No defect in T-cell priming, secondary response, or tolerance induction in response to inhaled antigens in Fms-like tyrosine kinase 3 ligand-deficient mice

Journal of Allergy and Clinical Immunology

Volumn 115, Issue 1, 2005, Pages 192-199

  Walzer, Thierry ^a   Brawand, Pierre ^a   Swart, David ^a   Tocker, Joel ^a   De Smedt, Thibaut ^a,b  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

Dendritic cells; inflammation; knock out; lung; tolerance

Indexed keywords

ANTIGEN; VASCULOTROPIN RECEPTOR 3;

AIRWAY; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CELL COUNT; CELL SUBPOPULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; KNOCKOUT MOUSE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL;

ADMINISTRATION, INHALATION; ALLERGENS; ANIMALS; ANTIGEN PRESENTATION; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; HYPERSENSITIVITY; IMMUNE TOLERANCE; LUNG; LYMPHOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; RESPIRATORY SYSTEM; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 11344290647     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.08.046     Document Type: Article

References (33)

1. R.M. Steinman The dendritic cell system and its role in immunogenicity Annu Rev Immunol 9 1991 271 296
2. J. Banchereau, F. Briere, C. Caux, J. Davoust, S. Lebecque, and Y.J. Liu Immunobiology of dendritic cells Annu Rev Immunol 18 2000 767 811
3. K. Shortman, and Y.J. Liu Mouse and human dendritic cell subtypes Nat Rev Immunol 2 2002 151 161
4. R.M. Steinman, and M.C. Nussenzweig Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance Proc Natl Acad Sci U S A 99 2002 351 358
5. M. Gilliet, and Y.J. Liu Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells Hum Immunol 63 2002 1149 1155
6. C.A. Herrick, and K. Bottomly To respond or not to respond: T cells in allergic asthma Nat Rev Immunol 3 2003 405 412
7. B.N. Lambrecht, B. Salomon, D. Klatzmann, and R.A. Pauwels Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice J Immunol 160 1998 4090 4097
8. B.N. Lambrecht, M. De Veerman, A.J. Coyle, J.C. Gutierrez-Ramos, K. Thielemans, and R.A. Pauwels Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation J Clin Invest 106 2000 551 559
9. O. Akbari, R.H. DeKruyff, and D.T. Umetsu Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen Nat Immunol 2 2001 725 731
10. B.N. Lambrecht, and H. Hammad Taking our breath away: dendritic cells in the pathogenesis of asthma Nat Rev Immunol 3 2003 994 1003
11. M.A. Schon-Hegrad, J. Oliver, P.G. McMenamin, and P.G. Holt Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways J Exp Med 173 1991 1345 1356
12. E. Maraskovsky, K. Brasel, M. Teepe, E.R. Roux, S.D. Lyman, and K. Shortman Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified J Exp Med 184 1996 1953 1962
13. P. Bjorck Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice Blood 98 2001 3520 3526
14. K. Brasel, T. De Smedt, J.L. Smith, and C.R. Maliszewski Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures Blood 96 2000 3029 3039
15. H.J. McKenna, K.L. Stocking, R.E. Miller, K. Brasel, T. De Smedt, and E. Maraskovsky Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells Blood 95 2000 3489 3497
16. P. Brawand, D.R. Fitzpatrick, B.W. Greenfield, K. Brasel, C.R. Maliszewski, and T. De Smedt Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs J Immunol 169 2002 6711 6719
17. M.J. Barnden, J. Allison, W.R. Heath, and F.R. Carbone Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements Immunol Cell Biol 76 1998 34 40
18. L.S. van Rijt, J.B. Prins, P.J. Leenen, K. Thielemans, V.C. de Vries, and H.C. Hoogsteden Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in a mouse model of asthma Blood 100 2002 3663 3671
19. K.Y. Vermaelen, I. Carro-Muino, B.N. Lambrecht, and R.A. Pauwels Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes J Exp Med 193 2001 51 60
20. B. Leon, G. Martinez del Hoyo, V. Parrillas, H.H. Vargas, P. Sanchez-Mateos, and N. Longo Dendritic cell differentiation potential of mouse monocytes: monocytes represent immediate precursors of CD8- and CD8+ splenic dendritic cells Blood 103 2004 2668 2676
21. J.C. Huh, D.H. Strickland, F.L. Jahnsen, D.J. Turner, J.A. Thomas, and S. Napoli Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma J Exp Med 198 2003 19 30
22. B.N. Lambrecht, I. Carro-Muino, K. Vermaelen, and R.A. Pauwels Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats Am J Respir Cell Mol Biol 20 1999 1165 1174
23. K. Vermaelen, and R. Pauwels Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma Am J Respir Cell Mol Biol 29 2003 405 409
24. N. Yamashita, H. Tashimo, H. Ishida, F. Kaneko, J. Nakano, and H. Kato Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF) Cell Immunol 219 2002 92 97
25. H. Hammad, B.N. Lambrecht, P. Pochard, P. Gosset, P. Marquillies, and A.B. Tonnel Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7 J Immunol 169 2002 1524 1534
26. A.A. Itano, S.J. McSorley, R.L. Reinhardt, B.D. Ehst, E. Ingulli, and A.Y. Rudensky Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity Immunity 19 2003 47 57
27. D.A. Wolvers, C.J. Coenen-de Roo, R.E. Mebius, M.J. van der Cammen, F. Tirion, and A.M. Miltenburg Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: studies with OVA and human cartilage gp-39 J Immunol 162 1999 1994 1998
28. O. Akbari, G.J. Freeman, E.H. Meyer, E.A. Greenfield, T.T. Chang, and A.H. Sharpe Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity Nat Med 8 2002 1024 1032
29. M.B. Lutz, and G. Schuler Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 23 2002 445 449
30. B. Pulendran, J.L. Smith, M. Jenkins, M. Schoenborn, E. Maraskovsky, and C.R. Maliszewski Prevention of peripheral tolerance by a dendritic cell growth factor: flt3 ligand as an adjuvant J Exp Med 188 1998 2075 2082
31. J.L. Viney, A.M. Mowat, J.M. O'Malley, E. Williamson, and N.A. Fanger Expanding dendritic cells in vivo enhances the induction of oral tolerance J Immunol 160 1998 5815 5825
32. J.H. Edwan, G. Perry, J.E. Talmadge, and D.K. Agrawal Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation J Immunol 172 2004 5016 5023
33. E. Williamson, G.M. Westrich, and J.L. Viney Modulating dendritic cells to optimize mucosal immunization protocols J Immunol 163 1999 3668 3675