Endogenous glucocorticoids modulate neutrophil function in a murine model of haemolytic uraemic syndrome

Clinical and Experimental Immunology

Volumn 139, Issue 1, 2005, Pages 65-73

  Gomez S A ^a,b   Fernandez G C ^a,b   Camerano, G ^a   Dran, G ^a   Rosa, F A ^a,b   Barrionuevo, P ^a,b   Isturiz, M A ^a,b   Palermo, M S ^a,b,c  

^a ACADEMIA NACIONAL DE MEDICINA   (Argentina)

^b CONICET ^*  (Argentina)

^c INST DE INVEST HEMATOLOGICAS   (Argentina)

Author keywords

Glucocorticoids; HUS; Inflammatory response; Neutrophils; Stx2

Indexed keywords

BOVINE SERUM ALBUMIN; COLLAGEN TYPE 1; FIBRINOGEN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLUCOCORTICOID; MIFEPRISTONE; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; VEROTOXIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ESCHERICHIA COLI; HEMOLYTIC UREMIC SYNDROME; IN VITRO STUDY; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE FUNCTION; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; STEROIDOGENESIS;

ANIMALS; APOPTOSIS; CELL ADHESION; CELL MIGRATION INHIBITION; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; FIBRINOGEN; GLUCOCORTICOIDS; HEMOLYTIC-UREMIC SYNDROME; HORMONE ANTAGONISTS; LEUKOCYTE COUNT; MALE; MICE; MICE, INBRED BALB C; MIFEPRISTONE; NEUTROPHILS; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; RECEPTORS, GLUCOCORTICOID; SERUM ALBUMIN, BOVINE; SHIGA-LIKE TOXIN II; TETRADECANOYLPHORBOL ACETATE;

EID: 11244310595     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02659.x     Document Type: Article

References (43)

1. Paton JC, Paton AW. Pathogenesis and diagnosis of shiga toxin-producing Escherichia coli. Clin Microbiol Rev 1998; 11: 450-79.
2. Proulx F, Seidman EG, Karpman D. Pathogenesis of Shiga toxin-associated hemolytic uremic syndrome. Pediatr Res 2001; 50:163-71.
3. Walters MD, Matthei IU, Kay R, Dillon MJ, Barratt TM. The polymorphonuclear leucocyte count in childhood haemolytic uraemic syndrome. Pediatr Nephrol 1989; 3:130-4.
4. Fitzpatrick MM, Shah V, Filler G, Dillon MJ, Barratt TM. Neutrophil activation in the haemolytic uraemic syndrome: free and complexed elastase in plasma. Pediatr Nephrol 1992; 6:50-3.
5. Forsyth KD, Simpson AC, Fitzpatrick MM, Barrat TM, Levinsky RJ. Neutrophil mediated endothelial injury in haemolytic uraemic syndrome. Lancet 1989; 2:411-4.
6. Salkowski CA, Vogel SN. Lipopolysaccharide increases glucocorticoid receptor expression in murine macrophages. A possible mechanism for glucocorticoid-mediated suppression of endotoxicity. J Immunol 1992; 149:4041-7.
7. Gómez S, Fernández GC, Vanzulli S, Dran G, Rubel CJ, Berki T, Isturiz MA, Palermo MS. Endogenous glucocorticoids attenuate Shiga toxin-2 induced toxicity in a mouse model of Hemolytic Uremic Syndrome. Clin Exp Immunol 2003; 133:200-7.
8. Blalock EJ. The syntax of immune-neuroendocrine communication. Immunol Today 1985; 15:504-11.
9. Baybutt HN, Holsboer NJ. Inhibition of macrophage differentiation and function by cortisol. Endocrinology 1990; 127:476-80.
10. Goulding NJ, Euzger HS, Butt SK, Perretti M. Novel pathways for glucocorticoid effects on neutrophils in chronic inflammation. Inflamm Res 1998; 47:S158-S165.
11. Duner KI. A new kinetic single stage Limulus amoebocyte lysate method for the detection of endotoxin in water and plasma. J Biochem Biophys Meth 1993; 26:131-42.
12. Fernández GC, Rubel C, Dran G, Gomez S, Isturiz MA, Palermo MS. Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome. Clin Immunol 2000; 95:227-34.
13. Sheridan PL, Evans RM, Horwitz KB. Phosphotryptic peptide analysis of human progesterone receptor. New phosphorylated sites formed in nuclei after hormone treatment. J Biol Chem 1989; 264:6520-8.
14. Leech M, Hutchinson P, Holdsworth SR, Morand EF. Endogenous glucocorticoids modulate neutrophil migration and synovial P-selectin but not neutrophil phagocytic or oxidative function in experimental arthritis. Clin Exp Immunol 1998; 112:383-8.
15. Yazawa H, Kato T, Nakada T, Sendo F. Glucocorticoid hormone suppression of human neutrophil-mediated tumor cell cytostasis. Int J Cancer 1999; 81:74-80.
16. Coligan J, Knisblek A, Margulies D, Shevach E, Warren S, eds. In vitro assays for mouse lymphocyte function. In: Coligan J, Knisblek A, Margulies D et al., eds. Current Protocols in Immunology, National Institute of Health, USA. New York: Wiley & Sons, Inc., 1994: 3.20.3-4.
17. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Meth 1991; 139:271-9.
18. Garnotel R, Monboisse JC, Randoux A, Haye B, Borel JP. The binding of type I collagen to lymphocyte function-associated antigen (LFA) 1 integrin triggers the respiratory burst of human polymorphonuclear neutrophils. Role of calcium signaling and tyrosine phosphorylation of LFA 1. J Biol Chem 1995; 270:27495-503.
19. Betsuyaku T, Liu F, Senior RM, Haug JS, Brown EJ, Jones SL, Matsushima K, Link DC. A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation. J Clin Invest 1999; 103:825-32.
20. Lundgren-Akerlund E, Olofsson AM, Berger E, Arfors KE. CD11b/ Cd18-dependent polymorphonuclear leucocyte interaction with matrix proteins in adhesion and migration. Scan J Immunol 1993; 37:569-74.
21. Vaday GG, Lider O. Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behaviour and inflammation. J Leukoc Biol 2000; 67:149-59.
22. Kreis C, La Fleur M, Menard C, Paquin R, Beaulieu AD. Thrombospondin and fibronectin are synthesized by neutrophils in human inflammatory joint disease and in a rabbit model of in vivo neutrophil activation. J Immunol 1989; 143:1961-8.
23. Frieser M, Hallmann R, Johansson S, Vestweber D, Goodman SL, Sorokin L. Mouse polymorphonuclear granulocyte binding to extracellular matrix molecules involves beta 1 integrins. Eur J Immunol 1996; 26:3127-36.
24. Nakagawa M, Terashima T, Dýachkova Bondy GP, Hogg JC, van Eeden SF. Glucocorticoid-induced granulocytosis. Contribution of marrow release and demargination of intravascular granulocytes. Circulation 1998; 98:2307-13.
25. Lagasse E, Weissman IL. bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med 1994; 179:1047-52.
26. Condino-Neto A, Whitney C, Newburger PE. Dexamethasone but not indomethacin inhibits human phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity by down-regulating expression of genes encoding oxidase components. J Immunol 1998; 161:4960-7.
27. Turi S, Nemeth I, Vargha I, Matkovics B. Oxidative damage of red blood cells in haemolytic uraemic syndrome. Pediatr Nephrol 1994; 8:26-9.
28. Dandona P, Mohanty P, Hamouda W, Aljada A, Kumbkarni Y, Garg R. Effect of dexamethasone on reactive oxygen species generation by leukocytes and plasma interleukin-10 concentrations: a pharmacodynamic study. Clin Pharmacol Ther 1999; 66:58-65.
29. King AJ, Sundaram S, Cendoroglo M, Acheson DWK, Keusch GT. Shiga toxin induces superoxide production in polymorphonuclear cells with subsequent impairment of phagocytosis and responsiveness to phorbol esters. J Infect Dis 1999; 179:503-7.
30. Wagner JG, Roth RA. Neutrophil migration during endotoxemia. J Leukoc Biol 1999; 66:10-24.
31. Oishi K, Machida K. Inhibition of neutrophil apoptosis by antioxidants in culture medium. Scand J Immunol 1997; 45:21-7.
32. Hart SP, Ross JA, Ross K, Haslett C, Dransfield I. Molecular characterisation of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes. Cell Death Differ 2000; 7:493-503.
33. Sixt M, Hallmann R, Wendler O, Scharffetter-Kochanek K, Sorokin LM. Cell adhesion and migration properties of beta 2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. J Biol Chem 2001; 276:18878-87.
34. Werr J, Xie X, Hedqvist P, Ruoslahti E, Lindbom L. Integrins are critically involved in neutrophil locomotion in extravascular tissue in vivo. J Exp Med 1998; 187:2091-6.
35. Karpman D, Papadopoulou D, Nilsson K, Sjogren AC, Mikaelsson C, Lethagen S. Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome. Blood 2001; 97:3100-8.
36. van de Kar NC, van Hinsbergh VW, Brommer EJ, Monnens LA. The fibrinolytic system in the hemolytic uremic syndrome: in vivo and in vitro studies. Pediatr Res 1994; 36:257-64.
37. Mori S, Heldin CH, Claesson-Welsh L. Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling. J Biol Chem 1993; 268:577-83.
38. Werr J, Johansson J, Erksson EE, Hedqvist P, Ruoslahti E, Lindbom L. Integrin α2β1 (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue. Blood 2000; 95:1804-9.
39. Salamone G, Giordano M, Trevani AS, Gamberale R, Vermeulen M, Schettinni J, Geffner JR. Promotion of neutrophil apoptosis by TNF-alpha. J Immunol 2001; 166:3476-83.
40. Liu J, Akahoshi T, Sasahana T, Kitasato H, Namai R, Sasaki T, Inoue M, Kondo H. Inhibition of neutrophils apoptosis by verotoxin 2 derived from Escherichia coli O157:H7. Infect Immun 1999; 67:6203-5.
41. Liu J, He T, He Y, Zhang Z, Akahoshi T, Kondo H, Zhong S. Prolongation of functional life-span of neutrophils by recombinant verotoxin 2. Chin Med J (Engl) 2002; 115:900-3.
42. Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann G. A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1992; 89:9991-5.
43. Keusch GT, Acheson WK, Aaldering L, Erban J, Jacewicz MS. Comparison of the effects of Shiga-like toxin 1 on cytokine- and butyrate-treated Human Umbilical and Saphenous Vein Endothelial Cells. J Infect Dis 1996; 173:1164-70.