Optimization of the encapsulation and release of β-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres

International Journal of Pharmaceutics

Volumn 183, Issue 1, 1999, Pages 67-71

  Rojas, Judith ^a   Pinto Alphandary, Huguette ^a   Leo, Eliana ^b   Pecquet, Sophie ^c   Couvreur, Patrick ^a   Fattal, Elias ^a  

^a UNIV PARIS SUD   (France)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Lactoglobulin; Biodegradable microspheres; Encapsulation; Poly(DL lactide co glycolide); Release kinetic; Tween 20

Indexed keywords

BETA LACTOGLOBULIN; MICROSPHERE; POLYGLACTIN; POLYSORBATE 20;

CONFERENCE PAPER; DRUG RELEASE; DRUG SOLUBILITY; EMULSION; ENCAPSULATION; EVAPORATION; PH; PRIORITY JOURNAL;

HYDROGEN-ION CONCENTRATION; LACTIC ACID; LACTOGLOBULINS; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS;

EID: 0033030477     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00046-0     Document Type: Conference Paper

References (5)

1. Blanco-Prieto M.J., Leo E., Delie F., Gulik A., Couvreur P., Fattal E. Study of the influence of several stabilizing agents on the entrapment and in vitro release of pBC 264 from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method. Pharm. Res. 13:1996;1137-1139.
2. Couvreur P., Blanco-Prieto M.J., Puisieux F., Roques B., Fattal E. Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides. Adv. Drug Deliv. Rev. 28:1997;85-96.
3. Hora S.M., Rana R.K., Nunberg J.H., Tice T.R., Gilley R.M., Hudson M.E. Release of human serum albumin from poly(lactide-co-glycolide) microspheres. Pharm. Res. 7:1990;1190-1194.
4. Leo E., Pecquet S., Rojas J., Couvreur P., Fattal E. Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent method. J. Microencapsulation. 15(4):1998;421-430.
5. Rojas J., Pinto-Alphandary H., Gulik A., Leo E., Pecquet S., Couvrer P., Fattel E. A polysorbate-based non ionic surfactant can modulate loading and release of β-lactoglobulin entrapped in multiphase poly(DL-lactide-co-glycolide) microspheres. Pharm. Res. 16:1999;255-260.