Subsets of CD8+ T cells in longterm asymptomatic vertically HIV-1 infected children;Subpoblaciones de células T CD8+ en niños asintomá ticos infectados verticalmente por el VIH-1

Medicina Clinica

Volumn 122, Issue 1, 2004, Pages 6-11

  Resino, Salvador ^a   Bellón, José M ^a   Pérez, Alicia ^a   Gurbindo Gutiérrez, M Dolores ^a   Muñoz Fernández, M Angeles ^a  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

CD8+ T cell subsets; Children; HIV 1; Non progression

Indexed keywords

CD28 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN;

ADOLESCENT; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; EFFECTOR CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; SCHOOL CHILD; SYMPTOMATOLOGY; T LYMPHOCYTE;

EID: 1142274607     PISSN: 00257753     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0025-7753(04)74125-1     Document Type: Article

References (52)

1. Italian Register HIVc. Features of children perinatally infected with HIV-1 surviving longer than 5 years. Lancet 1994;343:191-5.
2. Resino S, Gurbindo M, Bellón J, Sánchez-Ramón S, Muñoz-Fernández M. Predictive markers of clinical outcome in vertically HIV-1 infected infants. A prospective longitudinal study. Pediatr Res 2000;47:509-15.
3. Nielsen K, McSherry G, Petru A, Frederick T, Wara D, Bryson Y, et al. A descriptive survey of pediatric human immunodeficiency virus-infected long-term survivors. Pediatrics 1997;99:E4.
4. Resino S, Bellón J, Jiménez JL, Gurbindo D, Muñoz-Fernández MA. Papel de las citocinas y las quimiocinas en la no-progresión de la infección por el VIH-1 en niños infectados verticalmente. Med Clin (Barc) 2000;114:641-6.
5. Pantaleo G, Menzo S, Vaccarezza M, Graziosi C, Cohen OJ, Demarest JF, et. al. Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med 1995;332:209-16.
6. Cao Y, Qin L, Zhang L, Safrit J, Ho DD. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type I infection. N Engl J Med 1995;332:201-8.
7. Propato A, Schiaffella E, Vicenzi E, Francavilla V, Baloni L, Paroli M, et al. Spreading of HIV-specific CD8(+) T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum Immunol 2001;62: 561-76.
8. Akbar AN, Terry L, Timms A, Beverley PC, Janossy G. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol 1988;140:2171-8.
9. Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, et. al. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 1997;186: 1407-18.
10. Resino S, Abad M, Bellón JM, Gurbindo M, León J, Muñoz-Fernández MA. Variación del perfil inmunológico en función de la progresión de la infección por el virus de la inmunodeficiencia humana en niños tratados con terapia antirretroviral. Med Clin (Barc) 2002;118:241-6.
11. Bouscarat F, Levacher-Clergeot M, Dazza MC, Strauss KW, Girard PM, Ruggeri C, et al. Correlation of CD8 lymphocyte activation with cellular viremia and plasma HIV RNA levels in asymptomatic patients infected by human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 1996;12:17-24.
12. Roederer M, Dubs JG, Anderson MT, Raju PA, Herzenberg LA. CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest 1995;95:2061-6.
13. Rabin RL, Roederer M, Maldonado Y, Petru A, Herzenberg LA. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J Clin Invest 1995;95:2054-60.
14. Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations. J Infect Dis 1994;169:730-8.
15. Benito JM, Zabay JM, Gil J, Bermejo M, Escudero A, Sánchez E, et al. Quantitative alterations of the functionally distinct subsets of CD4 and CD8 T lymphocytes in asymptomatic HIV infection: changes in the expression of CD45RO, CD45RA, CD11b, CD38, HLA-DR, and CD25 antigens. J Acquir Immune Defic Syndr Hum Retrovirol 1997;14:128-35.
16. González-Nicolás J, Resino S, Jiménez JL, Alvarez S, Fresno M, Muñoz-Fernández MA. Tumor necrosis factor-alpha and nitric oxide in vertically HIV-1-infected children: implications for pathogenesis. Eur Cytokine Netw 2001;12:437-44.
17. Borthwick NJ, Bofill M, Gombert WM, Akbar AN, Medina E, Sagawa K, et al. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28-T cells. Clin Immunol Immunopathol 1994;71:2-7.
18. Plaeger-Marshall S, Isacescu V, O'Rourke S, Bertolli J, Bryson YJ, Stiehm ER. T cell activation in pediatric AIDS pathogenesis: three-color immunophenotyping. Clin Immunol Immunopathol 1994;71:27-32.
19. De Martino M, Rossi ME, Azzari C, Gelli MG, Galli L, Vierucci A. Different meaning of CD38 molecule expression on CD4+ and CD8+ cells of children perinatally infected with human immunodeficiency virus type 1 infection surviving longer than five years. Pediatr Res 1998;43:752-8.
20. McCloskey TW, Kohn N, Lesser M, Bakshi S, Pahwa S. Immunophenotypic analysis of HIV-infected children: Alterations within the first year of life, changes with disease progression, and longitudinal analyses of lymphocyte subsets. Cytometry 2001;46:157-65.
21. Muñoz-Fernández MA, Obregón E, Navarro J, Borner C, Gurbindo MD, Sampelayo TH, et al. Relationship of virologic, immunologic, and clinical parameters in infants with vertically acquired human immunodeficiency virus type 1 infection. Pediatr Res 1996;40:597-602.
22. Resino S, Correa R, Bellón JM, Muñoz-Fernández MA. Preserved Immune System in long-term asymptomatic vertically HIV-1 infected children. Clin Exp Immunol 2003;132:105-12.
23. Wolthers KC, Schuitemaker HFM. Rapid CD4+ T-cell turnover in HIV-1 infection: a paradigm revisted. Immunol Today 1998;19:44-8.
24. Clerici M, Stocks NI, Zajac RA, Boswell RN, Lucey DR, Via CS, et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging. J Clin Invest 1989;84: 1892-9.
25. Nicholson J, Kidd P, Mandy F, Livnat D, Kagan J. Three-color supplement to the NIAID DAIDS guideline for flow cytometric immunophenotyping. Cytometry 1996;26:227-30.
26. Navarro J, Resino S, Bellón JM, Abad M, Gurbindo MD, Fernández-Cruz E, et al. Association of CD8+ T lymphocyte subsets with the most commonly used markers to monitor HIV-1 infection in children treated with highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2001;17:525-32.
27. Nicholson JK, Hubbard M, Jones BM. Use of CD45 fluorescence and side-scatter characteristics for gating lymphocytes when using the whole blood lysis procedure and flow cytometry. Cytometry 1996;26:16-21.
28. Resino S, Navarro J, Bellón JM, Gurbindo D, León JA, Muñoz-Fernández MA. Naïve and memory CD4+ T-cells and T-cell activation markers in HIV-1 infected children on HAART. Clin Exp Immunol 2001;125:266-73.
29. Schlesinger M, Peters V, Jiang JD, Roboz JP, Bekesi JG. Increased expression of activation markers on CD8 lymphocytes in children with human immunodeficiency virus-1 infection. Pediatr Res 1995;38:390-6.
30. Resino S, Correa R, Bellón J, Sánchez-Ramón S, Muñoz-Fernández M. Characterizing Immune Reconstitution after Long-Term HAART in Pediatric AIDS. AIDS Res Hum Retrovir 2002;18:1395-406.
31. Resino S, Bellón J, Gurbindo D, Ramos J, León J, Clemente J, et al. Reconstitución inmune en niños VIH-1 tras 2 años con terapia antirretroviral potente. Med Clin (Barc) 2002;118:601-4.
32. Mackall CL, Hakim FT, Gress RE. T-cell regeneration: all repertoires are not created equal. Immunol Today 1997;18:245-51.
33. Burke A, Anderson D, Benson W, Turnicky R, Mannan P, Liang YH, et al. Localization of human immunodeficiency virus 1 RNA in thymic tissues from asymptomatic drug addicts. Arch Pathol Lab Med 1995;119:36-41.
34. Resino S, Galán I, Bellón JM, Navarro M, León JA, Muñoz-Fernández MA. Characterising the immune system after long-term undetectable viral load in HIV-1-infected children. J Clin Immunol 2003;23:279-89.
35. Correa R, Muñoz-Fernández MA. Effect of HAART on thymic reconstitution of CD4 T lymphocytes in vertically HIV-infected children. AIDS 2002;16:1181-3.
36. Jackson DG, Bell JI. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J Immunol 1990;144:2811-5.
37. Giorgi JV, Hultin LE, McKeating JA, Johnson TD, Owens B, Jacobson LP, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999;179:859-70.
38. Burgisser P, Hammann C, Kaufmann D, Battegay M, Rutschmann OT. Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment. The Swiss HIV Cohort Study. Clin Exp Immunol 1999;115:458-63.
39. Dianzani U, Funaro A, DiFranco D, Garbarino G, Bragardo M, Redoglia V, et al. Interaction between endothelium and CD4+CD45RA+ lymphocytes. Role of the human CD38 molecule. J Immunol 1994;153:952-9.
40. Tussey L, Speller S, Gallimore A, Vessey R. Functionally distinct CD8+ memory T cell subsets in persistent EBV infection are differentiated by migratory receptor expression. Eur J Immunol 2000;30:1823-9.
41. Cyster JG, Goodnow CC. Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords. J Exp Med 1995;182:581-6.
42. Randolph DA, Huang G, Carruthers CJ, Bromley LE, Chaplin DD. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo. Science 1999;286:2159-62.
43. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401:708-12.
44. Weninger W, Crowley MA, Manjunath N, Von Andrian UH. Migratory properties of naive, effector, and memory CD8(+) T cells. J Exp Med 2001;194:953-66.
45. Levy JA. Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 1993;57: 183-289.
46. Caruso A, Licenziati S, Canaris AD, Cantalamessa A, Fiorentini S, Ausenda S, et al. Contribution of CD4+, CD8+CD28+, and CD8+CD28- T cells to CD3+ lymphocyte homeostasis during the natural course of HIV-1 infection. J Clin Invest 1998;101:137-44.
47. Zanussi S, Simonelli C, D'Andrea M, Caffau C, Clerici M, Tirelli U, et al. CD8+ lymphocyte phenotype and cytokine production in long-term non-progressor and in progressor patients with HIV-1 infection. Clin Exp Immunol 1996;105:220-4.
48. Resino S, Navarro J, Bellón JM, Gurbindo D, León JA, Muñoz-Fernández MA. Asociación de subpoblaciones linfocitarias T con marcadores pronósticos de la infección pediátrica por el VIH. Med Clin (Barc) 2001;117:201-16.
49. Caruso A, Fiorentini S, Licenziati S, Alessandri G, Ricotta D, Imberti L, et al. Expansion of rare CD8+ CD28- CD11b- T cells with impaired effector functions in HIV-1-infected patients. J Acquir Immune Defic Syndr 2000;24:465-74.
50. Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002;8:379-85.
51. Wang EC, Lehner PJ, Graham S, Borysiewicz LK. CD8high (CD57+) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein-Barr virus-transformed B cell lines. Eur J Immunol 1994; 24:2903-9.
52. Azuma M, Cayabyab M, Phillips JH, Lanier LL. Requirements for CD28-dependent T cell-mediated cytotoxicity. J Immunol 1993;150:2091-101.