Characterization of the Binding Site for Inhibitors of the HPV11 E1-E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass Spectrometry

Analytical Chemistry

Volumn 76, Issue 7, 2004, Pages 2095-2102

  Davidson, Walter ^b   McGibbon, Graham A ^a,c   White, Peter W ^a   Yoakim, Christiane ^a   Hopkins, Jerry L ^b   Guse, Ingrid ^a   Hambly, David M ^a   Frego, Lee ^b   Ogilvie, William W ^a   Lavallée, Pierre ^a   Archambault, Jacques ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; CRYSTAL STRUCTURE; DERIVATIVES; ENZYME INHIBITION; MASS SPECTROMETRY; POLYPEPTIDES;

BINDING SITES;

PROTEINS;

BENZOPHENONE DERIVATIVE; CARBON; E1 HELICASE; E2 TRANSACTIVATION DOMAIN POLYPEPTIDE; GLUTAMIC ACID; HELICASE; INDAN 1,2 DIONE; INDANONE DERIVATIVE; LYSC PROTEINASE; METHIONINE; METHYL GROUP; POLYPEPTIDE; PROTEIN INHIBITOR; PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG; V8 PROTEINASE; VIRUS DNA; VIRUS PROTEIN; VIRUS PROTEIN E1; VIRUS PROTEIN E2;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DNA REPLICATION; GENE MUTATION; HUMAN PAPILLOMAVIRUS TYPE 11; HUMAN PAPILLOMAVIRUS TYPE 6; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PHOTOAFFINITY LABELING; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TRANSACTIVATION; TRANSACTIVATION DOMAIN; WART VIRUS;

ANTIVIRAL AGENTS; BENZOPHENONES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HUMANS; MASS SPECTROMETRY; PAPILLOMAVIRIDAE; PHOTOAFFINITY LABELS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TRANS-ACTIVATION (GENETICS); TRYPSIN; VIRAL PROTEINS;

EID: 11144357573     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac035335o     Document Type: Article

References (31)

1. Shah, K. V.; Howley, P. M. In Fields Virology, 3rd ed.; Fields, B. N., Knipe, D. M., Howley, P. M., Eds.; Lippincott-Raven Publishers: Philadelphia, 1996; pp 2077-2109.
2. Beutner, K. R.; Ferenczy, A. Am. J. Med. 1997, 102, 28-37.
3. Chiang, C. M.; Ustav, M.; Stenlund, A.; Ho, T. F.; Broker, T. R.; Chow, L. T. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 5799-5803.
4. Howley, P. M. In Fields Virology, 3rd ed.; Fields, B. N., Knipe, D. M., Howley, P. M., Eds.; Lippincott-Raven Publishers: Philadelphia, 1996; pp 2045-2076.
5. Sanders, C. M.; Stenlund, A. J. Biol. Chem. 2000, 275, 3522-3534.
6. Bonne-Andrea, C.; Santucci, S.; Clertant, P.; Tillier, F. J. Virol. 1995, 69, 2341-2350.
7. Phelps, W. C.; Barnes, J. A.; Lobe, D. C. Antiviral Chem. Chemother. 1998, 9, 359-377.
8. Bernard, H. U. Antiviral Ther. 2002, 7, 219-237.
9. Yoakim, C.; Ogilvie, W. W.; Goudreau, N.; Haché, B.; Naud, J.; O'Meara, J. A. Bioorg., Med. Chem. Lett. 2003, 13, 2539-2541.
10. White, P. W.; Pelletier, A.; Brault, K.; Titolo, S.; Wardrop, E.; Thauvette, L.; Fazekas, M.; Cordingley, M. G.; Archambault, J. J. Biol. Chem. 2001, 276, 22426-22438.
11. Titolo, S.; Pelletier, A.; Sauvé, F.; Brault, K.; Wardrop, E.; White, P. W.; Amin, A.; Cordingley, M. G.; Archambault, J. J. Virol. 1999, 73, 5282-5293.
12. White, P. W.; Titolo, S.; Brault, K.; Thauvette, L.; Pelletier, A.; Welchner, E.; Bourgon, L.; Doyon, L.; Ogilvie, W. W.; Yoakim, C.; Cordingley, M.; Archambault, J. J. Biol. Chem. 2003, 278, 26765-26772.
13. Yoakim, C.; Goudreau, N.; McGibbon, G. A.; O'Meara, J. A.; White, P.; Ogilvie, W. W. Helv. Chim. Acta 2003, 86, 3427-3444.
14. Hatanaka, Y.; Sadakane, Y. Curr. Top. Med. Chem. 2002, 2, 272-288.
15. Dormán, G.; Prestwich, G. D. Trends Biotechnol. 2000, 18, 64-77.
16. Fleming, S. A. Tetrahedron 1995, 51 12479-12520.
17. Brunner, J. Annu. Rev. Biochem. 1993, 62, 483-514.
18. Dormán, G.; Prestwich, G. D. Biochemistry 1994, 33, 5661-5673.
19. Brinegar, C. A.; Cooper, G.; Stevens, A.; Hauer, C. R.; Shabinowitz, J.; Hunt, D. F.; Fox, J. E. Proc. Natl. Acad. Sci. U.S.A. 1988, 85, 5927-5931.
20. Li, H.; Macdonald, D. M.; Hronowski, X.; Costello, C. E.; Leeman, S. E.; Boyd, N. D. J. Biol. Chem. 2001, 276, 10589-10593.
21. Borchers, C. H.; Hochleitner, E. O.; Tomer, K.; Neamati, N. Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics, 2002.
22. Borchers, C. H.; Boer, R.; Klemm, K.; Figala, V.; Witte, S.; Denzinger, T.; Ulrich, W. R; Hass, S.; Ise, W.; Gekeler, V.; Przybylski, M. Mol. Pharmacol. 2002, 61, 1366-1376.
23. Jensen, O. N.; Steen, H. Mass Spectrom. Rev. 2002, 21, 163-182.
24. Sachon, E.; Bolbach, G.; Chassaing, G.; Lavielle, S.; Sagan, S. J. Biol. Chem. 2002, 277, 50409-50414.
25. Last-Barney, K.; Davidson, W.; Cardozo, M.; Frye, L. L.; Grygon, C. A.; Hopkins, J. L.; Jeanfavre, D. D.; Pav, S.; Qian, C.; Stevenson, J. M.; Tong, L. ; Zindell, R.; Kelly, T. A. J. Am. Chem. Soc. 2001, 123, 5643-5650.
26. Emmett, M. R.; White, F. M.; Hendrickson, C. L.; Shi, D.-H. S.; Marshall, A. G. J. Am. Soc. Mass Spectrom. 1998, 9, 333-340.
27. Martin, S. E.; Shabinowitz, J.; Hunt, D. F.; Marto, J. A. Anal. Chem. 2000, 72, 4266-4274.
28. Stone, K. L.; Williams, K. R. In A Practical Guide to Protein and Peptide Purification and Microsequencing, 2nd ed.; Matsudaria, P., Ed.; Academic Press: San Diego, 1993; pp 45-69.
29. Harris, S. F.; Botchan, M. Science 1999, 284, 1673-1677.
30. Anston, A. A.; Burns, J. E.; Moroz., O. V.; Scott, D. J.; Sanders, C. M. ; Bronstein, I. B.; Dodson, G. G., Wilson, K. S.; Maitland, N. J. Nature 2000, 403, 805-809.
31. Sakai, H.; Toshiharu, Y.; Benson, J. D.; Dowhanick, J. J.; Howley, P. M. J. Virol. 1996, 70, 1602-1611.