Effect of dexamethasone on reactive oxygen species generation by leukocytes and plasma interleukin-10 concentrations: A pharmacodynamic study

Clinical Pharmacology and Therapeutics

Volumn 66, Issue 1, 1999, Pages 58-65

  Dandona, Paresh ^a,b   Mohanty, Priya ^a   Hamouda, Wael ^a   Aljada, Ahmad ^a   Kumbkarni, Yuvraj ^a   Garg, Rajesh ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; HYDROCORTISONE; INTERLEUKIN 10; REACTIVE OXYGEN METABOLITE;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG INHIBITION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE; MONONUCLEAR CELL; NEUTROPHIL; PRIORITY JOURNAL;

ADULT; ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; HUMANS; INTERLEUKIN-10; LEUKOCYTES; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; NEUTROPHILS; REACTIVE OXYGEN SPECIES; REFERENCE VALUES; VOLUNTARY WORKERS;

EID: 0032788408     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(99)70054-8     Document Type: Article

References (22)

1. 1. Cato AC, Wade E. Molecular mechanisms of anti-inflammatory action of glucocorticoids. Bioessays 1996;18:371-8.
2. 2. Schwiebert LA, Beck LA, Stellato C, Bickel CA, Bochner BS, Schleimer RP, et al. Glucocorticosteroid inhibition of cytokine production: relevance to antiallergic actions [published erratum appears in J Allergy Clin Immunol 1996 Sep;98:718]. J Allergy Clin Immunol 1996;97:143-52.
3. 3. Jevnikar AM, Singer GG, Brennan DC, Xu HW, Kelley VR. Dexamethasone prevents autoimmune nephritis and reduces renal expression of Ia but not costimulatory signals. Am J Pathol 1992;141:743-51.
4. 4. Sternberg EM, Chrousos GP, Wilder RL, Gold PW. The stress response and the regulation of inflammatory disease. Ann Intern Med 1992;117:854-66.
5. 5. Wilckens T. Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction. Trends Pharmacol Sci 1995;16:193-7.
6. 6. Umeki S, Soejima R. Hydrocortisone inhibits the respiratory burst oxidase from human neutrophils in whole cell and cell free systems. Biochim Biophys Acta 1990;1052:211-5.
7. 7. Roilides E, Uhlig K, Venzon D, Pizzo PA, Walsh TJ. Prevention of corticosteroid-induced suppression of human polymorphonuclear leukocyte-induced damage of Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon. Infect Immun 1993;61:4870-7.
8. 2 production by polymorphonuclear leukocytes of patients receiving corticosteroids. J Clin Lab Immunol 1990;33:117-23.
9. 9. Dandona P, Thusu K, Hafeez R, Abdel-Rahman E, Chaudhuri A. Effect of hydrocortisone on oxygen free radical generation by mononuclear cells. Metabolism 1998;47:788-91.
10. 10. Dandona P, Suri M, Hamouda W, Aljada A, Kumbkarni Y, Thusu K. Effect of hydrocortisone on reactive oxygen species generation by polymorphonuclear leucocytes (PMNL). Crit Care Med [in press].
11. 11. Mossman TR. Properties and functions of interleukin-10. Adv Immunol 1994;56:1-26.
12. 12. Howard M, O'Garra A. Biological properties of interleukin-10. Immunol Today 1992;13:198-200.
13. 2 cytokine response by (rat) CD4+ T cells in vitro. J Immunol 1996; 156:2406-12.
14. 14. Simpson KL, Keelan JA, Mitchell MD. Labor associated changes in interleukin-10 production and its regulation by immunomodulators in human choriodecidua. J Clin Endocrinol Metab 1998;83:4332-7.
15. 15. Dandona P, Thusu K, Cook S, Snyder B, Makowski J, Armstrong D, et al. Oxidative damage to dna in diabetes mellitus. Lancet 1996;347:444-5.
16. 16. Nicotera T, Thusu K, Dandona P. Elevated production of active oxygen in bloom's syndrome cell lines. Cancer Res 1993;53:5104-7.
17. 17. Tosi MF, Hamedani A. A rapid specific assay for super-oxide release from phagocytes in small volumes of whole blood. Am J Clin Pathol 1992;97:566-73.
18. 18. Hancock JT, Jones OT. The inhibition of diphenylene iodonium and its analogues of Superoxide generation by macrophages. Biochem J 1987;242:103-7.
19. 19. Ontjes DA. Adrenal corticosteroids, corticotropin releasing hormone, adrenocorticotropin and anti-adrenal drugs. In: Munson PL, Mueller RA, Breese GR, editors. Principles of pharmacology, basic concepts and clinical applications. New York: Chapman and Hall; 1995. p. 749-87.
20. k B transcription factors. Presented at the 79th Annual Meeting of the Endocrine Society, June 1997, San Francisco, California.
21. 21. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 1995;270:283-6.
22. 22. Barnes PJ, Karin M. Nuclear factor KB: a pivitol transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-71.