J. Microencapsul. 7:347-355 (1991).
9. 9. T. Heya, H. Okada, Y. Tanigawara, Y. Ogawa, and H. Toguchi. Effects of counteranion of TRH and loading amount on control of TRH release from copoly(dl-lactic/glycolic acid) microspheres prepared by an in water drying method. Int. J. Pharm. 69:69-75 (1991).
10. 10. H. Jeffery and R. Boldmeier. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharm. Res. 10:362-368 (1992).
11. 11. J. Herrmann and R. Boldmeier. Somatostatin containing biodegradable microspheres prepared by a modified solvent evaporation method based on W/O/W multiple emulsions. Int. J. Pharm. 126:129-138 (1995).
12. 12. H. Rafati, A. G. A. Coombes, J. Adler, J. Holland, and S. S. Davis. Protein-loaded poly(DL-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics. J. Contr. Rel. 43:89-102 (1997).
13. 13. E. Leo, S. Pecquet, J. Rojas, P. Couvreur, and E. Fattal. Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent method. J. Microencapsul. 15:421-430 (1998).
14. 14. C. N. Schugens, N. Laurelle, C. H. Nihant, C. H. Granfils, R. Jerome, and P. H. Teyssie. Effect of the emulsion stability on the morphology and porosity of semicrystalline poly L-lactide microparticles prepared by w/o/w double emulsion-evaporation. J. Contr. Rel. 32:161-176 (1994).
15. 15. M. J. Blanco-Prieto, E. Leo, F. Delie, A. Gulik, P. Couvreur, and E. Fattal. Study of the influence of several stabilizing agents on the entrapment and in vitro release of pBC 264 from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method. Pharm. Res. 13:1137-1139 (1996).
16. 16. M. J. Blanco-Prieto, E. Fattal, A. Gulik, J. C. Dedieu, B. Roques, and P. Couvreur. Characterization and morphological analysis of a cholecystokinin derivative peptide-loaded poly (lactide-co-glycolide) microsphere prepared by a water-in-oil-in water emulsion solvent evaporation method. J. Contr. Rel. 43:81-87 (1997).
17. 17. H. K. Sah, R. Toddywala, and Y. W. Chien. Biodegradable microcapsules prepared by a w/o/w technique: effects of shear force to make a primary w/o emulsion on their morphology and protein release. J. Microencapsul. 12:589-69 (1995).
18. 18. J. L. Courthaudon, E. Dickinson, Y. Matsumara, and D. C. Clark. Competitive adsorption of β-lactoglobulin + Tween 20 at the oil-water interface. Colloids Surf. 56:293-300 (1991).
19. 19. J. Chen and E. Dickinson. Protein/surfactant interfacial interactions Part 3. Competitive adsorption of protein + surfactant in emulsions. Colloids and Surfaces A: Physicochemical and Engineering Aspect. 101:77-85 (1995).
20. 20. S. M. Hora, R. K. Rana, J. H. Nunberg, T. R. Tice, R. M. Gilley, and M. Hudson. Release of human serum albumin from poly(lactide-co-glycolide) microspheres. Pharm. Res. 7:1190-1194 (1990).
21. 21. Y. F. Maa and C. C. Hsu. Effect of primary emulsion stability on microsphere size and protein-loading in the double emulsion process. J. Microencapsul. 14:225-241 (1997).
22. 22. N. Nihant, C. H. Schugens, C. Grandfils, R. Jerome, and P. H. Teyssie. Polylactide microparticles prepared by double emulsion/ evaporation technique. I. Effect of primary emulsion stability. Pharm. Res. 11:1479-1484 (1994).
23. 23. T. Verrecchia, P. Huve, M. Veillard, G. Spenlehauer, and P. Couvreur. Adsorption/desorption of human serum albumin at the surface of poly(lactic acid) nanoparticles prepared by a solvent evaporation process. J. Biomed. Materi. Res. 27:1019-1028 (1993).
24. 24. E. Dickinson and S. Hong. Surface coverage of β-lactoglobulin at the oil-water interface: influence of protein heat treatment and various emulsifiers. J. Agric. Food Chem. 42:1602-1606 (1994).