Integrin α2β1 (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue

Blood

Volumn 95, Issue 5, 2000, Pages 1804-1809

  Werr, Joachim ^b   Johansson, Joakim ^b   Eriksson, Einar E ^b   Hedqvist, Per ^b   Ruoslahti, Erkki ^b   Lindbom, Lennart ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CHEMOATTRACTANT; COLLAGEN GEL; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTEGRIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EXTRAVASCULAR SPACE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE MOTILITY; MOLECULAR DYNAMICS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0034161512     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.5.1804.005k11_1804_1809     Document Type: Article

References (21)

1. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301.
2. Downey GP. Mechanisms of leukocyte motility and chemotaxis. Curr Opin Immunol. 1994;6:113.
3. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood. 1994;84:2068.
4. Hemler ME. VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol. 1990;8:365.
5. Kubes P, Niu XF, Smith CW, Kehrli ME Jr, Reinhardt PH, Woodman RC. A novel beta 1-dependent adhesion pathway on neutrophils: a mechanism invoked by dihydrocytochalasin B or endothelial transmigration. FASEB J. 1995;9:1103.
6. 4 integrin. Circ Res. 1997;81:196.
7. 1 Integrins are critically involved in neutrophil locomotion in extravascular tissue in vivo. J Exp Med. 1998;187:2091.
8. Bohnsack JF, Zhou XN. Divalent cation substitution reveals CD18- and very late antigen-dependent pathways that mediate human neutrophil adherence to fibronectin. J Immunol. 1992;149:1340.
9. Staatz WD, Fok KF, Zutter MM, Adams SP, Rodriguez BA, Santoro SA. Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen. J Biol Chem. 1991;266:7363.
10. Koivunen E, Gay DA, Ruoslahti E. Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library. J Biol Chem. 1993;268:20,205.
11. Raud J, Hallden G, Roquet A, et al. Anti-IgE-induced accumulation of leukocytes, mediators, and albumin in skin chamber fluid from healthy and atopic subjects. J Allergy Clin Immun. 1995;97:1151.
12. Lawson MA, Maxfield FR. Ca(2+)- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature. 1995;377:75.
13. Wilkinson PC. How do leukocytes perceive chemical gradients? FEMS Microbiol Immunol. 1990;2:303.
14. Salcedo R, Wasserman K, Patarroyo M. Endogenous fibronectin of blood polymorphonuclear leukocytes: stimulus-induced secretion and proteolysis by cell surface-bound elastase. Exp Cell Res. 1997;233:33.
15. Kuntz RM, Saltzman WM. Neutrophil motility in extracellular matrix gels: mesh size and adhesion affect speed of migration. Biophys J. 1997;72:1472.
16. Bretscher MS. Circulating integrins: alpha 5 beta 1, alpha 6 beta 4 and Mac-1, but not alpha 3 beta 1, alpha 4 beta 1 or LFA-1. EMBO J. 1992;11:405.
17. Huttenlocher A, Ginsberg MH, Horwitz AF. Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J Cell Biol. 1996;134:1551.
18. Weber C, Katayama J, Springer TA. Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils. Proc Natl Acad Sci U S A. 1996;93:10,939.
19. Masuyama J-I, Berman JS, Cruikshank WW, Morimoto C, Center DM. Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro. J Immunol. 1992;148:1367.
20. Friedl P, Noble PB, Zänker KS. T lymphocyte locomotion in a three-dimensional collagen matrix. Expression and function of cell adhesion molecules. J Immunol. 1995;154:4973.
21. Malawista SE, de Boisfleury Chevance A. Random locomotion and chemotaxis of human polymorphonuclear leukocytes (PMN) in the presence of EDTA: PMN in close quarters require neither leukocyte integrins nor external divalent cations. Proc Natl Acad Sci USA 1997;94:11,577.