Benzodioxocin-3-ones and N-acyl-3-amino-3-buten-2-ones: Novel classes of cathepsin K cysteine protease inhibitors

Journal of Peptide Research

Volumn 63, Issue 3, 2004, Pages 265-269

  Yamashita, D S ^a   Xie, R ^a   Lin, H ^a   Wang, B ^a   Shi, S D H ^a   Quinn, C J ^a   Hemling, M E ^a   Hissong, C ^a   Tomaszek, T A ^a   Veber, D F ^a,b  

^a GLAXOSMITHKLINE   (United States)

^b NONE   (United States)

Author keywords

Benzodioxocin 3 one; Cathepsin K; Covalent adduct; Cysteine protease; Enzymology; Inhibitor enzyme complex; Irreversible; Mass spectrometry; Michael acceptor; N acyl 3 amino 3 buten 2 one; Papain; Time independent

Indexed keywords

ACETAL; CATHEPSIN K; CYSTEINE PROTEINASE INHIBITOR; KETONE DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COVALENT BOND; DRUG DESIGN; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TIME;

CATHEPSINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; KETONES; MOLECULAR STRUCTURE;

EID: 11144357589     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2004.00138.x     Document Type: Article

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